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2015

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Motivations To Gamble In Younger And Older Adults, John Bryan R. E. Smith Jan 2015

Motivations To Gamble In Younger And Older Adults, John Bryan R. E. Smith

Theses and Dissertations (Comprehensive)

Gambling is a form of entertainment that is enjoyed by many adults, ranging from university students to older adults. A small subset of gambling research focuses on the motivations to pursue gambling, and very little research has investigated if age differences exist in motivation. Older adults typically experience decreased sense of control compared to university students (Mirowsky 1995, 2013), and it was hypothesized that this would be a key motivational difference. Through two experiments, this research aimed to investigate if different motivation models for gambling should be used for different age groups. Two competing models are tested: Loroz’s (2004) model …


“Are The Girls Out To Bingo? And Is “Frenchie” Gettin Tipsy? On A Sudbury Saturday Night”: Gambling Among Older Francophones In North-Eastern Ontario, Éric R. Thériault Jan 2015

“Are The Girls Out To Bingo? And Is “Frenchie” Gettin Tipsy? On A Sudbury Saturday Night”: Gambling Among Older Francophones In North-Eastern Ontario, Éric R. Thériault

Theses and Dissertations (Comprehensive)

Since its legalization, gambling has become a popular form of entertainment in Canada (e.g., Tepperman & Wanner, 2012). Despite this increase in popularity, little research has been done examining gambling among older adults, and even in this area of research there is a lack of attention to minority groups (e.g., Ariyabuddhiphongs, 2012; Munro, Cox-Bishop, McVey, & Munro., 2003). Tirachaimongkol and colleagues (2010) proposed a theoretical pathways model to help explain problem gambling risk in older adults. This model includes three “clusters” of risk factors, including individual vulnerability factors, social and environmental factors, and behavioural regulation factors. The second cluster is …


Growth Potential In Relationships: A Promotion-Focus Perspective, Amanda E. Kohler, Justin Cavallo Jan 2015

Growth Potential In Relationships: A Promotion-Focus Perspective, Amanda E. Kohler, Justin Cavallo

Theses and Dissertations (Comprehensive)

Relationship research has long emphasized the importance of felt security for interpersonal wellbeing, but has focused less on how opportunities for growth influence relationship well-being. The present research investigates whether people’s motivational states may influence the extent to which people value growth in their romantic relationships. Drawing on regulatory focus theory, which distinguishes between promotion (concerned with advancement) and prevention (concerned with security) self-regulatory orientations, it was hypothesized that promotion-focused individuals would be more satisfied with relationships that offered greater opportunity for growth than with those that offered greater opportunity for security. In three experimental studies, participants evaluated others’ (Study …


Exploring Interactions Between Police And People With Mental Illness, Krystle L. Shore Ms. Jan 2015

Exploring Interactions Between Police And People With Mental Illness, Krystle L. Shore Ms.

Theses and Dissertations (Comprehensive)

Contact between people with mental illness (PMI) and police is on the rise. The current study analyzed a six-month period of official police data (N = 400 occurrences) to provide a description of the PMI that came into contact with police and the typical characteristics and outcomes of these encounters. Results indicated that these interactions were initiated by family members and are taking place at home. Police are most commonly resolving the situations formally with apprehensions under the Mental health Act (55%), however only half of the time these apprehensions result in the PMI being admitted into hospital care, …


The Development And Application Of A Measure To Assess The Interpersonal Qualities Of Self-Talk, Elizabeth L. Price Jan 2015

The Development And Application Of A Measure To Assess The Interpersonal Qualities Of Self-Talk, Elizabeth L. Price

Theses and Dissertations (Comprehensive)

In three studies, this research describes the development and potential application of a new self-report measure, the Interpersonal Self-Talk Scale (IPSTS). Based on Kiesler’s (1983) Interpersonal Circle: Acts Version, and the Revised Interpersonal Adjective Scales (IAS-R; Wiggins et al., 1988) the IPSTS was designed to measure the distinct interpersonal qualities of self-talk. In Study 1 (N = 316), a principal components analysis of the IPSTS items yielded two underlying dimensions of dominance and affiliation. The preliminary octant subscales displayed good internal consistency reliability and circumplex structure, and the IPSTS was shown to measure a construct that is reasonably …


Critical Champions Or Careless Condemners? Exploring News Media Constructions In Cases Of Wrongful Conviction, Katherine Rozad Jan 2015

