Digital Commons Network^™

Analysis Of Protease Activity Using Membrane- Coated Biomimetic Microspheres, Jennifer M. Fetzer

Biomedical Engineering ETDs

Poisoning by Botulinum Neurotoxins (BoNTs) leads to the severe neuroparalytic illness known as botulism, which is characterized by flaccid paralysis, respiratory failure, and death. BoNTs are the most acutely toxic substances on the planet, so detection at physiologically relevant concentrations is difficult. Because current treatments for botulism cannot reverse existing paralysis, rapid detection is key, and current diagnostic techniques are not meeting this need. We have developed a flow-based assay platform that allows for detection of the Light Chain of BoNT/A as well as a means to study the action of the toxin on its protein substrate in a system …

Imaging Tumor Acidity: Ph-Low Insertion Peptide Probe For Optoacoustic Tomography, Yana Reshetnyak

Physics Faculty Publications

Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-Low Insertion Peptide (pHLIP) conjugated to near infrared fluorescent dye. It was proved that tumor targeting is a pH-dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers.

Mccarthy Quoted On Invasive Species Kudzu, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Dna-Pkcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression And Metastasis., Jonathan F Goodwin, Vishal Kothari, Justin M Drake, Shuang Zhao, Emanuela Dylgjeri, Jeffry L. Dean, Matthew J. Schiewer, Christopher Mcnair, Jennifer K. Jones, Alvaro Aytes, Michael S. Magee, Adam E. Snook, Ziqi Zhu, Robert Den, Ruth C. Birbe, Leonard G. Gomella, Nicholas A. Graham, Ajay A. Vashisht, James A. Wohlschlegel, Thomas G. Graeber, R. Jeffrey Karnes, Mandeep Takhar, Elai Davicioni, Scott A. Tomlins, Cory Abate-Shen, Nima Sharifi, Owen N. Witte, Felix Y. Feng, Karen E. Knudsen

Department of Cancer Biology Faculty Papers

Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo interrogation demonstrate that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis. Accordingly, suppression of DNA-PKcs inhibits tumor metastases. Clinical assessment revealed that DNA-PKcs is significantly elevated in advanced disease and independently predicts for metastases, recurrence, and reduced overall survival. Further investigation demonstrated that DNA-PKcs in advanced tumors is highly activated, independent of DNA damage indicators. Combined, these findings reveal unexpected DNA-PKcs functions, identify DNA-PKcs as a potent driver …

Optimum 3d Matrix Stiffness For Maintenance Of Cancer Stem Cells Is Dependent On Tissue Origin Of Cancer Cells, Esmaiel Jabbari, Samaneh K. Sarvestani, Leily Daneshian, Seyedsina Moeinzadeh

Faculty Publications

Introduction

The growth and expression of cancer stem cells (CSCs) depend on many factors in the tumor microenvironment. The objective of this work was to investigate the effect of cancer cells’ tissue origin on the optimum matrix stiffness for CSC growth and marker expression in a model polyethylene glycol diacrylate (PEGDA) hydrogel without the interference of other factors in the microenvironment.

Methods

Human MCF7 and MDA-MB-231 breast carcinoma, HCT116 colorectal and AGS gastric carcinoma, and U2OS osteosarcoma cells were used. The cells were encapsulated in PEGDA gels with compressive moduli in the 2-70 kPa range and optimized cell seeding density …

Faunal Data For Pleistocene-Holocene Archaeological Sites In Thailand And Peninsular Malaysia, Cyler Conrad

Anthropology Datasets

Faunal data, R script and figures are provided as a zip file (OQ_SEA-master.zip) created from the repository hosted at https://github.com/cylerc/OQ_SEA. Within this zip file there is a folder called “data,” where all summary and raw faunal counts are included. Original citation information from which this data is derived is included in the Readme document. Tables are presented as number of identified specimens (NISP), minimum number of individuals (MNI) or presence/absence data within each .csv. Column headings represent stratigraphic units or contexts that the original publications use. x=classification present in context/unit. In Thailand, zooarchaeological data is included from Spirit Cave, Banyan …

