Digital Commons Network^™

What Would The Babel Fish Say?, Monica Gagliano

Animal Sentience

Starting with its title, Key’s (2016) target article advocates the view that fish do not feel pain. The author describes the neuroanatomical, physiological and behavioural conditions involved in the experience of pain in humans and rodents and confidently applies analogical arguments as though they were established facts in support of the negative conclusion about the inability of fish to feel pain. The logical reasoning, unfortunately, becomes somewhat incoherent, with the arbitrary application of the designated human criteria for an analogical argument to one animal species (e.g., rodents) but not another (fish). Research findings are reported selectively, and questionable interpretations are …

Toward A Better Understanding Of Community Benefits Assessment Practices., Peter B. Meyer, Lauren Heberle

Faculty and Staff Scholarship

No abstract provided.

State Of Metropolitan Housing Report: Living In Community: Housing For People Living With Disabilities And Our Aging Population, Lauren Heberle, B. Mcreynolds, A. Sizemore, S. Sizemore, T. Malone, J. Beard, Cate Fosl

Faculty and Staff Scholarship

No abstract provided.

Legislation's Culture, Richard K. Neumann Jr.

Hofstra Law Faculty Scholarship

American statutes can seem like labyrinthine mazes when compared to some countries’ legislation. French codes are admired for their intellectual elegance and clarity. Novelists and poets (Stendhal, Valéry) have considered the Code civil to be literature. Swedish legislation might be based on empirical research into problems the legislation is intended to remedy, and the drafting style, though modern today, is descended from an oral tradition of poetic narrative.

Comparing these legislative cultures with our own reveals that the main problem with American legislation is not too many words. It is too many ideas — a high ratio of concepts per …

Dogging Darwin: America's Revolt Against The Teaching Of Evolution, J. Herbie Difonzo

Hofstra Law Faculty Scholarship

More than four in ten Americans believe that God created humans in their present form 10,000 years ago. American antagonism toward the teaching of evolution is deeply rooted in fundamentalist radition and an aversion to intellectualism. These forces have combined to demonize Charles Darwin to such an extent that sectarian-based legal and political attacks on evolution show no signs of abating. Darwin's day in court began in 1925 with the famous Scopes Monkey Trial. It continued into the 21' century with Kitzmiller v. Dover Area Schools. Throughout, the core creationist agenda has remained the same, although an evolution in labeling …

Zika Funding And Partisan Politics, Janet L. Dolgin

Hofstra Law Faculty Scholarship

No abstract provided.

Transcriptional Regulation Of Dual-Specificity Phosphatase 4 (Dusp4) By Muscle Ring Finger 1 (Murf1) And Myogenic Regulatory Factors, Ashley Noel Haddock

UNF Graduate Theses and Dissertations

Skeletal muscle atrophy can occur at any age and as a result of numerous physiological conditions and thus, it was necessary to better identify the molecular underpinnings of the atrophy cascade so that new therapeutic targets to treat muscle wasting might be identified. MuRF1 was first identified as a marker of skeletal muscle atrophy over a decade ago; however, recent work suggests that this E3 ubiquitin ligase may participate in muscle wasting by regulating the transcriptional activity of genes differentially expressed in response to muscle atrophy. Dusp4, a dual-specificity phosphatase and member of the MAPK cascade, is induced in response …

Mechanisms Of Innate And Adaptive Immune Function In Parkinson Disease, Heather Elizabeth Allen

All ETDs from UAB

Parkinson disease (PD) is a common neurodegenerative movement disorder characterized pathologically by loss of dopaminergic neurons in the substantia nigra and aggregation of alpha-synuclein (α-syn) into large inclusions. The association of mutations and gene multiplications in SNCA, the gene encoding α-syn, with rare familial forms of PD led to the discovery that α-syn plays a key role in the pathogenesis of PD. The mechanism by which α-syn mediates its toxicity remains uncertain. A leading hypothesis states that the toxic effects of α-syn are mediated by activation of both the innate and adaptive immune systems within the central nervous system. Supporting …

Pattern Formation And Semilinear Evolution Equations In Function Spaces, Kwadwo Antwi-Fordjour

All ETDs from UAB

predictors, and find that under the test of group differences, MacKinnon and White’s HC2

