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Mmv Malaria Box Activity Screening In Dormant Plasmodium Falciparum Phenotypes, Sandra Galusic

USF Tampa Graduate Theses and Dissertations

The causative agent of malignant tertian malaria, Plasmodium falciparum undergoes an arrested growth phenotype of its erythrocytic stage when under drug-stress. Recent artemisinin treatment failures seem to be indicative of such induction followed by recrudescence rather than actual therapeutic failure. Likewise, P. vivax hypnozoites are the prototypic dormants and the latent infections for which they are responsible prove most difficult to treat. Dihydroartemisinin, an artemisinin-derivative, can be used to exploit this mechanism by inducing a dormant state in ring-stage P. falciparum parasites and in turn, their recovery may be used as a screening period for compounds that inhibit or foster …

Mindfulness Attributes As Predictors Of Treatment Outcomes In Children Who Stutter, Jenna Lee Graepel

USF Tampa Graduate Theses and Dissertations

A recent U.S.-based survey (Boyle et al,. 2011) estimated stuttering prevalence in American children ages 3-17 years at 1.6% or 1 in 63 children. In comparison to the reported 1 in 68 school age children living with Autism Spectrum Disorder (Centers for Disease Control and Prevention, 2010), stuttering affects nearly as many. These estimates suggest that Speech-Language Pathologist (SLPs) should increasingly develop their skill sets for identifying and providing interventions for children who stutter.

The evidence base for school-age fluency intervention, while promising, leaves much room for further development (Nippold, 2011). The majority of current interventions revolve around the traditional …

Minocycline Treatment And The Necessity To Develop A Novel Outcome Measure For Children With Angelman Syndrome, Joseph Christopher Grieco

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS) is a rare genetic disorder affecting 1/10,000 to 1/20,000 births. This disorder arises through the genetic disruption of the maternal UBE3A allele, which when coupled with epigenetic silencing of the paternal allele UBE3A allele, gives rise to an absence of UBE3A protein in the central nervous system. Clinical manifestations of the syndrome vary in severity and include poor motor function, deficits in language and severe intellectual impairments. Previous research in the Angelman syndrome mouse model revealed abnormalities in dendritic spine density and morphology of hippocampal pyramidal cells. As seen in humans with AS, mice show abnormal behavioral …

Community Identity And Social Practice During The Terminal Classic Period At Actuncan, Belize, Kara Ann Fulton

USF Tampa Graduate Theses and Dissertations

This research examines the relationship between the ways in which urban families engaged local landscapes and the development of shared identities at the prehispanic Maya city of Actuncan, Belize. Such shared identities would have created deep historical ties to specific urbanized spaces, which enabled and constrained political expansion during the Terminal Classic period (ca. A.D. 800–900), a time when the city experienced rapid population growth as surrounding centers declined. This research contributes to the understanding of urban processes of growth and decay in this region, and how they are linked to the behaviors of social factions in settlements.

For communities, …

Immunological Characterization Of Duffy Binding Protein Of Plasmodium Vivax, Miriam Thankam George

USF Tampa Graduate Theses and Dissertations

Plasmodium vivax Duffy binding protein (DBP) is an essential ligand for reticulocyte invasion making it a premier asexual blood stage vaccine candidate. However, strain-specific immunity due to DBPII allelic variation may complicate vaccine efficacy, suggesting that an effective DBPII vaccine needs to target immune responses to conserved epitopes that are potential targets of strain-transcending neutralizing immunity. Anti DBPII monoclonal antibodies, which were previously characterized by COS7 cell binding assay as inhibitory and non-inhibitory to DBPII-erythrocyte binding, were mapped to DBPII gene fragment libraries using phage display. Inhibitory mAb 3C9 binds to a conserved conformation-dependent epitope in subdomain 3 while non-inhibitory …

Theoretically Guided Examination Of Caregiver Strain And Its Relationship With School-Based Mental Health Services Utilization And Parent Engagement In Services, Amy Lynn Green

USF Tampa Graduate Theses and Dissertations

Broadly, the purpose of this study was to address the gaps in the knowledge base of caregiver strain through an examination of this and other theoretically related constructs in a sample of parents of high-risk youth. In the last two decades, a growing body of research has pointed to the significance of strain that can result from this caregiving experience, particularly as it relates to patterns of mental health services utilization. Despite the fact that the majority of children who receive mental health receive them from the school, few studies have examined caregiver strain in the context of school-based mental …

