Digital Commons Network^™

Review Of Indian Spectacle: College Mascots And The Anxiety Of Modern America, By Jennifer Guiliano., David Karen

Sociology Faculty Research and Scholarship

No abstract provided.

Erlotinib For Advanced Hepatocellular Carcinoma: A Systematic Review Of Phase Ii/Iii Clinical Trials, Jing Zhang, Yuan Zong, Gang-Zhu Xu, Ke Xing

Saudi Medical Journal

Objectives: To evaluate the efficacy and safety of erlotinib for the treatment of advanced hepatocellular carcinoma (HCC). Methods: A systematic literature search was undertaken in June 2015. Phase II/III trials of erlotinib for the treatment of advanced HCC were included. A descriptive analysis was applied. The study was conducted in College of Medicine, Honghui Hospital, Xi’an Jiaotong University, Xi’an, China, between June 2015 and January 2016. Results: Ten trials, comprising 9 phase II and one phase III trial, were included in the systematic review. The tumor response rate was 0% in 4 of the phase II trials, <10% in 3 of the phase II trials and the phase III trial, and >20% in 2 …

Alfentanil Versus Ketamine Combined With Propofol For Sedation During Upper Gastrointestinal System Endoscopy In Morbidly Obese Patients, Ertugrul Kılıc, Barıs Demiriz, Nurgül Isıkay, Abdullah E. Yıldırım, Selman Can, Cem Basmacı

Saudi Medical Journal

Objectives: To observe the effects of both propofol/alfentanil and propofol/ketamine on sedation during upper gastrointestinal system endoscopy in morbidly obese patients (UGSEMOP). Methods: In a prospective, double-blinded, randomized clinical study, 52 patients scheduled for UGSEMOP were assigned to either group A (n=26; 10 µg/kg intravenous [IV] alfentanil) or group K (n=26; 0.5 mg/kg IV ketamine). Each patient was administered 0.7 mg/kg propofol for induction. If it was needed, the patients were administered an additional dose of IV propofol. This study was performed in Sehitkamil State Hospital, Gaziantep, Turkey, between January 2014-2015. Total propofol consumption, time to achieve Modified Aldrete Scores …

Effect Of Iron Overload On Renal Functions And Oxidative Stress In Beta Thalassemia Patients, Mahmood Rasool, Arif Malik, Uzma Jabbar, Irshad Begum, Mahmood H. Qazi, Muhammad Asif, Muhammad I. Naseer, Shakeel A. Ansari, Jummanah Jarullah, Absarul Haque, Mohammad S. Jamal

Saudi Medical Journal

Objectives: To check the amount of cellular damage caused by serial transfusions of blood in thalassemia patients. Methods: A cross-sectional study was conducted in the University of Lahore, Lahore, Pakistan between August 2012 and December 2012. A total of 43 thalassemia patients underwent at least 10 blood transfusions. Comprehensive biochemical analysis of blood was performed to record the levels of creatinine, urea, uric acid, albumin, liver function tests, malondialdehyde (MDA), and ferritin. Results: Serum creatinine (0.732±0.23mg/dl) and uric acid (6.7±0.94mg/dl, p <0.05) were significantly higher in patient groups as compared with the control. Ferritin levels were significantly higher in patients as compared with the control (3103.9±1747.4, p <0.05). Hemoglobin levels were observed in controls 14±1.3g/dl and in patients 7.1±1.03g/dl. No clear relationship exists between age and hematological parameters of thalassemic patients. Serum ferritin level is positively related with serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase and MDA ( p <0.05). Conclusion: Serum MDA and serum ferritin of patients (r=0.593, p <0.05) reflects that both are crucial parameters estimating the cellular damage in patients suffering from thalassemia.

