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Juvenile Sentencing In Illinois: Addressing The Supreme Court Trend Away From Harsh Punishments For Juvenile Offenders, Maureen Dowling

Northern Illinois University Law Review

The United States Supreme Court has steadily been changing the way it approaches juvenile sentencing since 2005. This ideological shift has occurred as a response to the increase in biological and sociological studies, which point toward fundamental differences between juveniles and adults. This Note addresses how the new mandates by the Supreme Court have been implemented around the country, with a focus on statutory changes Illinois should make moving forward. Specifically, this Note argues that there are several adjustments Illinois will have to make in regards to the way it sentences juvenile homicide offenders, in order to be considered Constitutional …

Effect Of Sirna Pre-Exposure On Subsequent Response To Sirna Therapy, Hamidreza Montazeri Aliabadi, Parvin Mahdipoor, Cezary Kucharski, Nicole Chan, Hasan Uludag

Pharmacy Faculty Articles and Research

PURPOSE. An alternative cancer therapy based on RNA interference (RNAi) has shown considerable promise but the possibility of resistance development is not known. This study explored the possibility of therapeutic resistance against siRNA nanoparticles in human cancer cells. METHODS. Two approaches to siRNA treatment were undertaken using lipid-modified polyethylenimines, a single high concentration (shock) and repeated increasing concentrations (gradual). The targets were Mcl-1, RPS6KA5 and KSP in MDA-MB-435 cells. RESULTS. There was no evidence of resistance development in shock-treated cells, while the decrease in mRNA levels of targeted proteins was not as robust in naïve cells in gradual treatment. However, …

Serpentine Ecosystem Responses To Varying Water Availability And Prescribed Fire In The U.S. Mid-Atlantic Region, Jessica Schedlbauer

Biology Faculty Publications

No abstract provided.

Comparative Analysis Of The Flexural Stiffness Of Pinniped Vibrissae, Carly C. Ginter Summarell, Sudeep Ingole, Frank E. Fish, Christopher D. Marshall

Biology Faculty Publications

No abstract provided.

The Art And Science Of Literary Study, Jamie Carr

Reconstruction: Studies in Contemporary Culture

The discipline of literary studies has recently gained powerful allies in the sciences and popular media. Scholars in the cognitive sciences, including neuroscience and cognitive psychology, have newly taken up literature's defense, conducting empirical studies to prove that literature has value—particularly researching whether fiction reading produces empathy. Both the media reports, and the empirical studies themselves, however, fail to acknowledge a long history of literary criticism and theory that articulate similar claims. Implicit in this subtext, is the privileging of empirical over interpretive or theoretical ways of knowing. In this discourse, literary criticism is broadly criticized for its variability and …

Feasibility Of A Group-Based Self-Management Program For Ethnically Diverse People With Hiv/Aids In Hawaii, Kathleen M. Sullivan, Jillian Inouye

Asian/Pacific Island Nursing Journal

HIV/AIDS has transformed from a terminal to a chronic health condition affecting individuals for decades rather than years. Yet the development of care models that enhance client-focused HIV disease management skills is still in progress, especially in HIV resource-poor locales. This pilot study tested the feasibility of implementing the group-based Positive Self-Management Program (PSMP) to participants recruited from Oahu, Hawaii. The PSMP is a self-management program developed at Stanford University. A paucity of data exists on the efficacy of implementing the specialized PSMP that addresses unique needs of persons living with HIV. With a focus on enhancing self-efficacy beliefs, examples …

Structural Variation Of Alpha-Synuclein With Temperature By A Coarse-Grained Approach With Knowledge-Based Interactions, Peter Mirau, Barry L. Farmer, Ras B. Pandey

Faculty Publications

Despite enormous efforts, our understanding the structure and dynamics of α-synuclein (ASN), a disordered protein (that plays a key role in neurodegenerative disease) is far from complete. In order to better understand sequence-structure-property relationships in α-SYNUCLEIN we have developed a coarse-grained model using knowledge-based residue-residue interactions and used it to study the structure of free ASN as a function of temperature (T) with a large-scale Monte Carlo simulation. Snapshots of the simulation and contour contact maps show changes in structure formation due to self-assembly as a function of temperature. Variations in the residue mobility profiles reveal clear distinction among three …

Taylor: A Magazine For Taylor University Alumni, Parents And Friends (Summer 2015), Taylor University

The Taylor Magazine (1963-Present)

The Summer 2015 edition of Taylor Magazine, published by Taylor University in Upland, Indiana.

