Digital Commons Network^™

Integrated Molecular Pathway Analysis Informs A Synergistic Combination Therapy Targeting Pten/Pi3k And Egfr Pathways For Basal-Like Breast Cancer, Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. Van De Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons, Lao H. Saal

Markey Cancer Center Faculty Publications

Background: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling pathways driving basal-like tumorigenesis are not fully elucidated.

Methods: One hundred sixteen unselected breast tumors were subjected to integrated analysis of phosphoinositide 3-kinase (PI3K) pathway related molecular aberrations by immunohistochemistry, mutation analysis, and gene expression profiling. Incidence and relationships between molecular biomarkers were characterized. Findings for select biomarkers were validated in an independent series. Synergistic cell killing in vitro and in vivo tumor …

Elliott V. Young Appellant's Brief Dckt. 44068

Not Reported

No abstract provided.

Breeding Season Avian Community Composition And Prey Availability In Eucalyptus And Slash Pine Plantations Of Southwestern Louisiana, Elizabeth J. Messick

Electronic Theses and Dissertations

The increased demand for wood products related to industries such as bioenergy and paper has resulted in a need for a consistent supply of raw materials. Eucalyptus (Eucalyptus spp.) plantations have the potential to boost wood production for pulpwood and biomass feedstocks. Species characteristics such as rapid, indeterminate growth, coppice regrowth, resistance to disease and insects, and tolerance of a range of environmental conditions make these species successful short-rotation woody crops (SRWCs). Camden white gum (Eucalyptus benthamii), a more cold tolerant species, has made management of eucalyptus plantations viable in southern portions of the United States such …

Lactic Acid Bacteria And Their Use In Swine Direct-Fed Microbials, Mari-Ellen Davis, Joshua M. Rehberger, Charles Maxwell, Thomas G. Rehberger, Mike King

Patents Granted

TRFs useful for identifying strains of interest are provided. A method of identifying one or more strain that can be used as a direct-fed microbial is also provided. One or more strain identified by the method is additionally provided. A method is also provided for administering to an animal an effective amount of the one or more strain. Additionally provided is an isolated strain chosen from at least one of Lactobacillus acidophilus strain P1B c6 (NRRL B-50103), Lactobacillus salivarius strain o246e 33w (NRRL B-50102), Pediococcus acidilactici strain o246e 42 (NRRL B-50171), and Pediococcus acidilactici strain P1J e3 (NRRL B-50101). An …

Surveillance, Epidemiological, And Virological Detection Of Highly Pathogenic H5n1 Avian Influenza Viruses In Duck And Poultry From Bangladesh, Wahedul Karim Ansari, Md Safiullah Parvej, Mohamed E. El Zowalaty, Sally Jackson, Stephen A. Bustin, Adel K. Ibrahim, Md Tanvir Rahman, Han Zhang, Mohammad Ferdousur Rahman Khan, Md Mostakin Ahamd, Md. Fasiur Rahman, Marzia Rahman, Khm Nazmul H. Nazir, Sultan Ahmed, Md Liakot Hossenn, Md Abdul Kafi, Mat Yamage, Nitish C. Debnath, Graba Ahmed, Hossam Ashour, Md Masoud, Ayman Noreddin, Md B. Rahman

Pharmacy Faculty Articles and Research

Avian influenza viruses (AIVs) continue to pose a global threat. Waterfowl are the main reservoir and are responsible for the spillover of AIVs to other hosts. This study was conducted as part of routine surveillance activities in Bangladesh and it reports on the serological and molecular detection of H5N1 AIV subtype. A total of 2169 cloacal and 2191 oropharyngeal swabs as well as 1725 sera samples were collected from live birds including duck and chicken in different locations in Bangladesh between the years of 2013 and 2014. Samples were tested using virus isolation, serological tests and molecular methods of RT-PCR. …

Contributors, Marvels & Tales Editors

Marvels & Tales

No abstract provided.

Reviews, Marvels & Tales Editors

Marvels & Tales

Contes: Charles Perrault. Edited by Tony Gheeraert. Review by Charlotte Trinquet du Lys, University of Central Florida.

The Golden Age of Folk and Fairy Tales: From the Brothers Grimm to Andrew Lang. Edited by Jack Zipes. Review by Brittany Warman, The Ohio State University.

Long, Long Tales from the Russian North. Translated and edited by Jack V. Haney. Review by Jeana Jorgensen, Butler University.

Channeling Wonder: Fairy Tales on Television. Edited by Pauline Greenhill and Jill Terry Rudy. Review by Amanda Firestone, University of Tampa.