Critical Champions Or Careless Condemners? Exploring News Media Constructions In Cases Of Wrongful Conviction, Katherine Rozad

Theses and Dissertations (Comprehensive)

Countless incidences occur throughout the world each and every day. However, only a few of these occurrences are deemed newsworthy by the media. One area of information quite often categorized as “newsworthy” is that surrounding crime. Within crime-related news coverage are occasionally cases of wrongful conviction – miscarriages of justice in which the innocent are labeled “guilty” and wrongly punished. Despite decades of research in both the areas of crime and media, as well as wrongful conviction studies, no research to date has examined the way that cases of wrongful conviction are constructed in the media from the beginnings of …


Purification And Characterization Of Bcsc; An Integral Component Of Bacterial Cellulose Export, Emily D. Wilson Ms Jan 2015

Purification And Characterization Of Bcsc; An Integral Component Of Bacterial Cellulose Export, Emily D. Wilson Ms

Theses and Dissertations (Comprehensive)

Biofilms are a growing concern in the medical field due to their increased resistance to antibiotics. When found in a biofilm, bacteria can have antibiotic resistance 10-1000 times that of their planktonic counterparts. Therefore, it is important to study the formation of biofilms. Cellulose biofilms are formed by Enterobacteriaceae, such as many Escherichia coli and Salmonella spp. strains. Biofilms provide these species with benefits including antimicrobial protection, development of bacterial communities, promotion of DNA exchange, uptake of nutrients, and, in the case of cellulose biofilms, immune system evasion. Cellulose biofilms are controlled by the Bacterial cellulose synthesis (Bcs) complex located …


Neither War, Nor Peace: Everyday Politics, Peacebuilding And The Liminal Condition Of Bosnia-Herzegovina And Northern Ireland, Branka Marijan Jan 2015

Neither War, Nor Peace: Everyday Politics, Peacebuilding And The Liminal Condition Of Bosnia-Herzegovina And Northern Ireland, Branka Marijan

Theses and Dissertations (Comprehensive)

This thesis focuses on cultural and everyday practices of local populations in post-conflict peacebuilding. It builds on the “everyday” turn in critical peacebuilding literature by recognizing the everyday as political. Rather than examining the practices of political elites this thesis is concerned with the ordinary citizens of these societies. In other words, I show that it is through practices and cultural forms of expression that local populations enact their agency, at times supporting and at times contesting the broader peacebuilding project. Moreover, rather than viewing the everyday acts as hidden or as evidence of resistance to the dominant peacebuilding approaches …


Social Factors Influencing Early Reading Development From Kindergarten To Grade One In English-Speaking Public Schools In Ontario And Quebec, Katherine Wood Jan 2015

Social Factors Influencing Early Reading Development From Kindergarten To Grade One In English-Speaking Public Schools In Ontario And Quebec, Katherine Wood

Theses and Dissertations (Comprehensive)

This research study examines the influence of providing parents with early literacy or socio-emotional instruction on their children’s performance in reading and social skill development. Parents were offered four interactive workshops designed to assist them in identifying everyday opportunities to reinforce either early reading skills or early social skills development. Two reading skills approaches were explored, traditional text reading and traditional text reading with computer-assisted learning opportunities. These two reading approaches were contrasted with a set of social development workshops derived from social-emotional learning models. Children’s performance was measured at three time intervals from early kindergarten to early in grade …


From Lending In The Andes To Thriving In Latin America: Caf’S Continuity, Growth And Long-Term Financing In The Region, Veronica Rubio Vega Jan 2015

From Lending In The Andes To Thriving In Latin America: Caf’S Continuity, Growth And Long-Term Financing In The Region, Veronica Rubio Vega

Theses and Dissertations (Comprehensive)

What explains the Development Bank of Latin America’s (CAF, in Spanish) continuity and expansion since the 1990s? This thesis explores how an initially small Andean development bank crafted a successful strategy to survive in a troubled region and eventually thrive as an important lending source. This thesis argues that CAF’s expansion can be attributed to four main factors: 1) leadership, 2) institutional design, 3) member governments’ preferences and 4) Brazil’s push for regional cooperation beyond trade.

