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2015

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Perceptions Of Facial Attractiveness: Outcomes Of Orthognathic Surgery, Brittany Bross Reid Jan 2015

Perceptions Of Facial Attractiveness: Outcomes Of Orthognathic Surgery, Brittany Bross Reid

All ETDs from UAB

PERCEPTIONS OF FACIAL ATTRACTIVENESS: OUTCOMES OF ORTHOGNATHIC SURGERY BRITTANY REID DEPARTMENT OF ORTHODONTICS ABSTRACT Perceptions of physical attractiveness contribute to generalized assumptions that can create significant bias in social decision-making. Because these biases exist, patients often seek ways to improve facial harmony and overall appearance. Orthodontics and orthognathic surgery are treatment modalities that may be considered as a means to achieve facial balance. Orthodontists and oral surgeons must have an understanding of facial beauty and how to properly carry out techniques in order to preserve or improve facial balance. More importantly, the treatment goals of the patient and clinician(s) must …

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Patient Activation: An Examination Of The Relationship Between Care Management With Patient Activation-Customized Coaching And Patient Outcomes, Cindy L. Reistroffer Jan 2015

Patient Activation: An Examination Of The Relationship Between Care Management With Patient Activation-Customized Coaching And Patient Outcomes, Cindy L. Reistroffer

All ETDs from UAB

As part of healthcare reform, patient engagement is becoming an important area of focus. Most recently, patient activation, as part of engagement, has been studied; however, interventions to improve activation are not well identified. The purpose of this dissertation was to empirically examine whether enrollment in care management with patient activation (PA)-customized coaching was associated with patient outcomes of utilization, medication adherence, and clinical outcomes. The study utilized the chronic care model framework and theoretical insights from social cognitive theory to examine the relationships among three hypotheses. Secondary data related to commercially-insured enrollees in Priority Health were used to test …

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Geographic Access To Interventional Cardiology Services In Maine, James P. Rhudy Jan 2015

Geographic Access To Interventional Cardiology Services In Maine, James P. Rhudy

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Introduction: Acute coronary syndrome is the most common cause of death in the U.S. and the world; ST segment elevated myocardial infarction is the most acute form. The preferred reperfusion therapy is immediate primary percutaneous coronary intervention at an interventional cardiology center. It is intuitive, but not known, whether delay in receipt of reperfusion therapy because of geographic distance is associated with increased coronary mortality. Even so, clinical practice guidelines recommend organizing coronary care in each community in regional systems. Hub-and-spoke has been proposed as a regionalized coronary care model. Article synthesis: The first article in this dissertation, titled Effectiveness …

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Characterization Of Directionally Solidified Gray Iron, Elis Annexy Rivera-Martinez Jan 2015

Characterization Of Directionally Solidified Gray Iron, Elis Annexy Rivera-Martinez

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Even with decades of study, the complex development of solidification microstructures in cast iron is incompletely understood. Because Fe-C eutectic can produce different morphologies, and even different phases, depending on growth velocities and composition, understanding the conditions under which each forms are important. Directional solidification was used to observe the behavior of gray cast iron under carefully controlled solidification conditions. Specifically, alloys with industrially relevant amounts of silicon and manganese were studied, using a Bridgman furnace to investigate the effects of alloying additions and solidification velocity on graphite spacing and growth temperature of gray iron. An experimental technique for measuring …

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Glutamate And The Biology Of Malignant Glioma, Stephanie Marie Robert Jan 2015

Glutamate And The Biology Of Malignant Glioma, Stephanie Marie Robert

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Malignant gliomas are the most prevalent primary brain tumor. They are highly aggressive and lack effective treatment options. Standard therapy includes a combination of radiation, chemotherapy, and tumor resection; however, even with aggressive treatment, median patient survival remains a dismal 12 – 14 months after diagnosis. Research has focused on understanding the unique biological mechanisms involved in glioma growth and survival in an effort to design novel therapies to treat this devastating disease. In the unique environment of the brain, gliomas have developed the ability to grow and survive at the cost of the normal surrounding brain tissue. Glutamate, the …

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Stress, Bullying, Cortisol, And Depresive Symptoms In 9th Grade Adolescents, Susan Gordon Williams Jan 2015