Evaluation Of Anti-Migraine Drugs In An In Vivo Rat Model Of Chronic Migraine, Shannon Nicole Stiles

Graduate Theses/Dissertations

Approximately 2% of the US population is affected by chronic migraine (CM). CM is a recurring, neurological disorder characterized by painful headache, along with autonomic, gastrointestinal, and other somatic symptoms. Prolonged sensitization of the trigeminal system, which is implicated in CM, is comprised of peripheral primary trigeminal ganglion neurons that provide sensory innervation of the head and face and second order neurons in the spinal trigeminal nucleus (STN). The goal of my study was to evaluate anti-migraine drugs for their ability to inhibit ongoing peripheral and central sensitization of trigeminal nociceptors. An in vivo animal model was used to determine …

Investigation Of Nocifensive And Cellular Effects Of Dihydroergotamine In A Model Of Chronic Migraine, Jennifer Elise Denson

Graduate Theses/Dissertations

The goal of my study was to investigate the nocifensive behavioral and cellular effects of dihydroergotamine (DHE) and sumatriptan in a model of sustained trigeminal activation. Trigeminal nerves provide sensory innervation to the head and face and their activation has been implicated in migraine pathology. The most commonly prescribed medications for migraine treatment are the triptan class of drugs. However, triptans are not an effective therapy for all migraine patients and some develop triptan resistance. Ergot-derivatives, including DHE, could be a potential alternative for this subpopulation of patients. To cause activation of the trigeminal system, adult male Sprague Dawley rats …

Influence Of Caregiver Activation On Health Of Informal Caregivers Of Persons With Alzheimer’S, Trinity Rose Parker

Doctor of Psychology (PsyD)

Abstract Caregiver activation is related to a caregiver’s knowledge, skill and confidence to provide multiple levels of care of another individual. To date there is little research assessing caregiver activation within the population of informal caregivers of Alzheimer’s patients. Forty-four informal caregivers of persons with Alzheimer’s were recruited through caregiver resource centers and online communities in the state of Oregon, completed a self-report survey. The purpose of this study was to identify the predictive qualities and influence of caregiver activation on informal caregiver physiological and psychological health as well as positive health behaviors. General health, emotional wellbeing, self-efficacy, and caregiver …

Approaches To The Design Of Biotechnical Streambank Stabilization: Volume I—A Guide To The Literature, Dennis A. Lyn, John F. Newton

JTRP Technical Reports

Streambank stabilization has traditionally been performed with riprap for which reliable design and installation procedures are available. Due to concerns about the environmental impact of riprap, there has been increasing interest in more natural biotechnical (or bioengineering) alternatives. A review of the litera­ture on biotechnical approaches to streambank stabilization has been per­formed, with a focus on those works that might be particularly useful in developing design guidelines or standards for the Indiana Department of Transportation. Works that synthesized the literature (up to about the year 2000) and so covered a broad range of topics, were examined, including monographs and manuals …

Comparison Of Different Modulators That Affect Macrophage Activation In Vitro, Alda Alexa Díaz Pérez

Graduate Theses and Dissertations

Inflammation is known as a mechanism to regulate and control infections as well as promote tissue repair. Macrophages (Mф) are known to be a major cell type in the initiation, sustainability and resolution of inflammation. Moreover, Mф are essential for the remodeling process that is also known as the wound healing response. The objective of this research was to compare five modulators (acetylsalicylic acid (ASA), dexamethasone (DEX), prostaglandin E2 (PGE2), iloprost, and resolvin D1 (RvD1) for their anti-inflammatory effects on macrophages in vitro. Then, Mф phenotype in terms of gene expression and secreted cytokine response was determined. Our study compared …

