Digital Commons Network^™

Makenzie Petzel Honors Portfolio, Makenzie Jo Petzel

Honors Capstone Portfolios

Makenzie Petzel's honors portfolio captured in December 2015.

Zachary Petzel Honors Portfolio, Zachary Andrew Petzel

Honors Capstone Portfolios

Zachary Petzel's honors portfolio captured in December 2015.

Anna Rice Honors Portfolio, Anna Grace Rice

Honors Capstone Portfolios

Anna Rice's honors portfolio captured in December 2015.

2015-December-01-What Is That Strange Thing In The Parking Garage?, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Applying The Philosophies Of The Beacon Model, Michael P. Raisch

Creativity and Change Leadership Graduate Student Master's Projects

The purpose of this project is to apply all the knowledge and skills learned from a master’s degree in Creative Studies at Buffalo State college combined with personal experience in order to share perspective on what a “Beacon” is and how its core values are the foundation for enriching your life as well as the lives of those around you and how it all relates to Creativity. Furthermore, this project applies the concepts from the Beacon model more deeply through supporting philosophies and how the Halloween holiday naturally serves as a Beacon. There is a relationship due to the fact …

Methylseleninic Acid Promotes Antitumour Effects Via Nuclear Foxo3a Translocation Through Akt Inhibition, Míriam Tarrado-Castellarnau, Roldán Cortés, Miriam Zanuy, Josep Tarragó-Celada, Ibrahim H. Polat, Richard Hill, Teresa W-M Fan, Wolfgang Link, Marta Cascante

Toxicology and Cancer Biology Faculty Publications

Selenium supplement has been shown in clinical trials to reduce the risk of different cancers including lung carcinoma. Previous studies reported that the antiproliferative and pro-apoptotic activities of methylseleninic acid (MSA) in cancer cells could be mediated by inhibition of the PI3K pathway. A better understanding of the downstream cellular targets of MSA will provide information on its mechanism of action and will help to optimize its use in combination therapies with PI3K inhibitors. For this study, the effects of MSA on viability, cell cycle, metabolism, apoptosis, protein and mRNA expression, and reactive oxygen species production were analysed in A549 …

Endoplasmic Reticulum Stress And Ethanol Neurotoxicity, Fanmuyi Yang, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Ethanol abuse affects virtually all organ systems and the central nervous system (CNS) is particularly vulnerable to excessive ethanol exposure. Ethanol exposure causes profound damages to both the adult and developing brain. Prenatal ethanol exposure induces fetal alcohol spectrum disorders (FASD) which is associated with mental retardation and other behavioral deficits. A number of potential mechanisms have been proposed for ethanol-induced brain damage; these include the promotion of neuroinflammation, interference with signaling by neurotrophic factors, induction of oxidative stress, modulation of retinoid acid signaling, and thiamine deficiency. The endoplasmic reticulum (ER) regulates posttranslational protein processing and transport. The accumulation of …

Rethinking Chutes: Incentives, Investment, And Innovation, Simone M. Sepe, Charles K. Whitehead

Cornell Law Faculty Publications

Eighty-two percent of public firms have golden parachutes (or “chutes”) under which CEOs and senior officers may be paid tens of millions of dollars upon their employer’s change in control. What justifies such extraordinary payouts?

Much of the conventional analysis views chutes as excessive compensation granted by captured boards, focusing on the payouts that occur following a takeover. Those explanations, if they ever were complete, miss the mark today. This Article demonstrates, theoretically and empirically, that chutes are less relevant to a firm during a takeover than they are before a takeover, particularly in relation to firms that invest in …

Chronic Systemic Immune Dysfunction In African-Americans With Small Vessel-Type Ischemic Stroke, Candice M. Brown, Cheryl D. Bushnell, Gregory P. Samsa, Larry B. Goldstein, Carol A. Colton

