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2015

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Patient Activation: An Examination Of The Relationship Between Care Management With Patient Activation-Customized Coaching And Patient Outcomes, Cindy L. Reistroffer Jan 2015

Patient Activation: An Examination Of The Relationship Between Care Management With Patient Activation-Customized Coaching And Patient Outcomes, Cindy L. Reistroffer

All ETDs from UAB

As part of healthcare reform, patient engagement is becoming an important area of focus. Most recently, patient activation, as part of engagement, has been studied; however, interventions to improve activation are not well identified. The purpose of this dissertation was to empirically examine whether enrollment in care management with patient activation (PA)-customized coaching was associated with patient outcomes of utilization, medication adherence, and clinical outcomes. The study utilized the chronic care model framework and theoretical insights from social cognitive theory to examine the relationships among three hypotheses. Secondary data related to commercially-insured enrollees in Priority Health were used to test …

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Geographic Access To Interventional Cardiology Services In Maine, James P. Rhudy Jan 2015

Geographic Access To Interventional Cardiology Services In Maine, James P. Rhudy

All ETDs from UAB

Introduction: Acute coronary syndrome is the most common cause of death in the U.S. and the world; ST segment elevated myocardial infarction is the most acute form. The preferred reperfusion therapy is immediate primary percutaneous coronary intervention at an interventional cardiology center. It is intuitive, but not known, whether delay in receipt of reperfusion therapy because of geographic distance is associated with increased coronary mortality. Even so, clinical practice guidelines recommend organizing coronary care in each community in regional systems. Hub-and-spoke has been proposed as a regionalized coronary care model. Article synthesis: The first article in this dissertation, titled Effectiveness …

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Heat Induced Momentum Flux In Brownian Motors And The Adiabatic Piston, Nathan Ryan Ridling Jan 2015

Heat Induced Momentum Flux In Brownian Motors And The Adiabatic Piston, Nathan Ryan Ridling

All ETDs from UAB

When a mesoscopic object (Brownian object) is inserted into a fluid, it is subject to frequent collisions with fluid molecules (environment). Through these collisions, energy is exchanged between the environment and the Brownian object. When the Brownian particle and its environment are in thermal equilibrium, the net energy exchange will be zero due to the detailed balance and fluctuation-dissipation theorem, and the Brownian object will diffuse without net drift. However, when the environment is in non-equilibrium, the detailed balance no longer holds and the Brownian object can undergo drift. The mechanism responsible for its drift is not well understood. In …

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Characterization Of Directionally Solidified Gray Iron, Elis Annexy Rivera-Martinez Jan 2015

Characterization Of Directionally Solidified Gray Iron, Elis Annexy Rivera-Martinez

All ETDs from UAB

Even with decades of study, the complex development of solidification microstructures in cast iron is incompletely understood. Because Fe-C eutectic can produce different morphologies, and even different phases, depending on growth velocities and composition, understanding the conditions under which each forms are important. Directional solidification was used to observe the behavior of gray cast iron under carefully controlled solidification conditions. Specifically, alloys with industrially relevant amounts of silicon and manganese were studied, using a Bridgman furnace to investigate the effects of alloying additions and solidification velocity on graphite spacing and growth temperature of gray iron. An experimental technique for measuring …

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Engineering Faculty Perspectives On The Nature Of Quality Teaching, Jacqueline C. Mcneil, Matthew W. Ohland Jan 2015

Engineering Faculty Perspectives On The Nature Of Quality Teaching, Jacqueline C. Mcneil, Matthew W. Ohland

Faculty and Staff Scholarship

There is wide agreement that teaching quality matters in higher education, but faculty have varied ideas about the definition of quality. Faculty definitions of quality teaching were coded using an existing framework. The most common definition of teaching quality (held by 49% of participants) is associated with elitism and restricted access—the best way to improve education is to admit better students. These faculty focus on education as “knowledge transfer” and “learning content.” Another 38% of faculty had a transformational perspective, more focused on process than content, valuing “empowering students,” “developing students,” and “creating an environment for learning.” These faculty refer …

