Digital Commons Network^™

The Protective Role Of Mlcp-Mediated Erm Dephosphorylation In Endotoxin-Induced Lung Injury In Vitro And In Vivo, Anita Kovacs-Kasa, Boris A. Gorshkov, Kyung-Mi Kim, Sanjiv Kumar, Stephen M. Black, David J. Fulton, Christiana Dimitropoulou, John D. Catravas, Alexander D. Verin

Bioelectrics Publications

The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute lung injury (ALI). We demonstrate that ectopic expression of a constitutively-active (C/A) MLCP regulatory subunit (MYPT1) attenuates the ability of LPS to increase endothelial (EC) permeability. Down-regulation of MYPT1 exacerbates LPS-induced expression of ICAM1 suggesting an anti-inflammatory role of MLCP. To determine whether MLCP contributes to LPS-induced ALI in vivo, we utilized a nanoparticle DNA delivery method to specifically target lung EC. Expression of a C/A MYPT1 reduced LPS-induced lung inflammation and vascular permeability. Further, increased expression of the …

Effects Of High Voltage Nanosecond Electric Pulses On Eukaryotic Cells (In Vitro): A Systematic Review, Tina Batista Napotink, Matej Reberšek, P. Thomas Vernier, Babara Mali, Damijan Miklavčič

Bioelectrics Publications

For this systematic review, 203 published reports on effects of electroporation using nanosecond high-voltage electric pulses (nsEP) on eukaryotic cells (human, animal, plant) in vitro were analyzed. A field synopsis summarizes current published data in the field with respect to publication year, cell types, exposure configuration, and pulse duration. Published data were analyzed for effects observed in eight main target areas (plasma membrane, intracellular, apoptosis, calcium level and distribution, survival, nucleus, mitochondria, stress) and an additional 107 detailed outcomes. We statistically analyzed effects of nsEP with respect to three pulse duration groups: A: 1–10 ns, B: 11–100 ns and C: …

Comparing Offline Decoding Performance In Physiologically Defined Neuronal Classes, Matthew D. Best, Kazutaka Takahashi, Aaron J. Suminski, Christian Ethier, Lee E. Miller, Nicholas G. Hatsopoulos

Biomedical Engineering Faculty Research and Publications

Objective: Recently, several studies have documented the presence of a bimodal distribution of spike waveform widths in primary motor cortex. Although narrow and wide spiking neurons, corresponding to the two modes of the distribution, exhibit different response properties, it remains unknown if these differences give rise to differential decoding performance between these two classes of cells. Approach: We used a Gaussian mixture model to classify neurons into narrow and wide physiological classes. Using similar-size, random samples of neurons from these two physiological classes, we trained offline decoding models to predict a variety of movement features. We compared offline …

Application Of Visual Cues On 3d Dynamic Visualizations For Engineering Technology Students And Effects On Spatial Visualization Ability: A Quasi-Experimental Study, Petros Katsioloudis, Vukica Jovanovic, Mildred Jones

STEMPS Faculty Publications

Several theorists believe that different types of visual cues influence cognition and behavior through learned associations; however, research provides inconsistent results. Considering this, a quasi-experimental study was done to determine if there are significant positive effects of visual cues (color blue) and to identify if a positive increase in spatial visualization ability for students in engineering technology courses is observed. According to the results of this study it is suggested that the use of the specific visual cue (color blue) provides no statistically significant higher scores versus the treatment that did not utilize any visual cues.

Sphingosine 1-Phosphate Lyase Ablation Disrupts Presynaptic Architecture And Function Via An Ubiquitin- Proteasome Mediated Mechanism, Dn Mitroi, Au Deutschmann, M Raucamp, I Karunakaran, K Glebov, M Hans, J Walter, J Saba, M Gräler, D Ehninger, E Sopova, O Shupliakov, D Swandulla, Echten-Deckert G Van

Peninsula Medical School

No abstract provided.

