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The Role Of Mammalian Tribbles Homolog 3 (Trb3) In Macrophage Biology; Evidence For Reciprocal Regulation Of Macrophage Function In Foam Cell Formation, Dennis Steverson

All ETDs from UAB

Atherosclerosis is disease characterized by dysregulated lipid metabolism and chronic inflammation. Macrophages are critical to the progression of the disease and are involved in the pathophysiology at all stages of the disease. In the early stages, macrophages are responsible for fatty streak formation by becoming foam cells through lipid uptake. In the later stages, macrophages contribute to the degradation of the fibrous cap and are largely responsible for chronic inflammation in atherosclerotic plaques. Tribbles homolog 3 (TRB3) is a pseudokinase that inhibits Akt activation by blocking its phosphorylation site. TRB3 is expressed on numerous cell types in the body (pancreatic …

Long-Term Stability Of Lefort I Maxillary Downdraft With Rigid Internal Fixation, Stephen Leonard Strickland

All ETDs from UAB

ABSTRACT Objective: The objective of this study is to evaluate the skeletal and dental stability of a Le Fort I maxillary downgraft after a minimum 4year follow up period. Methods: This retrospective cohort study evaluated 18 patients' post-surgical stability after Le Fort I maxillary downgraft performed by a Z-osteotomy. Pre-surgical (T1), post-surgical (T2), post-orthodontic (T3), and long-term follow-up (T4) cephalometric radiographs were digitized and analyzed with Dolphin Imagining via a custom analysis to evaluate linear and angular skeletal and dental relapse. Results - The average Le Fort I maxillary down graft was 3.6mm. The average post-surgical orthodontic phase was 7.4 …

Light Transmitting Fiber Posts - An In Vitro Evaluation., Antigoni Stylianou

All ETDs from UAB

Objectives: The primary purpose of this study is to measure and compare the light transmission, radiopacity and microscopic structure of a new fiber optic post compared to a clinically successful fiber post. Materials and Methods: A. The radiopacity of seven posts was evaluated in terms of average intensity values calculated in histograms produced by computer-based software. B. The two types of fiber posts were examined by scanning electron microscopy (SEM) and evaluated by computer-assisted image analysis. C. Two experimental groups with sample size n=12 included the D.T. Light posts and iLumi Fiber Optic posts. Two aluminum assemblies forming two cylindrical …

Three-Dimensional Age-Related Changes Of The Adult Face; African American Female Population, Christina Theresa Sutherland

All ETDs from UAB

Objectives: Treatment of older adults is one of the fastest growing areas in orthodontic practice. The objectives of this study are to: 1. Investigate the aging of the female African American face using three-dimensional surface imaging to understand how the soft tissue of the face matures in relation to the teeth and 2.) Compare the effects of aging on African American female faces to aging of Caucasian female faces. Methods: This is a cross-sectional study of 100 African American females with balanced faces. Five age groups (in years) were included: [20-30], [31-40], [41-50], [51-60], [61-70]. Three-dimensional (3D) surface images of …

Deleterious Effects Of Hyperglycemia On Cognitive Functioning In The Cardia Study Cohort, Michele Holland Talley

All ETDs from UAB

DELETERIOUS EFFECTS OF HYPERGLYCEMIA ON COGNITIVE FUNCTIONING IN THE CARDIA STUDY COHORT MICHELE LYN HOLLAND TALLEY SCHOOL OF NURSING ABSTRACT With an aging society, maintaining cognitive functioning into older age is becoming more important. Because of the impact cognitive functioning has on daily activities, any disruption may inhibit the ability to perform such daily activities successfully. To prevent disruptions, determinants of cognitive functioning must be considered. Such determinants may or may not be modifiable. Some predictors may be demographic, metabolic, or inflammatory in nature. In addition, predictors or determinants may differ based on genetic predisposition to Alzheimer’s disease. As part …

