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Autophagy Is Induced Upon Platelet Activation And Is Essential For Hemostasis And Thrombosis, Madhu M. Ouseph, Yunjie Huang, Meenakshi Banerjee, Smita Joshi, Laura Macdonald, Yu Zhong, Huijuan Liu, Xianting Li, Binggang Xiang, Guoying Zhang, Masaaki Komatsu, Zhenyu Yue, Zhenyu Li, Brian Storrie, Sidney W. Whiteheart, Qing Jun Wang

Molecular and Cellular Biochemistry Faculty Publications

Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is implicated in a broad spectrum of human diseases. Its role in platelet function has only recently been examined. Our biochemical and imaging studies demonstrate that the core autophagy machinery exists in platelets, and that autophagy is constitutively active in resting platelets. Moreover, autophagy is induced upon platelet activation, as indicated by agonist-induced loss of the autophagy marker LC3II. Additional experiments, using inhibitors of platelet activation, proteases, and lysosomal acidification, as well as platelets from knockout mouse strains, show that agonist-induced LC3II loss is a consequence of platelet signaling …

Educational Policies Committee Agenda, September 3, 2015, Utah State University

Educational Policies Committee

• Subcommittee Reports
• Curriculum Subcommittee
• Course Approvals
• Program Proposals
• Academic Standards Subcommittee
• General Education Subcommittee

Study Compares Hospitalized Infection Risk For Biologics In Ra, Staff

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No abstract provided.

Spectroscopic Separation Of Čerenkov Radiation In High-Resolution Radiation Fiber Dosimeters, Arash Darafsheh, Rongxiao Zhang, Stephen Chad Kanick, Brian W. Pogue, Jarod C. Finlay

Dartmouth Scholarship

We have investigated Čerenkov radiation generated in phosphor-based optical fiber dosimeters irradiated with clinical electron beams. We fabricated two high-spatial resolution fiber-optic probes, with 200 and 400  μm core diameters, composed of terbium-based phosphor tips. A generalizable spectroscopic method was used to separate Čerenkov radiation from the transmitted signal by the fiber based on the assumption that the recorded signal is a linear superposition of two basis spectra: characteristic luminescence of the phosphor medium and Čerenkov radiation. We performed Monte Carlo simulations of the Čerenkov radiation generated in the fiber and found a strong dependence of the recorded Čerenkov …

The Alestle - Vol. 68 No. 3 - 09/03/2015, Southern Illinois University Edwardsville

The Alestle

Vol. 68 No. 3

Inspiring Action: Measuring The Effect Of Motivational Frames On Social Movement Mobilization, Rebecca Louise Smith

Dissertations and Theses

In order to probe how social movement messages foster participant mobilization, this study utilized an experimental design to investigate collective action frames, core messaging tasks that define problems, assign blame, convey a plan of action, and inspire participation. The study compared the effects of climate change messages that contain motivational frames with those that do not, incorporating the influence of resonance, and exposure to competing and counter frames. Results revealed that motivational frames contributed to mobilization, especially intention to act, under conditions of resonance and with exposure to counter frames. Salience primed participants to respond to motivational frames, however for …

Neurobiology Of Seasonal Life-History Transitions, Ashley Rae Lucas

Dissertations and Theses

Many animals exhibit seasonal changes in life-history stages, and these seasonal transitions are often accompanied by dramatic switches in behavior. While the neuroendocrine mechanisms that regulate such behavioral transitions are poorly understood, arginine vasotocin (AVT) and neuropeptide Y (NPY) are excellent candidates because they regulate reproductive and feeding behavior, respectively. In this study, I asked if seasonal changes in AVT and/or NPY are concomitant with spring migration away from the breeding grounds, as male and female red-sided garter snakes (Thamnophis sirtalis parietalis) are transitioning from reproductive to non-reproductive behavior during this time. To address this question, I collected …

What Difference Does It Make? An Essay Review Of Beyond Versus: The Struggle To Understand The Interaction Of Nature And Nurture; James Tabery; Mit Press: Cambridge, Ma, 2014, Peter J. Taylor