Crime In The Nfl: Does An Arrest History Lead To Better Performance?, Austin D. Crist

CMC Senior Theses

Teams in the National Football League will do whatever it takes to win football games, even if that means having players with a criminal arrest history on their roster. However, does being arrested result in improved performance? Do NFL players with an arrest history perform better than those without one? I examine the effect a criminal arrest record has on player performance in the NFL from 2000-2014, using the top 30 ranked players within each position group. The position I chose to analyze were: Quarterbacks, Running Backs, Wide Receivers, Defensive Linemen, Linebackers, and Defensive Backs. My findings show that having …

A Comparative Examination Of International Carbon Trading Mechanisms, Allison Moors

CMC Senior Theses

A Comparative Examination of International Carbon Trading Mechanisms

Nietzschean Ethics: One's Duty To Overcome, Emmanuel Hurtado

CMC Senior Theses

Abstract

In this paper, I will analyze Nietzsche’s argument for a moral error theory and examine the implications of his view. In order to arrive at the best possible interpretation I will heavily incorporate many passages from Nietzsche’s original works so that I can delve into a textual analysis of Nietzsche. Because Nietzsche is notoriously vague at times and often contradictory, I recognize that this is far from the only appropriate interpretation. However, I hope that it is one which has at least some intuitive appeal. Eventually, I hope to prove that despite his rejection of moral truths, Nietzsche’s theory …

Diversity And Innovation: The Effects Of Diverse Creator Teams On Video Game Characteristics And Sales, Jill C. Rosok

CMC Senior Theses

I analyze the effects of gender diversity on video game production teams. I hypothesize teams with greater gender diversity produce more games with uncommon characteristics than less diverse teams, and the games these teams develop generate higher revenue and unit sales compared to games developed by less diverse teams. I find teams with more women disproportionately develop games that are non-violent and have playable female leads. I examine whether there is an optimal ratio of women to hire for each game genre in order to maximize revenue by analyzing the relationship between the percentage of women on a team in …

Poetic Labor: Meaning And Matter In Robert Frost's Poetry., Lina Pan

CMC Senior Theses

This thesis examines Frost’s conception of poetry as the labor of human value. It investigates how Frost consciously shaped his notions of “sound of sense” and metaphor, which he deemed fundamental elements of poetic labor, in contradistinction to the Modernist poetics of Eliot and Pound. The author closely examines a representative sample of Frost’s poetry and prose as critiques of Modernist poetic theory and its implications for what Frost deemed the essential human function of poetry. The thesis will interest scholars studying strains of English poetic thought that developed concurrently with and against Modernist poetic thought. More broadly, it will …

Consumer Neuroscience: A Multi-Disciplinary Approach To Marketing Leveraging Advances In Neuroscience, Psychology And Economics, Bridget E. Blum

CMC Senior Theses

For decades, neuroscience has greatly contributed to our foundational understanding of human behavior. More recently, the findings and methods of neuroscience have been applied to study the process of decision-making in order to offer advanced insights into the neural mechanisms that influence economic and consumer choices. In this thesis, I will address how customized marketing strategies can be enriched through the integration of consumer neuroscience, an integrative field anchored in the biological, cognitive and affective mechanisms of consumer behavior. By recognizing and utilizing these multidisciplinary interdependencies, marketers can enhance their advertising and promotional mix to elicit desired neural and affective …

Playing God: An Analysis Of Video Game Religion, Joshua K. Boren

CMC Senior Theses

Video games offer a liberating, virtual-community building and meaning-making out-of-body experience for those that wholeheartedly engage in them. The lore and backstory of some of the most popular games (League of Legends, Kingdom Hearts, and World of Warcraft) are heavily influenced by all types of religion. In addition, and contrary to popular perception, a growing number of video games offer a global medium for instilling positive morals in society. As a result, video games become a religious placeholder or pseudo-religion for many of the most devoted gamers, because they offer many of the same experiences that religions do. …

Escaping The Poverty Trap: Formal Savings And Asset Accumulation In Rural Malawi, Audrey Breitwieser