Neurology Faculty Publications

The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 weeks post-stroke compared to control individuals. Cases were African-Americans with lacunar stroke (n = 30), and controls were age-matched African-Americans with no history of stroke or other major neurologic disease (n = 37). Blood was obtained > 6 weeks post-stroke and was analyzed for inflammatory biomarkers. Freshly isolated peripheral blood mononuclear cells were stimulated with lipopolysaccharide …

A Clinical Trial To Validate Event-Related Potential Markers Of Alzheimer's Disease In Outpatient Settings, Marco Cecchi, Dennis K. Moore, Carl H. Sadowsky, Paul R. Solomon, P. Murali Doraiswamy, Charles D. Smith, Gregory A. Jicha, Andrew E. Budson, Steven E. Arnold, Kalford C. Fadem

Neurology Faculty Publications

INTRODUCTION: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).

METHODS: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.

RESULTS: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task …

Evaluating Positive Behavior Interventions And Supports (Pbis) : Examining Teachers' Perceptions Of Managing Student Conduct And Student Achievement In Pbis And Non-Pbis Schools., Carla Marie Soeder-Kolodey

Electronic Theses and Dissertations

This capstone investigated the impact of the implementation of positive behavior interventions and supports (PBIS) in schools across Kentucky on teachers’ perceptions of student behavior and on student academic achievement scores, using a causal comparative design. Schools in Kentucky were selected at random according to school type: elementary, middle, and high school. Special schools, or schools serving populations overlapping into multiple categories, were eliminated from the study. Schools were then identified by their level of implementation of PBIS: Control represented the schools that had not received any training in PBIS, PBIS represented schools that had started the implementation of PBIS, …

Heat Transfer Mechanisms In Water-Based Nanofluids., Masoudeh Ahmadi

Electronic Theses and Dissertations

Nanofluids are a class of heat transport fluids created by suspending nano-scaled metallic or nonmetallic particles into a base fluid. Some experimental investigations have revealed that the nanofluids have remarkably higher thermal conductivities than those of conventional pure fluids and are more suited for practical application than the existing techniques of heat transfer enhancement using millimeter and/or micrometer-sized particles in fluids. Use of nanoparticles reduces pressure drop, system wear, and overall mass of the system leading to a reduction in costs over existing enhancement techniques. In this work, the heat transfer coefficient is determined experimentally using copper oxide (CuO) based …

Impact Of Urban Factors And Invasive Species On White-Footed Mouse (Peromyscus Leucopus) Habitat Use And Foraging Behavior In An Urban Forest Park., William Persons

Electronic Theses and Dissertations

White-footed mice (Peromyscus leucopus) select for areas of greater canopy cover at the macro scale, and for areas with more CWD at the micro-scale. White-footed mice potentially avoid habitats with higher invasive species richness. White-footed mice preferentially foraged under the honeysuckle canopy in response to changes in temperature and humidity. This study suggests that the interaction between P. leucopus and ground layer invasive species is complex, and that the effect of moonlight may be diminished in this urban park. Urban ecosystems demonstrate high levels of anthropogenic land-use change, modification of abiotic inputs, and altered disturbance regimes. These changes result …

Assessing The Water Quality Benefits Of Green Infrastructure Stormwater Control Measures., Sam Abdollahian

Electronic Theses and Dissertations

Permeable pavements systems and tree boxes are a common type of Green Infrastructure (GI) Stormwater Control Measures (SCMs) that are often used for mitigating the stormwater runoff. In this study two permeable pavement systems and a tree box installed along parking lanes of an urban street in Louisville, KY, were investigated to evaluate their performance on improving stormwater runoff quality. The water quality monitoring was accomplished by analysis of samples collected from stormwater runoff and the captured stormwater volume at the bottom of the permeable pavements’ sub-base reservoir and by a drain gauge (lysimeter) installed in the tree box. Pollutants …

Development Of A Vascularized, Induced Pluripotent Stem Cell-Derived Liver-Tissue Mimic For Therapeutic Applications., Venkat Madhav Ramakrishnan