Working Papers on Science in a Changing World

Beyond versus makes its contribution to the thriving industry of books that clarify or recast nature-nurture issues through seven conceptual moves. The first is to posit a divide between sociological and philosophical inquiry. As Tabery depicts them, commentators on the science invoked in nature-nurture debates often focus on the racist or other political views of disputants or on their flawed understanding of scientific concepts. Tabery, in contrast, as a philosopher of science, explains past and present disagreements as stemming from “a disagreement concerning how explanation works in science.” (The other moves include explanatory and terminological divides, connecting associations to mechanisms, …

Review Of Fluorescence Guided Surgery Visualization And Overlay Techniques, Jonathan T. Elliott, Alisha V. Dsouza, Scott C. Davis, Jonathan D. Olson, Keith Paulsen, David Roberts, Brian Pogue

Dartmouth Scholarship

In fluorescence guided surgery, data visualization represents a critical step between signal capture and display needed for clinical decisions informed by that signal. The diversity of methods for displaying surgical images are reviewed, and a particular focus is placed on electronically detected and visualized signals, as required for near-infrared or low concentration tracers. Factors driving the choices such as human perception, the need for rapid decision making in a surgical environment, and biases induced by display choices are outlined. Five practical suggestions are outlined for optimal display orientation, color map, transparency/alpha function, dynamic range compression, and color perception check.

The Role Of Perlecan And Endorepellin In The Control Of Tumor Angiogenesis And Endothelial Cell Autophagy., Stephen Douglass, Atul Goyal, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

During tumor growth and angiogenesis there is a dynamic remodeling of tissue architecture often accompanied by the release of extracellular matrix constituents full of biological activity. One of the key constituents of the tumor microenvironment is the large heparan sulfate proteoglycan perlecan. This proteoglycan, strategically located at cell surfaces and within basement membranes, is a well-defined pro-angiogenic molecule when intact. However, when partially processed by proteases released during cancer remodeling and invasion, the C-terminal fragment of perlecan, known as endorepellin, has opposite effects than its parent molecule. Endorepellin is a potent inhibitor of angiogenesis by exerting a dual receptor antagonism …

A Bomb Set To Drop: Parthenogenetic Marmorkrebs For Sale In Ireland, A European Location Without Non-Indigenous Crayfish, Zen Faulkes

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Ireland is one of the few locations in Europe where non-indigenous North American crayfish species have not been introduced, and is a refuge for endangered white-clawed crayfish, Austropotamobius pallipes (Lereboullet, 1858). The parthenogenetic crayfish species Marmorkrebs, Procambarus fallax f. virginalis (Hagen, 1870), is sold in the pet trade in Ireland within the recorded range of A. pallipes. Marmorkrebs risk being introduced into Irish waters, where they could threaten A. pallipes populations, particularly as a vector for crayfish plague.

Modification Of Lrb Complex Members In Arabidopsis Thaliana, Carly Wiersma, Matthew Christians

Student Summer Scholars Manuscripts

Plants can adapt and respond to their environment in a variety of ways. They have evolved sophisticated mechanisms, specifically, to respond to light. The LRBs (Light Response BTB) are E3 ligases, which are proteins involved in the degradation of other proteins in light. The LRBs are also involved in the degradation of Frigida (FRI), a protein that regulates flowering time. LRB is able to degrade FRI and allow the plant to flower. The mechanism that LRB employs to degrade FRI remains unknown. There is evidence that LRB attaches a protein tag to FRI and this may play a role in …

Phase Iii Study Of Pasireotide Long-Acting Release In Patients With Metastatic Neuroendocrine Tumors And Carcinoid Symptoms Refractory To Available Somatostatin Analogues, Edward M. Wolin, Barbara Jarzab, Barbro Eriksson, Thomas Walter, Christos Toumpanakis, Michael A. Morse, Paola Tomassetti, Matthias M. Weber, David R. Fogelman, John Ramage, Donald Poon, Brian Gadbaw, Jiang Li, Janice L. Pasieka, Abakar Mahamat, Fredrik Swahn, John Newell-Price, Wasat Mansoor, Kjell Öberg

Markey Cancer Center Faculty Publications

In a randomized, double-blind, Phase III study, we compared pasireotide long-acting release (pasireotide LAR) with octreotide long-acting repeatable (octreotide LAR) in managing carcinoid symptoms refractory to first-generation somatostatin analogues. Adults with carcinoid tumors of the digestive tract were randomly assigned (1:1) to receive pasireotide LAR (60 mg) or octreotide LAR (40 mg) every 28 days. Primary outcome was symptom control based on frequency of bowel movements and flushing episodes. Objective tumor response was a secondary outcome. Progression-free survival (PFS) was calculated in a post hoc analysis. Adverse events were recorded. At the time of a planned interim analysis, the data …