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Glutamate And The Biology Of Malignant Glioma, Stephanie Marie Robert Jan 2015

Glutamate And The Biology Of Malignant Glioma, Stephanie Marie Robert

All ETDs from UAB

Malignant gliomas are the most prevalent primary brain tumor. They are highly aggressive and lack effective treatment options. Standard therapy includes a combination of radiation, chemotherapy, and tumor resection; however, even with aggressive treatment, median patient survival remains a dismal 12 – 14 months after diagnosis. Research has focused on understanding the unique biological mechanisms involved in glioma growth and survival in an effort to design novel therapies to treat this devastating disease. In the unique environment of the brain, gliomas have developed the ability to grow and survive at the cost of the normal surrounding brain tissue. Glutamate, the …

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Aerobic And Resistance Training Improves Mood State Among Adults Living With Hiv., Jason R. Jaggers, Gregory A. Hand, Wesley D. Dudgeon, Stephanie Burgess, Kenneth D. Phillips, Larry Durstine, Steven N. Blair Jan 2015

Aerobic And Resistance Training Improves Mood State Among Adults Living With Hiv., Jason R. Jaggers, Gregory A. Hand, Wesley D. Dudgeon, Stephanie Burgess, Kenneth D. Phillips, Larry Durstine, Steven N. Blair

Faculty and Staff Scholarship

The purpose of this investigation was to examine the effects of combined aerobic and resistance exercise training among self-reported mood disturbances, perceived stress, frequency of self-reported symptoms, and symptom distress in a sample of HIV+ adults. For this purpose, 49 participants were randomly assigned into an exercise (EX) or control (CON) group. Those in the EX group completed 50 min of supervised aerobic and resistance training at a moderate intensity twice a week for 6 weeks. The CON group reported to the university and engaged in sedentary activities. Data were collected at baseline before randomization and 6 weeks post intervention. …

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Bioavailability Of Dietary Oxalate, Mary Catherine Robertson Jan 2015

Bioavailability Of Dietary Oxalate, Mary Catherine Robertson

All ETDs from UAB

Urolithiasis, or kidney stone disease, is a costly and painful health problem affecting about 8.8% of Americans with prevalence on the rise. Calcium oxalate stones account for about 80% of all stones. Increased urinary excretion of calcium and oxalate is a risk factor and central feature of such stones; dietary oxalate contributes up to 50% of urinary oxalate. The purpose of our research is to determine if physical manipulation such as chewing or blending prior to ingestion may render some oxalate more accessible for absorption in spinach, a high-oxalate food. In this crossover, controlled trial we enrolled six healthy, non-stone …

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Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez Jan 2015

Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez

All ETDs from UAB

Little is known about how weight gain in those born very preterm is associated with blood pressure and if cortisol, a stress biomarker, plays a mediating role. Also, the influence of infant feeding practices on weight gain has been only sporadically addressed. The purpose of this exploratory, descriptive, cross-sectional study was to examine the relationships between infant feeding practices, weight gain, and blood pressure noting any mediating effect cortisol may have between weight gain and blood pressure in 18-to-24 month old corrected age toddlers born very preterm. A convenience sample of 36 18-to-24 month old corrected age toddlers were enrolled. …

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Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes Jan 2015

Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes

All ETDs from UAB

Bacillus anthracis (Ba) is a Gram,-positive zoonotic bacterium that causes inhala- tional, cutaneous and intestinal Anthrax Disease. Although the infectious form of Ba is its endospore (spore), only the tripartite toxin-producing vegetative bacteria causes disease pathology. While current vaccination strategies target the Protective Antigen (PA) com- ponent of this toxin, vaccine-elicited immunity to the spore form of Ba is lacking. How- ever, vaccines targeting spore components of Ba have the potential to neutralize the in- fectious form of Ba. We sought to determine if antibodies elicited through immunization with the main antigenic component of the spore surface- Bacillus collagen-like protein …

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Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach Jan 2015

Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach

All ETDs from UAB

In this study, we investigated the role MARCKS's Effector Domain plays in lung and brain cancer biology. Initially, we identified that MARCKS was present in a range of lung cancer histologies including: squamous cell, adenocarcinoma, and normal lung tissues among others. In addition, lung adenocarcinoma patients with a mutation in the MARCKS gene correlated with decreased survival as determined by The Cancer Genome Atlas. In vitro studies identified that the phosphorylation status of MARCKS's Effector Domain was able to influence lung cancer radiation sensitivity. When MARCKS's Effector Domain was in a non-phosphorylated state, A549 lung cancer cell lines experienced increased …

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The Mechanism Of Small Molecule Viral Fusion Inhibitors, Michael Joseph Rowse Jan 2015

The Mechanism Of Small Molecule Viral Fusion Inhibitors, Michael Joseph Rowse

All ETDs from UAB

All negative stranded RNA viruses (NSRV) have genomes encapsidated by oligomerized nucleoprotein (N). The N-RNA complex acts as the template for both transcription and replication. The crystal structure of the N protein from the model NSRV vesicular stomatitis virus (VSV) established the structural basis for the oligomerization of N-protein and the encapsidation of RNA. To determine how the structure of N protein changes in response to specific sequences of RNA, we developed a strategy to digest the random RNA encapsidated in the recombinant N-protein and reencapsidated specific RNA sequences. Poly-rA, poly-rC, poly-rU, and poly-rG sequences were encapsidated and co-crystallized with …

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Analysis Of Tetragonal To Monoclinic Phase Transformation Caused By Accelerated Artificial Aging And The Effects Of Microstructure In Stabilized Zirconia, Thomas J. Lucas Jan 2015

Analysis Of Tetragonal To Monoclinic Phase Transformation Caused By Accelerated Artificial Aging And The Effects Of Microstructure In Stabilized Zirconia, Thomas J. Lucas

All ETDs from UAB

This investigation addresses the issue that yttria stabilized zirconia is being used as a dental biomaterial without substantial evidence of its long-term viability. Furthermore, stabilized zirconia (SZ) undergoes low temperature degradation (LTD), which can lead to roughening of the surface. A rougher exterior can lead to increased wear of the antagonist in the oral environment. Despite the LTD concerns, SZ is now widely used in restorative dentistry, including full contour crowns. A comparison of aging methods to determine the role of artificial aging on inducing the transformation has not been extensively studied. Therefore, simulations of the transformation process were investigated …

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Assessment Of Antipsychotic Medication Effects On Dynamic Functional Network Connectivity In Patients With Schizophrenia, Kristin Lottman Jan 2015

Assessment Of Antipsychotic Medication Effects On Dynamic Functional Network Connectivity In Patients With Schizophrenia, Kristin Lottman

All ETDs from UAB

Schizophrenia, a psychiatric disorder affecting approximately 1% of the population, is often characterized as a disorder of dysconnectivity. Evaluation of the dysconnectivity hypothesis of schizophrenia has been extensively examined via functional neuroimaging studies in order to enhance insight into the disorder’s pathology. In particular, resting-state functional connectivity analyses have reported widespread aberrant network connectivity between brain regions in patients; however, consistencies in the directionality of abnormalities are often variable across studies. Recent investigations have begun to analyze functional connectivity dynamically as it is likely these inconsistencies may be a result of the static nature of traditional connectivity measures. In this …

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A Low-Power Analog-Signal-Processing-Unit For Wirelessly-Powered Implantable Recording System, Qingyun Ma Jan 2015

A Low-Power Analog-Signal-Processing-Unit For Wirelessly-Powered Implantable Recording System, Qingyun Ma

All ETDs from UAB

Bio-electric signals convey information and phenomenon of the physiological activities of organisms, such as gene, protein sequences, neural, and cardiac rhythms. Various types of bio-electrical signals are extensively used for diagnostics as well as therapeutic interventions. Bio-electrical signals are low-amplitude, low-frequency and numerous unique properties (spiking, small oscillation, local field potential interference). The original signal's amplitude is so small that directly lower the output resolution of the analog to digital converter (ADC). Furthermore, the detected signals are corrupted with, local field potential, white noise, system noise, and other interference, so the relevant information could be easily missed during the digitization. …