Theoretically, this thesis draws upon two sets of interrelated academic debates to explain CAF’s growth: 1) International Political Economy (IPE) and International Organization (IO) …


The Effect Of Gvs On Path Trajectory And Body Rotation In The Absence Of Visual Cues During A Spatial Navigation Task, Tanya Karn Jan 2015

The Effect Of Gvs On Path Trajectory And Body Rotation In The Absence Of Visual Cues During A Spatial Navigation Task, Tanya Karn

Theses and Dissertations (Comprehensive)

Background: The vestibular system has been shown to contribute to mechanisms of locomotion such as distance perception. Galvanic vestibular stimulation (GVS) is a tool used to perturb the vestibular system, and causes significant deviations in path trajectory during locomotion. Previous research has suggested that applying GVS during straight-line locomotion tasks is not sufficient to determine the effects of the vestibular system on locomotion. However, spatial navigation challenges one’s ability to navigate throughout the environment using idiothetic cues to constantly update one’s position. The purpose of the current study was to determine the effects of GVS on both path trajectory and …


Mechanisms Controlling Stem Cell Differentiation, Tran Doan Ngoc Tran Jan 2015

Mechanisms Controlling Stem Cell Differentiation, Tran Doan Ngoc Tran

LSU Doctoral Dissertations

Mesenchymal stem cells are multipotent cells that can differentiate into many cell types. However, the molecular mechanism controlling this process remains unclear. We utilized rat dental follicle stem cells (rDFSCs) and human adipose derived stem cells (hASCs) to study the mechanisms controlling osteogenesis and adipogenesis. Elevations in the intracellular Ca2+ concentration are a phenomenon commonly observed during stem cell differentiation but cease after the process is complete. The Transient Receptor Potential Melastatin 4 (TRPM4) is an ion channel that controls Ca2+ signals in excitable and non-excitable cells. However, there are no studies on TRPM4 in stem cells. In another study, …


“Don’T Talk About It”: Investigating The Effects Of Pei’S Cultural Silence On Abortion Access And Advocacy From The Perspective Of Advocates And Support People, Emily A. Rutledge Jan 2015

“Don’T Talk About It”: Investigating The Effects Of Pei’S Cultural Silence On Abortion Access And Advocacy From The Perspective Of Advocates And Support People, Emily A. Rutledge

Theses and Dissertations (Comprehensive)

As an arm of a greater study that investigates the impacts of PEI's abortion restriction over the past two decades, "Don't talk about it" explores the situation from the perspective of support people and advocates to abortion access including; their emotional experiences of support and advocacy, the associated risks and repercussions, as well as their understandings of the barriers, facilitators and impacts of compromised access to off-Island services for PEI women and girls. Key findings show an overarching culture of silence and blame surrounding abortion on PEI, reinforced by stigma and repercussions for those speaking out. This silence serves to …


Enhancing Canadian Girls’ Resilience Through Girls-Only Programming, Ayesha Umme-Jihad Jan 2015

Enhancing Canadian Girls’ Resilience Through Girls-Only Programming, Ayesha Umme-Jihad

Theses and Dissertations (Comprehensive)

Canadian girls face a number of complex issues as they transition through girlhood and into adolescence. Despite the barriers they face, girls can be resilient with the development of internal and external assets. Presently, we know that protective factors developed in girls-only programs between the critical ages of 9 and 13 enhance girls’ resilience in the short-term (Alcade, Hayward, Loomis, & Hodgson, 2012). This thesis project operationalizes protective factors as confidence, critical thinking skills, connectedness, and parental relationships. Risk factors are operationalized as adversity within environments, depression, negative behaviours, and substance use. A mixed methods approach is used to investigate …


Positive Parenting In Adolescence And Its Association With Future Hopes And Fears In Adulthood: A Longitudinal Analysis, Harmanpreet Chauhan Jan 2015

Positive Parenting In Adolescence And Its Association With Future Hopes And Fears In Adulthood: A Longitudinal Analysis, Harmanpreet Chauhan

Theses and Dissertations (Comprehensive)

During young adulthood (ages 20-39), individuals begin to develop a future orientation by thinking about their possible selves. In this longitudinal study, young adults’ future hopes and fears were examined in relation to their perceptions of the parenting style they experienced in adolescence. An interview was conducted with participants at age 26 and 32 to assess their future possible selves. Participants discussed both hoped-for and feared selves. The long-term impact of parenting on future hopes and fears was examined by exploring the possible impact of perceived parenting styles experienced in adolescence. Interviews were conducted in 2005 and 2011 with 26 …


Nucleolar Proteins Are Essential For Ribosome Biogenesis And Nuclear Homeostasis In Drosophila Melanogaster, Yubo Wang Jan 2015

