Digital Commons Network^™

The Role Of P62/Imp2 In Breast Cancer Progression, Yang Li

Open Access Theses & Dissertations

Breast cancer is one of the most common types of cancer in women. In most patients with breast cancer, it is not the primary tumor that leads to death, but rather metastatic tumors. Once breast cancer spreads to other organs in the body, the disease becomes almost incurable. It is estimated that about 20% to 50% of patients diagnosed with primary breast cancer will develop metastatic disease. Considering this, it is important to understand the molecular and cellular mechanisms behind metastatic breast cancer and to identify new proteins that regulate the metastatic process. These proteins may be used as targets …

Health Assessment For Loved Ones: Development And Validation Of A New Instrument To Measure Well-Being In Military Spouses, Christi Luby

Open Access Theses & Dissertations

Since 2001, over 2.7 million US troops have deployed in support of the ongoing conflicts in the Middle East. Combat stress and deployments affect Service members, and consequently affect their spouses/intimate partners. In addition, these spouses often act as the social support system to other spouses experiencing traumatic events, such as death, injury, or illness of their deployed soldier. These indirect exposures to trauma may make spouses vulnerable; yet little research has focused on how the lived experiences of spouses of deployed and returning US Service members have affected their well-being. The purpose of this three-part study was to develop …

Damas Y Caballeros, Guadalupe Mendez

Open Access Theses & Dissertations

Collected Poetry - Manuscript over socio - political and culturally relevant context.

On The Path To Multi-Electron Redox Chemistry With Bimetallic Systems, Nathalie Metta

Open Access Theses & Dissertations

The following study is presented in two sections, in the first, a novel digold (II) complex with semi-bridging chlorides supported by two bulky formamidinates was synthesized for the purpose of studying late-transition metal multi-electron redox chemistry. Electrochemical analysis shows one non-reversible reduction. Although the electrochemistry of this complex is restricted, the compound shows interesting electronic properties. The crystal structure reveals a geometry distortion of the Au2ï?­-Cl2 core. The coupling of an unoccupied orbital and an occupied orbital through a vibrational mode, causes a distortion in the geometry of the molecule lowering the D2h symmetry to C2h. This is an example …

Bayesian Adaptive Penalized Splines In Nonparametric Regression And In Spectral Time Series Analysis, Luis Angel Mora

Open Access Theses & Dissertations

A Bayesian approach to nonparametric regression using Penalized splines (P-splines) is presented. The approach uses the linear mixed model formulation of P-spines. The usual model assumes a single value for the smoothing parameter controlling the amount of smoothing of the fitted function. The main focus of the Thesis is on spatially adaptive smoothing where the smoothing parameter is a function of the covariate so that different amounts of smoothing are applied in different regions of the covariate. An application to spectral time series analysis will be demonstrated. Markov chain Monte Carlo methods are used to make inference based on the …

Identification Of A Novel Phosphoserine Site On Crkl Regulated By Interleukin-2 And Protein Phosphatase-1, Stephanie Moreno

Open Access Theses & Dissertations

CrkL, a 36 kD adaptor protein, is part of the Crk family of proteins which have been implicated in a variety of human malignancies. CrkL is of special interest in hematopoietic malignancies because of an increased level of expression in myeloid and lymphoid derived cells lines. CrkL remains understudied but it has been shown to interact with Bcr-Abl in chronic myelogenous leukemia (CML) and is currently being used as a prognostic marker for patients by evaluating phosphorylation levels. Though regulation of CrkL by tyrosine phosphorylation has been studied extensively, the role of serine and threonine phosphorylation in an IL-2 dependent …

Re-Specifying The Sacred Values Scale, Adon Lee Neria

Open Access Theses & Dissertations

An object or value becomes sacred when a person feels compelled to protect and admire it. When a person holds a Sacred Value (SV) they are less likely to accept compromises, or "taboo tradeoffs," to that value and will behave less rationally to protect it from perceived slights. Though research on SV has replicated well, there has yet to be a popularized scale measuring it. A previous attempt at developing a multidimensional scale for measuring the degree to which a person holds any value as sacred was made that resulted in a 15-item measure. Though this version demonstrated good predictive …