Low Power Oscillator Based Sensor Signal Monitoring System, A K M Arifuzzman

All ETDs from UAB

With the advances in the integrated circuit technologies, various types of micro- and nano-sensors are increasingly being utilized in different fields such as medical monitoring, wireless health monitoring, structural health monitoring, where low power consumption, small dimensions, multi-signal sensing capabilities and wireless telemetry are required. Various types of bio-electrical signals are used in the medical sensor systems for diagnostics as well as therapeutic interventions. Usually, bio-signals have the common features of low frequency, and low amplitude level. In this work, a low current sensor signal monitoring system has been proposed and developed, which possesses several merits in terms of high …

The Use Of Minecraft As An Educational Tool To Improve Student Performance In The Classroom, James Roberts

Graduate Research Papers

While the author will be speaking directly of his experiences in a classroom and district setting, he argues that these same ideas can be carried out by others who would perform the same tests that he does. The idea behind exploratory class is to give students in grades 6 through 8 the opportunity to see what kinds of classes that are offered at Panorama schools as well as introduce them to possible career choices like automotive repair or construction trades that they might find interesting and wish to pursue later in life. Since there are over 60 students in each …

“Yellow Crowfoot In The Pond,/Not Lotus, Not Lily”: Mapping The River, Mapping Voices, Pamela J. Rader

Asian American Literature: Discourses & Pedagogies

This paper examines the prosody of Chin’s eponymous poem, "The Phoenix Gone, The Terrace Empty," through an eco-critical lens. While it does not dismiss the hybrid cultural influences of the poem, it focuses on the ways the non-human agents, or the figures in the poem’s landscape, “speak.” Poetry, like the poem’s terraced gardens, traces tension between the controlling human forces experienced by the narrating female I personas and the natural world’s affective inclinations.

Bringing Active Learning Into High School Economics: Some Examples From The Simpsons, Joshua C. Hall, Alex Peck, Marta Podemska-Mikluch

Economics Faculty Working Papers Series

In this brief educational note, we provide several examples of directed classroom activities for the high school economics classroom using the long-running television show The Simpsons. In doing so, we provide an overview of the scholarly literature on using popular culture to teach economics. Our examples highlight how popular culture can be successfully employed at the secondary level to engage and teach students through active learning. We conclude with some thoughts for secondary social studies teachers looking to enhance economic instruction.

Human Capacities And The Problem Of Universally Equal Dignity: Two Philosophical Test Cases And A Theistic Response, Matthew R. Petrusek

Theological Studies Faculty Works

No abstract provided.

Geophysical Imaging Of Karst Features In Missouri, Jeremiah Chukwunonso Obi

Doctoral Dissertations

"Automated electrical resistivity tomography (ERT) supported with multichannel analysis of surface waves (MASW) and boring data were used to map karst related features in Missouri in order to understand karst processes better in Missouri. Previous works on karst in Missouri were mostly surficial mapping of bedrock outcrops and joints, which are not enough to define the internal structure of karst system, since most critical processes in karst occur underground. To understand these processes better, the density, placement and pattern of karst related features like solution-widened joints and voids, as well as top of bedrock were mapped. In the course of …

Two Complete Mitochondrial Genomes From Praticolella Mexicana Perez, 2011 (Polygyridae) And Gene Order Evolution In Helicoidea (Mollusca, Gastropoda), Russell L. Minton, Marco A. Martinez Cruz, Mark L. Farman, Kathryn E. Perez

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Helicoidea is a diverse group of land snails with a global distribution. While much is known regarding the relationships of helicoid taxa, comparatively little is known about the evolution of the mitochondrial genome in the superfamily. We sequenced two complete mitochondrial genomes from Praticolella mexicana Perez, 2011 representing the first such data from the helicoid family Polygyridae, and used them in an evolutionary analysis of mitogenomic gene order. We found the mitochondrial genome of P. mexicana to be 14,008 bp in size, possessing the typical 37 metazoan genes. Multiple alternate stop codons are used, as are incomplete stop codons. Mitogenome …

Hate Speech And Double Standards, Thomas M. Keck

Political Science - All Scholarship

Many European states ban the public expression of hateful speech directed at racial and religious minorities, and an increasing number do so for anti-gay speech as well. These laws have been subjected to a wide range of legal, philosophical, and empirical investigation, but this paper explores one potential cost that has not received much attention in the literature. Statutory bans on hate speech leave democratic societies with a Hobson’s choice. If those societies ban incitements of hatred against some vulnerable groups, they will inevitably face parallel demands for protection of other such groups. If they accede to those demands, they …

