Digital Commons Network^™

Associations Of Perfluoroalkyl Substances (Pfass) With Lower Birth Weight: An Evaluation Of Potential Confounding By Glomerular Filtration Rate Using A Physiologically Based Pharmacokinetic Model (Pbpk), Marc-André Verner, Anne E. Loccisano, Nils-Halvdan Morken, Miyoung Yoon, Huali Wu, Robin Mcdougall, Mildred Maisonet, Michele Marcus, Reiko Kishi, Chihiro Miyashita, Mei-Huei Chen, Wu-Shiun Hsieh, Melvin E. Andersen, Harvey J. Clewell Iii, Matthew P. Longnecker

ETSU Faculty Works

Background: Prenatal exposure to perfluoroalkyl substances (PFAS) has been associated with lower birth weight in epidemiologic studies. This association could be attributable to glomerular filtration rate (GFR), which is related to PFAS concentration and birth weight.

Objectives: We used a physiologically based pharmacokinetic (PBPK) model of pregnancy to assess how much of the PFAS–birth weight association observed in epidemiologic studies might be attributable to GFR.

Methods: We modified a PBPK model to reflect the association of GFR with birth weight (estimated from three studies of GFR and birth weight) and used it to simulate PFAS concentrations in maternal and cord …

A 3d Radiographic Evaluation Of Crestal Bone Changes Around Immediately Loaded Endosseous Implants, Keerthi Senthil

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this clinical investigation is to evaluate and compare the 3-dimensional radiographic crestal bone changes around 4 immediately placed and loaded implants supporting full arch fixed mandibular prosthesis in 2 groups of patients. The Test group comprises of patients with failing mandibular teeth needing extraction. ( due to caries, periodontal disease, fractures or prosthetic reasons).The Control group comprises of patients with a fully edentulous mandible presenting for fixed implant supported prosthesis with at least 6 months after the last extraction or bone grafting procedure. Stereolithographic bone model obtained from the patient’s DICOM files was used to fabricate the …

Soft-Sediment Deformation And Dune Collapse In The Navajo Sandstone, Colby Ford

Loma Linda University Electronic Theses, Dissertations & Projects

The Canyon Overlook Trail of Zion National Park follows an outcrop of Navajo Sandstone, which displays a uniquely well-exposed assemblage of features associated with failure of the lee face of a large eolian dune, and run-out over an expanse of interdune sediments downwind of that bedform. Exposed features include dramatic folds in the interdune succession and a stacked series of thrust sheets incorporating both interdune and overlying dune deposits. Thrust surfaces display consistent strikes, parallel to those of undeformed foresets, and incorporate zones of brittle failure and fluid deformation, including folds overturned in the direction of foreset dip. These features …

High-Resolution Correlation Of A Time-Bounded Unit Of The Pisco Formation, Peru, Daniel J. O'Hare

Loma Linda University Electronic Theses, Dissertations & Projects

Correlation of beds in the Pisco Basin across significant distances is problematic and has not yet been effectively achieved. I chose to examine an interval bounded by two time markers, an 40Ar/39Ar-dated white tuff at the base and an 40Ar/39Ar-dated tuff couplet at the top. This interval was chosen because of the continuity and excellent exposure of the tuff beds at six distinct locations in a linear transect 30 km long. Correlation of units was achieved through 40Ar/39Ar dating, lithology, sedimentary structures, and magnetic susceptibility. The vertical and lateral variability in lithology, fossil assemblages, structures, and sequences was examined in …

Getting To The Doctor: Bpss Factors Of Health Care Utilization In Fragile Families, Veronica P. Kuhn

Loma Linda University Electronic Theses, Dissertations & Projects

The number of fragile families where a child is born to unwed parents has increased greatly over the past half-century and now represents a diverse population in the United States (Ventura, 2009). These families, who are predominantly African American and Hispanic (Hummer & Hamilton, 2010) and are more likely to live in poverty and experience poorer health, face significant barriers to access and utilize health care services (De Marco & De Marco, 2009; Williams, 2008). Limited research exists on how these facets of the illness experience might differ for fragile families whose resources are limited prior to illness. The Biopsychosocial …