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The Business Of Forgetting: How Atlanta Became A Future-Oriented City, 1865-1895, Tyler Malugani Jan 2015

The Business Of Forgetting: How Atlanta Became A Future-Oriented City, 1865-1895, Tyler Malugani

All ETDs from UAB

Modern Atlanta contains very few physical representations of its history. This stems from an ideal created by businessmen and New South boosters who placed profits and capitalistic endeavors above history and tradition. After the Civil War when General William Tecumseh Sherman left the city of Atlanta in ashes, this ideal was put into practice. The emphases and style of both the physical and economic reconstruction show the beginnings of Atlanta’s future-orientation. Likewise, the urge to promote Atlanta and its economy through national and world expositions in the 1880’s and 1890’s illustrate how this ideal matured into second-nature. The three decades …

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Some Contributions To Bayesian Regularization Methods With Applications To Genetics And Clinical Trials, Himel Mallick Jan 2015

Some Contributions To Bayesian Regularization Methods With Applications To Genetics And Clinical Trials, Himel Mallick

All ETDs from UAB

Variable selection refers to the class of problems where one tries to find an optimal subset of relevant variables, which can be used to accurately predict the outcome of a certain response variable. Typically, a large number of variables are often collected; however, all but a few important variables are relevant for the prediction of the outcome, so the underlying representation is sparse. To this end, variable selection is fundamental in high-dimensional data analysis, playing a crucial role in important scientific discovery and decision-making, and has received enormous attention in the literature. Regularization method is one attractive approach that has …

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Robust Discrete Choice Models For Pedestrian-Vehicle Interactions At Unsignalized Locations, Shrikanth Mamidipalli Jan 2015

Robust Discrete Choice Models For Pedestrian-Vehicle Interactions At Unsignalized Locations, Shrikanth Mamidipalli

All ETDs from UAB

There has been a growing emphasis on improving multimodal serviceability of transportation systems. The integration of pedestrian behavior in mainstream traffic models, hence, is gaining traction. Advances in modeling pedestrian-vehicle interactions can aid in better understanding and development of control strategies for pedestrian safety. In support of such efforts, this study delivers an improved understanding of pedestrian and driver behavior at crossing locations through the development of discrete gap choice models to model the interaction between pedestrian and drivers at unsignalized crossing locations. First a comprehensive literature review was performed and latest advances in modeling pedestrian-vehicle interaction at various types …

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Spectroscopic Characterization Of Iron-Doped Ii-Vi Compounds For Laser Applications, Alan David Martinez Jan 2015

Spectroscopic Characterization Of Iron-Doped Ii-Vi Compounds For Laser Applications, Alan David Martinez

All ETDs from UAB

The middle Infrared (mid-IR) region of the electromagnetic spectrum between 2 and 15 μm has many features which are of interest to a variety of fields such as molecular spectroscopy, biomedical applications, industrial process control, oil prospecting, free-space communication and defense-related applications. Because of this, there is a demand for broadly tunable, laser sources operating over this spectral region which can be easily and inexpensively produced. II-VI semiconductor materials doped with transition metals (TM) such as Co2+, Cr2+, or Fe2+ exhibit highly favorable spectroscopic characteristics for mid-IR laser applications. Among these TM dopants, Fe2+ has absorption and emission which extend …

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Synaptic And Neurochemical Profiles Of The Nucleus Accumbens In Postmortem Schizophrenia, Lesley Mccollum Jan 2015

Synaptic And Neurochemical Profiles Of The Nucleus Accumbens In Postmortem Schizophrenia, Lesley Mccollum

All ETDs from UAB

Schizophrenia is a mental illness affecting 1% of the population worldwide. Treatment options are limited for patients, due in part to the lack of understanding of the pathophysiological mechanisms of schizophrenia. In order to improve treatment, it is vital to gain a better understanding of the underlying pathology of the disorder. One region of particular interest is the nucleus accumbens (NAcc). Part of the ventral striatum, this region is thought to play a role in schizophrenia pathology for multiple reasons: afferent input of many brain regions implicated in schizophrenia is integrated here; the dopamine and glutamate systems, both known to …

