Digital Commons Network^™

Agricultural Conservation Practice Effectiveness: Impacts Measured In The Outlet Larkin Creek Watershed In Northeastern Arkansas, Sarah Katherine Vogt

Student Theses and Dissertations

In an effort to control nonpoint source pollution, conservation practices are used by farmers. Outlet Larkin Creek Watershed was used to determine the effectiveness of agricultural conservation practices by measuring water quality parameters and comparing the percent reduction by the BMP tool (Merriman et al. 2009). The watershed is located in northeastern Arkansas as a subwatershed to the L’Anguille River Watershed. Weekly water samples were taken for water quality analysis prior to (2010) and after (2012-2014) conservation practices were implemented. Analyses were conducted with water quality parameters as well as aquatic and sediment toxicity bioassays. Overall, results of this study …

Trna-Derived Short Non-Coding Rna As Interacting Partners Of Argonaute Proteins., Megumi Shigematsu, Yohei Kirino, Phd

Computational Medicine Center Faculty Papers

The advent of next-generation sequencing technologies has not only accelerated findings on various novel non-coding RNA (ncRNA) species but also led to the revision of the biological significance and versatility of fundamental RNA species with canonical function, such as transfer RNAs (tRNAs). Although tRNAs are best known as adapter components of translational machinery, recent studies suggest that tRNAs are not always end products but can further serve as a source for short ncRNAs. In many organisms, various tRNA-derived ncRNA species are produced from mature tRNAs or their precursor transcripts as functional molecules involved in various biological processes beyond translation. In …

Nitric Oxide-Releasing Aspirin Suppresses Nf-Κb Signaling In Estrogen Receptor Negative Breast Cancer Cells In Vitro And In Vivo, Niharika Nath, Mitali Chattopadhyay, Deborah B. Rodes, Anna Nazarenko, Ravinder Kodela, Khosrow Kashfi

Publications and Research

Estrogen receptor negative (ER(−)) breast cancer is aggressive, responds poorly to current treatments and has a poor prognosis. The NF-κB signaling pathway is implicated in ER(−) tumorigenesis. Aspirin (ASA) is chemopreventive against ER(+) but not for ER(−) breast cancers. Nitric oxide-releasing aspirin (NO-ASA) is a safer ASA where ASA is linked to an NO-releasing moiety through a spacer. In vitro, we investigated anti-proliferation effects of NO-ASA (para- and meta-isomers) against ER(−) breast cancer cells MDA-MB-231 and SK-BR-23, effects on NF-κB signaling, and reactive oxygen species by standard techniques. In vivo, effects of NO-ASA were evaluated in a mouse xenograft model …

Moving Toward Interaction: Epistemic Injustice, Julia Kristeva, And Disability, Joshua R. Dohmen

Electronic Theses and Dissertations Archive

This dissertation argues that the discourse of epistemic injustice and Julia Kristeva's oeuvre offer important insights into disability oppression, and that interaction is a promising form of resistance. "Interaction" as used here, is a term adopted from both Kristeva and José Medina to signify a social relation in which persons or groups come into contact while the specificity of each party is maintained. Thus, interaction is defined in contrast to integration. In the first chapter I argue that institutionalization, medicalization, and cultural anxieties about mental disability constitute and cause epistemic injustices against disabled subjects. I then show why epistemic interaction, …

Children's Responses To Cooperative And Competitive Games: A Person X Situation Analysis, Thomas David Mulderink

Theses and Dissertations

This dissertation examined the relations between goal structure, task-completion order, time, and individual differences in agreeableness for school-aged children completing a tower building task. The tower building task (Graziano et al., 1997) allows for the study of in-game behavior during competitive and cooperative tasks with a similar structure. Children completed a total of 13-trials (six per goal structure) under two different goal structures in order to observe changes both prosocial and destructive behaviors over time. Results revealed that children engage in more destructive behaviors over time under contrient goal structure conditions after working together relative to groups that completed contrient …

Targeting Neddylation Induces Dna Damage And Checkpoint Activation And Sensitizes Chronic Lymphocytic Leukemia B Cells To Alkylating Agents, C Paiva, J C. Godbersen, A Berger, J R. Brown, A V. Danilov

Dartmouth Scholarship

Microenvironment-mediated upregulation of the B-cell receptor (BCR) and nuclear factor-κB (NF-κB) signaling in CLL cells resident in the lymph node and bone marrow promotes apoptosis evasion and clonal expansion. We recently reported that MLN4924 (pevonedistat), an investigational agent that inhibits the NEDD8-activating enzyme (NAE), abrogates stromal-mediated NF-κB pathway activity and CLL cell survival. However, the NAE pathway also assists degradation of multiple other substrates. MLN4924 has been shown to induce DNA damage and cell cycle arrest, but the importance of this mechanism in primary neoplastic B cells has not been studied. Here we mimicked the lymph node microenvironment using CD40 …

Greatness, Don Wall

Manuscripts

No abstract provided.