Paternal Depression In The Peripartum Period: An International Delphi Study, Cassidy J. Freitas

Loma Linda University Electronic Theses, Dissertations & Projects

This dissertation aims to reach consensus on the defining factors of Paternal Peripartum Depression (PPPD) as well as identify research priorities through the Delphi method. Peripartum Depression is a major health issue for parents and their children. Fathers are at risk for peripartum depression due to the changes in identity, relationship, and biology they face during their transition to parenthood. A father’s mental health plays an intimate role in the overall health and outcomes of his family, but up until this point has been significantly overlooked. Due to the paucity of research and lack of clear consensus on the identifying …

Executive Dysfunction Is Predictive Of Clinical Symptomatology In 22q11.2 Deletion Syndrome, Chinonyere Kemdirim Bello

Loma Linda University Electronic Theses, Dissertations & Projects

By adulthood, 25%- 30% of individuals with 22q11.2 deletion syndrome (22qDS) develop a psychotic disorder, often schizophrenia, and it is not understood why. Given the known genetic etiology of this disorder and the greatly elevated risk for development of schizophrenia, this group offers the possibility of defining a seemingly homogenous maturational pathway to psychosis. Neurocognitive deficits have been increasingly recognized as an important dimension of schizophrenia, particularly in the executive domain. Thus, we assessed multiple aspects of executive cognition in 22qDS, in order to: 1) characterize performance across this domain as compared to age-matched healthy controls; and 2) determine whether …

Online Psychoeducational Therapy For Chronic Pain, Cynthia Marie Nakoski

Loma Linda University Electronic Theses, Dissertations & Projects

The pain experience consists of many factors including biological, psychological, social and spiritual that can exacerbate and perpetuate it, often leading to chronic pain. Provision of an online psychoeducational course, inclusive of social networking capabilities, offers remote access to invaluable information for the enhancement of self-efficacy in the treatment of chronic pain. The focus of this doctoral project was the creation of a website that includes pain management lessons comprised of Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, Family Therapy, and Spirituality modules. The website incorporates psychometrics, automated course tracking, and social network components allowing for research reporting, self-paced interactive …

Behavioral Assessment And Referral For Patients With Cardiovascular Disease, Sarah June Sadeghi

Loma Linda University Electronic Theses, Dissertations & Projects

Cardiovascular disease (CVD) is the most frequent cause of death in the United States. CVD affects more than a third of the U.S. population translating to approximately $431.8 billion in direct and indirect costs (Rosamond et al., 2007 as cited in Hunter et al., 2009). Given the significant rates of mental health issues exhibited in cardiovascular patients coupled with the lack of standard screening practices of psychosocial risk factors implicated in cardiovascular disease, the introduction of adequate assessment and referrals to mental health providers could substantially benefit health outcomes of patients.

The aims of this project are to: 1) provide …

Effect Of Vestibular Adaptation Exercises On Chronic Motion Sensitivity, Danah Alyahya

Loma Linda University Electronic Theses, Dissertations & Projects

Dizziness is one of the most common complaints reported to primary care physicians. It is often associated with vestibular dysfunction and typically impacts postural stability. Motion sickness, or motion sensitivity, is stimulated by abnormal spatial orientation and is a common symptom related to dizziness and postural instability. The main cause of the motion sensitivity is aberrant sensory input from the visual, vestibular and somatosensory systems. The aim of this study was to measure the effect of vestibular adaptation exercises on postural stability in young healthy adults with subjective awareness of chronic motion sensitivity.