Stress, Bullying, Cortisol, And Depresive Symptoms In 9th Grade Adolescents, Susan Gordon Williams

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ABSTRACT Stress and bullying are known contributors to depressive symptoms in adolescents. Prevalence of depressive symptoms in adolescents is estimated to range from13% to 34% in recent studies. Ninth graders are in a transitional period developmentally,biologically, physically, and psychosocially. Few studies have examined the relationship between stress, bullying, and depressive symptoms from a biobehavioral perspective in 9th graders. The purpose of this study was to examine stress, bullying, and depressive symptoms including a biomarker of stress, salivary cortisol diurnal rhythm, to determine if there is mediation between the individual variables of stressful life events, perceivedstress, bullying, and depressive symptoms. The …

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“The Ladies” Who Founded Moma: How Three Female Art Collectors Created One Of The World's Leading Museums, Amy Katherine Williamson Jan 2015

“The Ladies” Who Founded Moma: How Three Female Art Collectors Created One Of The World's Leading Museums, Amy Katherine Williamson

All ETDs from UAB

This thesis examines three visionary women who were instrumental in founding the Museum of Modern Art in 1929: Lillie P. Bliss, Mrs. John D. Rockefeller, and Mrs. Cornelius Sullivan. In reaction to the lack of modern art in New York City’s museums, these women combined their collections, money, and resources to present Matisses, Picassos, and other modern masters to create what would become the core of the museum’s permanent collection. Both challenging and accepting the limitations of gender, the women enlisted the help of A. Conger Goodyear and Alfred Barr to help them navigate the art world whilst they built …

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Exploring The Effects Of Direct Contact Compression On Osteogenesis, Shannel Wright Jan 2015

Exploring The Effects Of Direct Contact Compression On Osteogenesis, Shannel Wright

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Clinically, the concept of bone building being the result of mechanical adaptation in healthy individuals has been accepted since Wollf’s Law in 1892. Despite many attempts to understand this mechanism, very little is known about the role mechanical forces play on bone molecularly. Current biomechanical theory supports the concept of osteocytes and bone lining cells creating a three-dimensional network that provides biochemical signaling as a result of mechanical loading. With pressure gradient and interstitial fluid flow models being used as methods of mechanical loading, yet there are still unanswered questions about the validity of both models. The suggested solution lies …

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Nonsense Suppression In A Cftr Mouse Model And Analysis Of Animo Acids Inserted At Cftr Premature Termination Codons In Mammalian Cells, Xiaojiao Xue Jan 2015

Nonsense Suppression In A Cftr Mouse Model And Analysis Of Animo Acids Inserted At Cftr Premature Termination Codons In Mammalian Cells, Xiaojiao Xue

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A nonsense mutation introduces a premature terminations codon (PTC) into an open reading frame (ORF) upstream of a normal stop codon and results in truncated protein production. In frame PTCs account for ~11% of all mutations that cause human genetic diseases. To treat PTC-associated disorders, one approach is to use drugs that facilitate the insertion of amino acids carried by near-cognate aminoacyl-tRNAs at PTCs. Aminoglycosides were shown to suppress nonsense mutations and restore full-length protein production. This process is also termed as readthrough. However, their low efficiency and their potential to induce ototoxicity and nephrotoxicity limits their long-term application for …

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Domain Interactions And Structural Cooperativity In Two Classes Of Drug Targets Investigated By Differential Scanning Calorimetry: I. Abc Transporters: Cystic Fibrosis Transmembrane Conductance Regulator And P-Glycoprotein; Ii. Bacillus Subtilis Nad+Synthetase., Zhengrong Yang Jan 2015

Domain Interactions And Structural Cooperativity In Two Classes Of Drug Targets Investigated By Differential Scanning Calorimetry: I. Abc Transporters: Cystic Fibrosis Transmembrane Conductance Regulator And P-Glycoprotein; Ii. Bacillus Subtilis Nad+Synthetase., Zhengrong Yang

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PART I. Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) cause the lethal genetic disease cystic fibrosis (CF). The most common CF-causing mutation is the deletion of F508 (F508del) in its N-terminal nucleotide binding domain (NBD1), which causes CFTR misfolding and premature degradation. By studying the in vitro thermal unfolding of the isolated NBD1 ± F508del using differential scanning calorimetry (DSC), we show that F508del significantly reduces the thermodynamic and kinetic stability of NBD1. We propose that the non-native contact between the partially denatured F508del-NBD1 and other domains may cause the misfolding of F508del-CFTR. This work …