The Disney Middle Ages: A Fairy-Tale and Fantasy Past. Edited …

All Pbl Starts Here: The Problem, Woei Hung

Interdisciplinary Journal of Problem-Based Learning

One essential piece of implementing of PBL is the problem. There have been calls from practitioners in the PBL field for a systematic process for designing effective PBL problems. Yet, the research efforts to explore, develop, and test PBL problem design methods or processes are still sparse. From an instructional designer and researcher’s perspective, I deem problem design to be the first step to ensure not only the proper affordance of the learning goal but also the students’ overall learning process in PBL implementation. PBL problem design is the area I have studied most consistently and passionately. In this paper, …

Insects Have Agency But Probably Not Sentience Because They Lack Social Bonding, J. H. Van Hateren

Animal Sentience

Klein & Barron (2016) argue that insects have sentience because of functional similarities between the insect brain and vertebrate midbrain. Based on a recent theory of agency and consciousness, I argue that the functional similarities merely point to an advanced form of agency. Insects presumably lack the capacity for social bonding that may be required for subjective experiencing.

Optimization Of A Genomic Editing System Using Crispr/Cas9-Induced Site-Specific Gene Integration, Jillian L. Mccool Ms., Nick Hum, Gabriela G. Loots

STAR Program Research Presentations

The CRISPR-Cas system is an adaptive immune system found in bacteria which helps protect against the invasion of other microorganisms. This system induces double stranded breaks at precise genomic loci (1) in which repairs are initiated and insertions of a target are completed in the process. This mechanism can be used in eukaryotic cells in combination with sgRNAs (1) as a tool for genome editing. By using this CRISPR-Cas system, in addition to the “safe harbor locus,” ROSAβ26, the incorporation of a target gene into a site that is not susceptible to gene silencing effects can be achieved through few …

Reverse-Engineering The Brain: The Parts Are As Complex As The Whole., Jens G. Pohl

Collaborative Agent Design (CAD) Research Center

The purpose of this paper is to review the current state of neuroscience research with a focus on what has been achieved to date in unraveling the mysteries of brain operations, major research initiatives, fundamental challenges, and potentially realizable objectives. General research approaches aimed at constructing a wiring diagram of the brain (i.e., connectome), determining how the brain encodes and computes information, and whole brain simulation attempts are reviewed in terms of strategies employed and difficulties encountered. While promising advances have been made during the past 50 years due to electron microscopy, the development of new experimental methods, and the …

The Curse As A Garment In Greek Tragedy, Judith Fletcher

Ancient Studies Faculty Publications

This article considers how Greek tragedy adapts the metaphor of the curse as a garment used in Ancient Near Eastern rituals and treaties. Using this comparative material, I analyze the fatal garments used by female characters in Aeschylus’ Agamemnon, Sophocles’ Women of Trachis, and Euripides’ Medea.

Homo-Oligomerization Of The Gβ5-Rgs7 Complex And Its Regulation By R7bp And G Protein Activation, Junior Tayou

Open Access Dissertations

G-protein coupled receptors (GPCRs) mediate the transmission of extracellular signals to generate specific intracellular responses that are crucial for most physiological processes. Timely inactivation of GPCR signal is facilitated by regulators of G-protein signaling (RGS) proteins. This dissertation was focused on the R7 subfamily of RGS proteins. The R7 proteins which include RGS6, RGS7, RGS9 and RGS11 are multi-domain proteins consisting of the RGS, GGL (Gγ-like), DEP (originally identified in Disheveled, EGL-10, and Pleckstrin) and DHEX (DEP helical extension) domains. This subfamily exists as obligate dimers with the atypical Gβ subunit, Gβ5. These complexes are highly expressed in neurons and …

Multipronged Approach To Study Glaucoma-Associated Phenotypes, Sumana Rameshbabu Chintalapudi

Theses and Dissertations (ETD)

Glaucoma refers to a group of conditions characterized by death of RGCs, increase in intraocular pressure is usually a precursor to glaucoma and irreversible optic neuropathy leads to visual impairment and blindness. Recent advances have seen a surge of new ideas and technologies to aid in the early detection, efficacious treatments and neuroprotection. Despite advances we face several challenges in understanding the pathophysiology of glaucoma. One of the many challenges scientists and ophthalmologists are facing is, to better understand IOP, its role in glaucomatous damage and design safer, more predictable IOP-lowering therapies. Another challenge is to find a practical method …

“If You’Re Not That As An Asian Woman, You’Re Not Shit As An Asian Woman.”: (Re)Negotiating Racial And Gender Identities, Andi T. Remoquillo

College of Liberal Arts & Social Sciences Theses and Dissertations

This studies utilizes a critical, postcolonial feminist lens when analyzing the ways in which Asian-American women are (re)negotiating their gender and sexual identities within the contemporary United States. Through the use of empirical research, as well historical content and discourse analyses, this M.A. thesis deconstructs the ways in which Western society has constructed Asian/Asian-American women as the hypersexual Other, and revisits the ways in which empowerment, agency, and autonomy are reconfigured by Asian-American women themselves.

