Digital Commons Network^™

Full Issue, Children's Book Review

Children's Book and Media Review

No abstract provided.

Mr. And Mrs. God In The Creation Kitchen, Rita Christensen

Children's Book and Media Review

No abstract provided.

Back Into Mommy's Tummy, Rita Christensen

Children's Book and Media Review

No abstract provided.

La Primera Luna Llena De Gatita, Selma Alexandre

Children's Book and Media Review

No abstract provided.

When Sheep Sleep, Donna Cardon

Children's Book and Media Review

No abstract provided.

Delaware Riverkeeper Network V. Secretary Pennsylvania Departm

2016 Decisions

Agency

Mitochondrial Akt Regulation Of Hypoxic Tumor Reprogramming., Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, Dario C. Altieri

Department of Cancer Biology Faculty Papers

Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms are not completely understood. Using a phosphoproteomics screen, we now show that active Akt accumulates in the mitochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex. In turn, this pathway switches tumor metabolism toward glycolysis, antagonizes apoptosis and autophagy, dampens oxidative stress, and maintains tumor cell proliferation in the face of severe hypoxia. Mitochondrial Akt-PDK1 signaling correlates with unfavorable prognostic markers and shorter survival in glioma patients and may provide an "actionable" therapeutic target in cancer.

Clawpack: Building An Open Source Ecosystem For Solving Hyperbolic Pdes, Donna Calhoun

Mathematics Faculty Publications and Presentations

Clawpack is a software package designed to solve nonlinear hyperbolic partial differential equations using high-resolution finite volume methods based on Riemann solvers and limiters. The package includes a number of variants aimed at different applications and user communities. Clawpack has been actively developed as an open source project for over 20 years. The latest major release, Clawpack 5, introduces a number of new features and changes to the code base and a new development model based on GitHub and Git submodules. This article provides a summary of the most significant changes, the rationale behind some of these changes, and a …

Mythcon 47 - Faces Of Mythology: Ancient, Medieval, And Modern, The Mythopoeic Society

Mythcon Programs

Inspired by the 60th anniversary of C.S. Lewis's Till We Have Faces and The Last Battle, this year's theme focuses on the mythology that has shaped and "given faces" to so many of our beloved characters, ranging from the myths of the Ancient Greeks to the legends of the Middle Ages and even to the modern mythology of the American Southwest. Similarly, this mythological influence is also evident in the works of many of our favorite mythopoeic authors, from J.R.R. Tolkien to J.K. Rowling, from Ursula K. Le Guin to Alan Garner, and many, many more.

Arnold V. City Of Stanley Respondent's Brief Dckt. 43868

Idaho Supreme Court Records & Briefs, All

No abstract provided.

How Does Learning About Affixes (Prefixes And Suffixes) Help English Language Learners (Ells) Understand The Meaning And Use Of Affixes?, Melissa Jean Cook

School of Education and Leadership Student Capstone Theses and Dissertations

The research question addressed in this paper is: How does learning about affixes (prefixes and suffixes) through games and songs help English Language Learners (ELLs) understand the meaning and function of affixes? It documents one teacher’s teaching of common prefixes and suffixes to 3rd grade ELLs with the use of games and songs in the classroom to increase student learning and engagement. The data includes pretests, posttests and a survey. The findings of this study include, 1) some students were secure before the lessons in their knowledge of prefixes re- and mis- and suffix -er ; 2) the data was …

Summer Session Archaeological Dig Yields Thousands Of Artifacts, Christina Steube

University of Mississippi News

UM students help uncover Chickasaw relics in Oktibbeha County

Ex-Post Livestock Diseases, And Pastoralists' Averting Decisions In Tanzania, Mazbahul Ahamad

Department of Agricultural Economics: Dissertations, Theses, and Student Research

Little is known about the factors affecting pastoralists’ livestock vaccination decisions. In this thesis, we use a novel survey-based dataset on pastoralists living in the Ruaha landscape in Tanzania, and employ several econometric approaches to identify the factors affecting pastoralists’ decision-making process about livestock vaccination when disease occurrence and severity, vaccination and healthcare access costs and other related variables are known. Results from binary choice models that account for excess zeros indicate that socially and economically active households are more likely to vaccinate their livestock. The results also identify positive marginal effects of illness incidence and having wage earners and …

Week Of August 8, 2016, New York Medical College

InTouch

• NYMC Welcomes SOM Class of 2020
• Andrew Mutnick, M.D. '01, Is Named SOM Associate Dean for Student Affairs
• SOM Office of Admissions Seeks MMI Interviewers
• SOM Offers High School Students Hands-On Look at Medicine

