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Review: A Novel Multiple Sclerosis Model Utilizing Cuprizone And Rapamycin, Mara Bahri

University Honors Theses

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system leading to debilitating long-term neurologic damage, primarily due to the limited ability of remyelination in the adult human brain. This review summarizes the current knowledge regarding the combined administration of Cuprizone (CPZ) and rapamycin as a novel animal model for MS. Utilization of CPZ induces non-immune mediated demyelination, therefore bypassing complexities of the immune system and allowing analysis of de-/remyelination. Furthermore, remyelination occurs simultaneous with demyelination due to ongoing oligodendrocyte progenitor cells (OPCs) differentiation into mature oligodendrocytes (OLGs).

The immunosuppressive agent, rapamycin inhibits the regulatory pathway Akt/mTOR, …

Determinants Of Activity Levels In African Americans With Mild Cognitive Impairment., Barry W. Rovner, Md, Robin J. Casten, Phd, Benjamin E. Leiby, Phd

Department of Neurology Faculty Papers

Engaging in cognitive, social, and physical activities may prevent cognitive decline. In a sample of older African Americans with mild cognitive impairment (MCI; N=221), we investigated the cross-sectional relationships between activity levels and participants' demographic, clinical, and neuropsychological characteristics. The average age of participants was 75.4 years (SD, 7.0); 177 (80.1%) were women. Participation in cognitive/social activities was positively associated with education, depression, literacy, mobility, instrumental activities of daily living (IADL), verbal learning, and subcomponents of executive function. A linear regression identified IADLs, education, depression, and verbal learning as independent predictors. Participation in physical activities was positively associated with sex, …

Diabetes And Physical Activity, Jameela Banu

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Diabetes has been on the rise globally. Although many factors contribute to the increasing risk and manifestation of this disease lack and decreased physical activity/ exercise stands out as one of the major factors. Treatment interventions for prediabetic and diabetic patients include diet and lifestyle changes with enhanced physical activity/ exercise. Several types of physical activity are available for these patients but, recommendations have to be made on an individual basis after giving due consideration to the comorbidities and other risks and barriers. Implementation of progressive resistance therapy may be successful in maintaining glucose homeostasis in diabetic patients.

Assessing The Information Needs And Information Sources Of Urban And Peri-Urban Livestock Keepers In Kinondoni And Morogoro Urban Districts, Tanzania., Consolata Angello 1, Jangawe Msuya 2, Doris Matovelo 3

Library Philosophy and Practice (e-journal)

This paper discusses the information needs of urban and peri-urban livestock keepers and the various information sources used and their effectiveness in disseminating livestock information. Mixed method approach was the methodology used in the study whereby quantitative data was gathered using questionnaires while qualitative data was gathered using in-depth interviews and participant observations. Findings from this study revealed that livestock keepers had various information needs such as disease control (95.3%), nutrition and feeds (62.2%), markets (56.3%), housing techniques (29.1%) and loans (20.1%). Urban livestock keepers also used different sources of information to access information including veterinary shops (77.2%), extension services …

Current Challenges In Atrial Fibrillation Ablation, Edward John Davies

Peninsula Medical School Theses

The ablative management of atrial fibrillation, despite a number of landmark discoveries, remains one of the most challenging fields in interventional electrophysiology. It is generally accepted that successful isolation of the pulmonary veins is a highly effective way of managing paroxysmal forms of AF. However, despite almost a decade of research into alternative lesion patterns, the solution to persistent AF remains beyond our grasp. A variety of strategies have been proposed to target key areas in the atria; these use various complex mapping systems, usually based on tailored lesion sets to try and improve outcomes. None have proven to be …

Visual Odometry And Mapping In Natural Environments For Arbitrary Camera Motion Models, George Terzakis

School of Engineering, Computing and Mathematics Theses

This is a thesis on outdoor monocular visual SLAM in natural environments. The techniques proposed herein aim at estimating camera pose and 3D geometrical structure of the surrounding environment. This problem statement was motivated by the GPS-denied scenario for a sea-surface vehicle developed at Plymouth University named Springer. The algorithms proposed in this thesis are mainly adapted for the Springer’s environmental conditions, so that the vehicle can navigate on a vision based localization system when GPS is not available; such environments include estuarine areas, forests and the occasional semi-urban territories. The research objectives are constrained versions of the ever-abiding problems …

Memories From Rudbøl, 1923-1927: My Teaching At Rudbøl Danish School, M.R. Mikkelsen

The Bridge

All four of my grandparents emigrated from Denmark in the 1890s. The first time any member of my immediate family visited Denmark was almost a century later, when my wife Marge and I, together with our two sons David and Philip, went over to spend an eight-month sabbatical leave from Iowa State University in Denmark in 1981.