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Emergency Department Wait Time Communication Strategies And Patient Throughput Efficiency, Tom R. Mcdougal Jan 2015

Emergency Department Wait Time Communication Strategies And Patient Throughput Efficiency, Tom R. Mcdougal

All ETDs from UAB

This study investigates hospital strategies used to inform patients of anticipated wait times in the Emergency Department (ED) and the association of such strategies with patient throughput efficiency. When hospitals are inefficient in ED patient throughput, conditions of overcrowding often occur. Overcrowding of the ED is a problem for many hospitals. When such conditions exist, there is evidence in the literature that it leads to lower patient satisfaction, care quality, and financial position of the hospital. Therefore, improving patient throughput efficiency is a priority for hospitals. To improve patient throughput efficiency, hospitals use a variety of strategies. This study focuses …

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They Pull Your Grown Up Card For This, Jamie Mcfaden Jan 2015

They Pull Your Grown Up Card For This, Jamie Mcfaden

All ETDs from UAB

THEY PULL YOUR GROWN-UP CARD FOR THIS JAMIE MCFADEN MASTER OF ARTS IN ENGLISH ABSTRACT They Pull Your Grown-Up Card for This is a collection of six nonfiction pieces. The majority of the pieces in the collection are personal essays with the exception of one written specifically as nonfictional prose and another that adheres to the memoir tradition. Major themes coursing through this body of work include notions of family, friendship, and self-awareness.

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A New Form Of Rod Photoreceptor Light Adaptation, Alex S. Mckeown Jan 2015

A New Form Of Rod Photoreceptor Light Adaptation, Alex S. Mckeown

All ETDs from UAB

In the first step in light perception, rod and cone photoreceptors convert photon absorption into an electrical impulse that is transmitted through the visual pathway. While the biochemistry and the signaling physiology have largely been defined in dark-adapted, isolated mammalian rods, there are still unanswered questions regarding photoreceptor light adaptation processes that involve extracellular components. In particular, the proteins of the interphotoreceptor matrix have not been considered in the studies of rod signaling and adaptation. This thesis details a new form of light adaptation, now known as adaptive potentiation (AP), in which extracellular components act on rods to transiently increase …

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Effect Of Vigilance On Driving Performance In Commercial Motor Vehicle Drivers, Ben Mcmanus Jan 2015

Effect Of Vigilance On Driving Performance In Commercial Motor Vehicle Drivers, Ben Mcmanus

All ETDs from UAB

Driving is a complex task requiring constant information processing made possible by attention. Because there are 5.7 million commercial motor vehicle (CMV) drivers in the United States, it is imperative to investigate factors affecting driving performance as well as methods to reduce motor vehicle collisions (MVCs) with the primary goal of eliminating transportation-related unintentional fatal and nonfatal injuries. Vigilance is a cognitive processing component that may play an important role in CMV driving safety. Two experiments were conducted to examine the effect of vigilance on simulated driving performance in varying conditions. Experiment 1 focused specifically on the effect of vigilance …

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Malware Detection Through Disassembled Function Analysis, Ralph Frank Mcsweeney Jan 2015

Malware Detection Through Disassembled Function Analysis, Ralph Frank Mcsweeney

All ETDs from UAB

Antivirus software vendors have been forced into an industry of reaction because an abundance of new malware is discovered daily. The antivirus industry, handicapped by a low ratio of malware analysts to malware and antiquated techniques, floods the market with products with regrettably low detection rates, often only marginally outperforming competitors. This thesis presents a new function-edge-based set detection and identification method which significantly outperforms traditional antivirus techniques. The technique used reduces a malware binary to its fundamental assembly code and performs functional analysis using a newly created function hashing technique. Function hash edges are created by combining calling and …

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Stat4 Regulates Multiple Pathogenic Mechanisms Of Cd4 T Cells In Experimental Autoimmune Encephalomyelitis, A Model Of Multiple Sclerosis, Ian Lee Mcwilliams Jan 2015

Stat4 Regulates Multiple Pathogenic Mechanisms Of Cd4 T Cells In Experimental Autoimmune Encephalomyelitis, A Model Of Multiple Sclerosis, Ian Lee Mcwilliams