Electronic Theses and Dissertations

This dissertation describes the incorporation of several technologies (stem cells, gene therapy, tissue engineering and regenerative medicine) into a single project that aims to produce a liver-tissue mimic for therapeutic applications. The liver is arguably one of the most complex organs in the body. In addition to its remarkable capacity to regenerate, it performs a host of vital functions. As a result, its impairment has widespread systemic consequences. The work described herein focused on the liver in the context of cardiovascular disease and used the heritable disorder Familial Hypercholesterolemia (FH) as a clinical disease model. As (a) the only definitive …

The Relevance Of Client-Healthcare Provider Communication To The Appraisal Of Illness Uncertainty In Women With Fibromyalgia Syndrome., Melody Dawn Reibel

Electronic Theses and Dissertations

Illness uncertainty and impaired client-healthcare provider (HCP) communication are critical healthcare problems for women with fibromyalgia syndrome (FMS). However, the relationship between illness uncertainty and client-HCP communication has not been previously examined. The purposes of this dissertation were to (a) gain a deeper understanding of the lived experiences of women with FMS, (b) to examine the relationships among client-HCP communication, illness uncertainty, helplessness, and subjective well-being (SWB) in women with FMS, and (c) evaluate the psychometric properties of the patient-HCP communication scale (PHCPCS) in women with FMS. A mixed-methods design enhanced validity of the findings. The qualitative pilot study showed …

Circulating Angiogenic Stem Cells In Diabetes., Nagma Zafar

Electronic Theses and Dissertations

Circulating angiogenic stem cells (CACs) are rare cells found in peripheral blood that have been shown to contribute to endothelial repair and new blood vessel formation. These cells could be biomarkers and/or therapeutic targets for the assessment and prevention of cardiovascular disease (CVD), which is the leading cause of mortality globally and in the United States. Diabetes is an independent risk factor for CVD, and there are inconsistent reports on the role of CACs in diabetic vasculopathy. To study this further we tested the hypothesis that diabetes depletes circulating levels of CACs, due to hyperglycemia or insulin resistance and that …

A Phenomenological Study Of Anticipated Intimacy And Sexual Expression Needs Of Aging Male And Female Baby Boomers., Charles Shawn Oak

Electronic Theses and Dissertations

The purpose of this study was to understand the phenomenon of how heterosexual Baby Boomers define and understand intimacy, sexual expression, along expectations and desires relating to their respective expressions across the lifespan through their individual experiences and reflections. A set of guiding questions were used in a hermeneutic phenomenological qualitative research design. Data was gathered from thirteen subjects (n=13) using the Rappaport Time Line (RTL) that was used to develop individualized semi-structured interviews and follow-up interviews that were professionally transcribed. These were coded to identify emergent themes. Results of the study provided insight into the phenomenon of how heterosexual …

Regulation Of The Retinoblastoma Tumor Suppressor By The Novel Ras Effector Nore1a., Thibaut François Barnoud

Electronic Theses and Dissertations

Ras is the most frequently mutated oncogene in human cancers. It acts as a critical branch point in signal transduction, regulating numerous downstream effectors involved in cell growth and differentiation. While Ras can activate many growth promoting pathways, it can paradoxically regulate growth inhibitory pathways leading to apoptosis and cell cycle arrest. One of the ways Ras can inhibit the growth of cells is via a family of effectors called the RASSF proteins. RASSF5 (NORE1A) is a tumor suppressor that is frequently inactivated in human tumors by epigenetic mechanisms. NORE1A binds directly to Ras and promotes Ras-induced senescence. We have …

Improving The Accuracy Of Middle School Students' Self-Assessment, Peer Assessment, And Mathematics Achievement., Elizabeth Popelka