Count Models With Multiple Inflations, Arvind Tripathi

All ETDs from UAB

The goal of this research is to develop new statistical models for the analysis of count data even if data exhibit over dispersion or under dispersion and has multiple inflated counts. Although many statistical models are available for the analysis of count data, there is no available statistical model that can address the presence of more than expected multiple counts together with over/under dispersion. In our first paper, we develop a multiple-inflation negative binomial (MINB) model and use the expectation maximization (EM) algorithm along with a numerical optimization to obtain maximum likelihood estimates. We applied the one step smoothly clipped …

Just Past The Trestle, Gentry Chance Turner

All ETDs from UAB

JUST PAST THE TRESTLE GENTRY CHANCE TURNER MASTER OF ARTS ENGLISH ABSTRACT The fall of the Old South is the backdrop for this chronicle of one family's descent and resurrection throughout the violent upheaval of the twenty-first century. Several generations of Turner men are examined in this tale of power, hatred and the collateral damage of arrested development. The following chapters give a truncated vision of a lifetime of competing forces and the pain of escaping from "loved" ones.

Hepatocyte Clock And Alcohol-Dependent Disruption In Glycogen Metabolism, Uduak Sunday Udoh

All ETDs from UAB

Chronic alcohol consumption has been shown to significantly decrease hepatic glycogen, an important storage form of energy for the body and liver. Emerging studies indicate a link between metabolism and the molecular circadian clock. Previously, we have shown that chronic alcohol consumption disrupts the liver molecular clock mechanism. However, it is not known how this alteration impacts hepatic energy (e.g., glycogen) metabolism and contributes to alcohol hepatotoxicity. This dissertation investigates the impact chronic alcohol consumption has on time-of-day-dependent oscillations of various aspects of liver glycogen metabolism, and the importance of the liver circadian clock in these metabolic alterations. Chapter 1: …

Difference In Recommended-To-Actual Nurse Staffing And Patient Falls, Shawn Ulreich

All ETDs from UAB

Patient falls are a serious safety concern in hospitals. Injuries from falls can be devastating to patients and are now subject to reimbursement penalties from the Center for Medicare and Medicaid Services. Patient falls have been identified by the American Nurses Association as a nursing sensitive indictor suggesting that improvements in the quality or quantity of nurses may impact this outcome. Moreover, the literature suggests that nurse staffing levels have an impact on various patient outcomes such as patient falls. Therefore, identifying appropriate nurse staffing levels to minimize patient falls is critically important to hospitals. A variety of staffing metrics …

Individual, Family, And Social Factors Associated With Adolescent Obesity: A Policy Relevant Focus, Janice Marguerite Utley

All ETDs from UAB

INDIVIDUAL, FAMILY, AND SOCIAL FACTORS ASSOCIATED WITH ADOLESCENT OBESITY: A POLICY RELEVANT FOCUS JANICE M. UTLEY PUBLIC HEALTH ABSTRACT This dissertation is comprised of three papers that examined individual, family, and social factors associated with adolescent overweight and obesity with the aim of generating data that could inform the design of policy interventions to prevent or reverse rising prevalence. The first investigation was a type of literature review called a scoping study that examined the extent, range, and type of research activity on adolescent obesity that used a multilevel or hierarchical design to look at two or more contextual areas …

A Novel Role For Usp14 In Regulating Non-Proteolytic Ubiquitin Signaling, Jada Hallengren Vaden

All ETDs from UAB

Loss of the deubiquitinating enzyme (DUB) USP14 in the ataxia (axJ) mice leads to altered neuromuscular junction (NMJ) structure, reduced synaptic transmission at the NMJ, and decreased mobility. However, the types of processes that USP14 regulates in the nervous system remain unclear. Because association with the proteasome stimulates USP14's ubiquitin hydrolase activity, it is thought to act primarily on proteasomal substrates. Therefore, one way for USP14 to support nervous system function is by modulating protein turnover. While a number of studies done in yeast and immortalized cell lines demonstrate that loss or inhibition of USP14 alters proteasome function, there is …

The Effects Of The Initially Transcribed Sequence On Reiterative Transcription In Escherichia Coli, Jeffery Michael Vahrenkamp