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Computational Studies On Alpha-Synuclein In Explicit Solvent: Implications In Parkinson’S Disease, Hongyi Yang Jan 2015

Computational Studies On Alpha-Synuclein In Explicit Solvent: Implications In Parkinson’S Disease, Hongyi Yang

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α-Synuclein (αS) is a cytosolic protein expressed at high levels in the human brain and concentrated in presynaptic nerve terminals. Although the precise nature of αS in vivo remains unclear, the aggregation of αS, from its soluble, functional forms into highly organized amyloid fibrils, has been substantially implicated in the pathology of a number of neurodegenerative diseases collectively known as synucleinopathies. The long-term goal of this project is to understand the molecular mechanisms that initiate αS oligomerization in aqueous solution. A novel computational methodology involving protein modeling and atomistic molecular dynamics (MD) simulations is used in this work. The objective …

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Impact Of Medicare Part D Coverage Gap On Medicare Beneficiaries With Copd: Adherence, Healthcare Resource Use, And Cost, Yanni Fan Yu Jan 2015

Impact Of Medicare Part D Coverage Gap On Medicare Beneficiaries With Copd: Adherence, Healthcare Resource Use, And Cost, Yanni Fan Yu

All ETDs from UAB

Medicare Part D provides prescription drug coverage for beneficiaries to support their pharmacological treatment; however, the complex deductible structure within benefit plans creates a major coverage gap and unexpected consequences. Some evidence has demonstrated reduced adherence resulting from the coverage gap; however, little research has evaluated the effect on healthcare resource use (HRU) and cost, and no studies have been conducted for beneficiaries with chronic obstructive pulmonary disease (COPD). This study examined the impact of the coverage gap on medication adherence as well as healthcare resource use and medical cost among beneficiaries with COPD. Claims data based on a 5% …

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Socs3 Deficiency In Myeloid Cells Promotes Tumor Development, Hao Yu Jan 2015

Socs3 Deficiency In Myeloid Cells Promotes Tumor Development, Hao Yu

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STAT3 signaling is a major intrinsic pathway for cancer inflammation owing to its frequent activation in malignant cells, and key role in regulating many genes crucial for inflammation in the tumor microenvironment. Persistently activated STAT3 increases tumor cell proliferation, survival, and invasion while suppressing anti-tumor immunity. Suppressor Of Cytokine Signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway, and generally function as tumor suppressors. The absence of SOCS3 in particular leads to heightened activation of the STAT3 transcription factor. In the present study, we demonstrate that genetic deletion of SOCS3 specifically in myeloid cells significantly enhances tumor growth, which …

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Orientalism Redux: Inci Eviner’S Harem, Pinar Zararsiz Jan 2015

Orientalism Redux: Inci Eviner’S Harem, Pinar Zararsiz

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ORIENTALISM REDUX: INCI EVINER’S HAREM PINAR ZARARSIZ (ART HISTORY) ABSTRACT This thesis examines the 2009 video Harem by Turkish artist Inci Eviner (b. 1956). Eviner’s work centralizes issues of gender in Turkish culture, the history of colonialism, and how historical location informs society at large. Eviner lives and works in Turkey, but exhibits internationally. Harem has been exhibited in Turkey, France, and England. Harem is based on a series of nineteenth-century Orientalist engravings by Antoine Ignace Melling, entitled Intérieur d'une partie du Harem du Grand-Seigneur (Interior of Part of the Harem of the Grand Signor) (1803-1819). Melling’s Harem du Grand-Seigneur …

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Nanostructured Multilayer Hydrogels Of Regulated Architecture: Synthesis And Stimuli-Responsive Properties, Oleksandra Zavgorodnya Jan 2015

Nanostructured Multilayer Hydrogels Of Regulated Architecture: Synthesis And Stimuli-Responsive Properties, Oleksandra Zavgorodnya