Electronic Theses and Dissertations

Despite the documented advantages of formative assessment (FA) strategies in elevating student achievement, much of the relevant research is dated and undermined by questionable design and inattention to K-12 settings. In order to fill these voids, this quantitative study tested the effect of a self- and peer-assessment-training instructional sequence, developed with recommendations from past research and employing explicitly described assessment measures and criteria, on middle school students’ assessment accuracy and subsequent mathematics achievement. The researcher hypothesized a correlation between measurable growth in assessment accuracy and gains in achievement, as well as a reciprocal effect of self- and peer-assessment ability. The …

A Plant-Made Cholera Toxin B Subunit Enhances Mucosal Wound Healing And Protects Against Ulcerative Colitis And Colon Cancer., Keegan J Baldauf

Electronic Theses and Dissertations

This dissertation describes the previously unidentified effects of a plant-produced recombinant cholera toxin B subunit (CTBp) on the gastrointestinal (GI) tract and its ability to protect against inflammation in a mouse model of colonic injury and ulcerative colitis (UC). To comprehensively analyze CTBp’s impacts on the GI tract, we employed global analysis methodologies based on multi-color flow cytometry to analyze immune cell populations in GI and systemic lymphatic compartments, gene expression microarray to decipher transcript-level changes in the colon and small intestine, and 16S rRNA sequencing to characterize fecal microbiota. Based on a drastic shift observed in the immune cell …

Exclusive-Or Preprocessing And Dictionary Coding Of Continuous-Tone Images., Takiyah K. Cooper

Electronic Theses and Dissertations

The field of lossless image compression studies the various ways to represent image data in the most compact and efficient manner possible that also allows the image to be reproduced without any loss. One of the most efficient strategies used in lossless compression is to introduce entropy reduction through decorrelation. This study focuses on using the exclusive-or logic operator in a decorrelation filter as the preprocessing phase of lossless image compression of continuous-tone images. The exclusive-or logic operator is simply and reversibly applied to continuous-tone images for the purpose of extracting differences between neighboring pixels. Implementation of the exclusive-or operator …

Application Of The Aeroacoustic Analogy To A Shrouded, Subsonic, Radial Fan., Bryan Buccieri

Electronic Theses and Dissertations

A study was conducted to investigate the predictive capability of computational aeroacoustics with respect to a shrouded, subsonic, radial fan. A three dimensional unsteady fluid dynamics simulation was conducted to produce aerodynamic data used as the acoustic source for an aeroacoustics simulation. Two acoustic models were developed: one modeling the forces on the rotating fan blades as a set of rotating dipoles located at the center of mass of each fan blade and one modeling the forces on the stationary fan shroud as a field of distributed stationary dipoles. Predicted acoustic response was compared to experimental data. The blade source …

Immunomodulation Of Myeloid-Derived Suppressor Cells By Particulate B-Glucan In Cancer., Sabrin Husein Albeituni

Electronic Theses and Dissertations

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that promote tumor progression. In this study, we investigated the effect of dectin-1 stimulation by yeast-derived particulate β-glucan in MDSC function and differentiation in cancer. In vivo treatment of mice bearing lewis lung carcinoma and mammary cell carcinoma with particulate β-glucan decreased tumor weight and splenomegaly, and reduced the accumulation of polymorphonuclear-MDSC (PMN-MDSC) but not monocytic-MDSC (M-MDSC) in the spleen and tumor. In addition, particulate β-glucan differentially modulated the function of different MDSC subsets; it enhanced PMN-MDSC respiratory burst and apoptosis, and induced the differentiation of M-MDSC into …

Evaluation Of Liver Transplant Prioritization Methods For Hepatocellular Carcinoma Patients Using Multistate Models., Sarah Katharine Alver