All ETDs from UAB

Transcription, the synthesis of a ribonucleic acid transcript using a nucleic acid template, is the first step in gene expression for all life. In most organisms, high fidelity transcription is achieved through the formation of an RNA:DNA hybrid which allows the RNA polymerase to maintain the correct register. Slippage, which would lead to improper base pairing, is prevented by the heterogeneous sequence of the DNA template. However, when homogenous tracts of bases are present in the template, slippage can occur, allowing a single base in the template to encode multiple bases in the transcript in a process called reiterative transcription. …

Characterization Of The Gtpase Rac1 As An Electrophilic-Sensitive Protein In Vascular Cells, Stephanie Brook Wall

All ETDs from UAB

The GTPase Rac1 is a protein which has been shown to be dysregulated in the context of a number of inflammatory diseases including atherosclerosis. Rac1 responds to extracellular signals and is involved in cellular cytoskeletal rearrangement, reactive oxygen species generation and cell cycle progression. When activated Rac1 interacts with effector proteins on the plasma membrane. This activation has recently been shown to be modulated by redox signaling via an active site cysteine. However, it is not known whether other redox signaling compounds can modulate Rac1 activity. An important redox signaling mediator is the electrophilic lipid, 15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2). This lipid …

Carbon Fiber Content Measurement In Composite, Qiushi Wang

All ETDs from UAB

. Carbon fiber reinforced polymers (CFRPs) have been widely used in various structural applications in industries such as aerospace and automotive because of their high specific stiffness and specific strength. Their mechanical properties are strongly influenced by the carbon fiber content in the composites. Measurement of the carbon fiber content in CFRPs is essential for product quality control and process optimization. In this work, a novel carbonization-in-nitrogen method (CIN) is developed to characterize the fiber content in carbon fiber reinforced thermoset and thermoplastic composites. In this method, a carbon fiber composite sample is carbonized in a nitrogen environment at elevated …

Aping Nobility: Reinterpreting The Mma "Monkey Cup", Ruoxin Wang

All ETDs from UAB

The “Monkey Cup” in the collection of the Metropolitan Museum of Art (MMA) exhibits a unique rendition of the monkeys robbing the sleeping peddler theme. Generally believed to have been created in the second quarter of the fifteenth century in Burgundian territories, the exact origin of the beaker is not known. Based on visual evidence and the socio-historical context, I propose that the “Monkey Cup” was created in the first quarter of the fifteenth century, and the attribution should be broadened to the greater circle of the Valois courts. In this thesis, I offer a new contextualized reading of the …

Characterizing The Nuclear Import And Functions Of Cystin, The Ciliary Protein Disrupted In The Cpk Mouse Model Of Recessive Polycystic Kidney Disease, Jacob Asher Watts

All ETDs from UAB

Autosomal recessive polycystic kidney disease (ARPKD; MIM 263200) is a ma-jor cause of pediatric morbidity and mortality. Typically, orthologous animal models are the mainstay for pathogenic studies of human diseases. However, gene-targeting of Pkhd1, the mouse ortholog of the ARPKD gene, results in mutants with little or no kidney disease. In contrast, disruption of the non-orthologous gene, Cys1, in the cpk mouse model closely phenocopies human ARPKD. We speculate that this phenotypic similarity suggests that the Pkhd1 and Cys1 genes encode proteins (FPC and cystin, respectively) that share, at least in part, common molecular pathways. Our laboratory, as well as …

Effectiveness Of Functional Electrical Stimulation Assisted Rowing To Improve Shoulder Pain And Aerobic Fitness In Manual Wheelchair Users With Spinal Cord Injury, Susan Wilbanks

All ETDs from UAB

Exercise is beneficial to adults with spinal cord injury (SCI) because of its ability to improve function and increase life expectancy. The goal of this dissertation was to determine an effective intervention for increasing aerobic fitness and decreasing shoulder pain in manual wheelchair users with SCI by identifying underlying mechanisms for shoulder pain, optimizing training and utilizing appropriate outcome measures. Three studies were conducted. The first study indicated that exercise interventions for adults with SCI are of low to moderate methodological quality, frequently using outcome measures associated with changes in body structures and functions, and not frequently examining effects on …