The Mouse That Trolled: The Long And Tortuous History Of A Gene Mutation Patent That Became An Expensive Impediment To Alzheimer's Research, Tania Bubela, Saurabh Vishnubhakat, Robert Cook-Deegan

Faculty Scholarship

This case study presents the tale of the academic discovery of a rare mutation for early-onset Alzheimer's disease that was patented by a sole inventor and licensed to a non-practicing entity (NPE), the Alzheimer's Institute of America (AIA). Our aims are (1) to relate this story about patents, research tools, and impediments to medical progress, and (2) to inform ongoing debates about how patents affect research, disposition of university inventions, and the distribution of benefits from publicly funded research. We present an account of the hunt for Alzheimer's genes, their patenting, assignment, and enforcement based on literature, litigation records and …

The Role Of Philornis Downsi In Avian Disease Transmission In The Galápagos Islands, Courtney Lauren Pike

Theses

Philornis downsi is a dipteran fly species known to parasitize passerine birds in the Neotropics. P. downsi is speculated to be a recently introduced species in Galápagos Islands, so it is important to understand its effects on the archipelago’s native and endemic avian species. Avian parasites and pathogens have been previously reported in the Galápagos, leading the Galápagos National Park and the Charles Darwin Foundation to focus efforts on the study and management of potential avian disease vectors. The main goal of this study was to determine whether P. downsi is a host for avian parasites and pathogens found in …

Evaluating The Validity Of Self-Reported Smoking In Mexican Adolescents, María Del Carmen Valladolid-López, Tonatiuh Barrientos-Gutiérrez, Luz Myriam Reynales-Shigematsu, Jim Thrasher, Ingris Peláez-Ballestas, Eduardo Lazcano-Ponce, Mauricio Hernández-Ávila

Faculty Publications

Objectives We aimed to evaluate the validity of the self-reported smoking indicator used in the Global Youth Tobacco Survey (GYTS).

Setting 43 middle and high-school classrooms from 26 schools were selected from Mexico City and Cuernavaca, Morelos.

Participants A total of 1257 students provided both a questionnaire and a urine sample.

Primary and secondary outcome Sensitivity and specificity of self-reported smoking compared to urinary cotinine. Validity indices were evaluated by subgroups of gender, social acceptability of smoking (ie, smoking parents or friends) and smoking frequency.

Results Sensitivity and specificity for current smoking were 93.2% and 81.7%, respectively. Validity indices remained …

Dumbbell-Pcr: A Method To Quantify Specific Small Rna Variants With A Single Nucleotide Resolution At Terminal Sequences., Shozo Honda, Yohei Kirino

Computational Medicine Center Faculty Papers

Recent advances in next-generation sequencing technologies have revealed that cellular functional RNAs are not always expressed as single entities with fixed terminal sequences but as multiple isoforms bearing complex heterogeneity in both length and terminal sequences, such as isomiRs, the isoforms of microRNAs. Unraveling the biogenesis and biological significance of heterogenetic RNA expression requires distinctive analysis of each RNA variant. Here, we report the development of dumbbell PCR (Db-PCR), an efficient and convenient method to distinctively quantify a specific individual small RNA variant. In Db-PCR, 5'- and 3'-stem-loop adapters are specifically hybridized and ligated to the 5'- and 3'-ends of …

State V. Bailey Clerk's Record Dckt. 43143

Not Reported

No abstract provided.

Unmanned Aerial Systems Research, Development, Education And Training At Embry-Riddle Aeronautical University, Michael P. Hickey Ph.D.

Publications

With technological breakthroughs in miniaturized aircraft-related components, including but not limited to communications, computer systems and sensors and, state-of-the-art unmanned aerial systems (UAS) have become a reality. This fast growing industry is anticipating and responding to a myriad of societal applications that will provide either new or more cost effective solutions that previous technologies could not, or will replace activities that involved humans in flight with associated risks.