Electronic Theses and Dissertations

The Model for End Stage Liver Disease (MELD), used for prioritizing liver transplantation, predicts mortality from liver disease. Patients with hepatocellular carcinoma (HCC) risk disease progression not reflected in their MELD score. Exception scores prioritize HCC patients higher than their MELD scores, but advantage them over non-HCC patients. To address this, a delay of six months for using exception scores has been implemented, and alternative HCC-specific scores have been developed. Using multistate models, this study projects waitlist dropout and transplant probabilities under the delay and under two alternative scores. The delay improves equity between HCC and non-HCC patients for the …

The Pedagogy Of Medical Humanities : Using Literature And The Visual Arts To Help Future Caregivers Maintain Their Compassion And Resilience., Lisa Higgins Shugoll

Electronic Theses and Dissertations

This dissertation argues that medical humanities education for students considering careers in healthcare should begin at the general undergraduate level and should have two primary objectives, (1) providing tools that will help students foster therapeutic, compassionate relationships with their patients, and (2) providing strategies that will help students maintain healthy habits of mind that afford resilience against compassion fatigue. I assert that in order for students to practice compassion for themselves and others three core objectives must be met. (1) Students must be exposed to the fundamentals of bioethics in order to understand the virtue of compassion itself, (2) they …

Trapped In The Tiebout Model : The Impact Of Federal Affordable Housing Programs On Migration Of Wealthier Residents., Yu-Chih Lin

Electronic Theses and Dissertations

Housing mobility programs have been implemented in America since the 1990s to solve poverty concentration and to improve the economic self-sufficiency of low-income families through housing subsidies. This policy was based on the assumption that mixed-income neighborhoods provide better resources and opportunities to low-income families so that program participants who relocate to low-poverty neighborhoods improve their economic status. Currently, few studies examine the effectiveness of housing mobility programs under a decentralized fiscal system. Specifically, the migration of program participants may stimulate Tiebout’s vote-with-feet mechanisms and may limit the duration of the newly-created mixed-income environment, leaving poverty concentration and poverty unsolved. …

Plasma Catalysis Using Low Melting Point Metals., Maria Carreon

Electronic Theses and Dissertations

Plasma catalysis is emerging as one of the most promising alternatives to carry out several reactions of great environmental importance, from the synthesis of nanomaterials to chemicals of great interest. However, the combined effect of a catalyst and plasma is not clear. For the particular case of 1-D nanomaterials growth, the low temperatures synthesis is still a challenge to overcome for its scalable manufacturing on flexible substrates and thin metal foils. Herein, the use of low-melting-point metal clusters under plasma excitation was investigated to determine the effectiveness in their ability to catalyze the growth of 1-D nanomaterials. Specifically, plasma catalysis …

A Culturally-Sensitive Model Of The Development Of Child Anxiety., Jenny Marie Petrie

Electronic Theses and Dissertations

Explanatory models significantly enhance the understanding of etiological influences that place children at risk for anxiety, yet little is known about processes that promote resilient outcomes in children. While contextual factors influence risk and protective processes, cultural constructs have not been incorporated into existing models of anxiety and the role of culture remains obscure. The current study proposes a culturally sensitive model for understanding the etiological and mitigating processes underlying anxious symptoms in ethnic minority youth, and preliminarily tests basic components of the proposed model within a non-clinical community sample of 49 African American (AA) parent-child dyads who completed self-report …

Iconoclastic Fervor : Sally Hazelet Drummond, Abstract Expressionism And Curatorial Practice., Hillary Sullivan

Electronic Theses and Dissertations

Sally Hazelet Drummond is an iconoclastic artist situated within the revolutionary movement of Abstract Expressionism. Drummond is the first female to graduate from the Hite Art Institute, earning a master’s in painting in 1952. During her study at the University of Louisville she explored Abstract Expressionism. In 1953 Drummond joined the Tanager Gallery, one of the Tenth Street artists’ co-ops. In the midst of Willem De Kooning, Ad Reinhardt and Mark Rothko, Drummond refined her work into a simplified, contemplative style that she continued to develop over the course of her life. Drummond described Abstract Expressionism as a kind of …