Methods: Fifty healthy male and female …

Dialectical Behavior Therapy And Adolescent Patient Treatment Dropout, Danessa Mayo

Loma Linda University Electronic Theses, Dissertations & Projects

Attrition in mental health treatment is an area of concern among the adolescent population, especially with patients engaged in deliberate self-harm. The purpose of this study was to examine the treatment attrition rate for adolescents with deliberate self-harm in an adapted dialectical behavior therapy intensive outpatient program. A total of 141 adolescents previously enrolled in the program were available for the study. Results demonstrated a 31.9% dropout rate. Graduates indicated greater improvement of overall distress from baseline to post-treatment than dropouts. Dropouts attended an average of 12 treatment sessions. Several factors were examined to identify potential predictors of patient treatment …

To A Better Understanding Of Professional Practice: Provider Decision-Making When Delivering Hiv Services, Carizma Amila Chapman

Loma Linda University Electronic Theses, Dissertations & Projects

Over the last several decades an abundance of research has been conducted on HIV/AIDS. These studies have focused on the infection, impact of the disease on the health and quality of life of people living with the infection, and on treatment effectiveness. However, limited studies are available that explore the experiences of providers delivering HIV/AIDS services. Research demonstrates that providers have an important impact on treatment, shaping not only patient retention, but also treatment adherence. The critical role HIV/AIDS providers have in shaping treatment makes understanding provider experiences a pertinent area of inquiry to understand HIV/AIDS care. In this study, …

Access To Oral Health For Children On Mainecare In The Lakes Region Towns Of Bridgton, Casco, Sebago, And Naples, Carissa L. Parent

Muskie School Capstones and Dissertations

Although we know that children covered by Medicaid often do not receive needed dental services, the extent of the problem in Maine is not fully understood. In particular, rural communities in Maine may face challenges for families to access dental services for their children given low reimbursement rates and fewer available providers. This project addresses these gaps in knowledge by examining MaineCare- funded utilization and dental care access for children with MaineCare in four rural Maine towns in the Lakes Region.

Apolipoprotein B Containing Lipoproteins Contribute To Host Innate Immune Pulmonary Defense Against Staphylococcus Aureus, Brett Manifold-Wheeler

Biomedical Sciences ETDs

Circulating lipoproteins are increasingly recognized as innate immune effector molecules. Severe hypolipidemia, which may occur with trauma or critical illness, is clinically associated with bacterial pneumonia. Importantly, pneumonia caused by Staphylococcus aureus is a major cause of morbidity and mortality in both hospital- and community-acquired pneumonia cases. Here we report that lipoprotein deficiency impairs early pulmonary innate defense against S. aureus quorum-sensing dependent pathogenesis. Specifically, apoB levels in the lung early post-infection are significantly reduced with lipoprotein deficiency, coinciding with impaired host control of S. aureus agr-signaling and increased agr-dependent morbidity and inflammation. Given that lipoproteins also inhibit LTA- and …

R-Ketorolac Targets Cdc42 And Rac1 And Alters Ovarian Cancer Behaviors Critical For Invasion And Metastasis, Yuna Guo

Biomedical Sciences ETDs

Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum) are attractive therapeutic targets in ovarian cancer based on their established importance in tumor cell migration, adhesion and invasion. Despite a predicted benefit, targeting GTPases has not yet been translated to clinical practice. Based on lead identification through high-throughput screening and computational shape homology approaches, R-ketorolac is identified as a Cdc42 and Rac1 regulator, an activity that is distinct from the anti-inflammatory, cyclooxygenase inhibitory activity of S-ketorolac. In this dissertation, R-ketorolac is established as an allosteric inhibitor of Cdc42 and Rac1. Studies on immortalized human ovarian adenocarcinoma cells (SKOV3ip), …

Exposure Of Neonatal Rats To Alcohol Has Differential Effects On Cytokine Levels In The Cerebellum And Hippocampus: Potential Role Of Microglia And Astrocytes, Lauren Topper

Biomedical Sciences ETDs

Drinking during pregnancy can result in fetal alcohol spectrum disorders (FASD), an umbrella term that encompasses a wide array of symptoms ranging from neurocognitive deficits to physical malformations. The mechanism for FASD is not yet fully understood, however recently, activation of the neuroimmune system has been suggested to play a role. Neuroinflammation, characterized by increased pro-inflammatory cytokine production and glial cell activation, has been observed following exposure to alcohol during the neonatal period. Furthermore, neuroimmune activation has been implicated in alcohol-induced neuronal death and/or damage. The studies herein investigate several components of the relationship between neuronal damage following developmental alcohol …

Post-Placental Iud Insertion: A Mixed Methods Assessment Of Women's Experiences, Shannon L. Carr