A Gift Of Christmas, Anne Szathowski

Manuscripts

No abstract provided.

Entire Issue Volume 3, Number 4

The Primary Source

Complete issue of Vol. 3, No. 4 of The Primary Source.

Red Teaming: Agroterrorism, Stephen M. Parke

Strategic Informer: Student Publication of the Strategic Intelligence Society

No abstract provided.

The Corporatization Of Academic Research: Whose Interests Are Served?, Risa L. Lieberwitz

Akron Law Review

The following article is the text of a speech given at the Association of American Law Schools annual meeting in January 2005, which has been edited and footnoted for publication in the Akron Law Review.

Food Security, Depression And Quality Of Life In Northern Plains Indians, Jacqueline S. Gray, Kevin Gonzaga, James G. Penland, Henry C. Lukaski, Patty Stensland

Journal of Indigenous Research

Major health disparities, high levels of poverty and food insecurity exist in many Native American and Alaskan Native (AI/AN) communities. Relatively little research has been done on these issues and possible relationships between them. A research program was designed with the objective of exploring the relationships between these various issues, if any existed, in one sub-group of AI/AN. In the study, the incidence of food insecurity was determined in a convenience sample of Northern Plains Indians (NPI) and correlated with measures of physical and mental health, body composition, quality of life, cultural identification and dietary intakes. Participants were 458 adult …

An Indigenous Epistemological Approach To Promote Health Through Effective Knowledge Translation, Selvi Roy, Barbara Campbell

Journal of Indigenous Research

Through indigenous epistemologies a holistic health framework is promoted and indigenous concepts like two-eyed seeing offer critical decolonizing conduits for knowledge translation and enhanced health outcomes. Yet, in health care settings dominance of scientific research-based evidence downplays tacit knowledge. For enhanced health outcomes in indigenous community settings, effective knowledge translation is essential through synthesis of research-based explicit knowledge and tacit know-how adapted to local needs. This paper discusses essential characteristics of effective knowledge translation practices, and presents two examples of best practices of knowledge translation in indigenous contexts.

The Fox Is Guarding The Henhouse: Enhancing The Role Of The Epa In Fonsi Determinations Pursuant To Nepa, Wendy B. Davis

Akron Law Review

This article suggests an enhanced role for the EPA and the other agencies that have authority to protect our natural resources, including the FWS, NPS, and others. These agencies should have authority to evaluate the environmental assessments leading to a FONSI and require preparation of an EIS pursuant to NEPA. This paper also suggests that these agencies need more authority in the substantive decision of choice of an alternative action pursuant to the EIS, and the determination of whether the proposed action should proceed based on the conclusions in the EIS. This could be accomplished with an amendment to the …

We Are...Marshall, July 8, 2015, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Burn Injury Alters The Intestinal Microbiome And Increases Gut Permeability And Bacterial Translocation, Zachary M. Earley, Suhail Akhtar, Stefan J. Green, Ankur Naqib, Omair Khan '15, Abigail R. Cannon, Adam M. Hammer, Niya L. Morris, Xiaoling Li, Joshua M. Eberhardt, Richard L. Gamelli, Richard H. Kennedy, Mashkoor A. Choudhry

Student Publications & Research

Sepsis remains one of the leading causes of death in burn patients who survive the initial insult of injury. Disruption of the intestinal epithelial barrier has been shown after burn injury; this can lead to the translocation of bacteria or their products (e.g., endotoxin) from the intestinal lumen to the circulation, thereby increasing the risk for sepsis in immunocompromised individuals. Since the maintenance of the epithelial barrier is largely dependent on the intestinal microbiota, we examined the diversity of the intestinal microbiome of severely burned patients and a controlled mouse model of burn injury. We show that burn injury induces …

Bats Swarm Where They Hibernate: Compositional Similarity Between Autumn Swarming And Winter Hibernation Assemblages At Five Underground Sites, Jaap Van Schaik, René Janssen, Thijs Bosch