Use Of Plastic Mulch For Vegetable Production, Tiffany Maughan, Dan Drost

All Current Publications

Plastic mulches are used commercially for both vegetables and small fruit crops. Vegetable crops well suited for production with plastic mulch are typically high value row crops. This fact sheet describes the advantages, disadvantages, installation, and planting considerations. It includes sources for plastic and equipment.

Gras-Fed Americans: Sick Of Lax Regulation Of Food Additives, Martha Dragich

Faculty Publications

Americans are “GRAS-fed” because of a “loophole” in the strict regime Congress provided for the regulation of food additives. Additives - and food products containing them - are exempt from this strict regime if they are accorded GRAS (Generally Recognized as Safe) status. The guidelines Congress provided for achieving that status by scientific evidence of safety are no longer observed. Most additives are determined by the producer alone to be GRAS. At the same time, Americans’ consumption of highly processed foods continues to rise, giving rise to long-term health problems that are increasingly tied to diet. The average American’s diet …

Bound For Beaumont: Eleanor Roosevelt's 1939 Train Trip Through East Texas And Beyond, Mary L. Scheer

East Texas Historical Journal

No abstract provided.

Ethj Vol-54 No-2

East Texas Historical Journal

No abstract provided.

Anthropogenic Influence On Blackfin Sucker (Thoburnia Atripinnis) Distribution, In The Upper Barren River System, Kentucky And Tennessee, Christa Rose Hurak

Online Theses and Dissertations

We evaluated the effects of land use and cover on endemic blackfin sucker (Thoburnia atripinnis) catch per unit effort and abundance within the Upper Barren River (UBR) system, a priority conservation area, in south-central Kentucky. Anthropogenic impacts have rendered T. atripinnis a “species of greatest conservation need” by the Kentucky Department of Fish and Wildlife Resources. This study focused on determining if land use surrounding blackfin sucker sampling sites and certain physicochemical parameters could be impacting their inhabitance at these sites. Data collection and ground truthing occurred between September 2015 and June 2016. ArcGIS was used to extract land use …

Molecular Basis Of Sex Differences In Cardiac Hypertrophy And Heart Failure, Maya James

Online Theses and Dissertations

Transforming growth factor beta ligands and receptors are known to be pro-hypertrophic and pro-fibrotic factors in the heart, and are known to contribute to the development of cardiac hypertrophy and heart failure. It is well established that premenopausal females possess a lower incidence of these pathologies. We and others have observed a greater level of fibrosis in male hearts compared to female hearts in rodent models of cardiac hypertrophy. It is well established that estrogen is cardioprotective in that it can prevent the development of cardiac hypertrophy, as well as abrogate the development of heart failure following sustained cardiac hypertrophy. …

Galápagos Sea Lion (Zalophus Wollekaeki) Play Behaviors On San Cristóbal Island, Ecuador, Mary Ann Kincer

Online Theses and Dissertations

My thesis concerns observations of play activities from videotapes of Galápagos sea lions on San Cristóbal Island from mid-summer of 2008. I begin with a discussion of ideas about play and types of play, elaborate the conceptual system of projects and routines in play, and provide a brief description of sea lion taxonomy and forms of play specific to Galápagos sea lions. Observing approximately 713 minutes of videotapes, I coded approximately 161.5 minutes of play projects and routines. Of the 713 minutes, 241 minutes were used in training, and 472 were coded independently by two coders for reliability. The two …

An Examination Of Intrinsic Existence Value Towards Wildlife Of Columbus Zoo And Aquariums Tourists: Evaluating The Impact Of Behind The Scenes Programming, Robert Maxwell Lakes

Online Theses and Dissertations

Changes in climate and the corresponding environmental issues are major concerns facing the world today. Human consumption, which is leading the rapid depletion of the earth’s finite resources and causing a dramatic loss of biodiversity, is largely to blame (Pearson, Lowry, Dorrian, & Litchfield, 2014). American zoos and aquariums are positioned to create positive experiential relationships between zoo tourists and animals that have the potential to positively change the zoo tourists’ conservation behaviors. Challenges to changing the conservation behaviors of zoo tourists are many. One particularly important challenge is conservation/environmental education. Zoos and aquariums aim to provide effective and quality …