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Ultrathin temperature-responsive hydrogels offer fast (in a matter of seconds) response to external stimuli and precise control over the hydrogel composition that has proven to be extremely important for bio-related applications and sensing. These hydrogels can typically uptake ~ 90% of water by volume and are capable of drastic and reversible volume change in response to applied stimuli which makes them ideal candidates to host and deliver small molecules and proteins. The multilayer hydrogels are fabricated by first covalently cross-linking hydrogen-bonded layer-by-layer (LBL) films that serve as templates for hydrogel assembly. This is followed by release of the uncross-linked polymers …

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Internet Use And Depression: The Roles Of Emotional Support And Online Support Groups, Aowen Zhu Jan 2015

Internet Use And Depression: The Roles Of Emotional Support And Online Support Groups, Aowen Zhu

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This paper explores the mediating mechanisms between internet use and depression among African Americans and Caribbean Blacks. The hypotheses are that emotional support and online support groups (OSGs) mediate the association between internet use and depression. Data come from the National Survey of American Life conducted between 2001 and 2003 that includes a nationally representative sample of African Americans and Black respondents of Caribbean descent (N=4771). Depression is measured by the Center for Epidemiological Studies-Depression scale with 12 questions. Internet use is measured as frequency of use. Emotional support is measured by a scale of 3 questions. OSGs are measured …

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Functional Role Of Mepe In Tooth Mineralization: Mediation By Tgf-Beta1, Angela Gullard Jan 2015

Functional Role Of Mepe In Tooth Mineralization: Mediation By Tgf-Beta1, Angela Gullard

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Transforming growth factor-β1 (TGF-β1) is one of the most abundant cytokines of the dentin-pulp complex that regulates a broad range of biological processes related to matrix synthesis and ultimately tooth formation, including secretion and mineralization of the dentin extracellular matrix (DECM). TGF-β1 mediates odontoblast cytodifferentiation from precursor dental pulp cells, being up-regulated in odontoblasts and then incorporated into the DECM as a reservoir that can be utilized in times of mechanical, chemical, or bacterial insult. Formation of the DECM is modulated by the actions of small integrin-binding ligand N-linked glycoproteins (SIBLINGs), which include DMP-1, DSPP, BSP, SPP1, and MEPE, with …

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Hospital-Based Skilled Nursing Facilities: Predictors Of Survival And Performance, Shivani Gupta Jan 2015

Hospital-Based Skilled Nursing Facilities: Predictors Of Survival And Performance, Shivani Gupta

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This three-paper dissertation examined the organizational and market factors predicting the response of hospital-based skilled nursing facilities (HBSNFs) to the changes in their environment such as the implementation of prospective payment system in 1998 and their role in coordination of care for patients in transition from acute care to home or a post-acute care facility. In the first study, population ecology of organizations framework was used to evaluate the organizational and market factors associated with HBSNFs’ closure after 1998. The event histories of all acute-care hospitals which had an open HBSNF in 1998 were examined across 15 years (1998-2012) to …

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Novel Non-Invasive Assessment Of Pulmonary Arterial Impedance Using Velocity Transfer Function And Its Relation With Right Ventricular Remodeling, Ankur Gupta Jan 2015

Novel Non-Invasive Assessment Of Pulmonary Arterial Impedance Using Velocity Transfer Function And Its Relation With Right Ventricular Remodeling, Ankur Gupta

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Pulmonary arterial (PA) impedance takes in to account pulsatile blood flow through elastic pulmonary arteries as compared to static pulmonary vascular resistance. Increased PA impedance is an early physiological manifestation of PA remodeling. Currently PA impedance can only be detected invasively, is expensive and cumbersome to calculate and thus not done in routine clinical practice. The ability to assess PA impedance non-invasively can provide fundamental insights in evaluation of patients with normal PA pressures or mild pulmonary hypertension such as in patients with chronic obstructive lung disease. Non-invasive evaluation of right ventricular (RV)-PA axis to detect patients who could develop …

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Microstructural Analysis Of Aluminum High Pressure Die Castings, Maria Diana David Jan 2015

Microstructural Analysis Of Aluminum High Pressure Die Castings, Maria Diana David