Pola Permintaan Daging Tingkat Rumah Tangga Di Indonesia: Analisa Data Mikro 2013, Sigit Nugroho, Sita Wardhani Suparyono

Jurnal Ekonomi dan Pembangunan Indonesia

The objective of this study is to understand the meat demand pattern of household in Indonesia. This study used the 2013 National Socio-Economic Survey (SUSENAS) and Agricultural Census (SP). The method used to understand the meat demand pattern is Quadratic Almost Ideal Demand System (QUAIDS) approach with Iterated Linear Least Square (ILLS) estimator. The result shows that urban, education, household size, and domestic meat supply have an influence on meat demand pattern and its elasticity.

Treatment Of Severe Metabolic Alkalosis With Continuous Renal Replacement Therapy: Bicarbonate Kinetic Equations Of Clinical Value, Lenar Yessayan, Jerry Yee, Stan Frinak, David Kwon, Balazs Szamosfalvi

Nephrology Articles

Concomitant severe metabolic alkalosis, hypernatremia, and kidney failure pose a therapeutic challenge. Hemodialysis to correct azotemia and abnormal electrolytes results in rapid correction of serum sodium, bicarbonate, and urea but presents a risk for dialysis disequilibrium and brain edema. We describe a patient with Zollinger-Ellison syndrome with persistent encephalopathy, severe metabolic alkalosis (highest bicarbonate 81 mEq/L), hypernatremia (sodium 157 mEq/L), and kidney failure despite 30 hours of intravenous crystalloids and proton pump inhibitor. We used continuous renal replacement therapy (RRT) with delivered hourly urea clearance of ~3 L/hour (24 hour sustained low efficiency dialysis with regional citrate anticoagulation protocol at …

Grey (Halichoerus Grypus) And Harbor Seal (Phoca Vitulina) Bycatch And Depredation In New England Sink-Gillnet Fisheries, Laura N. Sirak

All Theses And Dissertations

Marine mammals interact with commercial fisheries via competition for resources, depredation (feeding on fish caught in gear), entanglement, and bycatch in fishing gear. In New England, gray seals (Halichoerus grypus) and harbor seals (Phoca vitulina) are often taken as bycatch in sink-gillnet fisheries and are believed to depredate fish in gillnets. As seal populations increase, interactions with fisheries are also likely to increase, affecting both seal stocks and the New England fishing industry. This study aims to understand seal bycatch in the New England sink-gillnet fisheries by identifying the spatial and temporal trends in bycatch as …

Total Synthesis And Derivation Of Humulones And Lupulones As Possible Biologically Active Agents, Lucas R. Sass, Kristopher V. Waynant (Mentor)

Idaho Conference on Undergraduate Research

Humulones and lupulones have affirmed themselves as key ingredients in the multi-billion dollar brewing industry. Originally exploited for their bacteriostatic properties, these compounds also exhibit high levels of biological activity against a variety of diseases. Although quantifiable, the isolation and separation of specific humulones and lupulones has proven difficult, thus establishing efficient synthetic routes will be of value to those desiring exact bittering qualities and to the pharmaceutical community. Our investigations are towards developing a synthetic route to a library of humulones, lupulones, and their derivatives as possible biologically active agents against myriad diseases. The key step in our efficient …

Cooking And Eating The Other: Contemporary Representations Of Domestic Workers In Popular Media, Ashley Mcfarland

Dissertations, Theses and Capstone Projects (Full IR Collection)

The mass media governs relations among social groups, manufactures political sentiment and shapes opinions on economic relations between individuals to reproduce a self-perpetuating system of power for a minute elite. The construction and organized distribution of manipulated cultural images that communicate embellished or patently false messages about a social group is central to the success of a capitalist economic system. This thesis reveals how media production negatively influences public perception of housework and the women who perform the labor and thwarts efforts to obtain and enforce legislation to protect native and immigrant domestic workers. Using contemporary representations from The Help …