Inhibiting Androgen Receptor Nuclear Entry In Castration-Resistant Prostate Cancer, Julie A. Pollock, Suzanne E. Wardell, Alexander A. Parent, David B. Stagg, Stephanie J. Ellison, Holly M. Alley, Christina A. Chao, Scott A. Lawrence, James P. Stice, Ivan Spasojevic, Jennifer G. Baker, Sung Hoon Kim, Donald P. Mcdonnell, John A. Katzenellenbogen, John D. Norris

Chemistry Faculty Publications

Clinical resistance to the second-generation antiandrogen enzalutamide in castration resistant prostate cancer (CRPC), despite persistent androgen receptor (AR) activity in tumors, highlights the unmet medical need for next generation antagonists. We have identified and characterized tetra-aryl cyclobutanes (CBs) as a new class of competitive AR antagonists that exhibit a unique mechanism of action. These CBs are structurally distinct from current antiandrogens (hydroxyflutamide, bicalutamide, and enzalutamide), and inhibit AR-mediated gene expression, cell proliferation, and tumor growth in several models of CRPC. Conformational profiling revealed that CBs stabilize an AR conformation resembling an unliganded receptor. Using a variety of techniques, it was …

An Introduction To Nutrition For An Optometrist, Nl Szostek, H Buckhurst, P Buckhurst, C Purslow, A Collinson

School of Health Professions

The world of nutrition and nutritional supplements can sometimes be a minefield for both patients and optometrists. Whilst there is no formal training in this area for undergraduate optometrists, as primary healthcare professionals there is an existing duty to be able to advise patients on products which may help maintain the health of their eyes and vision (General Optical Council 2016). This article provides a basic introduction to health and nutrition, specifically with the optometrist in mind. Firstly, it explores what a healthy diet is and defines some commonly used terms; then it will go on to the role of …

Social Influences On Unconscious Plagiarism And Anti-Plagiarism, Timothy J. Hollins, Nicholas Lange, Ian Dennis, Christopher A. Longmore

School of Psychology

No abstract provided.

Improving Nanosatellite Imaging With Adaptive Optics, Anne Marinan, Kerri Cahoy, John Merk, Ruslan Belikov, Eduardo Bendek

Small Satellite Conference

Active and adaptive wavefront control can be useful on space platforms for a variety of observation applications. For example, to achieve high contrast imaging to a level of 1e-10 with a coronagraph (required to image an Earth- like planet around a Sun-like star), space telescopes require high spatial frequency wavefront control systems. To achieve intersatellite links through the atmosphere, wavefront correction is needed to counter the effects of atmospheric turbulence and scintillation. For deployable apertures, active correction is desired to properly align and calibrate optical systems. Deformable mirrors (DMs) are a key element of a wavefront control system, as they …

Engagement Of Kindergarten English Learners During The Dramatic Play Center, Megan Marie Morin

School of Education and Leadership Student Capstone Theses and Dissertations

The purpose of this study was to determine to what extent different activities within the dramatic play center engage English Learners in order to help increase oral language proficiency scores. Three kindergarten ELs were observed during their time at the dramatic play center and interviewed afterwards by the participant observer of the study to see what activities within the dramatic play center were the most engaging. This research was carried out using a mixed methods approach with an emphasis on the qualitative paradigm. The main findings were: students are more engaged when the dramatic play center is centered on a …

Increased Connection To Nature And Development Of Ecological Identity In The Illinois Master Naturalist Program, Laura Sjoquist

School of Education and Leadership Student Capstone Theses and Dissertations

The purpose of this qualitative research study was to examine the ways in which the Illinois Master Naturalist program affected adult learners’ connection to local natural areas and the development of an ecological identity. Participants in the Illinois Master Naturalist Program were interviewed to determine their experience in the program. During the interview they were asked to describe their connections to nature and their ecological identity prior to and after participation in the program. While more research is needed, it was concluded from the data that the Master Naturalist program did enable adult learners to develop a greater connection to …

Are Insects Sentient?, Michael Tye

Animal Sentience

I comment on the methodology used by Klein & Barron for dealing with the question of insect sentience and I briefly make a proposal of my own. Once it is granted that insects are sentient, a further question arises: which insects are subject to which states of sentience? Do insects feel pain, for example? If so, which ones? On the further question, I note, Klein & Barron have nothing to say.