All ETDs from UAB

Multiple Sclerosis (MS) is an autoimmune disease whereby the host immune system fails to recognize self vs non-self and targets myelin of the central nervous system. Currently there is no permanent cure for MS and the efficacy of immune modulatory treatments often wane over time, therefore we seek to determine novel pathogenic mechanisms to target therapeutically. CD4 T cells have been found within inflammatory CNS lesions of MS patients and are believed to be important mediators of MS pathology. To study CD4 T cells in the context of MS, we use the well-defined MS mouse model experimental autoimmune encephalomyelitis (EAE). …

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Dna Methylation Regulates Neuronal Synaptic Scaling And Intrinsic Membrane Excitability, Jarrod P. Meadows Jan 2015

Dna Methylation Regulates Neuronal Synaptic Scaling And Intrinsic Membrane Excitability, Jarrod P. Meadows

All ETDs from UAB

Learning and memory rely on long-lasting, experience-dependent adaptations in synaptic and non-synaptic forms of neuronal plasticity. Previous evidence implicates transcriptional and epigenetic mechanisms, including DNA cytosine methylation, as critical regulators of site-specific, Hebbian alterations in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). However, whether DNA methylation modulates cell-wide, non-Hebbian homeostatic adaptations like synaptic scaling and intrinsic plasticity (IP) is unclear. Whereas synaptic scaling involves bidirectional changes in postsynaptic receptor density in response to chronic alterations in neuronal activity, IP involves the activity-dependent attunement of passive and/or active membrane properties that govern action potential (AP) firing. This …

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A Three Dimensional Microphysiologic Liver Model For Toxicity Testing, Lindsay Mckinney Miller Jan 2015

A Three Dimensional Microphysiologic Liver Model For Toxicity Testing, Lindsay Mckinney Miller

All ETDs from UAB

Drug development is an expensive and time consuming process, requiring an average of over $1 billion and up to fifteen years of work for each newly released product. Drug-induced liver toxicity is the leading cause of post-market drug withdrawals despite the fact that extensive animal testing and clinical trials are required prior to approval of a novel drug or therapy. Due to both the specificity and genetic variability of hepatic regulation and metabolism in humans, animal models and single-cell hepatocyte testing cannot fully predict the metabolic response of a novel compound. In vitro organ culture in a three dimensional (3D) …

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Innate Immunity Mechanisms In Parkinson Disease, Mark Moehle Jan 2015

Innate Immunity Mechanisms In Parkinson Disease, Mark Moehle

All ETDs from UAB

Parkinson disease (PD) is a late onset, progressive neurodegenerative movement disorder with cardinal symptoms of tremor at rest, bradykinesia, postural instability, and rigidity. These motor symptoms of PD are caused by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). However, despite PDs first modern observation in 1817, little is understood about the causes and molecular mechanisms behind dopaminergic neuron loss. The relatively weak understanding of pathological mechanisms has hindered the development of treatments to slow or halt the progression of PD. However, recently, mounting evidence from post-mortem, imaging, and retrospective studies suggest an important role …

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The Impact Of Meal Timing On Cardiometabolic Syndrome Indicators In Shift Workers, Hylton Elisabeth Molzof Jan 2015

The Impact Of Meal Timing On Cardiometabolic Syndrome Indicators In Shift Workers, Hylton Elisabeth Molzof

All ETDs from UAB

Shift workers exhibit a greater risk for several cardiovascular and metabolic diseases including heart disease, obesity, hypertension, and type II diabetes (Boivin, Tremblay, & James, 2007; Chen, Lin, & Hsiao, 2010; Knutsson, Jonsson, Akerstedt, & Orth-Gomer, 1986; Kroenke et al., 2007). Shift workers have been reported to consume more pro-inflammatory diets than day workers (Wirth, Burch, Shivappa, Steck, et al., 2014) and to redistribute their food intake to the night during work (Lennernas, Hambraeus, & Akerstedt, 1995; Pasqua & Moreno, 2004). Numerous studies in animal models and humans have shown that eating during the sleep or inactive period is associated …

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