Digital Commons Network^™

Use Of Parthenolide Derivatives As Antileukemic And Cytotoxic Agents, Peter A. Crooks, Craig T. Jordan, Xiaochen Wei

Pharmaceutical Sciences Faculty Patents

To read this abstract, please download this patent.

Semi-Synthetic Mithramycin Derivatives With Anti-Cancer Activity, Jürgen Rohr, Daniel Scott, Markos Leggas, Jhong-Min Chen, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Patents

Mithramycin derivatives and their pharmaceutically acceptable salts are disclosed. The mithramycin derivatives can be used in the treatment of Ewing sarcoma or other cancer or neuro-disease associated with an aberrant erythroblast transformation- specific transcription factor.

Undergraduate Research Scholars Program Features Work Of Seven Stellar Students, Office Of University Communications

Gardner-Webb NewsCenter Archive

The Gardner-Webb University Undergraduate Research Scholars program funded a total of seven students during the summer 2016 term, which represents the greatest number of scholars in the program’s history. As part of their research project, each scholar spends five weeks of a summer term on campus working on his/her topic for 40 hours a week. At the same time, students are mentored by a dedicated faculty member, who provides information and guidance to ensure a successful research experience for the scholar.

WGWG: GWU Undergraduate Research Scholar Chris Beguhl

WGWG: GWU Undergraduate Research Scholar Mariah Case

WGWG: GWU Undergraduate Research Scholar …

Fisher V. Garrison Property And Cas. Ins. Respondent's Brief Dckt. 44117

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Hspa12b Attenuated Acute Myocardial Ischemia/Reperfusion Injury Via Maintaining Endothelial Integrity In A Pi3k/Akt/Mtor-Dependent Mechanism, Qiuyue Kong, Leyang Dai, Yana Wang, Xiaojin Zhang, Chuanfu Li, Surong Jiang, Yuehua Li, Zhengnian Ding, Li Liu

ETSU Faculty Works

Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury. HSPA12B is an endothelial-cell-specifically expressed heat shock protein. However, the roles of HSPA12B in acute myocardial I/R injury is unknown. Here we reported that myocardial I/R upregulated HSPA12B expression in ventricular tissues, and endothelial overexpression of HSPA12B in transgenic mice (Tg) limited infarct size, attenuated cardiac dysfunction and improved cardiomyocyte survival compared with their wild type littermates. These improvements were accompanied with the diminished myocardial no-reflow phenomenon, decreased microvascular leakage, and better maintained endothelial tight junctions. The I/R-evoked neutrophil infiltration was also suppressed in Tg hearts compared with its …

The Bg News September 20, 2016, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 20, 2016. Volume 96-Issue 10.

Myelinating Glia Differentiation Is Regulated By Extracellular Matrix Elasticity, Mateusz M. Urbanski, Lyle Kingsbury, Daniel Moussouros, Imran Kassim, Saraf Mehjabeen, Navid Paknejad, Alicia Meléndez

Publications and Research

The mechanical properties of living tissues have a significant impact on cell differentiation, but remain unexplored in the context of myelin formation and repair. In the PNS, the extracellular matrix (ECM) incorporates a basal lamina significantly denser than the loosely organized CNS matrix. Inhibition of non-muscle myosin II (NMII) enhances central but impairs peripheral myelination and NMII has been implicated in cellular responses to changes in the elasticity of the ECM. To directly evaluate whether mechanotransduction plays a role in glial cell differentiation, we cultured Schwann cells (SC) and oligodendrocytes (OL) on matrices of variable elastic modulus, mimicking either their …

Mlkl And Fadd Are Critical For Suppressing Progressive Lymphoproliferative Disease And Activating The Nlrp3 Inflammasome., Xixi Zhang, Cunxian Fan, Haiwei Zhang, Qun Zhao, Yongbo Liu, Chengxian Xu, Qun Xie, Xiaoxia Wu, Xianjun Yu, Jianke Zhang, Haibing Zhang

Department of Microbiology and Immunology Faculty Papers

MLKL, a key component downstream of RIPK3, is suggested to be a terminal executor of necroptosis. Genetic studies have revealed that Ripk3 ablation rescues embryonic lethality in Fadd- or Caspase-8-deficient mice. Given that RIPK3 has also been implicated in non-necroptotic pathways including apoptosis and inflammatory signaling, it remains unclear whether the lethality in Fadd(-/-) mice is indeed caused by necropotosis. Here, we show that genetic deletion of Mlkl rescues the developmental defect in Fadd-deficient mice and that Fadd(-/-)Mlkl(-/-) mice are viable and fertile. Mlkl(-/-)Fadd(-/-) mice display significantly accelerated lymphoproliferative disease characterized by lymphadenopathy and splenomegaly when compared to Ripk3(-/-)Fadd(-/-) mice. …

Volume 114, Number 3 - Tuesday, September 20, 2016, Saint Mary's College Of California

The Collegian

No abstract provided.