Crustal Structure Beneath The Eastern Nepal Himalayas And Southern Tibet From Receiver Function Analysis, Arjun Sharma Neupane

Open Access Theses & Dissertations

The Himalayas are the results of continental collision between the Indian plate and the Eurasian plate and serve as a natural site to study the physical causes and process of mountain building. The crustal structure beneath the Himalayas has been subject to numerous geophysical studies and the variation in the velocity structure across the Himalayan region suggests significant differences in the crustal structure between the southern and northern portion in that region. In this research, a P receiver function analysis has been conducted on data collected for 14 years (2000-2014) from 211 different stations in Eastern Nepal and Southern Tibet, …

Sexual Self-Esteem And Its Relation To Substance Use And Sexual Risk In A Sample Of Latino Men Who Have Sex With Men And Who Are Living With Hiv, Miriam Pando

Open Access Theses & Dissertations

The objective of the present study was to assess whether sexual self-esteem -- an individual's tendency to feel sexually pleased, attractive, and in control of their sexual thoughts, feelings, and behaviors -- influences the relationship between substance use and sexual risk behavior in a sample of men who have sex with men (MSM) and who are living with HIV. We sampled 106 Latino adult MSM living with HIV who were being treated at a clinic in El Paso, Texas that offers comprehensive HIV/AIDS services. We assessed demographic variables, as well as two domains of sexual self-esteem (i.e., overall feeling of …

Rare Pride Campaigns: Evaluating Participatory Communication In Conservation Efforts Throughout Indonesia, Lauren Elizabeth Perez

Open Access Theses & Dissertations

Communication scholars who study international development and social change have found that if facilitators of social change hope to find positive, lasting solutions to complex social and environmental issues, they must incorporate more participatory approaches. However, even the practitioners with the most noble intentions oftentimes fall short of facilitating truly participatory practices because their strategies are the product of linear processes for evaluating the change context. In this study, I apply Lennie and Tacchi's (2014) approach to evaluating communication for development in a case study of Pride Campaigns implemented by managers throughout Indonesia who partnered with the conservation non-governmental organization …

A Tectonic Analysis On The Central Region Of The Himalaya Collision Zone Using Double Difference Tomography, Chanel Perez

Open Access Theses & Dissertations

The Himalaya mountain range remains the only place on Earth undergoing continuous effects from the continental-continental collision between India and Asia. Because of this, the Himalayas have been subjected to extensive deformation and transpression, and contain five major shear zones. Extensive seismic analysis of the region, however, is lacking due to sparse seismograph coverage and complexity of the crustal structure. I examined seismic event data from two temporary seismic networks deployed in the central Himalaya, the HIMNT deployment from 2001-2003, and the Bhutan deployment from 2002-2003. Using this data I develop a 3-D earth model for the region using double-difference …

Student Experiences In College Readiness Programs: A Phenomenological Study, Marisa Elva Pierce

Open Access Theses & Dissertations

This study discusses the concept of college readiness initiatives and defines what educational systems expect from this level of readiness of a high school student. It demonstrates that the topic of college readiness is broad and particularly concerned with academic rigor, teacher preparedness, and administrative support systems. The purpose of this study is to examine an aspect of these initiatives that is not often addressed - how students experience these programs.

Attempts to research the topic of college readiness from the lens of the student yielded few studies on the issue. Consequently, seeking a grounded understanding of the meaning and …

Ac-Susceptibility And Epr Investigations Of Superspin Dynamics In Magnetite Nanoparticles, Alex D. Price

Open Access Theses & Dissertations

In this investigation we use two complementary techniques to distinguish between superparamagnetic blocking (SPB) and superspin-glass (SSG) freezing phenomena in magnetite nanoparticles. While these manifestations of the superspin dynamics are fundamentally different, they have similar "signatures", especially in dc-magnetization experiments. Even if ac-susceptibility measurements are employed, careful use of mathematical models to analyze the data are needed to uncover which type of phenomena (SPB or SSG freezing) occurs within the material. Yet, by utilizing electron paramagnetic resonance (EPR) on a 10 nm Fe3O4 nano-powder as well as on a ferrofluid (based on the same nanoparticle ensemble) we found a very …