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Microstructural analysis of aluminum high pressure die castings (HPDC) is challenging and time consuming. Automating the stereology method is an efficient way in obtaining quantitative data; however, validating the accuracy of this technique can also pose some challenges. In this research, a semi-automated algorithm to quantify microstructural features in aluminum HPDC was developed. Analysis was done near the casting surface where it exhibited fine microstructure. Optical and Secondary electron (SE) and backscatter electron (BSE) SEM images were taken to characterize the features in the casting. Image processing steps applied on SEM and optical micrographs included median and range filters, dilation, …

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Drivers Of Inter-Organizational Network Participation, Kimberly S. Davey Jan 2015

Drivers Of Inter-Organizational Network Participation, Kimberly S. Davey

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The purpose of this dissertation was to study market and organizational drivers associated with inter-organizational network participation. Inter-organizational networks are increasingly emerging across industries as a strategy for adapting to fundamental changes in competitive market environments. Specifically, this study empirically examined the association between market and organizational drivers for a sample of U.S. hospitals relative to their participation or non-participation in Medicare ACOs as a newly emergent inter-organizational network in the healthcare sector. This was a cross-sectional study of U.S. hospitals participating in Centers for Medicare and Medicaid Services (CMS) designated ACOs as of January 1, 2014 and hospitals not …

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G Protein-Coupled Inwardly-Rectifying Potassium (Girk) Chanels Mediate Entrainment Of Circadian Rhythms, Lauren Marie Hablitz Jan 2015

G Protein-Coupled Inwardly-Rectifying Potassium (Girk) Chanels Mediate Entrainment Of Circadian Rhythms, Lauren Marie Hablitz

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Circadian rhythms are 24-hour cycles in biological and behavioral processes. These cycles enable an organism to predict changes in its environment, like changes in food availability and seasonality. Although endogenously driven, these rhythms can entrain or synchronize to daily changes in the environment, allowing the animal to adapt. One way entrainment occurs is shifts in circadian phase following the presentation of nonphotic, or non-light, stimuli, such as exercise, arousal, or stress at certain times of day. The molecular mechanisms underlying nonphotic entrainment are poorly understood - specifically, how nonphotic cues alter excitability within the suprachiasmatic nucleus (SCN) of the hypothalamus, …

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The Investigation Of Quality Of Life, Perceived Disease Severity, And Adherence In Patients With The G551d Mutation Receiving Ivacaftor Therapy, Heather Young Hathorne Jan 2015

The Investigation Of Quality Of Life, Perceived Disease Severity, And Adherence In Patients With The G551d Mutation Receiving Ivacaftor Therapy, Heather Young Hathorne

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Cystic fibrosis (CF), a genetic disorder, is a chronic life threatening illness that affects 30,000 adults and children in the United States and 70,000 worldwide. Treatment for CF is complex and consuming, consisting of multiple time intensive regimens. The therapy regimen has been descried as extraordinary when compared even to therapy regimens for other chronic illnesses. Oral and nebulized medication therapy, airway clearance therapy, pancreatic enzyme replacement therapy and vitamin /nutritional supplements are all required for the multiorgan treatment regimen for CF. Daily prescribed therapy can include as many as 40-50 pills, breathing treatments lasting up to tow hours a …

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Nutrient Intake, Nutrient Targets And Feed Application To Promote Optimal Production And Feed Efficiency In The Sea Urchin Lytechinus Variegatus (Echinodermata: Echinoidea), Laura Elizabeth Heflin Jan 2015

Nutrient Intake, Nutrient Targets And Feed Application To Promote Optimal Production And Feed Efficiency In The Sea Urchin Lytechinus Variegatus (Echinodermata: Echinoidea), Laura Elizabeth Heflin

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Important considerations for the development of sea urchin aquaculture will include understanding nutrition and feed management. These reported investigations contribute to knowledge of dietary protein and carbohydrate requirements in Lytechinus variegatus and feed management strategies. The first evaluation of economic feasibility of sea urchin aquaculture as related to feed costs is presented and the geometric framework (GF) to assess nutrient intake targets is first applied to cultured aquatic organisms to yield recommendations for nutrient balancing in formulated urchin feed. Data- derived models for dietary protein and carbohydrate intake predict increased rates of growth and production among urchins fed diets containing …

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Cortisol Regulation, Perceived Discrimination, And Ethnic Differences In Pain Responses Among Persons With Knee Osteoarthritis, Matthew Herbert Jan 2015