September 20, 2016, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Using Geographic Information Systems To Identify Habitat For The Golden-Winged Warbler (Vermivora Chrysoptera) In Western New York, Jesse Michael Rubenstein

Theses

The Golden-winged Warbler (Vermivora chrysoptera) is a passerine species whose populations have decreased internationally by approximately 66 percent since the 1960s, and by approximately 50 percent in New York. Major causes for declines are from loss of shrubland habitat and through hybridization with the Blue-winged Warbler (Vermivora cyanoptera). This study utilized published data and expert opinion on Golden-winged Warbler (GWWA) habitat requirements to create habitat suitability models within the Western Finger Lakes Region of NY (NYSDEC Region 8) using a geographic information system. This region is an important area for migratory birds and is previously unstudied for GWWA. The concentration …

Cell Culture Investigation Of The Effects Of Aerogel Surface Topography And Dc Electric Field Stimulation On Pc12 Cell Neurite Growth, Kyle Jeremiah Lynch

Electronic Theses and Dissertations Archive

Polyurea crosslinked silica aerogel (PCSA) is an open pore light-weight and topographically rich material with tunable physical and chemical properties. Because of the unique properties of this material, and the ability to tailor the properties to specific needs and applications, PCSA has attracted significant interest from the biophysical and biomedical fields in recent years. Recent advances in cell biology and biophysics have demonstrated that cells respond to their micro- and nanoscale environmental cues in the presence and/or absence of electrical cues and stimuli. Aerogels offer a unique platform for studying the effects of topography, substrate stiffness, and porosity on cellular …

Heterogeneity Among Isolates Reveals That Fitness In Low Oxygen Correlates With Aspergillus Fumigatus Virulence, Caitlin H. Kowalski, Sarah R. Beattie, Kevin K. Fuller, Elizabeth A. Mcgurk, Yi-Wei Tang, Tobias Hohl, Joshua Obar, Robert Cramer Jr.

Dartmouth Scholarship

Previous work has shown that environmental and clinical isolates of Aspergillus fumigatus represent a diverse population that occupies a variety of niches, has extensive genetic diversity, and exhibits virulence heterogeneity in a number of animal models of invasive pulmonary aspergillosis (IPA). However, mechanisms explaining differences in virulence among A. fumigatus isolates remain enigmatic. Here, we report a significant difference in virulence of two common lab strains, CEA10 and AF293, in the murine triamcinolone immunosuppression model of IPA, in which we previously identified severe low oxygen microenvironments surrounding fungal lesions. Therefore, we hypothesize that the ability to thrive within these lesions …

Reproducibility And Rigor In Ree's Portfolio Of Research, Mark Mclellan, Patsy Brannon, Adriana Campa, Steven Daley-Laursen, Govind Kannan, Neil Olson, Robert Taylor, Dawn Thilmany

Biology Faculty Publications and Presentations

The Science Advisory Council was established in FY2016 as a subcommittee of the National Agricultural Research, Extension, Education, and Economics (NAREEE) Advisory Board to provide advice and guidance, on a scientific basis, on the overall strength, practicality, and direction of agricultural research, including emerging technology and scientific issues and report any findings publicly to the NAREEE Advisory Board.

In spring of 2016, the USDA Science Advisory Council was first charged by the Chief Scientist to examine a number of controversial and challenging issues. The first was to address the general subject of reproducibility in the agricultural and nutrition related sciences. …

What's New? The Zoo!: A Zippy History Of Zoos

Children's Book and Media Review

Where did zoos come from? This book takes you on a journey through history, from the first zoo 4400 years ago in present-day Iraq, to zoos all around the world that expanded throughout the last several centuries until just recently. Little snippets of zoo history are presented with the year and place of the event as well as illustrations.

Oh So Brave Dragon

Children's Book and Media Review

When little dragon shows off his bravery by letting out a fearful roar, he ends up frightening himself as well. He starts asking his woodland creature friends if they’ve seen or heard the monster, and they band together to overcome the imagined monster… and their own fear.

If You Were A Dog

Children's Book and Media Review

If you were a dog, what kind of dog would you be? Would you howl at the moon? In just a few words, this book takes you through the interesting lives of dogs, cats, fish, birds, bugs, frogs, and even dinosaurs, complete with sound effects for each. It ends with the best sort of thing to be: a kid!

The Fly

Children's Book and Media Review

This poor housefly doesn’t seem to understand why nobody likes him. First, the boy in the story tries to swat him just for wanting some of his breakfast. Then, even animals can’t seem to get along with him—cows are annoyed with him, frogs try to eat him, and birds try to catch him. When the fly returns home for another meal, the boy yet again flaps his swatter with the hopes of swatting the poor fly.