Risk Factors Of Trastuzumab-Induced Cardiotoxicity In Breast Cancer: A Meta-Analysis, Zeeshan Jawa, Ruth M. Perez, Lydia Garlie, Maharaj Singh, Rubina Qamar, Bijoy K. Khandheria, Arshad Jahangir, Yang Shi

College of Nursing Faculty Research and Publications

Background: 

Trastuzumab targets the human epidermal growth factor receptor 2 oncogene and in combination with first-line therapy results in significantly improved survival outcomes and has thus become standard of care in both adjuvant and metastatic settings. While it is estimated that 1% to 4% of patients treated with trastuzumab will develop heart failure and ∼10% will experience a reduction in left ventricular ejection fraction (LVEF), the patient risk factors associated with trastuzumab-induced cardiotoxicity (TIC) are unclear. This meta-analysis aims to consolidate previously published data to identify the risk factors most likely leading to TIC.

Methods: 

A search of the MEDLINE …

Detection In Aerial Images Using Spatial Transformer Networks, Daniel Chianucci

Theses

Many tasks in the field of computer vision rely on an underlying change detection algorithm in images or video sequences. Although much research has focused on change detection in consumer images, there is little work related to change detection on aerial imagery, where individual images are recorded from aerial platforms over time.

This thesis presents two deep learning approaches for detection in aerial images. Both systems leverage Spatial Transformer Networks (STN) that identify the coordinate transformation for their localization capabilities. The first approach is based on a semisupervised approach which learns to locate changes within a difference image. The second …

A Randomized Placebo-Controlled Pilot Study Of The Efficacy And Safety Of D-Cycloserine In People With Chronic Back Pain., Thomas J. Schnitzer, Souraya Torbey, Kristi Herrmann, Gagan Kaushal, Renita Yeasted, A. Vania Apkarian

College of Pharmacy Faculty Papers

BACKGROUND: Few effective pharmacological treatment options exist for chronic back pain, the leading cause of disability in the US, and all are associated with significant adverse effects.

OBJECTIVE: To determine the efficacy and safety of D-cycloserine, a partial agonist to the N-methyl-D-aspartate receptor, in the treatment of chronic low back pain.

METHODS: A total of 41 participants with chronic back pain who met all inclusion and exclusion criteria were enrolled in a double-blind, placebo-controlled randomized pilot trial of D-cycloserine. Treatment was administered orally for six weeks at escalating daily doses of 100 mg, 200 mg, and 400 mg, each for …

Correctional Change Through Neuroscience, Arielle R. Baskin-Sommers, Karelle Fonteneau

Fordham Law Review

Currently, the U.S. criminal justice system is under intense scrutiny. High- profile cases question the appropriateness of specific types of evidence, decision making in sentencing, and the treatment of convicted offenders. Clearly, these issues are not new. And, as has been historically the case, the justice system looks toward science for assistance in addressing and redressing problems with the delivery of justice.

Neuroscience And Criminal Law: Have We Been Getting It Wrong For Centuries And Where Do We Go From Here?, Elizabeth Bennett

Fordham Law Review

Moral responsibility is the foundation of criminal law. Will the rapid developments in neuroscience and brain imaging crack that foundation—or, perhaps, shatter it completely? Although many scholars have opined on the subject, as far as I have discovered, few come from a front-line perspective.

When Empathy Bites Back: Cautionary Tales From Neuroscience For Capital Sentencing, Sheri Lynn Johnson, Amelia Courtney Hritz, Caisa Elizabeth Royer, John H. Blume

Fordham Law Review

This Article examines the implications of emerging neuroscientific findings regarding empathy for capital trials. We have approached this task with caution because neuroscientists’ understanding of the human brain is still evolving. As with any new field, if neuroscience is completely trusted before it is thoroughly tested, there is a risk of embracing the new phrenology. Given the state of the research, our advice to defense lawyers is quite modest, but we believe that there are some important lessons for lawyers, judges, legislators, and other stakeholders in the capital punishment system.

Seeing Voices: Potential Neuroscience Contributions To A Reconstruction Of Legal Insanity, Jane Campbell Moriarty

Fordham Law Review

Part I of this Article explains the insanity defense in the United States. Next, Part II discusses some of the brain-based research about mental illness, focusing on schizophrenia research. Then, Part III looks at traumatic brain injury and the relationship among injury, cognition, and behavior. Finally, Part IV explains how a new neuroscience-informed standard might better inform our moral decision making about legal insanity.