CMC Senior Theses

Formal savings accounts can be an effective device for households to accumulate assets over time and thus have more funds available to better afford an expensive one-time payment, in the form of either addressing an economic shock or paying for an important life event. I explore this relationship using a field experiment in rural Malawi conducted from 2008-2010, and find that adoption of a formal savings account has no effect on the frequency of economic shocks that a household experiences, nor does it affect how households respond to shocks. However, I find that account adoption does significantly increase the frequency …

Ethical Considerations Facing The Regulation Of Self-Driving Cars In The United States, Richard Mancuso

CMC Senior Theses

Self-driving cars are here. Once an advanced technology that seemed futuristic, they are now closer than most believe. Many of the largest automobile manufacturers are working on autonomous vehicle technology of their own. Perhaps most well-known, though, are the cars being developed by Tesla and Google. Both companies have well-developed prototypes of fully autonomous vehicles, meaning they require no human input or supervision, and Tesla has promised widespread, consumer availability of this technology in the next one to two years.

Along with the availability of this technology to the public and transportation companies like Uber and Lyft, comes a need …

Environmental Impact Assessment: Gathering Experiences From Wave Energy Test Centres In Europe, Deborah Greaves, Daniel Conley, Davide Magagna, Eduardo Aires, Leitão J Chambel, Matthew Witt, Clare B. Embling, Brendan J. Godley, Anthony W.J. Bicknell, Jean Baptiste Saulnier, Teresa Simas, Am O’Hagan, J O’Callaghan, Brian Holmes, Jan Sundberg, Yago Torre-Enciso, Dorleta Marina

School of Engineering, Computing and Mathematics

No abstract provided.

A Video Game Design Based On Emotiv Neuroheadset, Rijin Raju, Chenguang Yang, Chunxu Li, Angelo Cangelosi

School of Engineering, Computing and Mathematics

No abstract provided.

Some Key Elements On Entomophagy In Africa: Culture, Gender And Belief, S. Niassy, H. D. Affognon, K. K.M. Fiaboe, K. S. Akutse, C. M. Tanga, S. Ekesi

All Peer-Reviewed Publications

Edible insects are a natural renewable food resource and, within the context of food security could be one solution for Africa. Although, entomophagy is still being practiced in Africa, there is a degree of rejection in certain milieu due to negative images associated with insects and poor awareness efforts. In order to understand the key elements that govern entomophagy in Africa, we conducted an online survey on edible insects in African countries and documented the importance of insects, cultures and believes associated to their use. We eventually looked at gender participation in entomophagy. Study showed that insect consumption can be …

Active Aggregation Among Sexes In Bean Flower Thrips (Megalurothrips Sjostedti) On Cowpea (Vigna Unguiculata), Saliou Niassy, Sunday Ekesi, Nguya K. Maniania, Benedict Orindi, Gerald B. Moritz, Willem J. De Kogel, Sevgan Subramanian

All Peer-Reviewed Publications

Male sexual aggregations are a common territorial, mating-related or resource-based, behaviour observed in diverse organisms, including insects such as thrips. The influence of factors such as plant substrate, time of day, and geographic location on aggregation of thrips is uncertain, therefore we monitored the dispersion of male and female bean flower thrips (BFT), Megalurothrips sjostedti (Trybom) (Thysanoptera: Thripidae), on cowpea, Vigna unguiculata (L.) Walp. (Fabaceae), over three cowpea growth stages and across three cowpea-growing areas of Kenya. Our results indicated that for all the crop growth stages, the density of BFTs varied over the time of day, with higher densities …

Rapid And High Throughput Molecular Identification Of Diverse Mosquito Species By High Resolution Melting Analysis., Yvonne Ukamaka Ajamma, Enock Mararo, David Omondi, Thomas Onchuru, Anne W.T. Muigai, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Mosquitoes are a diverse group of invertebrates, with members that are among the most important vectors of diseases. The correct identification of mosquitoes is paramount to the control of the diseases that they transmit. However, morphological techniques depend on the quality of the specimen and often unavailable taxonomic expertise, which may still not be able to distinguish mosquitoes among species complexes (sibling and cryptic species). High resolution melting (HRM) analyses, a closed-tube, post-polymerase chain reaction (PCR) method used to identify variations in nucleic acid sequences, has been used to differentiate species within the Anopheles gambiae and Culex pipiens complexes. We …