Nucleolar Proteins Are Essential For Ribosome Biogenesis And Nuclear Homeostasis In Drosophila Melanogaster, Yubo Wang

LSU Doctoral Dissertations

Four nucleostemin-like proteins (NS1-4) were identified previously in Drosophila melanogaster. NS1 and NS2 are nucleolar proteins, while NS3 and NS4 are cytoplasmic. Here we show that NS2 is homologous to the human nucleostemin-like protein, Ngp1, and that endogenous NS2 and exogenous GFP-NS2 enriches within peripheral regions of nucleoli in larval polyploid midgut cells. Like NS1, depletion of NS2 in midgut cells blocked the release of the 60S ribosomal subunit as detected by the accumulation GFP-RpL11 within nucleoli, and this likely led to a general loss of 60S subunit proteins as shown by immunoblot analyses. At the ultrastructural level, nucleoli in …


Method Development For The Assignment Of Nmr Peaks And The Determination Of Quaternary Protein Structure Using Reductive Methylation, Pamlea Nicole Brady Jan 2015

Method Development For The Assignment Of Nmr Peaks And The Determination Of Quaternary Protein Structure Using Reductive Methylation, Pamlea Nicole Brady

LSU Doctoral Dissertations

The work described herein is centered on reductive methylation, a chemical modification reaction, which allows for the introduction of methyl groups at the primary amines of the lysine side chain and at the N-terminus. The resulting methyl groups are effective probes for the study of protein structure and dynamics using nuclear magnetic resonance spectroscopy (NMR). Described herein is work conducted on the development of tools for the study of protein structure using reductive methylation, highlighting options for addressing limitations of the labeling method encountered by its practical use. Chapter 1 serves as a brief introduction to protein structure and the …


Evaluating And Increasing The Range Of Reinforcers For Individuals With Autism Spectrum Disorder, Megan Kliebert Wiggins Jan 2015

Evaluating And Increasing The Range Of Reinforcers For Individuals With Autism Spectrum Disorder, Megan Kliebert Wiggins

LSU Doctoral Dissertations

Prior research has demonstrated the utility of several preference-assessment methodologies to identify stimuli more likely to function as reinforcers for individuals with limited verbal repertoires. However, differing results have been obtained from studies evaluating the reinforcement effects of stimuli identified as high preference by one assessment method but low preference by another assessment method. The first focus of the project was to evaluate the reinforcing efficacy of edible and leisure items based on predictions from preference assessments. Results indicated that edible and leisure items approached frequently during a single-stimulus preference assessment but infrequently during a paired-stimulus preference assessment produced less …


Development And Optimization Of Non-Hydrostatic Models For Water Waves And Fluid-Vegetation Interaction, Ling Zhu Jan 2015

Development And Optimization Of Non-Hydrostatic Models For Water Waves And Fluid-Vegetation Interaction, Ling Zhu

LSU Doctoral Dissertations

The primary objective of this study is twofold: 1) to develop an efficient and accurate non-hydrostatic wave model for fully dispersive highly nonlinear waves, and 2) to investigate the interaction between waves and submerged flexible vegetation using a fully coupled wave-vegetation model. This research consists of three parts. Firstly, an analytical dispersion relationship is derived for waves simulated by models utilizing Keller-box scheme and central differencing for vertical discretization. The phase speed can be expressed as a rational polynomial function of the dimensionless water depth, $kh$, and the layer distribution in water column becomes an optimizable parameter in this function. …


Investigating The Photorecombination Dynamics In Molecular High-Harmonic Spectra, Benjamin Parker Wilson Jan 2015

Investigating The Photorecombination Dynamics In Molecular High-Harmonic Spectra, Benjamin Parker Wilson

LSU Doctoral Dissertations

The work presented in this dissertation will relate the photorecombination dynamics to photoionization dynamics in SF6 utilizing the self-probing mechanism, high harmonic generation (HHG). This work specifically aims to establish parameters for which the comparison is applicable and the macroscopic complications inherent in HHG do not interfere with the extraction of dynamic information. The first part of this work established the macroscopic experimental apparatus necessary for consistent spectroscopic observation. It is shown that using a gas jet that is an order of magnitude shorter than the Rayleigh length of the driving laser results in more consistent harmonic spatial profiles and …


Well-Quasi-Ordering By The Induced-Minor Relation, Chanun Lewchalermvongs Jan 2015