Mating-Type Locus Characterization And Variation In Pyrenophora Semeniperda, Julie Leanna Henry

Theses and Dissertations

Pyrenophora semeniperda is a generalist fungal pathogen that occurs primarily on monocot seed hosts. It is in the phylum Ascomycota, which includes both self-compatible (homothallic) and self-incompatible (heterothallic) species. Homothallic fungal species contain complementary mating-type (MAT) idiomorphs in a single unikaryotic strain, while heterothallic strains contain a single MAT idiomorph requiring interaction between strains of complementary mating-types for sexual reproduction to occur. Because the majority of P. semeniperda strains contained either MAT1 or MAT2, this species was provisionally categorized as heterothallic. However, many strains contain both MAT idiomorphs and appear to be homothallic. These results warranted a closer look at …

Describing Spiritual Growth In An Online Religious Education Course: A Phenomenological Perspective, Benjamin Trevor Fryar

Theses and Dissertations

An estimated 33% of all college students take at least one online class (Allen & Seaman, 2013). Online classes are offered across a wide range of domains, including courses designed for spiritual development. Little research exists examining students' experiences in these types of classes. The purpose of this research is to help address this gap by describing the phenomenon of spiritual growth in an online religious education course. Brigham Young University-Idaho (BYU-Idaho) offers online courses designed to help students grow spiritually. Semi-structured interviews were conducted with ten students who took one of these classes and who reported positive gains in …

Deceptive Advertising Or Evolving Science? How "Barefoot Running" Demonstrates Novel Strategies For Defending False Advertising Lawsuits Under State Deceptive Trade Practices Acts, Joshua T. Calo

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.

Summer 2015 Digsight Newsletter, Southern Adventist University

DIGSIGHT - Institute of Archaeology Newsletter

Winter 2015 issue of the Archaeology newsletter, DigSight. Features the article "THE FOURTH EXPEDITION TO LACHISH, 2015".

Serum Amyloid A Facilitates Early Lesion Development In Ldlr-/- Mice, Paulette A. Krishack, Clarissa V. Bhanvadia, John Lukens, Timothy J. Sontag, Maria C. De Beer, Godfrey S. Getz, Catherine A. Reardon

Physiology Faculty Publications

BACKGROUND: Atherosclerosis is a chronic inflammatory disorder, and several studies have demonstrated a positive association between plasma serum amyloid A (SAA) levels and cardiovascular disease risk. The aim of the study was to examine whether SAA has a role in atherogenesis, the underlying basis of most cardiovascular disease.

METHODS AND RESULTS: Mice globally deficient in acute-phase isoforms Saa1 and Saa2 (Saa^-/-) were crossed to Ldlr^-/- mice (Saa^-/-Ldlr^-/-). Saa^-/-Ldlr^-/- mice demonstrated a 31% reduction in lesional area in the ascending aorta but not in the aortic root or innominate …

Evaluation Of A Combination Approach To Pedagogy In A Soil Science Laboratory Classroom And An Environmental Site Assessment Sample, Emily Linda Gervais

Theses and Dissertations

Chapter 1 of this study explores research that has shown that the use of technology in the classroom can be beneficial to student learning. Additionally, a need for Environmental Site Assessment (ESA) instruction in university level core environmental science classrooms has been demonstrated. This study includes an investigation of the potential benefits of using a combination of pedagogies: web-based teaching tools and ESA instruction in a laboratory classroom. The research design included two class formats, one that employed web-based tools (PowerPoint and video) and ESA instruction, and one that did not, with four class sections. All classes were taught by …

Correlation Of Fluorescence Spectroscopy And Biochemical Oxygen Demand (Bod5) Using Regression Analysis, Alexander Tetteh Narteh

Theses and Dissertations

This research uses Regression analysis of fluorescence spectroscopy results to correlate with Biochemical Oxygen Demand (BOD5). Fluorescence spectroscopy was applied to samples taken from seven sample sites in the Provo and Orem waste water treatment plants found in Utah County. A total of 161 samples were collected for this research. 23 samples each were taken from four sites in the Provo waste water treatment plant namely Provo head works, aeration basin, primary filter settlement basin and the Provo effluent basin. The Orem head works, the clarifier and the Orem effluent basin were the three sample sites in the Orem waste …