Iwitness And Student Empathy: Perspectives From Usc Shoah Foundation Master Teachers, Brandon Jerome Haas

USF Tampa Graduate Theses and Dissertations

This qualitative interview study explores the perceptions of five USC Shoah Foundation Master Teachers who integrate IWitness in teaching about the Holocaust. The study focused on the perceptions of teachers as their students interact with survivor and witness testimony in IWitness as well as how IWitness provides a framework for moral education in comparison to other primary sources. Data gleaned from this study demonstrates the influence of personalized learning through testimony-based education on the development of empathy in secondary students. As IWitness is a new resource that engages students with Holocaust survivor testimony in innovative ways, this study fills a …

Muckraking And C.O.B.Y (Cry Of Black Youth): Uncovering A History Of Organizing In Belle Glade, Raymond A. Hamilton

USF Tampa Graduate Theses and Dissertations

This thesis examines a local activist group in the rural town of Belle Glade, Florida during the late 1960s and early 1970s. This research falls in line with many New Black Power studies. These New Black Power studies challenge existing notions of the Black Power and Civil Rights eras and their relationship to one another. It challenges the time frames, geography and ideology of both of the eras. This case study of a the group in Belle Glade is not the first to examine the similarities of the Black Power and Civil Rights eras, where many groups who affiliated with …

Use Of Anaerobic Adhesive For Prevailing Torque Locking Feature On Threaded Product, Alan Hernandez

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to determine if anaerobic adhesive can be used as a prevailing torque locking feature. Maintaining preload in critical joints is the usual standard that anaerobic adhesives are held to in aerospace and other industry. To test if anaerobic adhesive can be used as a prevailing torque locking feature a test procedure was developed and implemented to measure the removal torque of threaded fasteners after an allotted cure time. In total, 191 threaded fasteners of different material and coatings were tested in the unseated and seated states with various strengths and varieties of anaerobic adhesive. …

Analyzing The Effect Of Complaints, Investigation Of Allegations, And Deficiency Citations On The Quality Of Care In United States Nursing Homes (2007 – 2012), Kevin E. Hansen

USF Tampa Graduate Theses and Dissertations

The quality of care in nursing homes has been evaluated from many varying perspectives, but few studies have analyzed quality in light of complaints made to state survey agencies by residents, their family members, or other individuals interacting with the nursing home. This study analyzed complaints, investigation of complaint allegations, and complaint-related deficiency citations to determine their effect, if any, on the quality of care in nationwide nursing homes. Using the Online Survey Certification and Reporting (OSCAR) survey dataset for facility characteristics and the complaint investigation dataset for outcomes of complaint investigation, analyses conducted included descriptives, correlations, conceptual mapping for …

Neuroinflammatory Alterations Via Cd-36 In Traumatic Brain Injury, Diana G. Hernandez-Ontiveros

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) has become an increasingly unmet clinical need due to intense military conflicts worldwide. Directly impacted brain cells suffer massive death, with neighboring cells succumbing to progressive neurodegeneration accompanied by inflammatory and other secondary cell death events. Subsequent neurodegenerative events may extend to normal areas beyond the core of injury, thereby exacerbating the central nervous system’s inflammatory response to TBI. Recently CD-36 (cluster of differentiation 36/fatty acid translocase (FAT), a class B scavenger receptor of modified low-density lipoproteins (mLDLs) in macrophages, has been implicated in lipid metabolism, atherosclerosis, oxidative stress, and tissue injury in cerebral ischemia, and …

Situating Contraceptive Practices And Public Health Strategy In The Bronx: Perspectives From Female Youth, Healthcare Workers, And Reproductive Health Leaders, Hannah Louise Helmy

USF Tampa Graduate Theses and Dissertations

In the United States, concerns about adolescent childbearing and its perceived corollaries – negative health outcomes for mother and child, the disintegration of the nuclear family, and “over-dependence” on public resources – began to circulate widely in policy spheres and popular media in the 1970’s, resulting in a proliferation of policies, programs, and services designed to address its prevention. Although national birth rates among adolescents are currently at their lowest since peaking in the early 1990’s, this decline masks persistent and significant disparities between groups of young people by race, ethnicity, geography, and poverty level. The concomitant existence of social …