On The Shithouse Wall: The Communicative Value Of Latrinalia, Thomas Lively

Online Theses and Dissertations

Graffiti has communicative value, and it is a medium through which individuals voice their innermost thoughts, concerns, and beliefs. Restroom graffiti or "latrinalia" offers a unique space for graffiti writers to deliver their messages. The sole focus of this paper is to examine the meaning and communicative value of latrinalia as found in the men's restrooms of a medium-sized university. For this study, restrooms in 17 buildings were visited and a total of 965 instances of graffiti were recorded and codified into 14 different categories. The four most common categories of latrinalia were signature, sexual, artistic, and discriminatory. Latrinalia was …

Nemo's Plight: Political Economy, Green-Cultural Criminology, And Fish Abuse, Jordan Edward Mazurek

Online Theses and Dissertations

Using the Marine Aquarium Fish Trade as a case study, I propose an integrated theoretical framework in green criminology that strengthens the political economic "treadmill of production" theory (see Lynch et al., 2013) by incorporating an analysis of the "cultural grease" that ensures the treadmill’s smooth operation. Choosing fish as a subject matter, though, requires challenging the "thoroughgoing speciesism" (Beirne, 1999) inherent in the mammalian-centric animal abuse literature. To do this I draw from research in marine biology and animal cognition to philosophically establish that fish are moral agents, "subjects-of-a-life" (Regan, 1983) on par with mammals and thus worthy of …

Factors Influencing Pre-Fledging Mass Recession Of Nestling Tree Swallows, Katrina Deann Reeda Moeller

Online Theses and Dissertations

Fledglings of some aerial insectivores experience pre-fledgling mass recession, possibly to achieve an optimum wing loading by the time of fledging. However, studies of aerial insectivores to date have been limited to two species of swifts (Apodidae), and additional studies of species of aerial insectivores are needed to determine if factors contributing to pre-fledging mass recession vary among species. Thus, my objective was to examine factors contributing to pre-fledging mass recession by nestling Tree Swallows (Tachycineta bicolor). My study was conducted during the 2015 breeding season at the Blue Grass Army Depot in Madison County, Kentucky. Nestling Tree Swallows (n …

Beliefs And Motivations Of Foreign Language Learners, Noriko Okura

Online Theses and Dissertations

This study examines the Eastern Kentucky University students’ current characteristics, purposes, and expectations for learning Japanese and/or Spanish language. A survey was conducted to collect data on EKU students’ demographics, as well as motivations and foreign language learning beliefs. Two hundred thirty eight students completed the questionnaire that includes a modified version of Horwitz’s (1988) “Beliefs about Language Learning Inventory” (BALLI). Descriptive statistics including means, standard deviations, and frequencies were utilized to analyze the BALLI items. Results indicated that EKU students’ demographics are diverse. Students in Japanese and Spanish language classes differed primarily in their language beliefs related to their …

Biotic Assessment Of Two Central Kentucky Streams: Examining The Effects Of Wastewater Treatment And Anthropogenic Disturbance, Daniel John Ratterman

Online Theses and Dissertations

Globally, anthropogenic disturbance has altered many aquatic habitats, including lotic waters. Flowing, fresh water sustains life on Earth yet suffers the resulting waste products. Native, locally adapted ecosystems integrate or eliminate the byproducts of life. However an increase of human population, poor agricultural practices, accelerated overland runoff, a non-point source of pollution, and wastewater treatment plants (WTP), a point source of pollution, have all placed a strain on the world’s flowing, fresh, waters. The de-commissioning of two WTPs in the Kentucky River basin, and the commissioning of a new WTP in an adjacent watershed, provided an opportunity to examine the …

Enzyme Analysis Of Oxidatively Modified Proteins Post-Tbi, Brittany Rice

Online Theses and Dissertations

The brain is one of the most important organs in the body. It functions as a control center by regulating and coordinating actions and reactions, which is facilitated via signal transduction pathways. Its function is primarily dependent upon sufficient supply of glucose for energy metabolism. The dysfunction of the brain resulting from an external force is known as traumatic brain injury (TBI). Symptoms range from physical to psychological and effects can be mild, moderate, or severe depending on the extent of injury. TBI is associated with oxidative damage, the overproduction of reactive oxygen/nitrogen species. Reduced energy metabolism is a consequence …