Copper Chaperone In Streptococcus Mutans Biofilm Formation And Dispersion Of Biofilms By Small Molecules, Sandra Stephanie Garcia

All ETDs from UAB

program pilot study randomly assigned 100 women, aged 19 to 25 to two groups. One

Neurobiological Consequences Of Perinatal Ssri Exposure, Matthew Edward Glover

All ETDs from UAB

Selective serotonin reuptake inhibitors (SSRIs) have been a mainstay pharmacological treatment for women experiencing depression during pregnancy and postpartum for nearly three decades. Recently, though, growing evidence indicates that early-life SSRI exposure triggers long-lasting behavioral abnormalities. Clinically, children exposed to SSRIs in early life exhibit increased internalizing behavior, reduced social behavior, and increased risk for depression in adolescence. Similarly, in rodents, perinatal SSRI exposure leads to increased traits of anxiety- and depression-like behavior. Interestingly, certain individuals are more susceptible to early-life SSRI exposure than others, suggesting that perinatal SSRI exposure poses greater risks for negative outcome within certain populations; however, …

Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell

All ETDs from UAB

The virus capsids of many dsDNA bacteriophage are finely tuned macromolecular machines. Their functionality begins at assembly, when their capsids are built under the guidance of a class of proteins referred to as scaffolding proteins. The scaffolding protein of bacteriophage P22 is a flexible, highly elongated protein that binds to the interior surface of the P22 procapsid via its C-terminal domain. The finding that N-terminus is dispensable for procapsid binding prompted the development of chimeric scaffolding protein molecules, wherein N-terminal residues of scaffold are replaced with a variety of different peptide sequences or functional proteins that are then encapsidated within …

Methods For Measuring Individually Experienced Temperature And Food Intake In Controlled Thermal Environments, Molly Bernhard

All ETDs from UAB

The three studies to be presented assess individual-level heat exposure in free-living urban and rural environments and assess food intake in randomized controlled trials in a 2-hour exposure, and a 7-hour crossover heat exposure. The first interest was broad: examining heat exposure and its relation to potential health outcomes. To examine whether heat exposure could be measured in free-living organisms, a light and temperature monitoring device was repurposed and used in a pilot study of individual-level heat exposure in urban and rural community members. Differences between the current and most commonly accepted way of estimating heat exposure, weather station datasets, …

Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt

All ETDs from UAB

All eukaryotic cells contain a secretory pathway composed of membrane-bound compartments connected by vesicles that transport cargo from the endoplasmic reticulum (ER) through the Golgi apparatus to various destination within and outside the cell. The Golgi Brefeldin A-resistant Factor 1 (GBF1) is required for protein traffic between ER and Golgi and within the Golgi. GBF1 belongs to a family of Guanine nucleotide Exchange Factors (GEFs) that stimulate the nucleotide exchange of GDP for GTP on small GTPases called ADP-ribosylation factors (ARFs). Once GTP-bound, ARFs become active and initiate a cascade of events that lead to vesicle formation. Thus, GBF1 is …

Calcium Carbonate Composition And Other Measures Of Vulnerability Of The Skeletons And Shells Of Echinoderms And Gastropods Challenged By Ocean Acidification Or Climate Warming, Ashley Duquette Douglas

All ETDs from UAB

Marine invertebrate calcium carbonate (CaCO3) composition will likely be impacted by climate warming and ocean acidification (OA). Elevated temperature alters physiological processes that can induce stress, and OA alters the ability of calcareous marine invertebrates to maintain acid-base balances, calcify, and repair skeletal dissolution. The first of three chapters of this dissertation exploits a natural CO2 seep to evaluate impacts of chronic exposure to OA on the shells of four gastropods: the limpets Patella caerulea and P. rustica, top-shell snail Osilinus turbinatus, and whelk Hexaplex trunculus. All four gastropods experienced shell dissolution to various degrees and reduced shell integrity as …

The Function Of Prmt1 In Normal And Abnormal Megakaryopoiesis, Hairui Su

All ETDs from UAB

Protein arginine methylation is a common type of post-translational modifications. Protein arginine methyltransferase 1 (PRMT1) is the predominant PRMT that is involved in diverse physiological and pathological processes in mammalian cells. Dysregulation of PRMT1 is often positively correlated with cancer development, yet many aspects of PRMT1’s role in cancer, especially in acute megakaryoblastic leukemia (AMKL) remain unclear. We identified two PRMT1-methylated substrates and how they impact normal and abnormal megakaryopoiesis. In this dissertation, we demonstrate that dual-specificity protein phosphatase 4 (DUSP4) and RNA binding motif protein 15 (RBM15), two crucial factors for megakaryocytic (MK) differentiation, are methylated by PRMT1 and …