Well-Quasi-Ordering By The Induced-Minor Relation, Chanun Lewchalermvongs

LSU Doctoral Dissertations

Robertson and Seymour proved Wagner's Conjecture, which says that finite graphs are well-quasi-ordered by the minor relation. Their work motivates the question as to whether any class of graphs is well-quasi-ordered by other containment relations. This dissertation is concerned with a special graph containment relation, the induced-minor relation. This dissertation begins with a brief introduction to various graph containment relations and their connections with well-quasi-ordering. In the first chapter, we discuss the results about well-quasi-ordering by graph containment relations and the main problems of this dissertation. The graph theory terminology and preliminary results that will be used are presented in …


Caregiver Perceptions Of Speech-Language Pathologist (Slp) Communication: Examining How Slps Talk With Caregivers About Child Language Disorders, Karmen L. Porter Jan 2015

Caregiver Perceptions Of Speech-Language Pathologist (Slp) Communication: Examining How Slps Talk With Caregivers About Child Language Disorders, Karmen L. Porter

LSU Doctoral Dissertations

The purpose of this study was to identify how SLP communication regarding language disorders was perceived by caregivers. Employing a qualitative methodology, the caregivers of 10 children, identified with a language-based reading impairment, participated in semi-structured interviews concerning their experiences communicating with SLPs. As a whole, the findings showed the value caregivers place on receiving clear, concrete, and timely diagnostic information, the variability and complexity associated with caregivers’ understanding of language disorders, and the reciprocal relationship between key SLP communication practices, caregiver knowledge, and effective collaboration. Some of the key themes emphasized in regard to SLP communication practices included: recognition …


Examining The Supervisor-Similarity And Work-Family Conflict Relationship: Is Family-Supportive Supervision A Mediator?, Chela M. White-Ramsey Jan 2015

Examining The Supervisor-Similarity And Work-Family Conflict Relationship: Is Family-Supportive Supervision A Mediator?, Chela M. White-Ramsey

LSU Doctoral Dissertations

To say that interest in work-family conflict has increased is an understatement. With the number of dual-earner households increasing, the diversification of the workforce, and women quickly moving into industries that were once primarily male-dominated, the work-family literature is filled with various intonations of the concept. Drawing on insights from social identity and self-categorization theories, this dissertation examined how supervisor-subordinate demographic similarity might relate to the provision of family-supportive supervision and work-family conflict. 102 members of a professional organization dedicated to women who work in technology were surveyed to evaluate whether or not supervisor-subordinate racial and gender similarity would predict …


Ceo Compensation And Tax Loss Carrybacks, Pei-Yu Sun Jan 2015

Ceo Compensation And Tax Loss Carrybacks, Pei-Yu Sun

LSU Doctoral Dissertations

Erickson, Heitzman, and Zhang’s (2013) results indicate that firms engage in tax-motivated loss recognition to offset previously recorded income. Since tax and financial income by design is linked (Guenther, Maydew, and Nutter 1997), net operating loss reporting can impose significant costs on CEOs who have to recognize similar losses for financial reporting purposes. As a result, firms must motivate the CEO to accelerate loss recognition if the firm expects to benefit from the cash inflows generated by the tax refund. In the current study, I examine whether CEO cash-based compensation increases to offset the potential negative costs that can arise …


The Role Of Rhizobial Mutualisms In The Establishment And Colonization Of Exotic Acacia Species In Novel Ranges, Metha Martine Klock Jan 2015

The Role Of Rhizobial Mutualisms In The Establishment And Colonization Of Exotic Acacia Species In Novel Ranges, Metha Martine Klock

LSU Doctoral Dissertations

Comparing species establishment and expansion across regional and global scales and comparing congeners that differ in invasive capacity can provide novel insights into mechanisms driving species invasions. Acacia species introduced from Australia around the globe constitute an ideal group for comparing drivers of establishment across different regions and species. Acacias form mutualistic associations with nitrogen-fixing root-nodule bacteria (i.e. rhizobia), which may be a key factor in invasion success. In this dissertation, I examine the acacia-rhizobia mutualism across a suite of host species to explore a key mechanism influencing patterns and processes of acacia invasion. I used three complementary approaches to …


Dwelling Poetically, Proceeding Orphically: The Platonic Tradition And The Heideggerian Humanism Of Ernesto Grassi, Geoffrey Alexander Leeves Bain Jan 2015

