Digital Commons Network^™

Censoring And Fusion In Non-Linear Distributed Tracking Systems With Application To 2d Radar, Armond S. Conte Ii

Theses and Dissertations

The objective of this research is to study various methods for censoring state estimate updates generated from radar measurements. The generated 2-D radar data are sent to a fusion center using the J-Divergence metric as the means to assess the quality of the data. Three different distributed sensor network architectures are considered which include different levels of feedback. The Extended Kalman Filter (EKF) and the Gaussian Particle Filter (GPF) were used in order to test the censoring methods in scenarios which vary in their degrees of non-linearity. A derivation for the direct calculation of the J-Divergence using a particle filter …

Integrated Nanoscale Imaging And Spatial Recognition Of Biomolecules On Surfaces, Congzhou Wang

Theses and Dissertations

Biomolecules on cell surfaces play critical roles in diverse biological and physiological processes. However, conventional bulk scale techniques are unable to clarify the density and distribution of specific biomolecules in situ on single, living cell surfaces at the micro or nanoscale. In this work, a single cell analysis technique based on Atomic Force Microscopy (AFM) is developed to spatially identify biomolecules and characterize nanomechanical properties on single cell surfaces. The unique advantage of these AFM-based techniques lies in the ability to operate in situ (in a non-destructive fashion) and in real time, under physiological conditions or controlled micro-environments.

First, AFM-based …

Physicochemical And Structural Analysis Of Polymers As Putative Drugs, Meghan L. Thompson

Theses and Dissertations

Sulfated low molecular weight lignins (LMWLs) have shown good activity as anticoagulants by allosterically inhibiting thrombin, as well as promising agents for treating emphysema through inhibition of elastolysis, oxidation, and inflammation. Sulfated LMWLs are chemo-enzymatically synthesized from starting monomers caffeic, ferulic, and sinapic acid into sulfated dehydropolymers known as CDS, FDS, and SDS. To further the LMWLs’ development as drugs, their structural composition and physicochemical characteristics were defined in this work. The molecular weight distribution profile of the sulfated LMWLs from size exclusion chromatography performed on a high pressure liquid chromatography system (SEC-HPLC) changed from bimodal when no surfactant is …

Conjoined Lucuma Fruit Vessels: Evolution & Context In Nasca Art, Carley Elder

Theses and Dissertations

The function of a ceramic vessel is often evaluated in relation to its form. Vessels with complex forms can be challenging to analyze from this perspective and require a different approach. One such example is an overlooked yet long-lived specialized vessel type in the form of conjoined lúcuma fruits found throughout the ancient Andes. The main object of this study is a Nasca version of this vessel type in the Virginia Museum of Fine Art. This study explores the relationship between form and iconography, rather than function. It examines how Nasca potters adopted the conjoined lúcuma form vessel and adapted …

Measuring The Impact Of Recognized Patient-Centered Medical Homes (Pcmh), Rick Moore

Theses and Dissertations

This dissertation proposal seeks to understand if the increasingnumbers (density) of recognized PCMH practices incommunities affect avoidable hospitalizations related toambulatory care sensitive conditions (ACSC), as measured bythe AHRQ Composite Prevention Quality Indicators (PQI). Theresearch has two purposes: 1. Establish constructs and hypotheses to measurethe effect of the increasing numbers of NCQA-Recognized PCMH practices in communities(counties). 2. Using an outcomes-based measurement approach,investigate the relationship between growingdensities of NCQA-Recognized PCMH practicedoctors among all primary care doctors (PCD) ina community and the associated impact on theutilization of inpatient care, specifically related toACSCs, as measured by the AHRQ CompositePQIs.