Revitalizing Sec Rule 14a-8’S Ordinary Business Exclusion: Preventing Shareholder Micromanagement By Proposal, Stephen M. Bainbridge

Fordham Law Review

Who decides what products a company should sell, what prices it should charge, and so on? Is it the board of directors, the top management team, or the shareholders? In large corporations, of course, the answer is the top management team operating under the supervision of the board. As for the shareholders, they traditionally have had no role in these sort of operational decisions. In recent years, however, shareholders have increasingly used SEC Exchange Act Rule 14a-8 (the so-called “Shareholder Proposal Rule”) to not just manage but even micromanage corporate decisions. The Rule permits a qualifying shareholder of a public …

Vireo@Trecvid 2016: Multimedia Event Detection, Ad-Hoc Video Search, Video To Text Description, Hao Zhang, Lei Pang, Yi-Jie Lu, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

The vireo group participates in 3 tasks: multimedia event detection, ad-hoc video search, video-to-text description. In this paper, we will separately present frameworks for these tasks and discuss experimental results.

Vireo @ Trecvid 2016: Multimedia Event Detection, Ad-Hoc Video Search, Video-To-Text Description, Hao Zhang, Yi-Jie Lu, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

Multimedia events such as “birthday party” usually involve the complex interaction between humans and objects. Unlike actions and sports, these events rarely contain unique motion patterns to be vividly explored for recognition. To encode rich objects in the events, a common practice is to tag an individual video frame with object labels, represented as a vector signifying probabilities of object appearances. These vectors are then pooled across frames to obtain a video-level representation. The current practices suffer from two deficiencies due to the direct employment of deep convolutional neural network (DCNN) and standard feature pooling techniques. First, the use of …

Limiting Nutrient Contaminants From Agricultural Non-Point Sources: Nutrient Monitoring At Eku’S Meadowbrook Farm, Madison County, Kentucky, Walter S. Borowski, Jonathan M. Malzone

EKU Faculty and Staff Scholarship

Sources of contamination to U.S. waterways have largely shifted from industrial, point sources to agricultural and other non-point sources associated with common human activities. EKU’s Meadowbrook Farm explores best-practices in agriculture and animal husbandry that not only act to increase the efficiency of farm operations, but also to limit environmental effects such as the eutrophification of its neighboring watershed.

We recently started a collaboration with the Farm and the EKU Department of Agriculture, which are developing methods to sequester phosphorus and thus limit nutrient export to the adjacent Muddy Creek watershed. Our task is to quantify the amount of phosphorus …

The Doctrinal Structure Of Patent Law's Enablement Requirement, Jason Rantanen

Vanderbilt Law Review

This Article examines the formal law of enablement, focusing on a perceived split in the enablement doctrine: whether disclosure of a single mode of an invention is necessarily sufficient to satisfy the requirement of enablement or whether the full scope of the claim must be enabled. In examining this split, this Article articulates the enablement inquiry in conceptual terms, identifying two elements of the courts' analyses that are implicit in every enablement determination: the nature of enablement disputes, as challenges and the articulation of a target or targets that must be enabled. , With this understanding in mind, the "full …

Photocopies, Patents, And Knowledge Transfer: "The Uneasy Case" Of Justice Breyer's Patentable Subject Matter Jurisprudence, Dmitry Karshtedt

Vanderbilt Law Review

One aspect of Justice Stephen Breyer's discomfort with patents, as expressed in his opinion for the Supreme Court in Mayo v. Prometheus and his dissent from the order dismissing certiorari in LabCorp v. Metabolite, is strikingly similar to one of his critiques of copyright law in The Uneasy Case for Copyright, a well-known article he wrote as Professor Breyer more than forty-five years ago. In The Uneasy Case, Breyer argued that the burdens on duplication of technical articles imposed by copyright law restrict the flow of information and prevent scientists from enjoying spillover benefits of published research. His patent opinions …