Cortisol Regulation, Perceived Discrimination, And Ethnic Differences In Pain Responses Among Persons With Knee Osteoarthritis, Matthew Herbert

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Plasma cortisol concentrations obtained directly after the Trier Social Stress test are negatively associated with subsequent pain tolerances during the cold pressor task (CPT) among healthy non-Hispanic whites (NHWs), but not healthy African Americans (AAs). It is possible frequent exposure to perceived discrimination, a marker of chronic stress, explains this lack of association between cortisol regulation and pain tolerances among AAs. Our aim was to determine if 1) ethnic differences in pain sensitivity during the CPT could be partially explained by differences in cortisol regulation among persons with knee osteoarthritis (OA), 2) perceived discrimination was related to cortisol dysregulation, which …

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Professional Rationality And The Emotional Labor Of Gendered Caring In Nursing, Beverly Kay Hogan Jan 2015

Professional Rationality And The Emotional Labor Of Gendered Caring In Nursing, Beverly Kay Hogan

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ABSTRACT This dissertation offers an understanding of how the emotional labor of caring by female nurses is manifested, and whether this has changed from what has previously been described in the literature. A hybrid of Hochschild‘s (1983) theory of emotional labor is used with concepts from symbolic interactionist and critical theory to guide this inquiry. From this lens, relevant concepts affecting emotional labor are considered in order to examine how the organization of work roles for nurses enable or constrain their ability to manifest a caring presence. As the healthcare delivery system and nurses‘ roles have changed dramatically over the …

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Obesity And Mortality In Us-Residing Hispanic Adults, Carrie Howell Jan 2015

Obesity And Mortality In Us-Residing Hispanic Adults, Carrie Howell

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Previous epidemiological studies observed the lack of an association between increased body mass index (BMI: kg/m2) and all-cause mortality in US-residing Hispanic adults. The purpose of this dissertation was to examine the validity of three hypothesized explanations for the absence of significant associations. Using data on Hispanic participants from the National Health and Nutrition Examination Survey (NHANES) [1988-1994 and 1999-2004] and the National Health Interview Survey (NHIS), this dissertation examined whether: (1) BMI was associated with cause-specific mortality; (2) measures of body composition was associated with all-cause mortality; and (3) the BMI-all-cause mortality association differed as a function of Hispanic …

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Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez Jan 2015

Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez

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Little is known about how weight gain in those born very preterm is associated with blood pressure and if cortisol, a stress biomarker, plays a mediating role. Also, the influence of infant feeding practices on weight gain has been only sporadically addressed. The purpose of this exploratory, descriptive, cross-sectional study was to examine the relationships between infant feeding practices, weight gain, and blood pressure noting any mediating effect cortisol may have between weight gain and blood pressure in 18-to-24 month old corrected age toddlers born very preterm. A convenience sample of 36 18-to-24 month old corrected age toddlers were enrolled. …

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Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes Jan 2015

Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes

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Bacillus anthracis (Ba) is a Gram,-positive zoonotic bacterium that causes inhala- tional, cutaneous and intestinal Anthrax Disease. Although the infectious form of Ba is its endospore (spore), only the tripartite toxin-producing vegetative bacteria causes disease pathology. While current vaccination strategies target the Protective Antigen (PA) com- ponent of this toxin, vaccine-elicited immunity to the spore form of Ba is lacking. How- ever, vaccines targeting spore components of Ba have the potential to neutralize the in- fectious form of Ba. We sought to determine if antibodies elicited through immunization with the main antigenic component of the spore surface- Bacillus collagen-like protein …

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Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach Jan 2015

Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach

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In this study, we investigated the role MARCKS's Effector Domain plays in lung and brain cancer biology. Initially, we identified that MARCKS was present in a range of lung cancer histologies including: squamous cell, adenocarcinoma, and normal lung tissues among others. In addition, lung adenocarcinoma patients with a mutation in the MARCKS gene correlated with decreased survival as determined by The Cancer Genome Atlas. In vitro studies identified that the phosphorylation status of MARCKS's Effector Domain was able to influence lung cancer radiation sensitivity. When MARCKS's Effector Domain was in a non-phosphorylated state, A549 lung cancer cell lines experienced increased …

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