The research is quasi-experimental in …

Efficiency Of Unified Vs. Non-Unified State Judiciaries: An Examination Of Court Organizational Performance, William Raftery

Theses and Dissertations

State court systems function in much the same manner as any other government agency in terms of organization and management to utilize public resources in order to provide a public service. The question posed in the late 19th century was whether the courts should be organized and managed as they had been for centuries as local entities locally controlled and operated or transferred to the state level. The desired end was a more efficient use of public resources to achieve faster disposition of cases. This reorganization, called unification, was made up of three individual components: 1) consolidation required the reduction …

Individuals With Fetal Alcohol Spectrum Disorder: Predictive Factors For Successful Occupational Performance, Mary Culshaw

Theses and Dissertations

As awareness and diagnoses of FASD grow in Canada, there is increased need to support these individuals across their lifespan. One study suggested the prevalence of FASD may be as high as 10 per 1000 births (May & Gossage, 2001). The impact to society is growing as well, since this population requires support across their lifespan due to cognitive and sometimes physical impairments. It was estimated that the annual cost to Canadians was $53 billion (in 2007 dollar value) to support individuals aged 0-53 years (Stade et al., 2009). There is mounting evidence identifying the cognitive and physical impairments that …

The Integration History Of Kuwaiti Television From 1957-1990: An Audience-Generated Oral Narrative On The Arrival And Integration Of The Device In The City, Ahmad Hamada

Theses and Dissertations

This study attempts to compose an account of television history in Kuwait, one that focuses on its integration into society and is told from the audience's perspective and experience. This study represents a cultural alternative to the overwhelmingly national, institutional, and biographical focus that accompanies television history works in Kuwait and the Arab world.

The narrative is gathered and generated through the individual oral stories of 25 Kuwaitis over the age of 50, who generally represent the six geographical districts of Kuwait. Through their oral stories, the narrators examine the different areas in which television has integrated itself into society …

Decreased Sound Tolerance (Dst): Prevalence, Clinical Correlates, And Development Of A Dst Assessment Instrument, Therese Verkerke Cash

Theses and Dissertations

Decreased sound tolerance (DST) conditions, including misophonia and hyperacusis, are emerging clinical conditions in behavioral medicine. Misophonia involves an extreme emotional response (often anger, disgust, or annoyance) to specific sounds (such as people chewing, swallowing, tapping their foot on the floor, etc.), while hyperacusis is defined by high sensitivity to sounds below normal sound sensitivity thresholds. Although research on these DST conditions is increasing, clearly defined prevalence rates, associations with other mental health conditions, and development of assessment tools that can identify and differentiate DST symptoms are needed. Research and clinical reports also suggest that DST problems are more likely …

Examination Of Basal Neuroendocrine Levels In Oif/Oef/Ond Veterans, Sage E. Hawn

Theses and Dissertations

Abstract

EXAMINATION OF BASAL NEUROENDOCRINE LEVELS IN OIF/OEF/OND VETERANS

By Sage E. Hawn, B.S.

A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2015.

Major Director: Ananda B. Amstadter, PhD.

Associate Professor

Departments of Psychiatry, Psychology, & Human and Molecular Genetics

High rates of combat exposure exist among veterans of the recent conflicts, and are associated with debilitating mental health conditions, including posttraumatic stress disorder (PTSD). Numerous psychosocial and biologic factors are associated with PTSD, including the HPA-axis. The present study aimed to compare baseline neuroendocrine …

Conduction States Of The Human Dopamine Transporter, Krasnodara Cameron

Theses and Dissertations

Dysregulation of dopaminergic homeostasis has been established as the primary source of numerous neurological disorders including Parkinson’s and drug addiction. A tonic increase of dopamine (DA) in the nucleus accumbens is required for associating everyday events and behaviors with rewards. Yet many addictive exogenous compounds such as amphetamine (AMPH) and cocaine (COC) produce a much greater augmentation of synaptic DA levels that are linked to euphoria and a shift in behavior towards drug seeking. The protein responsible for maintaining extracellular levels of DA is the dopamine transporter (DAT). It is primarily located in the perisynaptic area at terminals of pre-synaptic …

Confederate Richmond: A City's Call To Arms, Tucker L. Modesitt

Theses and Dissertations

This work mainly focuses on putting the laborers of the Richmond Armory and the Tredegar Iron Works into the context of Civil War Richmond by focusing on their skills, backgrounds, and loyalties throughout the conflict. It highlights the similarities and differences between the two institutions and the legacies that they left behind in the years following the war. It also sheds light on some of the problems facing the Confederacy during the course of the war and its struggle to procure arms.