Risk Factors Of Pulmonary Hypertension In Brazilian Patients With Sickle Cell Anemia., Clarisse Lopes De Castro Lobo, Emilia Matos Do Nascimento, Renato Abelha, Ana Maria Mach Queiroz, Philippe Connes, Gilberto Perez Cardoso, Samir K. Ballas

Cardeza Foundation for Hematologic Research

This study was a prospective cross-sectional cohort study of 125 patients with sickle cell anemia (SS) between the ages of 16 to 60 years. Enrolled patients were followed-up prospectively for 15 months. Demographic, clinical, hematological and routine biochemical data were obtained on all patients. Six-minute walk test and Doppler Echocardiography were performed on all patients. A tricuspid regurgitant jet velocity (TRJV) < 2.5 m/sec was considered normal, 2.5 ≤ TRJV ≤ 3.0 was considered mild-moderate and > 3.0 m/sec, severe. Patients with abnormal TRJV were significantly older and more anemic, had significantly higher lactate dehydrogenase (LDH) levels, reticulocyte count and incidence of death. The logistic multimodal model implemented for the 125 patients indicated that age was …

Voting At Home Is Associated With Lower Cortisol Than Voting At The Polls, Jayme Neiman, Karl Evan Giuseffi, Kevin B. Smith, Jeffrey French, Israel Waismel-Manor, John R. Hibbing

Department of Political Science: Faculty Publications

Previous research finds that voting is a socially stressful activity associated with increases in cortisol levels. Here we extend this research by investigating whether different voting modalities have differential effects on the stress response to voting. Results from a field experiment conducted during the 2012 presidential elections strongly suggest that traditional “at the polls” voting is more stressful, as measured by increases in cortisol levels, than voting at home by mail-in ballot or engaging in comparable non-political social activities. These findings imply that increased low-stress voting options such as mail-in ballots may increase political participation among individuals who are sensitive …

Educational Policies Committee Minutes, September 3, 2015, Utah State University

Educational Policies Committee

• Subcommittee Reports
• Curriculum Subcommittee
• Course Approvals
• Program Proposals
• Academic Standards Subcommittee
• General Education Subcommittee

Curriculum Subcommittee Minutes, September 3, 2015, Utah State University

Educational Policies Committee

Introduction of Committee Members

Charge and Responsibilities of Committee

Approval of 2 April 2015 Minutes

Semester Course Approval Reviews

Program Proposals

• Creating an Associate of Science Degree Program in Agricultural Science
• Discontinuing the Food Technology Management Emphasis
• Discontinuing the Early Childhood Development Associate of Arts Degree at USU Eastern
• Offering a Minor in Behavioral Health

Other

• Utilizing Curriculog and Box

Exploring Holistic Comfort In Children Who Experience A Clinical Venipuncture Procedure, April Athena Bice

Dissertations

Children often experience the uncomfortable effects of invasive procedures as a part of primary health supervision and during times of illness. Inadequate procedural comfort management can lead to numerous lasting harmful effects including distrust of healthcare providers, future intensified pain responses, negative cognitive and emotional experiences, and psychosocial health problems (Czarnecki et al. 2011). Holistic comfort has been well documented in adult literature but little research exists on the understanding of holistic procedural comfort from the child's perspective.

The purpose of this study was to explore perspectives of children age 4 to 7 years and their caregivers regarding procedural …

Lanthorn, Vol. 50, No. 04, September 3, 2015, Grand Valley State University

Volume 50, July 13, 2015 - June 6, 2016

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Characterization Of Folic Acid And Poly(Amidoamine) Dendrimer Interactions With Folate Binding Protein: A Force-Pulling Study, Pascale R. Leroueil, Stassi Dimaggio, Abigail N. Leistra, Craig D. Blanchette