Primetimes Newsletter, Fall 2016, Office Of Lifespan Studies

PrimeTimes Newsletter

PrimeTimes is the newsletter of the Office of Lifespan Studies in the College of Science at Coastal Carolina University.

Managing Climate Change Refugia For Climate Adaptation, Toni Lyn Morelli, Christopher Daly, Solomon Z. Dobrowski, Deanna M. Dulen, Joseph L. Ebersole, Stephen T. Jackson, Jessica D. Lundquist, Constance I. Millar, Sean P. Maher, For Complete List Of Authors, See Publisher's Website.

College of Natural and Applied Sciences

Refugia have long been studied from paleontological and biogeographical perspectives to understand how populations persisted during past periods of unfavorable climate. Recently, researchers have applied the idea to contemporary landscapes to identify climate change refugia, here defined as areas relatively buffered from contemporary climate change over time that enable persistence of valued physical, ecological, and socio-cultural resources. We differentiate historical and contemporary views, and characterize physical and ecological processes that create and maintain climate change refugia. We then delineate how refugia can fit into existing decision support frameworks for climate adaptation and describe seven steps for managing them. Finally, we …

Los Baños Times, Vol. 36, No. 8, College Of Development Communication, University Of The Philippines Los Baños

Los Baños Times

No abstract provided.

Determination Of Dimethyl Trisulfide In Rabbit Blood Using Stir Bar Sorptive Extraction Gas Chromatography-Mass Spectrometry, Erica Mananadhar, Nujud Maslamani, Ilona Petrikovics, Gary A. Rockwood, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Cyanide poisoning by accidental or intentional exposure poses a severe health risk. The current Food and Drug Administration approved antidotes for cyanide poisoning can be effective, but each suffers from specific major limitations concerning large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. Dimethyl trisulfide (DMTS), a sulfur donor that detoxifies cyanide by converting it into thiocyanate (a relatively nontoxic cyanide metabolite), is a promising next generation cyanide antidote. Although a validated analytical method to analyze DMTS from any matrix is not currently available, one will be vital for the approval of DMTS …

Bulletin No. 42: The Mamacoke Conservation Area, Glenn Dreyer, Robert Askins, Scott Peterson

Bulletins

No abstract provided.

Embodied Resilience In Unaccompanied Latin American Children In A United States Reception Center, Marcos Oro Caldero

Creative Arts Therapies Theses

The purpose of this study was to explore ways in which a group of unaccompanied children (UC) from El Salvador, Guatemala, Honduras, and Brazil embodied resilience during their stay at a temporary reception center in the United States. The center was located in Illinois and received funding from the Office of Refugee Resettlement (ORR), under the U.S. Department of Health and Human Services. The 12-week clinical case study included a total of 19 male participants aged 12 to 17 years old attending dance/movement therapy sessions, which were scheduled weekly. Group progress notes and individual movement assessment coding sheets were completed …

Who Are You, Class Of 2019, Michelle Rahman

Who Are You Class of...Orientation Speeches

“One hundred and twelve first-year students make up the Class of 2019. Fourteen of you are entering with advanced standing, some from the far corners of the world. Four of you are part of our second LLM class. Four of you are international exchange students from Germany, Italy and Sweden. Others are from Saudi Arabia, Colombia, Brazil, Spain, South Africa, the Russian Federation, and Poland. No matter where you are from, you are here today due to the sacrifices of those who love you and you are standing on the shoulders of those who came before you and have paved …

Blimp-1–Mediated Cd4 T Cell Exhaustion Causes Cd8 T Cell Dysfunction During Chronic Toxoplasmosis, Sujin Hwang, Dustin A. Cobb, Rajarshi Bhadra, Ben Youngblood, Imtiaz A. Khan

Microbiology, Immunology, and Tropical Medicine Faculty Publications

CD8, but not CD4, T cells are considered critical for control of chronic toxoplasmosis. Although CD8 exhaustion has been previously reported inToxoplasma encephalitis (TE)–susceptible model, our current work demonstrates that CD4 not only become exhausted during chronic toxoplasmosis but this dysfunction is more pronounced than CD8 T cells. Exhausted CD4 population expressed elevated levels of multiple inhibitory receptors concomitant with the reduced functionality and up-regulation of Blimp-1, a transcription factor. Our data demonstrates for the first time that Blimp-1 is a critical regulator for CD4 T cell exhaustion especially in the CD4 central memory cell subset. Using a tamoxifen-dependent …