Mosquito Host Choices On Livestock Amplifiers Of Rift Valley Fever Virus In Kenya, David P. Tchouassi, Robinson O.K. Okiro, Rosemary Sang, Lee W. Cohnstaedt, David Scott Mcvey, Baldwyn Torto

All Peer-Reviewed Publications

Background: Animal hosts may vary in their attraction and acceptability as components of the host location process for assessing preference, and biting rates of vectors and risk of exposure to pathogens. However, these parameters remain poorly understood for mosquito vectors of the Rift Valley fever (RVF), an arboviral disease, and for a community of mosquitoes. Methods: Using three known livestock amplifiers of RVF virus including sheep, goat and cattle as bait in enclosure traps, we investigated the host-feeding patterns for a community of mosquitoes in Naivasha, an endemic area of Rift Valley fever (RVF), in a longitudinal study for six …

Plant Resting Site Preferences And Parity Rates Among The Vectors Of Rift Valley Fever In Northeastern Kenya, Samwel O. Arum, Christopher W. Weldon, Benedict Orindi, Caroline Tigoi, Francis Musili, Tobias Landmann, David P. Tchouassi, Hippolyte D. Affognon, Rosemary Sang

All Peer-Reviewed Publications

Background: Mosquito lifespan can influence the circulation of disease causing pathogens because it affects the time available for infection and transmission. The life-cycle of mosquitoes is determined by intrinsic and environmental factors, which can include the availability of hosts and suitable resting environments that shelter mosquitoes from extreme temperature and desiccating conditions. This study determined the parity rates (an indirect measure of survival) and plant resting preference of vectors of Rift Valley fever (RVF) in northeastern Kenya. Methods: Resting mosquitoes were trapped during the rainy and the dry season using a Prokopack aspirator from vegetation, whereas general adult populations were …

Success Stories And Emerging Themes In Conservation Physiology, Christine L. Madliger, Steven J. Cooke, Erica J. Crespi, Jennifer L. Funk, Kevin R. Hultine, Kathleen E. Hunt, Jason R. Rohr, Brent J. Sinclair, Cory D. Suski, Craig K. R. Willis, Oliver P. Love

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The potential benefits of physiology for conservation are well established and include greater specificity of management techniques, determination of cause–effect relationships, increased sensitivity of health and disturbance monitoring and greater capacity for predicting future change. While descriptions of the specific avenues in which conservation and physiology can be integrated are readily available and important to the continuing expansion of the discipline of ‘conservation physiology’, to date there has been no assessment of how the field has specifically contributed to conservation success. However, the goal of conservation physiology is to foster conservation solutions and it is therefore important to assess whether …

Phylogenetic Analysis Of Bunyamwera And Ngari Viruses (Family Bunyaviridae, Genus Orthobunyavirus) Isolated In Kenya, C. Odhiambo, M. Venter, O. Lwande, R. Swanepoel, R. Sang

All Peer-Reviewed Publications

Orthobunyaviruses, tri-segmented, negative-sense RNA viruses, have long been associated with mild to severe human disease in Africa, but not haemorrhagic fever. However, during a Rift Valley fever outbreak in East Africa in 1997-1998, Ngari virus was isolated from two patients and antibody detected in several others with haemorrhagic fever. The isolates were used to identify Ngari virus as a natural Orthobunyavirus reassortant. Despite their potential to reassort and cause severe human disease, characterization of orthobunyaviruses is hampered by paucity of genetic sequences. Our objective was to obtain complete gene sequences of two Bunyamwera virus and three Ngari virus isolates from …

Conditional Cash Transfers And Their Effect On Poverty, Inequality, And School Enrollment: The Case Of Mexico And Latin America, Maria Romano