Heart Of The Beholder: The Pathos, Truths And Narratives Of Thermopylae In _300_, James Christopher Holcom

USF Tampa Graduate Theses and Dissertations

This thesis argues that critical understanding of historical narratives needn’t be limited to cold, clinical applications of logic and reason. By doing a close textual reading of Frank Miller and Lynn Varley’s graphic novel, 300 and Zack Snyder’s 2007 film adaptation, I posit that critical analysis of popular narratives is better served when pathos takes a central role. Traditional rhetorical criticism tends to favor empirical evidence and fact over emotional, narrative truth. Yet, the writing, recounting and interpretation of history are more akin to arts than sciences. Historical narratives are subject to the same influences and techniques that make poetry, …

The Role Of The Interruption In Young Adult Epistolary Novels, Betty J. Herzhauser

USF Tampa Graduate Theses and Dissertations

Within the genre of young adult literature, a growing trend is the use of epistolary messages through electronic methods between characters. These messages are set apart from the formal text of the narrative of the novel creating a break in the text features and layout of the page. Epistolary texts require a more sophisticated reading method and level of interpretation because the epistolary style blends multiple voices and points of view into the plot, creating complicated narration. The reader must navigate the narrator’s path in order to extract meaning from the text. In this hermeneutic study, I examined the text …

Tampa Electric Company's Big Bend Utility Plant In Hillsborough County, Florida: A Case Study, Lynne M. Hodalski-Champagne

USF Tampa Graduate Theses and Dissertations

This is an in-depth analysis of coal fire burning power plants, their effects on human health and the environment. It also employed case study data from Tampa Electric Company’s Big Bend facility to examine environmental infractions at that facility. Tampa Electric Company’s Big Bend Utility Plant, violated the Clean Air Act, which led to a lawsuit filed by the Department of Justice on behalf of the United States Environmental Protection Agency and the Florida Department of Environmental Protection in 1997. This case study details the lawsuit, and subsequent settlement as well as Tampa Electric Company’s record of compliance since 2000. …

Comparison Of Isotope-Based Biomass Pathways With Groundfish Community Structure In The Eastern Gulf Of Mexico, Sheri Ann Huelster

USF Tampa Graduate Theses and Dissertations

This study compared traditional community analysis with stable-isotope trophic analysis to define process-based trophic elements of community structure in the eastern Gulf of Mexico, and developed a predictive capability regarding changes to fish community structure that would be expected from increasing eutrophication. Specifically, it used an existing trawl survey program (SEAMAP) to compare invertebrate herbivore (sponge and sea urchin) isotopes with groundfish isotopes, and then compared the resulting spatial patterns with spatial variation in community structure, as identified by cluster analysis. The comparison was applied to seven NMFS survey zones that extended offshore from the Caloosahatchee River, FL northwest to …

Was It Something They Said? Stand-Up Comedy And Progressive Social Change, David M. Jenkins

USF Tampa Graduate Theses and Dissertations

From our earliest origins in every civilization across the globe, comic performances have fulfilled an important social function. Yet stand-up comedy has not attracted the serious academic inquiry one might expect. This dissertation argues that in the absence of public intellectuals stand-up comics are important to how we talk about and negotiate complicated issues like gender and race. These comic texts are sites of cultural critique, public discourse, tools for articulation, a means of persuasion, and serve to galvanize communities.

This dissertation argues that stand-up comedy performances are a vital part of modern American intellectual and social life and are …

Ucsmp Teachers’ Perspectives When Using Graphing Calculators In Advanced Mathematics, Ilyas Karadeniz

USF Tampa Graduate Theses and Dissertations

Nowadays, technology plays a fundamental role in education, in general, and in mathematics education in particular. The graphing calculator has been an important technological tool in mathematics classrooms since its invention and introduction in 1985 by Casio. As graphing calculators provided so many uses, their contribution to the teaching and learning process has been investigated by many researchers who have shown the use of such technology can have a significant effect on improving mathematics teaching and learning.