Volume 52 - Issue 2 - Monday, September 19, 2016, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

Patterns And Predictors Of Recent Forest Conversion In New England, Alexandra M. Thorn, Jonathan R. Thompson, Joshua S. Plisinski

New Hampshire EPSCoR

New England forests provide numerous benefits to the region’s residents, but are undergoing rapid development. We used boosted regression tree analysis (BRT) to assess geographic predictors of forest loss to development between 2001 and 2011. BRT combines classification and regression trees with machine learning to generate non-parametric statistical models that can capture non-linear relationships. Based on National Land Cover Database (NLCD) maps of land cover change, we assessed the importance of the biophysical and social variables selected for full region coverage and minimal collinearity in predicting forest loss to development, specifically: elevation, slope, distance to roads, density of highways, distance …

Lanthorn, Vol. 51, No. 08, September 19, 2016, Grand Valley State University

Volume 51, July 11, 2016 - June 5, 2017

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Commonwealth Times 2016-09-19

Commonwealth Times, 1969-

No abstract provided.

Faculty Senate Executive Committee Agenda, September 19, 2016, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Items - September 2016
• Honors Program
• Libraries Advisory Council
• Parking Committee
• Student Code of Conduct

Total Diet Approach To Cancer Prevention: A Narrative Review Of The Literature Since 2011 Concerning The Association Of Colorectal Cancer And Meat Consumption, Krista E. King, Patricia M. Sheean

Nursing: School of Nursing Faculty Publications and Other Works

Diet serves as a primary prevention approach to reduce the global burden of cancer. In 2007, the World Cancer Research Fund and the American Institute for Cancer Research published the Second Expert Report (SER) Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective outlining lifestyle recommendations for primary cancer prevention. Results support a strong link between red and processed meat and colorectal carcinogenesis. Findings from the Colorectal Cancer 2011 Report: Food, Nutrition, Physical Activity, and the Prevention of Colorectal Cancer, a review conducted through the WCRF Continuous Update Project (CUP), strengthened the evidence and supported the …

My Love/Hate Relationship With The County Fair, Laura Hanby Hudgen

Erma Bombeck Writers' Workshop Blog

Anyone even remotely familiar with small towns knows that that the biggest event of the year (next to Friday Night Football) is the County Fair. For one week, normally sensible parents forego bedtimes, healthy eating, proper hygiene and a whole lot of money in favor of the carnival life. Every year I look forward to the fair. And every year I dread it. I have a love/hate relationship with the County Fair.

The Rider (2016-09-19), Jesus Sanchez

The Rider Archives

Vol.2 No.4

Four-Dimensional (4d) Subharmonic Aided Pressure Estimation For Monitoring Neoadjuvant Chemotherapy Response Of Breast Cancer, Kibo Nam, Maria Stanczak, Anush Sridharan, Adam C. Berger, Tiffany Avery, John R. Eisenbrey, Flemming Forsberg

Department of Radiology Posters

Introduction

Neoadjuvant chemotherapy is a well-established treatment option for patients with non-metastatic breast cancer. The patient response is correlated with survival. However, the optimal method for monitoring neoadjuvant therapy response has not been established. One factor that may affect the response of neoadjuvant therapy is the interstitial fluid pressure (IFP). Increased IFP prevents an effective delivery of therapeutic agents and reduces the efficacy of the therapy. Recently, subharmonic-aided pressure estimation (SHAPE) using contrast-enhanced ultrasound (CEUS) has been developed and its potential was demonstrated in animals as a non-invasive technique for IFP measurements. The SHAPE method estimates IFP based on the …

College Voice Vol. 100 No. 1, Connecticut College

2016-2017

No abstract provided.

Un “Viage”, Publicado En México, En 1835, Como Corolario Del Gran Fraude Lunar, Miguel A. Fernández Delgado Mafd

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

El Gran Fraude Lunar (Great Moon Hoax), orquestado en los Estados Unidos, tuvo varias versiones en diferentes países e idiomas. El presente documento, es el reflejo de cómo fue recibido en México, en donde se celebró con otro cuento, aunque esta vez anónimo sin intentar hacerlo pasar por verídico.

Intenciones Enmascaradas En La Pantalla Plateada. El Santo Y El Mimetismo Imperial, David S. Dalton

Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía

El cine Mexploitation de los 1960 y 1970 ha recibido poca atención académica debido a las supuestas fallas estéticas que emergieron cuando los directores de este movimiento yuxtaponían los tropos de la ciencia ficción y el horror hollywoodenses a películas protagonizadas por luchadores enmascarados. No obstante, este cine elucida los discursos imperialistas que abundaban en México a mediados del siglo veinte. En este ensayo analizamos el personaje del Santo —el luchador más exitoso del cine Mexploitation— a través de varias películas. Luego afirmamos que su cine postula una colonialidad liminal mexicana. El Santo interpretaba una versión ficticia de sí mismo …