Biomedical Sciences ETDs

Background: Post-placental intrauterine device (IUD) insertion has the potential to reduce rapid repeat pregnancies. As the procedure becomes more widely adopted in the US, it is important to understand womens perceptions about the procedure. Studies examining patient-centered outcomes are currently lacking. Objectives: The objectives of this study include: 1) To describe women's experiences with post-placental IUD insertion through postpartum semistructured interviews. 2) To establish a mean pain score for the procedure using a 100mm visual analogue scale (VAS). 3) To assess procedural pain using a 4-point Likert verbal rating scale (VRS). Methods: This concurrent mixed methods pilot study was conducted …

Mechanisms Of Innate Immune Regulation Of Dermonecrosis During Staphylococcus Aureus Skin Infections, Moriah J. Castleman

Biomedical Sciences ETDs

S. aureus is the dominant cause of skin and soft tissue infections (SSTIs) in humans. The importance of S. aureus as the primary cause of skin infections has increased exponentially over the last few decades since the emergence of resistance to β-lactam antibiotics. Furthermore, the rise of methicillin-resistant S. aureus (MRSA) strains has led to hospitals stays, increased financial burden and increased mortality. A significant proportion of MRSA infections have been attributed to community-acquired strains (CA-MRSA), specifically the USA300 isolates, which can cause deadly disease in otherwise healthy individuals. Due to the increase in antibiotic resistance and the lack of …

Analysis Of Coastal Wetland Geography And Policy In Humboldt Bay: Adapting Wetland Policies For A Changing Climate", Dylan Loudon

Student Projects

No abstract provided.

Trim28 Interacts With Ezh2 To Regulate Its Activity, Jing Li, Jing Li

Dissertations and Theses (Open Access)

In this dissertation, I discovered that TRIM28 interacts with EZH2 and regulates its activity in breast cancer cells. EZH2, the major H3K27 tri-methyltransferase, is over expressed in multiple subtypes of breast cancer; however, whether EZH2 plays an active role in breast cancer progression or treatment resistance is unknown. Here, we determined EZH2-interacting proteins in MCF7 cells by immunoprecipitation/mass spectrometry and detected TRIM28 with a high confidence score. TRIM28 is a transcription co-regulator with an N-terminal tri-partite RING finger, B-boxes and a coiled-coil domain (RBCC) and a C-terminal PHD/Bromo domain. Domain mapping revealed that the RBCC domain of TRIM28 interacts with …

Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy, Paloma Del C. Monroig

Dissertations and Theses (Open Access)

The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small molecule inhibitors represent an attractive approach to pursue this. However, the absence of molecular structures for most of the miRNAs makes it very difficult to predict which inhibitors can bind to them. Herein we designed a strategy to screen for small molecules by assesing whether they could directly bind/ interact with miR-10b/miR-21. As part of our …

Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity, Stephanie M. Dorta-Estremera Ph.D.

Dissertations and Theses (Open Access)

Humoral autoimmunity is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of humoral autoimmunity as a result of pDC activation have not been characterized. Moreover, the B cell subset(s) responsible for the generation of autoantibodies remains to be clearly identified.

The immunization of DNA-containing amyloids into non-autoimmune mice triggers the activation of pDCs and induction …

One Significant Step: How Reforms To Prison Districts Begin To Address Political Inequality, Erika L. Wood

University of Michigan Journal of Law Reform

Skyrocketing rates of incarceration over the last three decades have had profound and lasting effects on the political power and engagement of local communities throughout the United States. Aggressive enforcement practices and mandatory sentencing laws have an impact beyond the individuals who are arrested, convicted, and incarcerated. These policies have wide-ranging and enduring ripple effects throughout the communities that are most heavily impacted by criminal laws, predominantly urban and minority neighborhoods. Criminal justice policies broadly impact everything from voter turnout and engagement, to serving on juries, participating in popular protests, census data, and the way officials draw legislative districts. The …

When Is An Agency A Court? A Modified Functional Approach To State Agency Removal Under 28 U.S.C. § 1441, Nicholas Jackson