University Faculty Publications and Creative Works

Atomic force microscopy force-pulling experiments have been used to measure the binding forces between folic acid (FA) conjugated poly(amidoamine) (PAMAM) dendrimers and folate binding protein (FBP). The generation 5 (G5) PAMAM conjugates contained an average of 2.7, 4.7, and 7.2 FA per dendrimer. The most probable rupture force was measured to be 83, 201, and 189 pN for G5-FA2.7, G5-FA4.7, and G5-FA7.2, respectively. Folic acid blocking experiments for G5-FA7.2reduced the frequency of successful binding events and increased the magnitude of the average rupture force to 274 pN. The force data are interpreted as arising from a network of van der …

The George-Anne, Georgia Southern University

The George-Anne

• Opinions
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Hypoxic Regulation Of Riok3 Is A Major Mechanism For Cancer Cell Invasion And Metastasis, Dc Singleton, P Rouhi, Ce Zois, S Haider, Et Al

School of Biomedical Sciences

Hypoxia is a common feature of locally advanced breast cancers that is associated with increased metastasis and poorer survival. Stabilisation of hypoxia-inducible factor-1α (HIF1α) in tumours causes transcriptional changes in numerous genes that function at distinct stages of the metastatic cascade. We demonstrate that expression of RIOK3 (RIght Open reading frame kinase 3) was increased during hypoxic exposure in an HIF1α-dependent manner. RIOK3 was localised to distinct cytoplasmic aggregates in normoxic cells and underwent redistribution to the leading edge of the cell in hypoxia with a corresponding change in the organisation of the actin cytoskeleton. Depletion of RIOK3 expression caused …

Examining The Role Of Nef In The Resistance Of Siv–Infected Macrophages To Cd8+ T Cell Suppression, Jennifer Nina Rainho

Open Access Dissertations

SIV–specific CD8+ T cells kill SIV–infected CD4+ T cells in an MHC Class I (MHC–I) dependent manner. However, they are reportedly less efficient at killing SIV–infected macrophages. Since the viral accessory protein, Nef, has been shown to down–regulate MHC–I molecules and enhance CTL evasion in HIV–1 infected CD4+ T cells, we examined whether Nef played a role in protecting SIV–infected macrophages from killing by SIV–specific CD8+ T cells. To explore the role of Nef in CD8+ T cell evasion, we compared the ability of freshly sorted SIV–specific CD8+ T cells to readily suppress viral replication or eliminate CD4+ T cells …

Prospectus, September 2, 2015, Parkland College, Scott Barnes, Sarah Powers, Jessica Stanze, Brittany Webb, Matthew D. Moss, Jacob Kenter, Adam Vilmin, Zach Trueblood

Prospectus 2015

Foreign language enrollment decreases, Professors take center stage in faculty exhibit, Alternative buying options keep textbook costs low, Campus resources help students struggling with academics, Married professors show students how to keep an open mind, Study finds peak months for college students’ 1st drug use(AP), Director Wes Craven dies at 76(AP), Sanders says he would be prepared to use military force(AP), Cobras looking to strike this season, Men’s basketball reloading for high expectations, Parkland clubs highlighted at Student Activities Fair,

Snyder Edits Book On Hg Wells Ann Veronica, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Uc Transcript 2015-09-02, Northern Illinois University

University Council Archives

No abstract provided.

Opening Social | Biological Engineering, Usu College Of Engineering

College of Engineering News

Welcome back AGGIES! Here is to hoping your first week has been going well.

A Unique Biofilm In Human Deep Mycoses: Fungal Amyloid Is Bound By Host Serum Amyloid P Component, Melissa C. Garcia-Sherman, Tracy Lundberg, Richard E. Sobonya, Peter N. Lipke, Stephen A. Klotz

Publications and Research

Background/Objectives We have demonstrated the presence of Candida cell surface amyloids that are important in aggregation of fungi and adherence to tissue. Fungal amyloid was present in invasive human candidal infections and host serum amyloid P component (SAP) bound to the fungal amyloid. SAP is a protease-resistant glycoprotein that binds avidly to amyloid and interferes with host defence, especially against bacterial pathogens for which neutrophils are important. In this study, we investigated whether biofilm of fungal amyloid and SAP was a feature of other disseminated fungal infections. Methods Tissue specimens from 15 autopsies were systematically evaluated with multiple histochemical stains …

Uab Professor Recognized For Online Education, Staff

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No abstract provided.

September 2, 2015 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.