High-Sensitivity Mass Spectrometry For Probing Gene Translation In Single Embryonic Cells In The Early Frog (Xenopus) Embryo, Camille Lombard-Banek, Sally Ann Moody, Peter Nemes

Anatomy and Regenerative Biology Faculty Publications

Direct measurement of protein expression with single-cell resolution promises to deepen the understanding of basic molecular processes during normal and impaired development. High-resolution mass spectrometry provides detailed coverage of the proteomic composition of large numbers of cells. Here we discuss recent mass spectrometry developments based on single-cell capillary electrophoresis that extend discovery proteomics to sufficient sensitivity to enable the measurement of proteins in single cells. The single-cell mass spectrometry system is used to detect a large number of proteins in single embryonic cells in blastomeres in the 16-cell embryo of the South African clawed frog (Xenopus laevis) that give rise …

Changes In Urinary Bisphenol A Concentrations Associated With Placement Of Dental Composite Restorations In Children And Adolescents, Nancy Maserejian, Felicia L Trachtenberg, Olivia Brown Wheaton, Antonia M Calafat, Gayatri Ranganathan, Hae-Young Kim, Russ Hauser

NYMC Faculty Publications

BACKGROUND: Bisphenol A-glycidyl methacrylate (bis-GMA)-based dental composite restorations may release bisphenol A (BPA). The authors assessed changes in urinary BPA concentrations over a 6-month follow-up period in children and adolescents who received bis-GMA-based restorations.

METHODS: The authors collected data from 91 study participants aged 3 to 17 years who needed composite restorations. Participants provided urine samples and information on BPA-related exposures before and at approximately 1 day, 14 days, and 6 months after treatment. The authors used multivariable linear regression models to test associations between the number of surface restorations placed and the changes in urinary BPA concentrations.

RESULTS: Participants …

Preliminary Report Of The 2016 Season, Mark Schuler

Excavation Reports

No abstract provided.

Outliving Love: Marital Estrangement In An African Insurance Market, Casey Golomski

Anthropology

Marital estrangement and formal divorce are vital conjunctures for married women’s kinship relations and life course, where a horizon of future possibilities are revalued and negotiated at the interstices of custom, law, and social and ritual obligations. In this article, after delineating the forms of customary and civil marriage and the possibilities for divorce or estrangement from each, I describe how some married women in Swaziland and South Africa mediate this complex social field for their children and families through pensions and continuing to pay for their partners’ insurance coverage. This was not solely out of avarice to reap future …

Optical Dosimetry Tools And Monte Carlo Based Methods For Applications In Image Guided Optical Therapy In The Brain, Akshay N Prabhu Verleker

Open Access Dissertations

Purpose: The long-term goal of this research is to determine the feasibility of using near infra-red light to stimulate drug release in metastatic lesions within the brain. In this work, we focused on developing the tools needed to quantify and verify photon fluence distribution in biological tissue. To accomplish this task, an optical dosimetry probe and Monte Carlo based simulation code were fabricated, calibrated and developed to predict light transport in heterogeneous tissue phantoms of the skull and brain. Empirical model (EM) of photon transport using CT images as input were devised to provide real-time calculations capable of being translated …

The Effects Of Scarring On Face Recognition, Kevin J. Chan

Open Access Theses

The focus of this research is the effects of scarring on face recognition. Face recognition is a common biometric modality implemented for access control operations such as customs and borders. The recent report from the Special Group on Issues Affecting Facial Recognition and Best Practices for their Mitigation highlighted scarring as one of the emerging challenges. The significance of this problem extends to the ISO/IEC and national agencies are researching to enhance their intelligence capabilities. Data was collected on face images with and without scars, using theatrical special effects to simulate scarring on the face and also from subjects that …

A Study Of Applications Of 3d Animation For Emergency Medicine Pedagogy, Huilong Zheng

Open Access Theses

There is ample precedent for the use of 3D animation in education, though little research on specific applications in the field of medicine. An experiment was carried out to assess the suitability of 3D animation for educational purposes in emergency medicine courses. Two groups of experimental participants were assessed on their ability to respond to three emergency medical situations in simulated test scenarios. Both groups received equivalent information on how to treat the three different medical emergencies. The control group received the information in traditional lecture format. The experimental group instead received the information from a set of 3D animations. …