Fluid Flow Characterization Of High Turbulent Intensity Compressible Flow Using Particle Image Velocimetry, Marco Efrain Quiroz

Open Access Theses & Dissertations

A high turbulent intensity combustion chamber has been designed in order to operate with compressible (0.3 < M < 0.5) and preheated (T=500K) air-methane combustion. These conditions will allow the investigation of different flame regimes; most notably the proposed "Thickened Flame" regime. Initial design and flow validation has been completed in order to begin further experimentation. A 10 kHz Time Resolved Particle Image Velocimetry (TR-PIV) system and a 3 kHz Planer Laser Induced Fluorescence (PLIF) system have been integrated with the system in order to diagnose the flow field and the flame respectively. The exhaust and chamber cooling subsystems were designed to comply with safety regulations, and the control systems were set up in a way that allows automated (LabVIEW) and user controlled sequencing. This work's main purpose is to characterize and map the flow properties at maximum flow conditions (M > 0.3) in order to map the following; flow structures, kinetic energy at different length scales, velocity fluctuations and turbulent intensity. PIV measurements are carried out for three different volumetric flow rates (ð???Ì? = 25 scfm, 55 scfm, and 115 scfm) and three different grid geometries for each (BR= 67%, 61%, and 54%). Upon finding that the main flow structure consisted of jets caused by the grid at higher flowrates, experiments were done with a grid BR = 67% which was thinner (50% of original …

Studying Cellular And Molecular Interaction With Two-Photon Fluorescence Microscopy, Arifur Rahaman

Open Access Theses & Dissertations

Advances in microscopy and fluorescent probes provide new insight into studying cellular and molecular interactions. Two-photon fluorescence microscopy is one of the most important recent inventions in cellular and molecular study. This technology enables noninvasive study at cellular and molecular levels in three dimensions with submicrometer resolution. Two-photon excitation of fluorophores results from the simultaneous absorption of two photons. This excitation process has a number of unique advantages, such as reduced specimen photodamage and enhanced penetration depth. In this study, we used our two-photon microscope to observe predatorial behavior of fast moving bacterivorous marine organism Cafeteria roenbergensis and quantify Mycobacterium …

Punto Ciego, Adelmar Alvin Ramirez

Open Access Theses & Dissertations

Ciudad Juarez, another type of history shown through newspaper articles and headlines, going against the stereotypical values of violence and feminicides.

A Stochastic Approach For Pavement Condition Projections And Budget Needs For The Mtc Pavement Management System, Rafael Arturo Ramirez Flores

Open Access Theses & Dissertations

Pavement management decision-making is the most important task for officials in transportation agencies, who develop maintenance and rehabilitation programs. Information about historical pavement network performance is needed for decision-making; pavement management systems (PMS) provide means to organize road network data to improve the pavement network condition. PMS have prediction performance models to forecast the future condition of the pavement networks with information required for decision-making; these models can be deterministic or probabilistic. Pavement performance deterministic models are commonly used in PMS, but they do not consider the uncertainty in forecasting pavement performance. Pavement performance depends on many random factors like …

The Rock And The Hard Place: How The Prison Psychotherapist Balances Treatment Needs With Security Needs, Elijah Paige Ricks

Open Access Theses & Dissertations

Research on traditional psychotherapy suggests that the quality of the relationship between the therapist and client is the most important element of effective mental health work. In contrast, prison policies often require that staff maintain an emotional distance from offenders, and many elements of the prison environment and characteristics of the offenders may be counterproductive to the therapeutic relationship. Due to the competing demands of psychotherapy and prisons, it is important to understand how prison psychotherapists reconcile the aims of both in their work. This Dissertation examined the psychometric properties of a new measure of how prison therapists balance the …