Embry-Riddle Aeronautical University has a long history of aviation related research and education, and is heavily engaged in UAS activities. This document provides a summary of these activities. The document is divided …

July 13, 2015: Rummery Retreat, Seba In Spain, Summer Magazine, Saint Mary's College Of California

SMC Bulletin 2013-2020

No abstract provided.

Aspirin Triggered Resolution Phase Interaction Product D1: A Novel Treatment For Hyperoxic Acute Lung Injury, Ruan Rollin Cox, Jr.

USF Tampa Graduate Theses and Dissertations

Acute Lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are respiratory maladies that present immense clinical challenges. ALI affects 200,000 individuals annually and features a 40% mortality rate. ALI can be initiated by both pathogenic and sterile insults originating locally in the lungs or systemically. While immense research has been poured into this disease in an effort to find a therapeutic strategy, the heterogeneously diffuse nature of the disease has not yielded a cure for the disease. Death from this disease is strongly attributed to reduced gas exchange from a severely compromised alveolar-capillary barrier. The only …

My News

My News (2014-2020)

• Dr. Jean Bartels Named Interim President of Georgia Southern
• Georgia Southern Study Shows Overweight and Obese Teens Think They’re ‘Just Fine’
• Georgia Southern’s Garden of the Coastal Plain Named to Top 50 List
• Farm to Table Dinner Raises Funds, Materials for Zach S. Henderson Library

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern’s Garden of the Coastal Plain Named to Top 50 List
• Georgia Southern study shows overweight and obese teens think they’re ‘just fine’

Ordinance On State Assets Management Strategy (Odsuknd), Slovenia

Documents

No abstract provided.

Microwave-Assisted Synthesis Of Ss-Amino Alcohols, Hinalbahen Sanket Desai

Master's Theses and Doctoral Dissertations

ß-amino alcohols are common substructures in many biologically active compounds and can also be used as catalysts for asymmetric reactions. One common method for forming these moieties is by ring opening of unsymmetrical epoxides using amines via a substitution reaction. However, the majority of these methods requires excess of reagents, inorganic initiators, and/or extended reaction times. We have developed an efficient, regioselective route to synthesize amino alcohols via microwave-assisted aminolysis of several hindered and unhindered epoxides using amine nucleophiles of varying strengths. Microwave reactions can be done without Lewis acids or promoters, even for the most hindered trisubstituted epoxides. In …

Nervous System Development In Lecithotrophic Larval And Juvenile Stages Of The Annelid Capitella Teleta, Néva P. Meyer, Allan Carrillo-Baltodano, Richard E. Moore, Elaine C. Seaver

Biology

Background: Reconstructing the evolutionary history of nervous systems requires an understanding of their architecture and development across diverse taxa. The spiralians encompass diverse body plans and organ systems, and within the spiralians, annelids exhibit a variety of morphologies, life histories, feeding modes and associated nervous systems, making them an ideal group for studying evolution of nervous systems. Results: We describe nervous system development in the annelid Capitella teleta (Blake JA, Grassle JP, Eckelbarger KJ. Capitella teleta, a new species designation for the opportunistic and experimental Capitella sp. I, with a review of the literature for confirmed records. Zoosymposia. 2009;2:25-53) using …

Resolving Deep Relationships Of Pacmad Grasses: A Phylogenomic Approach, Joseph L. Cotton, William P. Wysocki, Lynn G. Clark, Scot A. Kelchner, J. Chris Pires, Patrick P. Edger, Dustin Mayfield-Jones, Melvin R. Duvall

Faculty Articles, Papers, and Other Scholarship

Background Plastome sequences for 18 species of the PACMAD grasses (subfamilies Panicoideae, Aristidoideae, Chloridoideae, Micrairoideae, Arundinoideae, Danthonioideae) were analyzed phylogenomically. Next generation sequencing methods were used to provide complete plastome sequences for 12 species. Sanger sequencing was performed to determine the plastome of one species, Hakonechloa macra, to provide a reference for annotation. These analyses were conducted to resolve deep subfamilial relationships within the clade. Divergence estimates were assessed to determine potential factors that led to the rapid radiation of this lineage and its dominance of warmer open habitats. Results New plastomes were completely sequenced and characterized for 13 PACMAD …