"You'll Never Leave Harlan Alive": Using Fx's Justified To Form A Cultural Understanding Of Crime In Harlan County, Kentucky, Morgan Stone

Online Theses and Dissertations

Rural southern violence has long been a sensationalized issue. From the Hatfield and McCoy feud to Deliverance, social issues unique to the rural south have received a significant amount of focus within modern popular culture. One of the most recent and popular examples of southern culture and violence is the television network FX’s Justified, set in Harlan County, Kentucky. The storyline follows US Marshal Raylan Givens as he is sent back to Kentucky after a misstep during his tenure in Miami. After arriving in his home state, he finds himself constantly drawn back to his hometown of Harlan, Kentucky, whether …

American Kestrels (Falco Sparverius) May Use Tail-Pumping To Maintain Balance, Joshua Suich

Online Theses and Dissertations

When perched, several species of small falcons, including American Kestrels (Falco sparverius), often pump their tails, but the possible function of this behavior is unknown. My objective was to use observations and experiments to examine the possible function(s) of tail-pumping by American Kestrels. Fieldwork was conducted from March 2015 to December 2015 at the Blue Grass Army Depot in Madison County, Kentucky. During observations of focal kestrels, I noted their behavior (e.g., landing on a perch, hunting, or consuming prey), including when and how often they pumped their tails (i.e., rapid movement of the tail down, then back up to …

Recruitment Of Monocytes To The Pre-Ovulatory Ovary, Alex Paige Whitaker

Online Theses and Dissertations

Ovulation is a recurring biological process that involves inflammatory reactions that degrade and restructure tissue. It requires the chemotaxis of leukocytes to the ovary to help regulate and promote these events. Hormonal signals and chemokines that are released during the peri-ovulatory period initiate the release of specific leukocyte populations, possibly from the spleen, that infiltrate the ovary and facilitate the release of oocytes from ovarian follicles. These studies utilized a super-ovulation protocol to initiate ovulation in immature balb/c and cd1 mice. Ovaries were collected at several times post human chorionic gonadotropin (hCG) injection and analyzed by multi-color flow cytometry. Oviducts …

Wellspring, Alicia Bones

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Before The Wind, Charles R. Decker

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

From A Poetry Handbook For Mining Engineers, Jolene M. Brink Mrs

Graduate Student Theses, Dissertations, & Professional Papers

This poetry collection utilizes A.G. Charleton’s Report Book for Mining Engineers (Whitehead, Morris & Co, 1908). The original 200-page report book contains questions and blank entries for the engineer to collect information for mine owners planning to sell or acquire property. The poems in from A Poetry Handbook for Mining Engineers use the artifact of this handbook—and the unanswered questions in the found text—to interrogate historic language surrounding mining and excavation, as well as material accumulation, alchemical practices, and the tradition of mining in northern Minnesota and the Norwegian village of Røros.

Toward An Ontology Of Exhaustion: On The Affective Structures Of Masculinity In The American Oilfield, John W. Jepsen

Graduate Student Theses, Dissertations, & Professional Papers

What is the significance of the oil encounter in the lives of men living and working in the modern oilfields of the United States? Engaging with both literary examples of the lives of men in the Interior West and the personal experiences and reflections of the author, this essay seeks to examine the connections between ideology and place as it works to shape the identity and affect of men in America's oilfields, ultimately ending in them identifying with the very resources their activities seek to exploit and exhaust. Utilizing Theodore Adorno's Minima Moralia as its moral touchstone, this essay works …

The Potential For Nigella Sativa In Treating In Risk Factors Related To The Metabolic Syndrome, Danielle L. Vaughn

Research Papers

No abstract provided.

Reading-Specific Flexibility Moderates The Relation Between Reading Strategy Use And Reading Comprehension During The Elementary Years, Emily K. Gnaedinger, Alycia M. Hund, Matthew S. Hesson-Mcinnis

Faculty Publications – Psychology

The goal was to test whether cognitive flexibility moderates the relation between reading strategy use and reading comprehension during the elementary years. Seventy-five second through fifth grade students completed a think aloud task and a metacognitive questionnaire to measure reading strategies, two card-sorting tasks to measure general and reading-specific cognitive flexibility, and one standardized measure of reading comprehension, as well as measures of oral reading fluency and vocabulary. As expected, oral reading fluency and vocabulary predicted reading comprehension, as did reading-specific flexibility. Importantly, reading-specific flexibility had a significant moderating effect, over and above the other effects. Specifically, weak reading-specific flexibility …