Investigating the impact of graphing calculators on student learning is important. It is also essential to research teachers’ perspectives on how using graphing …

Equifinality And Multifinality In Psychopathology: Can Cognitive And Emotional Processes Differentiate Internalizing, Externalizing, And Co-Occurring Psychopathology, Brittany Jordan-Arthur

USF Tampa Graduate Theses and Dissertations

Despite our knowledge of environmental risk factors for psychopathology, the equifinality and multifinality observed in the extant literature reveals how little is known about the role of these risk factors in the development of psychopathology. The purpose of this study was to identify processes that differentiate internalizing, externalizing and co-occurring psychopathology. Specifically, emotion identification skill and cognitive appraisal style were examined as processes where individual differences may contribute to the development of mental illness. To date no study has been conducted to examine whether emotion identification and appraisal style may differentiate forms of internalizing, externalizing and co-occurring psychopathology and lack …

Structure-Function Analysis Of The Dna Damage Repair Complex Str In Saccharomyces Cerevisiae, Jessica Ashley Kennedy

USF Tampa Graduate Theses and Dissertations

The RecQ family of helicases has been termed the “Caretakers of the Genome,” and rightfully so. These proteins are highly conserved from bacteria to humans and have been implicated in functions from homologous recombinatorial repair to damage checkpoint response to telomere maintenance and more. Mutant genes of three of the human RecQ helicases lead to syndromes characterized by a high incidence of cancer, premature aging and early death. Despite their implications in several biological functions and importance to the integrity of the human genome and suppression of cancer, many aspects of the RecQ family structure and function remain unknown. To …

Outcomes Of A Combined Mindfulness, Stuttering Modification, And Fluency Shaping Intervention For Children Who Stutter, Jennifer Kordell

USF Tampa Graduate Theses and Dissertations

A week-long intervention for five school-age children who stutter was implemented using techniques of fluency shaping, stuttering management, and mindfulness training. The purpose of this study was to investigate if children who stutter stuttered less frequently, stuttered with less struggle, and demonstrated changes in mindfulness measures after the completion of this week-long intervention. Pre- to post-treatment measures were analyzed by individual and group-level results. A comparative analysis between reading and narrative tasks was also performed. Findings indicate that three out of five children reduced the total number of disfluencies during the reading task, and two children reduced this total during …

Tornado Fatalities: An In-Depth Look At Physical And Societal Influences, Heather Joann Key

USF Tampa Graduate Theses and Dissertations

The purpose of this study is to model and determine significant predictors of tornado death index values, and to investigate these significant predictors and what makes people vulnerable to tornado fatalities through expert interviews. This study also provides an understanding of the study participant’s perceptions of their county’s vulnerability to tornado fatality and demonstrates a true integration of methods and fields by studying geographic, meteorological, and sociological phenomena by use of quantitative and qualitative methods. The study consists of two parts: 1) A quantitative exploration of variables hypothesized to predict Tornado Death Index (TDI) values, 2) A qualitative investigation to …

How You Categorize Influences How Helpful You Are: The Effect Of Categorization Mindset On Consumers’ Social Decisions, Hsiao-Ching Kuo

USF Tampa Graduate Theses and Dissertations

This dissertation demonstrates how categorization mindsets (introduced by Ulkumen et al., 2010) moderate the altruistic behavior of consumers in decisions that have consequences to others besides oneself. Categorization mindset refers to a way of thinking about options, and is induced by simple sorting or categorization tasks. Ulkumen et al. (2010) has shown that mindsets can be unidimensional (in terms of being focused on a single, salient dimension) or multidimensional (in that both salient and non-salient dimensions are processed). Across three experiments, this dissertation finds that a multidimensional mindset (compared to a unidimensional mindset) enhances the preference for other-oriented options among …

Facilitating A Transdisciplinary Approach In Teacher Education Through Multimodal Literacy And Cognitive Neuroscience, Margaret Billings Krause

USF Tampa Graduate Theses and Dissertations

This dissertation is a compilation of research and theoretical papers based on the affordances of multimodal literacies for marginalized learners and for pre-service teachers’ developing conceptualizations of literacy. Through a transdisciplinary lens, the author considers complex issues presented in traditional, print-based learning environments that potentially marginalize learners in their developing abilities to become successful participants in the multiple literacies in the real world.