Processing Of Language Switches In Bilingual Individuals With Aphasia: An Event-Related Potential Comparison, Lizette Rodarte

Open Access Theses & Dissertations

Switching between languages, or code-switching, is a common phenomenon in bilingual individuals. In proficient bilinguals, these switches are done with ease and are used for many purposes. Contrary to popular belief, these switches are rule-governed and follow grammatical structure. Bilingual individuals diagnosed with aphasia present with difficulty processing languages and these language switches. With the increase in bilingual individuals, it is likely that the speech-language pathology community will see an increase of bilingual individuals with aphasia on their caseload. For this reason, the purpose of this study is to increase our understanding of the neural processes involved in processing of …

Novel Classification Of Slow Movement Objects In Urban Traffic Environments Using Wideband Pulse Doppler Radar, Berta Rodriguez Hervas

Open Access Theses & Dissertations

Every year thousands of people are involved in traffic accidents, some of which are fatal. An important percentage of these fatalities are caused by human error, which could be prevented by increasing the awareness of drivers and the autonomy of vehicles. Since driver assistance systems have the potential to positively impact tens of millions of people, the purpose of this research is to study the micro-Doppler characteristics of vulnerable urban traffic components, i.e. pedestrians and bicyclists, based on information obtained from radar backscatter, and to develop a classification technique that allows automatic target recognition with a vehicle integrated system. For …

Carbon Based Nano-Composite Materials For Energy Storage Applications, Gerardo Rodriguez Melo

Open Access Theses & Dissertations

Energy storage systems and devices are an integral part of advanced electronic technology. Electronic technology is ever-advancing, but in order to do so, it must be supported by all its systems. The energy storage system is one key system that may dictate the performance and limitation of such electronics. Thus, research emphasis on energy storage devices has been on improving the performance of energy storage devices, such as: improved energy and power density, increased stability and cycle life, as well as reduced costs. Lithium-ion-batteries, and supercapacitors offer the potential to meet energy storage demands and to be improved further upon. …

Visual Arts Teacher Preparation, Lucina Rodriguez Zarate

Open Access Theses & Dissertations

Studies have found that visual arts education is an essential part of students' overall educational development. Students exposed to a robust visual arts education develop critical and analytical thinking skills, learn to evaluate their own work and the work of their peers, learn to interpret subject matter in various ways, and are encouraged to engage in their community, all of which help students develop a higher self-esteem and create a positive attitude towards learning. However, to achieve such positive results, visual arts educators need to acquire the proper training to learn how to develop and deliver well-rounded curricula with the …

Development Of A Yeast-Based Assay For The Functional Characterization Of Fkbp52/ Î?-Catenin Interactions With The Androgen Receptor, Theresa Anne Rodriguez

Open Access Theses & Dissertations

Prostate cancer development is uniquely dependent on the androgen receptorâ??s (ARâ??s) transcriptional regulation in response to hormone binding. Current therapies directly target AR acting as an antagonist at androgen binding sites. However, once androgen-dependence is lost, meaning the patient has progressed into a late-stage hormone resistant phenotype, all current treatments are essentially ineffective. Utilizing the yeast strain Saccharomyces cerevisiae we are capable of creating a model system that allows for the exogenous expression of AR while still retaining the chaperone components needed for this steroid receptor complex. The 52kDa FK506 binding protein (FKBP52) has been shown to be an important …

Performance Life Of Various Hot Mix Asphalt Mixtures In Texas, Danniel David Rodriguez

Open Access Theses & Dissertations

Typically, pavement engineers in subjectively estimate the service lives of various hot-mix asphalt (HMA) mixtures as part of the life-cycle cost analysis considering the staged design and rehabilitation of flexible pavements. This study proposes the performance lives for the various dense-graded (conventional) mixtures, stone-matrix asphalts (SMA), permeable friction courses (PFC), performance design mixtures and other mixtures placed in Texas. A necessary and significant aspect of the approach involved data mining and merging several pavement management databases (Letting Database, DCIS and PMIS) to obtain mixture longevity data along with historical PMIS information. The product of the linking process resulted in the …

Mobile Professional Development: Taxonomic Levels Of Learning On Teachers' Tpack Perceptions And Acquisition Of Technology Competencies, Raul Saldana Jr.