KIP Articles

During autumn in the temperate zone of both the new and old world, bats of many species assemble at underground sites in a behaviour known as swarming. Autumn swarming behaviour is thought to primarily serve as a promiscuous mating system, but may also be related to the localization and assessment of hibernacula. Bats subsequently make use of the same underground sites during winter hibernation, however it is currently unknown if the assemblages that make use of a site are comparable across swarming and hibernation seasons. Our purpose was to characterize the bat assemblages found at five underground sites during both …

Sugar-Induced Cephalic-Phase Insulin Release Is Mediated By A T1r2+T1r3-Independent Taste Transduction Pathway In Mice, John I. Glendinning, Sarah Stano, Marlena Holter, Tali Azenkot, Olivia Goldman, Robert F. Margolskee, Joseph R. Vasselli, Anthony Sclafani

Publications and Research

Sensory stimulation from foods elicits cephalic phase responses, which facilitate digestion and nutrient assimilation. One such response, cephalic-phase insulin release (CPIR), enhances glucose tolerance. Little is known about the chemosensory mechanisms that activate CPIR. We studied the contribution of the sweet taste receptor (T1r2+T1r3) to sugar-induced CPIR in C57BL/6 (B6) and T1r3 knockout (KO) mice. First, we measured insulin release and glucose tolerance following oral (i.e., normal ingestion) or intragastric (IG) administration of 2.8 M glucose. Both groups of mice exhibited a CPIR following oral but not IG administration, and this CPIR improved glucose tolerance. Second, we examined the specificity …

Adverse Home Environments And Its Influence On Academic Achievement, John Chillem

Theses and Dissertations

Higher incidences of academic deficiency resulting from previous adverse circumstances in the home environment were investigated. A review of Bronfrenbrenner's Ecological Systems Theory illustrated the impact of the home environment on a child's development which can greatly influence academic achievement in later years. A vast collection of literature was compiled and presented to shed insight on implications surrounding adverse home environments. The current study examined associations between college students' retrospective ratings using the validated Risky Family Questionnaire and their concurrent academic achievement. The specific measures of distress in home environments under consideration included family conflict, parental divorce, inadequate parenting styles, …

Inferring Interaction Type In Gene Regulatory Networks Using Co-Expression Data, Pegah Khosravi, Vahid H. Gazestani, Leila Pirhaji, Brian Law, Mehdi Sadeghi, Bahram Goliaei, Gary D. Bader

Publications and Research

Background

Knowledge of interaction types in biological networks is important for understanding the functional organization of the cell. Currently information-based approaches are widely used for inferring gene regulatory interactions from genomics data, such as gene expression profiles; however, these approaches do not provide evidence about the regulation type (positive or negative sign) of the interaction.

Results

This paper describes a novel algorithm, “Signing of Regulatory Networks” (SIREN), which can infer the regulatory type of interactions in a known gene regulatory network (GRN) given corresponding genome-wide gene expression data. To assess our new approach, we applied it to three different benchmark …

Volume 52, Number 47: July 08, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

Toll-Like Receptors And Dectin-1, A C-Type Lectin Receptor, Trigger Divergent Functions In Cns Macrophages, John C. Gensel, Yan Wang, Zhen Guan, Kyle A. Beckwith, Kaitlyn J. Braun, Ping Wei, Dana M. Mctigue, Phillip G. Popovich

Spinal Cord and Brain Injury Research Center Faculty Publications

Spinal cord injury (SCI) activates macrophages, endowing them with both reparative and pathological functions. The mechanisms responsible for these divergent functions are unknown but are likely controlled through stochastic activation of different macrophage receptor subtypes. Various danger-associated molecular patterns released from dying cells in the injured spinal cord likely activate distinct subtypes of macrophage pattern recognition receptors, including bacterial toll-like receptors (TLRs) and fungal C-type lectin receptors (e.g., dectin-1). To determine the in vivo consequences of activating these receptors, ligands specific for TLR2 or dectin-1 were microinjected, alone or in combination, into intact spinal cord. Both ligands elicit a florid …