University of Michigan Journal of Law Reform

This Note argues that courts should interpret 28 U.S.C. § 1441, which permits removal from state court to federal court, to allow removal from state administrative agencies when the agency performs “court-like functions.” Circuits that apply a literal interpretation of the statute and forbid removal from state agencies should adopt this “functional” approach. The functional approach, which this Note calls the McCullion-Floeter test, should be modified to comport with legislative intent and public policy considerations: first, state agency adjudications should not be removable when the adjudication requires technical expertise, which federal courts cannot obtain because they adjudicate cases in a …

Countermovement Jump Performance Changes Over The Course Of Collegiate Basketball Pre-Season Associated With Block Periodization Model Of Strength And Conditioning Program, Nobuhisa Yoshida, Caleb D. Bazyler, Takahiro Unebasami, Stephen Wells, Zachary Whitman, Danielle Lee, Mallory Stellhorn, Kimitake Sato, Michael H. Stone

ETSU Faculty Works

No abstract provided.

Period Change And Stellar Evolution Of Β Cephei Stars, Hilding R. Neilson, Richard Ignace

ETSU Faculty Works

The β Cephei stars represent an important class of massive star pulsators that probe the evolution of B-type stars and the transition from main sequence to hydrogen-shell burning evolution. By understanding β Cep stars, we gain insights into the detailed physics of massive star evolution, including rotational mixing, convective core overshooting, magnetic fields, and stellar winds, all of which play important roles. Similarly, modeling their pulsation provides additional information into their interior structures. Furthermore, measurements of the rate of change of pulsation period offer a direct measure of β Cephei stellar evolution. In this work, we compute state-of-the-art stellar evolution …

Orally Delivered Β-Glucans Aggravate Dextran Sulfate Sodium (Dss)-Induced Intestinal Inflammation, Sigrid E.M. Heinsbroek, David L. Williams, Olaf Welting, Sybren L. Meijer, Siamon Gordon, Wouter J. De Jonge

ETSU Faculty Works

β-Glucans have beneficial health effects due to their immune modulatory properties. Oral administration of β-glucans affects tumour growth, microbial infection, sepsis, and wound healing. We hypothesized that pre-treatment with orally delivered soluble and particulate β-glucans could ameliorate the development of aggravate dextran sulfate sodium (DSS) induced intestinal inflammation. To study this, mice were orally pre-treated with β-glucans for 14 days. We tested curdlan (a particulate β-(1,3)-glucan), glucan phosphate (a soluble β-(1,3)-glucan), and zymosan (a particle made from Saccharomyces cerevisiae, which contains around 55% β-glucans). Weight loss, colon weight, and feces score did not differ between β-glucan and vehicle treated groups. …

Redefining Significance: Experiences Of Humanities Faculty Engaged In Undergraduate Research, Susan Mendoza

Dissertations

Programs that actively engage students in research and scholarship are the touchstone for integrating undergraduate education with authentic scholarly inquiry. Recent empirical studies demonstrate that undergraduate research experiences (URE) are related to increased student learning and development, increased levels of retention, increased enrollment in graduate school, and increased understanding of research as a vocation and profession. However, these seminal studies focus on URE in the STEM (science, technology, engineering, and math) disciplines. Although there are some studies that explore undergraduate research in the social sciences and humanities, the accepted models and best practices of undergraduate research are entrenched in the …

Perceptions Of Teacher Evaluation Systems At Cte Centers In Michigan, Michael A. Martel

Dissertations

This study investigated Career and Technical Centers in Michigan and their teachers’ and principals’ perceptions of their teacher evaluation systems which include a student growth mandate. CTE center teachers and principals were asked to provide their perceptions on how well their teacher evaluation systems provide information to improve teaching and learning. Differences between teachers and principals were explored.

The study was quantitative in design using survey research to obtain perceptions of CTE center teachers and principals. The data collection tool utilized a Likert scale moving from strongly disagree to strongly agree. Open-ended questions provided system quality information from respondents. Demographic …

Annual Report On Building Energy Management, Real Estate Asset Management, Fiscal Year 2014-2015, Tennessee. Department Of General Services.

Energy-Efficiency Reports

No abstract provided.