Can Fair Value Accounting Create A Cognitive Bias? The Effects Of Recognized Level 3 Fair Value On Manager Selling Decisions, Karen Y. Green

Theses and Dissertations

This study examines the effects of the discretion allowed in fair value accounting on manager selling decisions of Level 3 fair value assets and liabilities. Grounded in motivated reasoning and prospect theory, the discretion permitted for Level 3 fair value assets and liabilities is predicted to have behavioral consequences. The study employs a 2 X 2 between- participant design, manipulating a conservative level of the discretion used to ascertain the fair value (more or less conservative) and the volatility of the historically recognized fair value (low or high). Both graduate students and accounting professionals were asked to read a case …

Therapist Adherence To Cognitive Behavioral Therapy For Anxious Youth Across A Case, Julia R. Cox

Theses and Dissertations

The field has developed many evidence-based treatments (EBTs); the integrity of EBTs being delivered, however, has been studied less than rigorously. Because many treatment manuals are developed to be delivered session-by-session, one way to assess treatment adherence, specifically, is across the course of the case: do therapists deliver treatment components in the order prescribed? The goals of this study were to characterize how therapists deviate from prescribed order and how adherence to order relates to child characteristics. Therapy process data were collected from a subsample of children (N = 33, aged 7-15) that received cognitive behavioral therapy (CBT) to address …

Exploring Dimensions Of Well-Being Among Spouses Of Active-Duty Service Members, Lisa A. Gray

Theses and Dissertations

During an era when the United States has been engaged in the longest waging wars in U.S. history, military families have been exposed to extraordinary amounts of stress and have had to learn to adapt in a culture where repeated deployments, recurrent family separations, and frequent relocations have become the norm. A surge in research in recent years on the families of Service members has brought increased attention to the unique challenges and demands of spouses, raising concerns about how to best meet their needs. Despite the increased attention, few studies have focused on spousal well-being. Acknowledging this lack of …

Social Studies, Donna B. Evans

Theses and Dissertations

Artist Statement

In my mixed media work, I focus on people who are in the process of being uprooted and exiled from their home. My work reflects the limbo refugees experience while they search for balance and a new place to settle. The cultural diaspora affects the transplanted individuals as well as the host communities. Everyone experiences and needs to adapt to change.

My abstracted images are created by manipulating layers of acrylic paint, photo gel transfers, gel medium, and tempera paint. I combine human forms with layers of English and foreign text while exploring concepts of displacement. I use …

Into The Fray, Frances Pearce

Theses and Dissertations

My sculpture and prints are about dismemberment and the destruction caused by war. To address the high cost of war, I make works that present the threat of injury, amputation, and prosthetics. I use Classical Greek art history references to address contemporary political, military, and social issues. I include images such as Amazonian women, horses, and doves. These images are coupled with references to the damage caused by conflict. While my work concerns destruction, paradoxically, my process involves additive construction. I take a mixed media approach to both my sculptures and my prints, and use a wide range of materials …

African American Women’S Perceptions Of Hiv Prevention Communication With Their Reproductive Health Providers, Valerie Burge-Hall

Theses and Dissertations

In spite of a decline in HIV incidence rates among African American women, they still bear the most significant disease burden among U.S. women. Findings from numerous studies indicate probable explanations for the disparity, such as the impact of poverty, limited healthcare access, low literacy, and living in areas with high HIV rates. Additionally, many study results provide insight regarding prevention strategies. However, the aim of this study is to explore African American women’s perceptions regarding what HIV prevention communication, if any, occurred with their reproductive health providers (RHPs). In this study, 20 African American women with unknown HIV status …

Vitamin C: A Potential Regulator Of Inflammatory Response, Bassem M. Mohammed

Theses and Dissertations

Introduction: Neutrophils (PMNs) and Macrophages are the first responders recruited consecutively to the site of injury/inflammation. PMNs’ response/fate as well as macrophage reprogramming ultimately determine the course of resolution of inflammation. Physiologic wound healing has a significant inflammatory component. An exaggerated inflammation however is self-defeating leading to delayed healing. Parenteral vitamin C (VitC) attenuated inflammation in murine sepsis models and in patients with sepsis. However information about the mechanisms by which VitC regulates these events is limited.