Natural Variation Of The Ire1a Gene Of Arabidopsis Thaliana And Its Effects On Abiotic Stress Tolerance, Brenna Cathryn Terry

All ETDs from UAB

The IRE1a protein is a key player in the response of plant cells to endoplasmic reticulum (ER) stress by activating bZIP60, a transcription factor implicated in effective ER stress response. Natural variation has been observed in the expression of the IRE1a gene in natural accessions of Arabidopsis thaliana, a model plant organism. Here, an attempt is made to correlate basal natural variation of IRE1a with response of the plant to abiotic stress. Abiotic stress response through IRE1a activity, specifically bZIP60 transcript splicing, does correspond to basal IRE1a expression. Additionally, alleles of the IRE1a gene were determined to exist as a …

Liberty And Collaboration For All: A Case Study On Collective Impact, Social Capital, And Community Inclusion, Laura Peyton Vickery

All ETDs from UAB

Disenfranchised communities often face exclusion at the hands of outside organizations trying to assist. Citizens within the community are excluded and left with few means of actively participating in the conversation and development surrounding these communities. This paper takes the position that the imbalance of power dynamics, where citizens become subjects, does not fully utilize the potential of those inside and those from outside the community. As discussed in Chapter 1, utilizing social capital to build networks and integrate insider and outsider organizations and resources will ultimately create optimization. Chapter 2 uncovers historical examples of civic life and a new …

Investigating The Mechanisms Of Dopaminergic Signaling In Regulating Refractive Error, Alexander Hadwyn Ward

All ETDs from UAB

Myopia is a significant public health problem. Most juvenile-onset myopia occurs because the eye becomes too long for its own optics. We study mechanisms regulating refractive error in an animal model, the tree shrew (Tupaia glis belangeri), a mammal closely related to primates. We use translucent diffusers to induce form deprivation myo-pia (FDM). A role of the retinal dopaminergic system has been validated during the de-velopment of FDM. In this study, in Specific Aim 1, we used intravitreal injections as a way to deliver sub-stances to the retina to investigate their effect on eye growth and induced myopia. However, a …

An Investigation Into The Developmental Response Of The Amphipod Hyalella Azteca To Different Predator-Related Chemical Cues, William Ryan James

All ETDs from UAB

Predator chemical cues have been widely demonstrated to influence developmental plasticity in aquatic prey. However, understanding the role that conspecifics have on an individual’s anti-predator response has received little attention. The present thesis investigated the developmental plasticity of individual and groups of the amphipod Hyalella azteca chronically exposed to kairomones from predatory sunfish. Previous field studies have suggested that small body size in H. azteca is a likely adaptive response to reducing predation by sunfish, but no experimental studies have been carried out to test if the amphipods have a developmental response to the presence of sunfish. Containers with single …

Egesta Of The Sea Urchin Lytechinus Variegatus Promote Weight Gain In The Shrimp Litopenaeus Vannamei, Karen Elizabeth Jensen

All ETDs from UAB

Long-term economic and environmental sustainability of aquaculture will be dependent on utilization of novel nutrient sources and remediation of effluent streams. Integrated Multi-Trophic Aquaculture (IMTA) is a method intended to maximize productivity and minimize waste by strategically reusing effluent from a primary, fed species in the production of one or more secondary, extractive species. Such relationships are based on the trophic role of the fed and extractive species in question. Sea urchin egesta are thought to play a role in nutrient cycling in natural habitats by providing an energy source for many coprophagous deposit feeders, suspension feeders, and microbes. The …

Motor Unit Remodeling During Neuromuscular Degeneration In Aging And Parkinson's Disease, Neil Anthony Kelly

All ETDs from UAB

The human neuromuscular system deteriorates progressively with age and disease. This results in denervation events and ultimately motor unit remodeling, which is revealed by abnormal “groups” of myofibers expressing the same myosin protein isoform – a phenomenon described as myofiber type grouping. Despite the acceptance of myofiber type grouping as a hallmark indicator of motor unit remodeling, traditional techniques of detecting it lack quantitative parameters and therefore comparative data in aging and disease are scarce. The purpose of this dissertation is to establish a statistically-driven, quantitative method for detecting myofiber type grouping and to use it to characterize the effects …