Bibliometric Study Of Literature On Leptospirosis For The Period 2006-2013, Kotti Thavamani

Library Philosophy and Practice (e-journal)

This paper attempts to assess the literary output in the field of Leptospirosis productivity for the period 2006-2013. Statistical analysis has been carried out using SPSS and other relevant measures. It shows that the year wise distributions of Leptospirosis records are increasing year after year except the years 2008, 2009 and 2011. It shows that 88.76% articles are of English language and followed by Spanish and French languages. It is observed that USA has contributed the highest number of records in the study period. Next major contribution belongs to England, Netherlands and India. India has the 4th position among the …

An Uncommon Presentation Of Amyloidosis, Brandon Kujawski, Ms3, Drew Johnson, Ms3, Kushan Radadia, Ms4, Eric Feduska, Md, Robert Ford, Md, Guldeep Uppal, Md, Mariam Kabir, Md, Phd, John Stewart, Md

The Medicine Forum

Introduction

AL amyloidosis is a rare disease, with only 1200-3200 new cases in the US per year.1 Two-thirds of patients are male; presentation typically occurs after age fifty.1,2,3 Amyloid can involve the kidneys (74%), heart (60-90%), liver (27%), peripheral nervous system (22%), and carpal tunnel (20%).3 We describe an atypical presentation of AL amyloidosis and highlight the importance of recognizing this disease in patients with systemic signs.

The Epa Is Only “Sort Of” Permitted To Regulate Greenhouse Gases Under The Clean Air Act: How Utility Air Regulatory Group V. Epa Shows The Supreme Court Is Still Hot And Cold On Climate Change, Kristen Curley

Touro Law Review

No abstract provided.

Adjudicating Cases Involving Adolescents In Suffolk County Criminal Courts, Honorable Fernando Camacho

Touro Law Review

No abstract provided.

Obituaries

Colby Magazine

No abstract provided.

Class Notes

Colby Magazine

No abstract provided.

Media

Colby Magazine

Terry Winters: Prints: 1999-2014, by Elizabeth Finch (Colby College Museum of Art) and Michael Semff

French Colonial Soldiers in German Captivity during World War II, by Raffael Scheck (History)

Photography, History, Difference, by Tanya Sheehan (Art)

Photography and Its Origins, edited by Tanya Sheehan (Art) and Andrés Mario Zervigón

Marine Historical Ecology in Conservation, by Loren McClenachan (Environmental Studies)

Montaigne, écrivain de la conciliation, by Valérie M. Dionne (French)

Haunted (The Arnaud Legacy), by Erika Mailman '91

Lean on Jesus: Christian Women in the Workplace, by Susie Yovic Hoeller '73

Find Your Voice: A Woman's Call to Action, by Tabby …

Feedback

Colby Magazine

After "Hidden Child" Saga, Much More to Learn

On Library Books and Strider's Serendipity

Recognize Journalists Killed by Terrorists

Long Live the Blackboard

Colby Conversation via Social Media

On Professor Tanya Sheehan and "The Anatomy of Art"

Reactions to "#Blizzardof2015/Campus closed for the first time since the Ice Storm of '98"

Posted 1/27

The Intersection Of Art And Medicine: Tanya Sheehan Breaks Down The Boundaries Between Disciplines, Gerry Boyle

Colby Magazine

Tanya Sheehan arrived at Georgetown University intending to become a medical doctor. She aced her organic chemistry lab section, eventually was turned off by the rote memorization the program emphasized, and then discovered art history and film studies. "That changed everything," she said, "but I never forgot about science and medicine."

Full Issue

Colby Magazine

Colby Magazine vol. 104, no. 1 (Spring 2014): full issue