Dwelling Poetically, Proceeding Orphically: The Platonic Tradition And The Heideggerian Humanism Of Ernesto Grassi, Geoffrey Alexander Leeves Bain

LSU Doctoral Dissertations

Martin Heidegger exerted an immense influence over twentieth century thought by providing profound insights into the nature of Being as well as scathing social critiques, focused on the destructive force of late modern technological reductionism. As part of Heidegger’s project, he elaborated upon a sophisticated history of Being in which two great monsters of Platonism and Humanism are cast as Antichrist and False Prophet. Subsequently, however, his own student Ernesto Grassi argued that Renaissance Humanism was not a stepping stone towards subjectivism and technological thinking, but rather stood in conformity with the fundamental essence of Heidegger’s own project. This study …


The Bioactive Compounds In Agricultural Products And Their Roles In Health Promoting Functions, Yixiao Shen Jan 2015

The Bioactive Compounds In Agricultural Products And Their Roles In Health Promoting Functions, Yixiao Shen

LSU Doctoral Dissertations

Bioactive compounds from different agricultural food products have attracted great interest from food industries and researchers for their health promoting functions such as antioxidant, antiaging, anti-inflammatory and anticancer performance. In this study, hydrophilic and lipophilic fraction of two economical agricultural products sweet sorghum millet and sweet potato, as well as two herbs, butterfly pea and basil were extracted. The profiles and contents of phenolics, fatty acids, tocopherols, carotenoids and phytosterols in these selected agricultural products were determined by chromatography and mass spectrum methods. Additionally, the anti-lipid-oxidation capability of sweet sorghum millet and basil, and anti-cancer potential of butterfly pea seed …


Thiol-Ene Scaffolds As Synthetic Augments And Silicate Ceramics As Osteogenic Components For Bone Tissue Engineering Applications, Cong Chen Jan 2015

Thiol-Ene Scaffolds As Synthetic Augments And Silicate Ceramics As Osteogenic Components For Bone Tissue Engineering Applications, Cong Chen

LSU Doctoral Dissertations

Bone tissue engineering approaches using polymer/ceramic composites show promise as effective biocompatible, absorbable, and osteoinductive materials. A novel class of in situ polymerizing thiol-acrylate based copolymers synthesized via an amine-catalyzed Michael addition was studied for its potential to be used in bone defect repair. Both pentaerythritol triacrylate-co-trimethylolpropane tris(3-mercaptopropionate) (PETA-co-TMPTMP) and PETA-co-TMPTMP with hydroxyapatite composites were fabricated in solid cast and foamed forms. These materials were characterized chemically and mechanically followed by an in vitro evaluation of the biocompatibility and chemical stability in conjunction with human adipose-derived mesenchymal pluripotent stem cells (hASC). The solid PETA-co-TMPTMP with and without hydroxyapatite (HA) exhibited …


The Saxophone Symposium: An Index Of The Journal Of The North American Saxophone Alliance, 1976-2014, Ashley Kelly Jan 2015

The Saxophone Symposium: An Index Of The Journal Of The North American Saxophone Alliance, 1976-2014, Ashley Kelly

LSU Doctoral Dissertations

The Saxophone Symposium is the journal of the North American Saxophone Alliance and is a peer-reviewed academic publication. Since 1976, its readership has enjoyed articles on a variety of saxophone related topics as well as reviews of contemporary recordings and publications. Aside from these academic applications, The Saxophone Symposium is an historical account of some of the saxophone culture in North America and beyond. Academic journals such as this are invaluable to both students and educators, and the ability to access the information within them is vital. Prior to the digital age, the majority of serious academic journals have been …


Regulation Of The Chloride Store In The Retinal Amacrine Cells, Vijai Krishnan Jan 2015

Regulation Of The Chloride Store In The Retinal Amacrine Cells, Vijai Krishnan

LSU Doctoral Dissertations

Nitric Oxide (NO) is a key gaseous messenger that has been shown to be produced by multiple cell types in the vertebrate retina. Research in our lab is aimed at unlocking critical synaptic functions of NO. A major finding from our lab is that NO affects synaptic responses in amacrine cells by altering the plasma membrane gradient for Cl-. This is due to release of Cl- from an internal store and this in turn dependent on a decrease in cytosolic pH. Determining the factors regulating cytosolic Cl- in neurons is fundamental to our understanding of the function of GABAergic and …