Pierson, Peer Review, And Patent Law, Lisa L. Ouellette

Vanderbilt Law Review

When has a researcher done enough to merit a patent? Should the patent belong to the researcher who first suggests an invention or the one who brings it to fruition? The canonical dispute over a fox in Pierson v. Post is used to illustrate the competing policy considerations in deciding when to award a new property right, including providing efficient incentives, setting forth clear rules to guide future behavior, and respecting natural rights. In patent law, all of these considerations suggest that in practice, many patents are awarded too early, before an applicant has demonstrated that the invention is likely …

Validating A Measure Of Beliefs In Health Prevention Screenings Among Old Adults In China, H. Xu, Paulin Tay Straughan, W. Pan, Z. Zhen, B. Wu

Research Collection School of Social Sciences

We aimed to examine the psychometric properties of a modified 16-item Attitudinal Index (AI), a measure of health beliefs in health prevention screenings among Chinese older adults. We used the 2013 Shanghai Longitudinal Survey of Elderly Life and Opinion data including 3418 respondents aged 60 and above. We examined the validity and reliability of the modified AI. Psychometric evaluation of the modified AI revealed good response patterns. The overall scale had good reliability (Cronbach’s alpha = 0.835) with four distinct dimensions: barriers, fatalism, unnecessary, and detects (Cronbach’s alpha = 0.815 to 0.908). Confirmatory factor analysis of the modified AI’s factor …

’A Beautiful Bridge’: Chinese Indonesian Associations, Social Capital And Strategic Identification In A New Era Of China Indonesia Relations, Charlotte Setijadi

Research Collection School of Social Sciences

In Indonesia, Chinese voluntary associations took on a new level of importance after the fall of Suharto’s New Order regime in 1998 that ushered in a revival of Chinese identity politics. At the same time, Sino-Indonesian relations are blossoming, and the rise of China as a global power means that Indonesia can only benefit from stronger ties with China in the future. In this new atmosphere of cooperation, I argue that Chinese Indonesian individuals and voluntary organizations play a crucial function as trade and cultural intermediaries. Drawing on both empirical and qualitative fieldwork data, in this paper, I examine how …

Overexpression Of Hdac1 Induces Functional Β-Cell Mass, Carrie Draney

Theses and Dissertations

Type 2 diabetes is a metabolic disorder that results in β-cell dysfunction and ultimate destruction, and leads to impaired glucose homeostasis. High rates of proliferation and differentiation of pancreatic β-cells occurs mostly during neonatal development. However, research shows these mechanisms remain intact as β-cell proliferation has been observed during pregnancy and obesity. We have shown that overexpression of the β-cell transcription factor Nkx6.1 is sufficient to induce β-cell proliferation. Exploration of the transcriptional targets of Nkx6.1 has identified histone deacetylase 1 (HDAC1) as a down-stream target of Nkx6.1. Here we demonstrate that HDAC1 overexpression is sufficient to induce β-cell proliferation, …

Creativity & Religion: A Self-Study Of Mormon Mindset In The Art Classroom, Shon Scot Feller

Theses and Dissertations

A high school art teacher investigates the relationship of his religious beliefs with his notions of what it means to be creative. This Mormon teacher examines his religious and experiential life through self-study, by drawing from autoethnographic and hermeneutic phenomenological strategies. He believes that everyone, including himself and his students, has a creative potential. He also analyzes how his Mormon religion affects his view of creativity and how creativity has affected his behavior as a Mormon. The conclusions he reaches uncover the need for balance between his creative self and his Mormon self and outlines several ways to merge these …

“Whatdunit?” Developmental Changes In Children’S Syntactically-Based Sentence Interpretation Abilities And Sensitivity To Word Order, James W. Montgomery, Julia L. Evans, Ronald B. Gillam, Alexander V. Sergeev, Mianisha C. Finney

Special Education and Rehabilitation Counseling Faculty Publications

Aim 1 of this study was to examine the developmental changes in typically developing English-speaking children’s syntactically-based sentence interpretation abilities and sensitivity to word order. Aim 2 was to determine the psychometric standing of the novel sentence interpretation task developed for this study, as we wish to use it later with children with Specific Language Impairment (SLI). Children listened to semantically implausible sentences in which noun animacy and the natural affordance between the nouns were removed, thus controlling for event probability. Using this novel “whatdunit?” agent selection task, 256 children 7-11 years listened to two structures with canonical word order …

