Digital Commons Network^™

High-Throughput Allele-Specific Expression Across 250 Environmental Conditions, Gregory A. Moyerbrailean, Allison L. Richards, Daniel Kurtz, Cynthia A. Kalita, Gordon O. Davis, Chris T. Harvey, Adnan Alazizi, Donovan Watza, Yoram Sorokin, Nancy J. Hauff, Xiang Zhou, Xiaoquan Wen, Roger Pique-Regi, Francesca Luca

Center for Molecular Medicine and Genetics

Gene-by-environment (GxE) interactions determine common disease risk factors and biomedically relevant complex traits. However, quantifying how the environment modulates genetic effects on human quantitative phenotypes presents unique challenges. Environmental covariates are complex and difficult to measure and control at the organismal level, as found in GWAS and epidemiological studies. An alternative approach focuses on the cellular environment using in vitro treatments as a proxy for the organismal environment. These cellular environments simplify the organism-level environmental exposures to provide a tractable influence on subcellular phenotypes, such as gene expression. Expression quantitative trait loci (eQTL) mapping studies identified GxE interactions in response …

Faculty Recital: 2016 Octubafest, Martin Cochran, Bernard H. Flythe, Judy Cole, Nicole Chamberlain

Bailey School of Music Concert Programs

Kennesaw State University presents 2016 Octubafest, a faculty recital featuring Martin Cochran, Artist-in-Residence in Euphonium and Bernard Flythe, Artist-in-Residence in Tuba, along with Judy Cole, Artist-in-Residence in Collaborative Piano.

Spectator 2016-10-19, Editors Of The Spectator

The Spectator

No abstract provided.

Bfs News Online, Georgia Southern University

Art: News & Publications (2008-2023)

• Questionables: Ceramics and Sculpture opens at the Averitt Center in November

Abq Free Press, October 19, 2016, Abq Free Press

ABQ Free Press

No abstract provided.

The Night Poopsie Came To Town, Laurie Stone

Erma Bombeck Writers' Workshop Blog

None of us know when we'll be tested in life. Some tests are big. Some are small. A test my husband Randy will never forget came on a June night in 1995 involving several confused neighbors, two police cruisers and a Chihuahua named Poopsie.

Qe: The Story So Far, Andrew Haldane, Matt Roberts, Chris Young, Tomasz Wieladek

Documents

No abstract provided.

Animal Welfare The Focus Of This Month's Cafe Scientifique, University Relations

Campus News Archive

Café Scientifique is an ongoing series that offers a space where anyone can come to explore the latest ideas in science and technology for the price of a cup of coffee.

Pleckstrin Homology (Ph) Domain Leucine-Rich Repeat Protein Phosphatase Controls Cell Polarity By Negatively Regulating The Activity Of Atypical Protein Kinase C, Xiaopeng Xiong, Xin Li, Yang-An Wen, Tianyan Gao

Markey Cancer Center Faculty Publications

The proper establishment of epithelial polarity allows cells to sense and respond to signals that arise from the microenvironment in a spatiotemporally controlled manner. Atypical PKCs (aPKCs) are implicated as key regulators of epithelial polarity. However, the molecular mechanism underlying the negative regulation of aPKCs remains largely unknown. In this study, we demonstrated that PH domain leucine-rich repeat protein phosphatase (PHLPP), a novel family of Ser/Thr protein phosphatases, plays an important role in regulating epithelial polarity by controlling the phosphorylation of both aPKC isoforms. Altered expression of PHLPP1 or PHLPP2 disrupted polarization of Caco2 cells grown in 3D cell cultures …

Interleukin-17a Promotes Cd8 T Cell Cytotoxicity To Facilitate West Nile Virus Clearance, Amber M. Paul, Dhiraj Acharya, Penghua Wang, Jianfeng Dai, David Gate

Publications

CD8 T cells are crucial components of immunity and play a vital role in recovery from West Nile virus (WNV) infection. Here, we identify a previously unrecognized function of interleukin-17A (IL-17A) in inducing cytotoxic-mediator gene expression and promoting CD8 T cell cytotoxicity against WNV infection in mice. We find that IL-17A-deficient (Il17a/) mice are more susceptible to WNV infection and develop a higher viral burden than wild-type (WT) mice. Interestingly, the CD8 T cells isolated from Il17a/ mice are less cytotoxic and express lower levels of cytotoxic-mediator genes, which can be restored by supplying recombinant IL-17A in vitro and in …