Three studies focus on pre-service teachers and their developing understanding of effective literacy-related classroom practices. Chapter Three explores potential affordances of a multimodal learning environment for pre-service teachers with self-identified reading difficulties. The phenomenological study highlights differing …

The Role Of Anxiety Sensitivity In The Relationship Between Posttraumatic Stress Symptoms And Negative Outcomes In Trauma-Exposed Adults, Brittany Belle Kugler

USF Tampa Graduate Theses and Dissertations

Background: The development of posttraumatic stress symptoms (PTS) following a traumatic event is related to significant functional impairment, diminished quality of life, and physical health issues. Yet it is not entirely clear why some traumatized individuals experience negative outcomes while others do not. The purpose of this study is to determine the role of several influential factors related to PTS severity and negative outcomes, such as diminished quality of life and physical health issues, following traumatic events. Method: One hundred and twenty-two trauma-exposed adults were recruited through the University of South Florida’s SONA system and through flyers on campus. Subjects …

Investigation Of Post-Translational Modifications In Staphylococcus Aureus, Christina Nadia Krute

USF Tampa Graduate Theses and Dissertations

The work presented herein details post-translational modifications (PTMs) in Staphylococcus aureus that are involved in mediating the stress response and normal cellular processes. The first PTM that was investigated is regulated intramembrane proteolysis (RIP) for the activation of the ECF sigma factor σS. We achieved this by analyzing the role of the site-1 protease, which we termed “putative regulator of sigmaS” (PrsS), as it is predicted to be the first enzyme in the RIP cascade, leading to the activation of σS. It was determined that the putative site-1 protease, prsS, mimics transcriptional profiles of sigS; with expression low in all …

System Threats And Gender Differences In Sexism And Gender Stereotypes, Sophie Lois Kuchynka

USF Tampa Graduate Theses and Dissertations

In the United States, women’s persistent gains in structural power may cause backlash among those motivated to preserve the status quo. The proposed study examines the conditions that prompt men and women to endorse sexism and promote gender stereotypes. System justification theory proposes that people are motivated to justify the socio-political system that governs them and threats to the stability of their system can increase individual’s motivated defenses. I expect men to show the strongest motivated defenses when the hierarchy is threatened or viewed as unstable, because to protect group-based interests men will reinforce the legitimacy of the system through …

Schreibersite: Synthesis, Characterization And Corrosion And Possible Implications For Origin Of Life, Nikita Latesha La Cruz

USF Tampa Graduate Theses and Dissertations

We present study of the synthesis and reactions of an analog of the meteoritic mineral schreibersite with formula (Fe,Ni)3P, believed to be a prebiotic source of reactive phosphorus that may have prompted the formation of phosphorylated biomolecules near the time of the origin of life (Pasek and Lauretta, 2005). The mineral was synthesized by mixing stoichiometric proportions of elemental iron, nickel and phosphorus and heating in a tube furnace at 820°C for approximately 235 hours under argon or under vacuum, a modification of the method of Skála and Drábek (2002). The mineral was characterized using X-ray diffractometry (XRD), X-ray photoelectron …

Experimental Reporting And Networks Of Political Information: Lorenzo Magalotti's Framing Of Courts And Nature, Bradley L'Herrou

USF Tampa Graduate Theses and Dissertations

This thesis explores changes in experimental reporting during the scientific revolution of the seventeenth century. In particular, I examine and compare some of the works of Count Lorenzo Magalotti, namely the Saggi di Naturali Esperienza or Essays on Natural Experiments and the Relazione d'Inghilterra. In 1667, as secretary of the Accademia del Cimento – the Tuscan experimental academy founded in 1657 – Magalotti (1637-1712) authored the Saggi, a collection of experimental reports. These reports included extensive written descriptions of experiments along with dozens of engravings depicting the instruments custom-made for the experiments. Magalotti also served as ambassador and agent of …

The Relationship Between Nurses' Emotional Intelligence And Patient Outcomes, Mary Kutash

USF Tampa Graduate Theses and Dissertations

Heart Failure readmissions (HFR) significantly contribute to all cause hospital readmissions rates. Current evidence on the effectiveness of interventions for reduction of HFR is inconclusive. Recent research suggests that nurses’ emotional intelligence (EI) may be associated with better patient outcomes.

The purpose of this study was to examine if nurses’ EI is significantly related to HFR and if that relationship is mediated through patient satisfaction with care. One hundred and thirty six Registered Nurses were recruited from 11 in-patient units at a large teaching hospital in the south eastern United States. Two surveys were mailed to eligible participants; the Bar-On …