Open Access Theses & Dissertations

As it stands, the integration of technology can be advantageous for teachers, students, administrators, and parents, yet teachers are expected to teach and facilitate learning with new technologies in order to prepare students to succeed in a global economy. As the Part D of the Enhancing Education Through Technology Act of 2001 (Part D - Enhancing Education Through Technology, n.d) states, one of its purposes is to "enhance ongoing professional development of teachers, principals, and administrators by providing constant access to training and updated research in teaching and learning through electronic means," one of its goals is to "encourage effective …

Heat Absorption Analysis By Falling Particles At High Temperatures For Concentrating Solar Power Systems, Arturo Sepulveda Fernandez

Open Access Theses & Dissertations

High temperature Heat Transfer Fluid (HTF) with Thermal Energy Storage (TES) for the Concentrated Solar Power (CSP) technology can provide a large and relatively cheaper storage option, as opposed to limited and expensive electrical battery storage with PV technology, and hence, it has potential to maintain a constant production when no sunlight is available. Research of material like aluminum, silicon, graphite could be potential candidates to work as thermal energy storage. Currently, nitrate and chloride molten salts are widely used as the TES medium for a CSP plant. However, molten salt, especially chlorides, must be handled carefully at high temperature …

The New Dynamics Of El Paso's Post Industrial Development: An Analysis Of The El Paso Chihuahua's Ballpark Controversy, Alan Matthew Serna

Open Access Theses & Dissertations

This Thesis has sought to highlight a controversial event that occurred in El Paso, Texas when a wealthy group of local business interests, entered into a public/ private agreement with the City of El Paso to bring Triple-A baseball to the city. In doing so, the partnership drew large amounts opposition to their plan, when it was revealed that the city hall building would be demolished to make way for a new stadium, and that the issue would not be put to a vote. After analyzing all of the behaviors utilized by both opponents and proponents of the ballpark during …

Using The Wrf Model To Simulate The Playa Breeze Over Dugway Proving Ground, Daniela Maria Spade

Open Access Theses & Dissertations

The aim of this model and observation based study is to investigate the Advanced Research Weather Research and Forecasting Model's (WRF-ARW, although WRF from hereout) ability to simulate the three-dimensional structure of playa breezes and drainage flows occurring in Dugway Proving Ground, Utah using sub-km nesting in addition to improved land use and terrain datasets (as compared to the default datasets provided with WRF), in addition to studying the diurnal cycle and interactions between the playa breeze and drainage flows. A playa breeze is a thermally forced air circulation system that develops near the edge of playas, which have properties …

The Effects Of Task Demands And Word Frequency On Language Source Encoding, Elva Natalia Strobach Oronoz

Open Access Theses & Dissertations

Source memory effects have been relatively unexplored in bilingual memory. Bilinguals have to perform certain source encoding operations to successfully determine the appropriate language from context. These operations have not been examined from a long-term memory perspective, and are not incorporated into models of source monitoring. Further, language source information is not incorporated into the major models of bilingual language processing. Five experiments examined bilingualsâ?? language source monitoring for low- and high-frequency words in English and Spanish. Each experiment placed different processing demands on participants. In Experiment 1, participants studied a mixed-language word list, then were subsequently tested for language …

Contributions To The Solution Of Large Nonlinear Systems Via Model-Order Reduction And Interval Constraint Solving Techniques, Leobardo Valera

Open Access Theses & Dissertations

Many engineering problems boil down to solving partial differential equations (PDEs) that describe real-life phenomena. Nevertheless, efficiently and reliably solving such problems constitutes a major challenge in computational sciences and in engineering in general.

PDE-based systems can reach sizes so large after they are discretized. The large size in these problems generate several issues, among them we can mention: large space of storing, computing time, and the most important, lost of accuracy. A popular approach to solving such problems is assume that the PDE's solution is in a subspace, and the solution is sought there. This assumption and later searching …