Better Late Than Never: Effective Air-Borne Hearing Of Toads Delayed By Late Maturation Of The Tympanic Middle Ear Structures, Molly C. Womack, Jakob Christensen-Dalsgaard, Kim L. Hoke

Biology Faculty Publications

Most vertebrates have evolved a tympanic middle ear that enables effective hearing of airborne sound on land. Although inner ears develop during the tadpole stages of toads, tympanic middle ear structures are not complete until months after metamorphosis, potentially limiting the sensitivity of post-metamorphic juveniles to sounds in their environment. We tested the hearing of five species of toads to determine how delayed ear development impairs airborne auditory sensitivity. We performed auditory brainstem recordings to test the hearing of the toads and used micro-computed tomography and histology to relate the development of ear structures to hearing ability. We found a …

Forgotten Memories Of A Social Justice Education: Difficult Knowledge And The Impossibilities Of School And Research, Debbie Sonu

Publications and Research

This paper is about memory, the elusive process of remembering and of an encounter between a researcher and a participant who after five years reunited to remember. The object under study is a high school social justice curriculum with a central focus on the development of social action projects. Grounded in Pitt and Britzman’s work on difficult knowledge, this paper asks: What do 10th grade students who spent four years attending a school committed to the Freirian principles of political engagement remember about their high school experience? Past and recent interviews are woven together to surface three emergent lines of …

Ionis Phase I Huntington’S Disease Trial At Halfway Mark: 'No Surprises So Far' Means Good News, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

In What Sense Are You A Person?, Pamela Barone, Antoni Gomila

Animal Sentience

According to Rowlands, personhood in nonhuman animals calls for a unified mental life and pre-reflective self-awareness provides this. The concept of “person” is fuzzy. Any attempt to define it with necessary and sufficient conditions faces the problem of borderline cases satisfying only some of the conditions to varying degrees. We ask about the implications of a metaphysical sense of personhood for its moral and legal sense. Finally, we address Rowlands’s reliance on pre-reflective self-awareness and present our own criteria for personhood.

A New Species Of Centruroides (Scorpiones: Buthidae) From Quiché, Northwestern Guatemala, Rony E. Trujillo, Luis F. De Armas

Euscorpius

A new species of the genus Centruroides Marx, 1890 is described from Sotzil Village (15.61775°N, -91.09745°W, 1173 m a.s.l.), Chajul Municipality, Quiché Department, Guatemala, on basis of one female and one male. It closely resembles Centruroides caral Armas et Trujillo, 2013 from northeastern Guatemala (240 Km southeast of Chajul), but male differs by having a most globose pedipalp manus, as well as metasoma clearly more attenuate (len-gth/width ratio: segments II–IV = 2.4, 2.7 and 1.4, respectively; 1.7, 2.2 and 2.5 in the holotype of C. caral, the only known specimen of this taxon). Data on its habitat and some …

Local Intra-Uterine Ang-(1-7) Infusion Attenuates Pge2 And 6-Keto Pgf1Α In Decidualized Uterus Of Pseudopregnant Rats, K. B. Brosnihan, V. M. Pulgar, M. S. Bharadwaj, L. A. Neves, L. M. Yamaleyeva

Pharmaceutical Sciences

No abstract provided.

Gsu View, 2016-10-18, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

Spartan Daily, October 18, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 147, Issue 20

Critical Review Of The Millennium Project In Nepal, Ashma Vaidya, Audrey L. Mayer

College of Forest Resources and Environmental Science Publications

“Our Common Future” harmonized development policies around a new sustainable development (SD) paradigm, and experts also emphasize the importance of a democratic and equitable approach to define and achieve sustainable development. However, SD targets and indicators are often defined by a suite of experts or a few stakeholder groups, far removed from on-the-ground conditions. The most common expert-led development framework, the United Nations’ Millennium Development Goals (MDGs), promoted one set of targets and indicators for all developing countries. While progress towards these targets was routinely reported at the national scale, these targets may not reflect context-specific sustainable development. We evaluated …

Ua12/2/1 College Heights Herald, Vol. 92, No. 14 [16], Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. This issue contains articles:

• Miller, Callie. Raising the Volume – Domestic Violence
• Collins, Emma. Med Center, Western Kentucky Orthopaedic & Neurosurgical Associates Debate WKU Proposal
• Perry, Natalie. Topper Corner Celebrates Opening with Ribbon Cutting
• Carlson, Kylie. Murray State University Invites WKU to Dead Poets in London
• Williams, Jamie. Student Government Association Members Resign After Allegations of Racism – Braxton Powell, John McKinney
• Johnson, Leah. WKU Receives Grant for Principal Training – Wallace Foundation
• King, Jennifer. Editorial Cartoon re: Suffrage for Felons
• Suffering Suffrage: Kentucky Should Automatically Allow Ex-felons Right …

Hazardousness Of Place: A New Comparative Approach To The Filipino Past, Greg Bankoff

Philippine Studies: Historical and Ethnographic Viewpoints

The historiography of the Philippines has been largely bounded by the nation-state, which has defined how its past has been conceived and to whom its peoples are mainly compared. A more transnational environmental history, however, seeks to situate the archipelago within the context of the daily threats that its peoples have to face. Thisarticle focuses on the hazardous nature of living in the islands and explores the ways in which Filipinos have adapted to natural hazards as a frequent life experience over time.Keywords: historiography • Philippines • disasters • risk • adaptation

Instrumentation And Institutionalization: Colonial Science And The Observatorio Meteorológico De Manila, 1865–1899, Kerby C. Alvarez

Philippine Studies: Historical and Ethnographic Viewpoints

The scientific endeavors of the Observatorio Meteorológico de Manila in the nineteenth century brought about major changes in colonial science in the Philippines. The observatory pioneered the modern study of weather, climate, and natural hazards through the use of instruments and apparatus it invented and produced. Thisarticle explores how, through its programs and projects, the observatory operationalized colonial science, particularly meteorology, to promote a new understanding of weather and natural phenomena and create new avenues for public engagement.Keywords: Observatorio de Manila • colonial science • Jesuits • meteorology • meteorological instruments

Romancing Tropicality: Ilustrado Portraits Of The Climate In The Late Nineteenth Century, Jr. Aguilar

Philippine Studies: Historical and Ethnographic Viewpoints

In contrast to the literature’s dominant focus on Western constructions of tropicality, thisarticle explores representations of the tropics by the colonized, specifically the climatological conditions of the Philippines as portrayed in the late nineteenth century by the Europe-based native intellectuals known as ilustrados. Their anticolonial sentiment was intertwined with visceral estrangement from Spain and idealized views of the tropics, which reversed the colonizers’ racial-geographic prejudice and asserted an identity as a civilizable tropical people capable of genius. Rizal’s return visit to the homeland in 1887, however, made him agree with the Spanish premise about the climate in order to argue …

Anti-Nogo-A Immunotherapy Does Not Alter Hippocampal Neurogenesis After Stroke In Adult Rats, Timothy O'Brien, Daniel Shepherd, Gwendolyn Kartje-Tillotson, Shih-Yen Tsai, Robert G. Farrer

Mathematics and Statistics: Faculty Publications and Other Works

Ischemic stroke is a leading cause of adult disability, including cognitive impairment. Our laboratory has previously shown that treatment with function-blocking antibodies against the neurite growth inhibitory protein Nogo-A promotes functional recovery after stroke in adult and aged rats, including enhancing spatial memory performance, for which the hippocampus is critically important. Since spatial memory has been linked to hippocampal neurogenesis, we investigated whether anti-Nogo-A treatment increases hippocampal neurogenesis after stroke. Adult rats were subject to permanent middle cerebral artery occlusion followed 1 week later by 2 weeks of antibody treatment. Cellular proliferation in the dentate gyrus was quantified at the …

The Murray Ledger And Times, October 18, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Current Volume 27 : Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

Daily Eastern News: October 18, 2016, Eastern Illinois University

October

No abstract provided.

Volume 90, Issue 4 (2016)

Obiter Dicta

No abstract provided.

Bfs News Online, Georgia Southern University

Art: News & Publications (2008-2023)

• Questionables: Ceramics and Sculpture Opens at Averitt Center in Nov.

Montell, William Lynwood, 1931-2023 (Fa 961), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 961. Project titled: [Student Collections: Agricultural Implements] Includes survey sheets from student collections with brief descriptions of agricultural implements in Boyle County, Breathitt County, Hardin County, Lincoln County, and Taylor County in Kentucky. Sheets include a brief description, terms, and a photo of the implement.