Methods: Humanized mice lacking VitC synthesis capability (Gulo^-/-) were used. VitC sufficient and deficient mice were challenged with sterile inflammation, or …

Ceo Managerial Ability, Corporate Investment Quality, And The Value Of Cash, Huiqi Gan

Theses and Dissertations

This study investigates how CEO managerial ability affects investment quality, investment efficiency, and the value of cash. Specifically, I examine whether higher managerial ability is associated with higher M&A quality, more efficient capital investments, and higher value of cash. Investment decision-making and implementation can signal a CEO’s managerial ability (Stein 2003), and shareholders assign more value to the cash of those firms with high ability CEOs. Thus, I predict that more able CEOs conduct higher quality M&A and make more efficient capital investment decisions. I also propose that the value of cash is higher for firms with more able CEOs. …

Determinants Of Turnover Intent In Higher Education: The Case Of International And U.S. Faculty, Jaehee Park

Theses and Dissertations

In spite of the increase in the number of the international academic workforce and their potential benefits, international status has been relatively under-studied in Public Management and Higher Education literature in comparison with studies of age, gender, and race. Given these realities, the present study identifies characteristics of internal and external variables that influence international and U.S. faculty turnover intentions in a large public South Eastern research university.

To understand the variations in short-term and long-term turnover levels while controlling for various demographic, structural, and external variables, eight Ordinary Least Square (OLS) regression analysis were performed using turnover intentions as …

Investigating The Effects Of Obesity Prevention Campaigns, Courtney C. Simpson

Theses and Dissertations

Public health campaigns might not be universally helpful and could have detrimental consequences. The current investigation explored the effects of obesity prevention campaigns. Their impact was assessed using an experiment in which participants were randomized to view either weight focused obesity prevention campaigns or obesity prevention campaigns that did not use weight related terms. Results demonstrated that compared with campaigns without weight related terminology, weight focused campaigns increased negative perceptions of obesity and decreased self-efficacy for health behavior change. No differences in body satisfaction, thin-ideal internalization, state anxiety, or frequency of positive health behaviors were found based on the type …

Chronic Behavioral And Cognitive Deficits In A Rat Survival Model Of Organophosphate Toxicity, Beverly Huang

Theses and Dissertations

Organophosphates (OPs) are a major class of pesticides and nerve agents that elicit acute toxicity by inhibiting acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine in the central and peripheral nervous systems. Acetylcholine accumulation following extensive AChE inhibition leads to an acute cholinergic syndrome characterized by autonomic dysfunction, involuntary movements, muscle fasciculations, respiratory distress, and seizures. Despite their classification as moderate to highly toxic, OP pesticides are the most widely used class of insecticides in the U.S., and are even more commonly used worldwide. Additionally, there is a growing concern that OP nerve agents could be …

Lost In Austen: An Immersive Approach To Pride & Prejudice, Erica Hughes

Theses and Dissertations

This paper is an account of the Theatre VCU mainstage production of Pride & Prejudice, in which I played the roles of Mrs. Bennet and of the vocal coach. In order to address the various skill levels of the cast, I planned to coach the production in a manner inspired by immersion language learning programs, with the cast speaking in dialect throughout the rehearsal process so as to learn the necessary vocal skills and to grow together as a theatrical ensemble. When the director of Pride & Prejudice was not receptive to this plan, I had to compromise and adapt …

Enhanced Epithelial-To-Mesenchymal Transition Associated With Lysosome Dysfunction In Podocytes: Role Of P62/Sequestosome 1 As A Signaling Hub, Guangbi Li