Web Computing For Bioinformatics Applications, Sean Wilkinson

All ETDs from UAB

This work explores web computing as a solution to current problems in informatics, including algorithm delivery, distributed computation, and data visualization. A novel computing platform called QMachine has been developed for use in clinical research environments for computationally intensive applications like medical image processing and genomics sequence processing. In such applications, the emergence of Big Data as the inevitable reference for the analysis of local (“small”) data from individual experiments or patients has presented numerous challenges. In particular, computational workflows that handle Big Data need significantly greater processing and memory resources. Advances in virtualization – especially in cloud computing – …

Stress, Bullying, Cortisol, And Depresive Symptoms In 9th Grade Adolescents, Susan Gordon Williams

All ETDs from UAB

ABSTRACT Stress and bullying are known contributors to depressive symptoms in adolescents. Prevalence of depressive symptoms in adolescents is estimated to range from13% to 34% in recent studies. Ninth graders are in a transitional period developmentally,biologically, physically, and psychosocially. Few studies have examined the relationship between stress, bullying, and depressive symptoms from a biobehavioral perspective in 9th graders. The purpose of this study was to examine stress, bullying, and depressive symptoms including a biomarker of stress, salivary cortisol diurnal rhythm, to determine if there is mediation between the individual variables of stressful life events, perceivedstress, bullying, and depressive symptoms. The …

Examining Punishment Severity: The Effect Of State Sanctioning On Dui Arrest Rates, Kimberly Williams

All ETDs from UAB

The purpose of this paper is to examine the state differences in arrest rates according to risk preference, and policy and sanction severity. The effects of policy and sanction severity on drinking and driving have been an increasing topic of discussion and study in both the political and scholarly world since the 1980s. This paper seeks to address the differences in state-level policies and sanctions concerning DUIs, focusing on the impact of punishment severity on DUI arrest rates. Results show that being located in the Western region of the United States has a significant positive effect on DUI arrest rates. …

“The Ladies” Who Founded Moma: How Three Female Art Collectors Created One Of The World's Leading Museums, Amy Katherine Williamson

All ETDs from UAB

This thesis examines three visionary women who were instrumental in founding the Museum of Modern Art in 1929: Lillie P. Bliss, Mrs. John D. Rockefeller, and Mrs. Cornelius Sullivan. In reaction to the lack of modern art in New York City’s museums, these women combined their collections, money, and resources to present Matisses, Picassos, and other modern masters to create what would become the core of the museum’s permanent collection. Both challenging and accepting the limitations of gender, the women enlisted the help of A. Conger Goodyear and Alfred Barr to help them navigate the art world whilst they built …

Septic Cavernous Sinus Thrombosis And Blindness Following Odontogenic Infection, Pai-Tai Tsai, Yuan-Wu Chen

Journal of Dental Sciences

No abstract provided.

College Faculty Experiences Assigning Service-Learning And Their Inclination To Continue, J. Shannon Chamberlin

Walden Dissertations and Doctoral Studies

The academic benefits and enhanced social responsibility that students derive from service-learning (SL), defined as experiential learning that ties community service to academic courses, have been well documented. However, for a college to fully institutionalize SL, a high proportion of faculty needs to include SL in their courses. Based in Kolb's experiential learning theory, the purpose of this study was to enhance planners' understanding of how college faculty's past experiences assigning SL influence their inclination to assign SL in future courses. In this basic qualitative interpretive study, data were collected from 13 individual interviews with faculty who assigned SL at …

Are Associations Between Parenting Style And Academic Achievement Moderated By Ethnicity And Individualism-Collectivism?, Thiago L. De Oliveira

Walden Dissertations and Doctoral Studies

Researchers have long been concerned in documenting the nature of associations between parenting styles and academic achievement in adolescents. Social learning theory has shown how domains such as individualism, collectivism, and ethnicity are associated with parent behavior. Research suggests compatibility between individualism and authoritative parenting and collectivism with authoritarian parenting styles, which could have critical implications in the relationship between parenting styles and academic achievement. Despite the robust research on parenting styles, no research has investigated the moderating roles of individualism and collectivism. Thus, the purpose of this study was to determine the associations between parenting style and academic achievement …