Histone Deacetylase 6 (Hdac6) Is Critical For Tumor Cell Survival And Promotes The Pro-Survival Activity Of 14-3-3Ζ Viadeacetylation Of Lysines Within The14-3-3Ζ Binding Pocket, Jeffrey Benjamin Mortenson

Theses and Dissertations

Our understanding of non-histone acetylation as a means of cellular regulation is in its infancy. Using a mass spectrometry approach we identified acetylated lysine residues and monitored acetylation changes across the proteome as a consequence of metabolic stress (hypoxia). We observed changes in acetylation status of non-histone lysines in tumor cells. Through the use of small molecule inhibitors of histone deacetylase enzymes (HDACs) and siRNA screening identified HDAC6 as a pro-survival regulator of lysine acetylation during hypoxia. The phospho-binding protein 14-3-3ζ acts as a signaling hub controlling a network of interacting partners and oncogenic pathways. We show here that lysines …

Respite Care And Marital Quality In Parents Of Children With Down Syndrome, Michelle Norton

Theses and Dissertations

Parents of a child with a disability are at greater risk than other couples for having higher stress, adjustment difficulties, and lower marital quality. Respite care has been shown to reduce stress in parents of children with disabilities. This study focused on parents who have a child with Down syndrome and their reported marital quality and respite care received. One hundred and twelve couples, each consisting of a mother and a father who lived with their child with Down syndrome, completed questionnaires including the Revised Dyadic Adjustment Scale, Experience in Close Relationships Questionnaire, Daily Hassles and Uplifts Scale, and a …

Using Beaver Works To Estimate Colony Activity In Boreal Landscapes, Carol A. Johnston, Steve K. Windels

Natural Resource Management Faculty Publications

Beaver ponds and beaver-impounded vegetation are indicators of past or present beaver activity that can be detected from aerial photography. A method to quantitatively relate these beaver works with the density of active beaver colonies could benefit beaver management, particularly in areas lacking beaver population data. We compared historical maps (1961–2006) of beaver works at Voyageurs National Park, Minnesota, USA with concurrent aerial surveys of beaver colonies. We tested 2 landscape-scale models of beaver colony density previously developed for a period of beaver population expansion (1940–1986), but they failed to predict colony density after 1986, a period of declining beaver …

Impact Of Individual And Population-Scale Dynamics On Growth And Reproduction Of Two Morphologies Of Macrocystis In Central California, Sarah Jeffries

Capstone Projects and Master's Theses

Morphological plasticity is common among seaweeds and such form alteration often results in the modification of other physiological processes, such as growth or reproduction. This study explored the consequences of morphological plasticity by comparing two of the common growth forms of the giant kelp Macrocystis, an ecologically important genus in nearshore temperate ecosystems. The aclonal pyrifera morphology of Macrocystis grows in deep water and reproduces via the production and release of microscopic zoospores, while the clonal integrifolia morphology grows in shallow water and reproduces primarily by vegetative growth of its rhizome. The effects of morphology on reproduction, biomass and …

Interference Effects For Intermediate Energy Electron-Impact Ionization Of H₂ And N₂ Molecules, Zehra Nur Ozer, Hari Chaluvadi, Don H. Madison, Mevlut Dogan

Physics Faculty Research & Creative Works

We have studied electron impact ionization of H₂ and N₂ molecules at intermediate energies to look for possible two center interference effects experimentally and theoretically. Here we report a study of the interference factor I for 250 eV electron-impact ionization. The experimental measurements are performed using a crossed-beam-type electron-electron coincidence spectrometer and theoretical calculations are obtained using the Molecular Three Body Distorted Wave Approximation (M3DW). We found that the I-factor demonstrated strong evidence for two-center interference effects for both H₂ and N₂. We also found that the I-factor is more sensitive to projectile angular scans …