Inter- And Intra-Individual Variation In Predator-Related Behavioral Plasticity Expressed By Female Green Swordtails (Xiphophorus Hellerii), Rachael A. Disciullo

School of Biological Sciences: Dissertations, Theses, and Student Research

Phenotypic plasticity is the ability of one genotype to express multiple phenotypes under variable environments. Behavioral plasticity is a type of phenotypic plasticity in which individuals adjust behavior in response to changes in environment. Often, behavioral plasticity is studied at the level of the population, rather than at the level of the individual. Further, few studies have considered the effect of individual traits, such as size and age, on the expression of behavioral plasticity, or, how individual plasticity may be correlated across different contexts. In this study, we used female green swordtails (Xiphophorus hellerii) to test the effects …

Einsiedeln On The Ohio Overseas Migrations Of Einsiedeln People To The United States In The 19th And Early 20th Centuries, Heinz Nauer

Swiss American Historical Society Review

Between 1850 and 1950, more than 3,000 men and women from Einsiedeln went overseas, most of them to the United States. It was not unique since many people also migrated from other regions of Switzerland, and the total migrations of Swiss overseas during that time represented only a very small fraction of the global movement of people in three main directions: from Europe to the Western Hemisphere, from India and southern China to Southeast Asia, and from Russia to the Far East. 1 Despite not being out of the ordinary, it seems useful to explore the history of overseas migrations …

Determining The Interruption Of Services While Performing V2i Communication Using The Spmd Prototype, Binaya Raj Joshi

Student Work

The use of Vehicle to Vehicle (V2V), Vehicle to Infrastructure (V2I), Vehicle to Roadside Unit (V2R) and Vehicle to Other (V2X) communications are increasingly applied over existing and upcoming transportation means by the United States Department of Transportation (USDOT) and other federal agencies. From previous statistical data, these technologies would primarily avoid or mitigate vehicle crashes and would provide more safety, mobility and various other benefits on the roads (“Traffic Safety Facts 2012,” 2013; “Traffic Safety Facts 2013” 2014). During the communication processes between vehicles, infrastructures and roadside units’ various sensitive data such as positions and speed of the vehicles, …

United States Environmental Protection Agency Response To The Office Of Science And Technology Policy Memo, 2013: Public Access Plan (November 2016)

Copyright, Fair Use, Scholarly Communication, etc.

EPA response to OSTP memo, 2013: Public Access Plan (November 2016)

Symptom Clusters., Andrea M. Barsevick

Department of Medical Oncology Faculty Papers

No abstract provided.

The Targetable Epigenetic Tumor Protein Ezh2 Is Enriched In Intraocular Medulloepithelioma., Sarah E. Avedschmidt, Anna M. Stagner, Ralph C Eagle, George J. Harocopos, Yali Dou, Rajesh C. Rao

Wills Eye Hospital Papers

Purpose: Intraocular medulloepithelioma (IM), the second most common primary neuroepithelial tumor of the eye, can lead to blindness in the affected eye and in rare cases, is deadly. Intraocular medulloepithelioma lacks targetable biomarkers for potential pharmacologic therapy. The purpose of this study was to identify actionable, tumor-specific proteins for potential diagnostic or therapeutic strategies. We hypothesize that the tumor-specific epigenetic enzyme EZH2 is selectively expressed in IM.

Methods: We conducted a retrospective case series study of five IM from five eyes of four children and one adult. Hematoxylin and eosin (H&E) stains of sections from formalin-fixed, paraffin-embedded blocks of IM …

The Relevance Of Sex Differences In Performance Fatigability, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Performance fatigability differs between men and women for a range of fatiguing tasks. Women are usually less fatigable than men, and this is most widely described for isometric fatiguing contractions and some dynamic tasks. The sex difference in fatigability is specific to the task demands so that one mechanism is not universal, including any sex differences in skeletal muscle physiology, muscle perfusion, and voluntary activation. However, there are substantial knowledge gaps about the task dependency of the sex differences in fatigability, the involved mechanisms, and the relevance to clinical populations and with advanced age. The knowledge gaps are in part …