The Impact Of Immigration Variables On Tuberculosis Rates In South Carolina, Lisa J. Dimitriadis

Walden Dissertations and Doctoral Studies

After HIV/AIDS, tuberculosis (TB) is the deadliest single infectious agent worldwide; globally in 2013, 1.5 million people died of the disease. Although TB infection rates in the United States are low compared to that of other countries, TB still remains a threat to public health in the U.S., especially among immigrant populations. The main purpose of this study was to investigate the correlations between the independent variables of immigration status, years of residence, and race/ethnicity and the dependent variable of TB infection within South Carolina between 2006 and 2012. To examine these possible relationships, this quantitative study employed the ecological …

Factors Associated With Graduation Among Latino Male High School Students, Judyann Watson

Walden Dissertations and Doctoral Studies

High dropout rates for minority students require additional educational research to understand and implement changes that will increase graduation rates. The purpose of this nonexperimental study was to examine factors that may be associated with graduation for Latino male students. Guided by Tinto's work, which holds that students remain in school when they feel academically or socially connected to an institution, this study addressed the impact of social factors, academic factors, and small learning communities (SLCs) on graduation rates. The research study used archival data and bivariate logistic regression to analyze the data for Latino male participants (n = 208) …

Power Of K Choices And Rainbow Spanning Trees In Random Graphs, Deepak Bal, Patrick Bennett, Alan Frieze, Paweł Prałat

Department of Mathematics Faculty Scholarship and Creative Works

We consider the Erdős-Rényi random graph process, which is a stochastic process that starts with n vertices and no edges, and at each step adds one new edge chosen uniformly at random from the set of missing edges. Let G(n, m) be a graph with m edges obtained after m steps of this process. Each edge ei (i = 1, 2,…, m) of G(n, m) independently chooses precisely k ∈ N colours, uniformly at random, from a given set of n–1 colours (one may view ei as a multi-edge). We stop the process prematurely at time M when the following …

Exploring Government Contractor Experiences Assessing And Reporting Software Development Status, Putnam P. Texel

Walden Dissertations and Doctoral Studies

Reports from academic, commercial, and government organizations have documented software-intensive system cost and schedule overruns for decades. These reports have identified lack of management insight into the software development process as one of many contributing factors. Multiple management mechanisms exist. However, these mechanisms do not support the assessment, and subsequent reporting, of software completion status. Additionally, the conceptual framework, based on industry standards, is limited in its relevance to this study due to an emphasis on what is needed while deferring implementation details. The purpose of this phenomenological study was to explore U.S. government contractors' lived experiences of assessing and …

Relationship Between Adverse Childhood Experiences And Illness Perceptions Among Individuals With Fibromyalgia, Susan D. Fay

Walden Dissertations and Doctoral Studies

Relationship between Adverse Childhood Experiences and Illness Perceptions among Individuals with Fibromyalgia

by

Susan D. Fay

MS, Drexel University, 1994

BS, Metropolitan State University of Denver, 1983

Dissertation Submitted in Partial Fulfillment

of the Requirements for the Degree of

Doctor of Philosophy

Psychology

Walden University

February 2015

Adverse childhood experiences (ACEs), including abuse and neglect, are a significant social health problem. Exposure to ACEs can place a child at a high risk for developing different diseases or illnesses in adulthood, including fibromyalgia. The purpose of this study was to determine if exposure to ACEs, moderated by perceived social support and/or …

Learning Disability Status And Gender As Predictors Of Self-Efficacy., Irene Ekohamen Aikhomu

Walden Dissertations and Doctoral Studies

In the school district under study, students with learning disabilities were

underperforming when compared to students without disabilities. Research has indicated that improved self-efficacy can promote improved student outcomes and that self- efficacy can be taught. Despite this known association, the school district under study has not provided students with such support. The current study addressed ways in which that gap may be attenuated. Guided by the framework of Bandura's theory of self-efficacy and social cognitive theory, the purpose of this study was to explore (a) whether students' perceptions of self-efficacy differed depending on whether or not they had diagnosed …