CMC Senior Theses

Over the past two decades, conditional cash transfer (CCT) has become one of the most widespread approaches to social development in Latin America. Spurred in large part by the evident and immediate success of Mexico’s CCT initiative, a multitude of countries began to invest heavily in this strategy hoping to reduce poverty and inequality in the short and long run. This paper examines the relationship between CCT program breadth and poverty, inequality, and secondary school enrollment over a thirteen year span in order to determine whether or not programs with the largest coverage were the most efficient. This question is …

Practical Paradise: Ethics For A Modern Age, Anthony P. Davanzo

CMC Senior Theses

This play demonstrates an interpretation of Nietzsche's philosophy in practice. The main character experiences loss and confusion, however, through this struggle arrives at a discovery of profound truth. If you've ever wondered how to live your life in the best way possible, the main character believes he's found the answer.

A Philosophically Appealing Nietzschean Theory Of Value, Gustavo Pires De Oliveira Dias

CMC Senior Theses

This thesis is an attempt to bring forth a novel and philosophically appealing reading of Nietzsche, especially as it pertains to his theory of value. I define philosophically appealing as the view with the least amount of inconsistencies that still reaches a simple and logical conclusion. I explore questions regarding Nietzsche’s nihilism, his normative and metaphysical claims, as well as his view on human nature. I aim to satisfy sophisticated readers by investigating complex philosophical issues related to my interpretation of Nietzsche. I also aim to satisfy less sophisticated readers by explaining how my view is applicable, and beneficial, to …

Who Will Be The First To Buy Autonomous Vehicles? An Application Of Everett Rogers’ Diffusion Of Innovations Theory, Reilly Jackson Umberger

CMC Senior Theses

Autonomous, otherwise known as self-driving, vehicles represent the future of transportation. Vehicles that drive themselves offer far reaching benefits from increased leisure and productivity for individuals to significant improvements in congestion and infrastructure for governments. The autonomous car will radically change the way we look at transportation, and they are right around the corner. However, the question remains: are we ready? Are we, as a society, ready to hand over the steering the wheel and trust autonomous vehicles with our safety? This paper predicts how the autonomous car will spread through society by analyzing and applying the product qualities and …

The Value Of Commerce In The Merchant Of Venice, Caroline B. Ward

CMC Senior Theses

This thesis explores the pervasive role of commerce in Shakespeare’s comedy The Merchant of Venice, with a particular focus on the characters of Antonio, Bassanio, Shylock, and Portia, and the dual locales of Venice and Belmont. The way in which various characters engage in commerce is a reflection of their individual motives and affiliations. At the same time, the rhetoric of commerce, worth, and value colors the speech of various characters, and influences seemingly extra-commercial considerations such as identity, friendship, religion, socioeconomic status, and love. Ultimately, a close analysis of commercial transaction and language in the play reveals the …

Transformative Experience: Are Real-World Experiences As Transformative As We Think?, Janelle Shiozaki

CMC Senior Theses

This thesis analyzes L.A. Paul’s concept of transformative experience. It specifically analyzes Paul’s criteria for transformative experiences (TEs), which are experiences that are so epistemically (ET) and personally transformative (PT) that an agent can’t know what it’s like to have a TE until having the experience itself. Paul argues that the transformative nature of these experiences prevent us from being able to make a rational choice using our normative way of decision-making. According to Paul, this is especially problematic because some of life’s biggest choices involve TEs. I begin with an overview of Paul’s main thought experiments that illustrate the …

Best Friends Forever? The Influence Of Technology On High-Quality And Low-Quality Childhood Friendships, Molly R. O'Donnell

CMC Senior Theses

This literature review provides a holistic assessment of childhood interaction by investigating the many ways in which new technologies have influenced both high-quality and low-quality childhood friendships. As technology becomes increasingly more prevalent in society and inevitably continues to evolve peer-to-peer communication, traditional approaches to social interaction have adopted entirely new mediums. Children are now being exposed to communication-altering devices younger than ever before, which has profoundly influenced their social relationships. This thesis explores past competing research on the topic of children and technology by explaining the many ways in which technology has both helped children develop high-quality peer relationships, …