Cubesat Nighttime Lights, Dee W. Pack, Brian S. Hardy

Small Satellite Conference

Monitoring of visible emissions at night from satellites has evolved into a useful capability for environmental monitoring and mapping the global human footprint. Pioneering work with Defense Meteorological Support Program (DMSP) sensors has been followed by new work with the Visible Infrared Imaging Radiometer Suite (VIIRS), and International Space Station (ISS) photography. We have been investigating the ability of CubeSats to carry out nightlights mapping missions and here present recent results from existing visible wavelength cameras on AeroCube satellites. CubeSat sensors were successfully tasked to image oil industry natural gas flares in the Persian Gulf region, urban areas and other …

Animal Grieving And Human Mourning, Matteo Colombo

Animal Sentience

King’s How animals grieve beautifully describes several ways in which animals and humans show a similar capacity for grief. Yet this book does not sufficiently emphasise the language-empowered capacity to objectify thinking and sentiments about death, which makes human mourning unique. Here I put this capacity into focus and relate it to the social-normative aspect of human mourning that seems to be missing in other animals.

Real-Time Pcr Detection And Phylogenetic Relationships Of Neorickettsia In Digeneans From Egypt, Phillipines, Thailand, Vietnam And The United States, Stephen E. Greiman, Jefferson A. Vaughan, Rasha Elmahy, Poom Adisakwattana, Nguyen Van Ha, Thomas J. Fayton, Amal I. Khalil, Vasyl V. Tkach

Student Publications

Neorickettsia (Rickettsiales, Anaplasmataceae) is a genus of obligate intracellular bacterial endosymbionts of digeneans (Platyhelminthes, Digenea). Some Neorickettsia are able to invade cells of the digenean's vertebrate host and are known to cause diseases of domestic animals, wildlife, and humans. In this study we report the results of screening digenean samples for Neorickettsia collected from bats in Egypt and Mindoro Island, Philippines, snails and fishes from Thailand, and fishes from Vietnam and the USA. Neorickettsia were detected using a real-time PCR protocol targeting a 152bp fragment of the heat shock protein coding gene, GroEL, and verified with nested PCR and sequencing …

Investigating The Role Of Anaerobic Bacteria In Colorectal Carcinoma, Oluwadara Coker

Theses

Colorectal cancer (CRC), with multifactorial influences of genetic, molecular, inflammatory, and environmental factors, is a leading cause of cancer-related deaths. Due to the high diversity and concentration of microbes found in the human colon, the microbiome has become a prime suspect of being a biological contributor. This prompts the need to investigate the relationship between microorganisms and CRC. Recent studies have shown that Fusobacterium nucleatum, Campylobacter showae, Leptrotrichia buccalis, and Selenomonas sputigena are overrepresented in colon tumors. These anaerobes have known associations to the oral microbiome and cause infections. Here, these findings are further expanded in an experimental attempt to …

Insects Join The Consciousness Fray, Bjorn H. Merker

Animal Sentience

Klein & Barron's review of recent insect neurobiology helps correct the impression that insect behavior is orchestrated without the benefit of central integrative mechanisms. Given their existence, the authors go on to ask whether these central mechanisms also feature the kind of integrative operations that support sentience, and propose that they do. Along the way they raise a number of conceptual and evidentiary issues of fundamental importance for the neuroscience of consciousness, allowing me to comment favorably on a number of them. I conclude by pointing to ways in which the conception of insect sentience they outline might be tested …

A Quest For Our Earliest Ancestors, Charles E. Reineke

UNLV Innovation

Brian Villmoare’s identification of a 2.8 million-year-old jawbone suggests our earliest human ancestors — that “branch of the human family tree that leads to us” — were thriving almost half-a-million years earlier than scientists had previously supposed.

Research Briefs

UNLV Innovation

• Unwelcome flora
• An attack on HIV
• Body-camera survey
• Up-close Nobel laureates
• A battery-powered partnership
• Gaming law
• Robotic “muscles”
• Full-day kindergarten
• Funds for biomedical research
• A low-oxygen fish

In Nursing And Allied Health, Recent Research Promises Patient Benefits, Kevin Dunegan

UNLV Innovation

By expanding research and encouraging collaboration, UNLV’s nursing and allied health faculty are advancing patient outcomes.

• Yu Kuang
• Kai-Yu Ho
• Barbara St. Pierre Schneider
• Jennifer Kawi
• Susan VanBeuge
• Steen Madsen

Research Briefs

UNLV Innovation

• Switch SUPERNAP, Intel Partner with UNLV to Boost Scientific Research and Economic Development
• How Long Is It Safe To Stay In Space?
• “Exquisitely Preserved” Fossil Find Sheds Light on a Distant Era
• Graduate Programs Earn High Marks from U.S. News
• Southwest Found To Be Among the Most “Climate-Challenged” Regions in the Nation
• Public Weighs in on Pros and Cons of Unmanned Aerial Systems
• Historical Nevada Newspapers To Be Digitized Through NEH Grant
• Earth’s Most Plentiful Mineral Finally Makes an Appearance
• $1.4 Million Grant To Expand Clinical Social Work Education & Research
• Researchers Employ Bluetooth Technology In Blood-Flow Sensor