The Quantum Efficiency Of Cdse Semiconducting Nanocrystals, Charles Bledsoe

Undergraduate Theses

CdSe molecules are semiconducting nanocrystals that absorb visible light and emit broad wavelengths of light in response. They utilize electromagnetic radiation not only for emitting broad wavelengths of visible light, but for fluorescence, conducting electricity, and vibrational relaxation. The Thermal Lensing technique (TL) can be used to study the lifetimes of the excited state transitions and the various nonradiative processes molecules can undergo in order to better understand the excited state dynamics of semiconducting nanocrystals, and in turn, better understand how these molecules may be applied in solar cells, lasers, and fluorescence labeling. Using known methods, four samples of CdSe …

Implicit Bias And Capital Decision-Making: Using Narrative To Counter Prejudicial Psychiatric Labels, Sean O'Brien, Kathleen Wayland

Faculty Works

Overreliance on psychiatric diagnostic labels in the defense of death penalty cases risks triggering prejudicial associations in the minds of decision-makers. This article emphasizes the importance of developing a mitigating counter-narrative of the defendant’s life story, based on an extensive longitudinal and developmental investigation of the defendant and his family’s life trajectory. It is the client’s life story, not diagnostic labels, that reveals his humanity. Cognitive psychology provides a useful framework for explaining human perceptions, and how implicit or explicit biases can interfere with the objective interpretation of data in ways that affect judgment and behavior.

Editorial: Phosphoinositides And Their Phosphatases: Linking Electrical And Chemical Signals In Biological Processes, Susy C. Kohout, Carlos A. Villalba-Galea

School of Pharmacy Faculty Articles

No abstract provided.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Dr. Jean Bartels Named Interim President of Georgia Southern

Pre-Med Student Researching Environmental Contaminants In Alligators, University Communications Illinois Wesleyan University

News and Events (Discontinued Series)

No abstract provided.

Characteristics Of A Novel Treatment System For Linear Accelerator–Based Stereotactic Radiosurgery, Ning Wen, Haisen Li, Kwang Song, Karen Chin-Snyder, Yujiao Qin, Jinkoo Kim, Maria Bellon, Misbah Gulam, Stephen Gardner, Anthony Doemer, Suneetha Devpura, James Gordon, Indrin Cherry, Farzan Siddiqui, Munther Ajlouni, Robert Pompa, Zane Hammoud, Michael Simoff, Steven Kalkanis, Benjamin Movsas, M. Salim Siddiqui

Internal Medicine Faculty Publications

The purpose of this study is to characterize the dosimetric properties and accuracy of a novel treatment platform (Edge radiosurgery system) for localizing and treating patients with frameless, image-guided stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Initial measurements of various components of the system, such as a comprehensive assessment of the dosimetric properties of the flattening filter-free (FFF) beams for both high definition (HD120) MLC and conical cone-based treatment, positioning accuracy and beam attenuation of a six degree of freedom (6DoF) couch, treatment head leakage test, and integrated end-to-end accuracy tests, have been performed. The end-to-end test of the …

Neuronal Interferon Signaling Is Required For Protection Against Herpes Simplex Virus Replication And Pathogenesis, Pamela C. Rosato, David A. Leib

Dartmouth Scholarship

Interferon (IFN) responses are critical for controlling herpes simplex virus 1 (HSV-1). The importance of neuronal IFN signaling in controlling acute and latent HSV-1 infection remains unclear. Compartmentalized neuron cultures revealed that mature sensory neurons respond to IFNβ at both the axon and cell body through distinct mechanisms, resulting in control of HSV-1. Mice specifically lacking neural IFN signaling succumbed rapidly to HSV-1 corneal infection, demonstrating that IFN responses of the immune system and non-neuronal tissues are insufficient to confer survival following virus challenge. Furthermore, neurovirulence was restored to an HSV strain lacking the IFN-modulating gene, γ34.5, despite its expected …

Convalescent Serum Therapy As Rapid Advance Treatment For Ebola In West Africa, J Bankole Thompson Md, Phd, Patricia F. Mejabi Msc., Olugbenga O. Mejabi Phd, S Ahmed Tejan-Sie Md

International Journal of African Development

The 2014 public health crisis in Guinea, Liberia, and Sierra Leone has brought Ebola Viral Disease (EVD) to everyone’s attention. Discovered in 1976, this deadly disease infrequently struck in remote areas of Africa. This article will critically review the literature and describe the pathobiology, transmission, signs and symptoms, diagnosis, treatment, and prevention of EVDwhich, was predicted by the Centers for Disease Control to potentially infect 1.4 million persons in Liberia and Sierra Leone by January 2015 (“Questions and Answers”, 2014). Thankfully this worst case scenario did not occur and we may be experiencing natural burn out of the outbreak along …