Theses and Dissertations

Autophagy is of importance in the regulation of cell differentiation and senescence in podocytes, the highly differentiated glomerular epithelial cells. It is possible that derangement of autophagy under different pathological conditions activates or enhances Epithelial-to-Mesenchymal Transition (EMT) in podocytes, resulting in glomerular sclerosis. To test this hypothesis, the present study produced lysosome dysfunction by inhibition of vacuolar- type H⁺-ATPase (V-ATPase) to test whether deficiency of autophagic flux enhances EMT in podocytes. By Western blot analysis, inhibition of lysosome function by V-ATPase inhibitor or its siRNA was found to induce a significantly enhanced EMT in cultured podocytes, as shown …

Sex Offender Management Policies And Their Unintended Cosequences: A National Survey Of The Perceptions Of Professionals, Corey Call

Theses and Dissertations

The mid-1990s brought sex offenders to the forefront of policy issues due to several highly publicized cases of abduction, sexual assault, and murder involving children. Following these cases, a number of sex offender management policies were passed to quell public concern over the safety of children due to sex offenders. Most notably, these new sex offender management policies mandated the creation of publicly available registries of sex offenders and enacted residence restrictions that forbid sex offenders from residing within certain distances from areas where children commonly congregate.

Although current sex offender management policies have been revealed to be largely ineffective …

Measuring Mental Health Provider Stigma: The Development Of A Valid And Reliable Self-Assessment Instrument, Jennifer L.K. Charles

Theses and Dissertations

Provider-based stigma is defined as the negative attitudes, beliefs, and behaviors of mental health providers toward clients they serve. Often unintentional and unknowingly conveyed, this phenomenon has been indicated in previous research (e.g. Lauber, Nordt, Braunschweig, & Rössler, 2006; Nordt, Rössler, & Lauber, 2006; Hugo, 2001; Schulze, 2007). Other instruments crafted to measure provider stigma have utilized theory in their development, without incorporating the voice of the client (e.g. Wilkins & Abell, 2010; Kennedy, Abell, & Mennicke 2014). To better address the social injustice posed by provider stigma, the profession requires a valid and reliable measure, guided by theory, which …

Intrinsic Motivation And Information Systems Security Policy Compliance In Organizations, Yurita Yakimin Abdul Talib

Theses and Dissertations

Incidents of computer abuse, proprietary information leaks and other security lapses have been on the increase. Most often, such security lapses are attributed to internal employees in organizations subverting established organizational IS security policy. As employee compliance with IS security policy is the key to escalating IS security breaches, understanding employee motivation for following IS security policy is critical. In addition to several types of extrinsic motives noted in prior studies, including sanctions, rewards, and social pressures, this study adds that an important contributing intrinsic factor is empowerment. Per Thomas and Velthouse’s (1990) intrinsic motivation model, empowerment is the positive …

Peracetic Acid Sterilization Of Electrospun Polycaprolactone Scaffolds, Suyog Yoganarasimha

Theses and Dissertations

Sterilization of tissue engineered scaffolds is an important regulatory issue and is at the heart of patient safety. With the introduction of new biomaterials and micro/nano structured scaffolds, it is critical that the mode of sterilization preserve these built-in features. Conventional sterilization methods are not optimal for engineered polymeric systems and hence alternate systems need to be identified and validated. PCL is polyester with a low melting point (heat labile), susceptible to hydrolysis and is popular in tissue engineering. Electrospinning generates some nanoscale features within the scaffold, the integrity of which can be affected by sterilization method. Chapter 1 explores …

“Frailty, Thy Name Is Woman”: Depictions Of Female Madness, Julianna Little

Theses and Dissertations

Concepts of mental health and normality cannot be understood apart from cultural norms and values. The most significant of cultural constructions that shape our view of madness is gender. Madness has been perceived for centuries metaphorically and symbolically as a feminine illness and continues to be gendered into the twenty-first century. Works of art and literature and psychiatric medicine influence each other as well as our understanding and perception of mental illness. Throughout history, images of mental illness in women send the message that women are weak, dangerous, and require containment. What are the cultural links between femininity and insanity, …