Digital Commons Network^™

Lipin1 Regulates Skeletal Muscle Differentiation Through Extracellular Signal-Regulated Kinase (Erk) Activation And Cyclin D Complex-Regulated Cell Cycle Withdrawal, Weihua Jiang, Jing Zhu, Xun Zhuang, Xiping Zhang, Tao Luo, Karyn Esser, Hongmei Ren

Saha Cardiovascular Research Center Faculty Publications

Lipin1, an intracellular protein, plays critical roles in controlling lipid synthesis and energy metabolism through its enzymatic activity and nuclear transcriptional functions. Several mouse models of skeletal muscle wasting are associated with lipin1 mutation or altered expression. Recent human studies have suggested that children with homozygous null mutations in the LPIN1 gene suffer from rhabdomyolysis. However, the underlying pathophysiologic mechanism is still poorly understood. In the present study we examined whether lipin1 contributes to regulating muscle regeneration. We characterized the time course of skeletal muscle regeneration in lipin1-deficient fld mice after injury. We found that fld mice exhibited smaller regenerated …

Patient-Specific Variations In Biomarkers Across Gingivitis And Periodontitis, Radhakrishnan Nagarajan, Craig S. Miller, Dolph Dawson, Mohanad Al-Sabbagh, J. L. Ebersole

Biostatistics Faculty Publications

This study investigates the use of saliva, as an emerging diagnostic fluid in conjunction with classification techniques to discern biological heterogeneity in clinically labelled gingivitis and periodontitis subjects (80 subjects; 40/group) A battery of classification techniques were investigated as traditional single classifier systems as well as within a novel selective voting ensemble classification approach (SVA) framework. Unlike traditional single classifiers, SVA is shown to reveal patient-specific variations within disease groups, which may be important for identifying proclivity to disease progression or disease stability. Salivary expression profiles of IL-1ß, IL-6, MMP-8, and MIP-1α from 80 patients were analyzed using four classification …

Influence Of Ph And Bulk Density On Carbon Dioxide Efflux In Three Urban Wetland Types, Christopher Chappell, Andra Johnson

Professional Agricultural Workers Journal

Abstract

The aim of this study was to understand soil carbon dioxide (CO₂) efflux of three different urban wetlands and how pH and bulk density relate to soil CO₂ efflux of each wetland. The three wetlands were bottomland, upland, and shrub/scrub. The study was conducted over a twenty week period using the Li-Cor 8100 “closed chamber” method to measure soil CO₂ efflux. The findings show that the bottomland wetland efflux was significantly higher than the shrub/scrub and upland wetland. The pH of shrub/scrub was significantly higher than the upland. The bulk density of the bottomland was …

Assessing The Impacts Of Inorganic And Organic Fertilizer On Crop Performance Under A Microirrigation-Plastic Mulch Regime, Niyi S. Omidire, Raymon Shange, Victor Khan, Russell Bean, Jewel Bean

Professional Agricultural Workers Journal

Abstract

This study was conducted at S & B Farm located in Eufaula, AL in 2014. The treatments were Inorganic fertilizer/“Farmer’s Mix” (NPK 13:13:13 + ammonium nitrate mixed in 3:1 ratio); Inorganic fertilizer/“Farmer’s Mix” (NPK 13:13:13 + ammonium nitrate mixed in 3:1 ratio + Bio-grow) plus microbe mix; and Organic Fertilizer – Mighty Grow (4-3-4) with a microbe mix. All fertilizers were applied prior to mulch application after which the following crops squash (Cucurbita pepo L.), cucumber (Cucumis sativus L.), and okra (Abelmoschus esculentus L. Moench) were directly seeded in a complete randomized …

Fatty Acid Transport Protein-2 Inhibitor Grassofermata/Cb5 Protects Cells Against Lipid Accumulation And Toxicity, Nipun Saini, Paul N. Black, David Montefusco, Concetta Dirusso

Department of Biochemistry: Faculty Publications

The inhibition of the fatty acid uptake into non-adipose tissues provides an attractive target for prevention of lipotoxicity leading to obesity-associated non-alcoholic fatty liver disease and type 2 diabetes. Fatty acid transport proteins (FATPs) are bifunctional proteins involved in the uptake and activation of fatty acids by esterification with coenzyme A. Here we characterize Grassofermata/CB5, previously identified as a fatty acid uptake inhibitor directed against HsFATP2. The compound was effective in inhibiting the uptake of fatty acids in the low micro-molar range (IC₅₀ 8–11μM) and prevented palmitate-mediated lipid accumulation and cell death in cell lines that are models for …

Heterogeneous Oxidation Of Catechol, Elizabeth A. Pillar, Ruixin Zhou, Marcelo I. Guzman

Chemistry Faculty Publications

Natural and anthropogenic emissions of aromatic hydrocarbons from biomass burning, agro-industrial settings, and fossil fuel combustion contribute precursors to secondary aerosol formation (SOA). How these compounds are processed under humid tropospheric conditions is the focus of current attention to understand their environmental fate. This work shows how catechol thin films, a model for oxygenated aromatic hydrocarbons present in biomass burning and combustion aerosols, undergo heterogeneous oxidation at the air–solid interface under variable relative humidity (RH = 0–90%). The maximum reactive uptake coefficient of O₃(g) by catechol γ_O3 = (7.49 ± 0.35) × 10^–6 occurs for …

September 25, 2015 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

SWOSU Faculty Senate September 25, 2015 Approved Minutes

Genomic Deoxyuracil: Targeting, Regulation And Repair, Nate Warren Holton

Theses and Dissertations

Maintaining genomic integrity is critical to avoid sequence mutations and genetic disease. However the immune system requires genomic rearrangements in order to produce novel antibodies and illicit a full immunological response. The expression of DNA modifying enzymes is essential for antibody production but the off target effects are not well understood. The work presented here was performed to elucidate molecular mechanisms responsible for the regulation and targeting of DNA editing enzymes, as well as characterize repair of these lesions at off target loci.

The Parthenon, September 25, 2015, Sara Ryan, Bradley Heltzel, Megan Osborne, Shalee Rogney

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.

A Pilot Study Of Demographic And Dopaminergic Genetic Contributions To Weight Change In Kidney Transplant Recipients, Ansley Stanfill, Donna Hathaway, Ann Cashion, Ramin Homayouni, Patricia Cowan, Carol Thompson, Behrouz Madahian, Yvette Conley

Nursing Faculty Publications

Kidney transplant recipients often experience a significant amount of weight gain in the first year post-transplantation. While demographic factors such as age, race, and sex have been associated with weight gain in this population, these factors do not explain all of the variability seen. A number of studies have suggested that genetics also plays a critical role in weight changes. Recently, alterations in the activity of the neurotransmitter dopamine have been associated with weight change, and gene expression studies in kidney transplant recipients have supported this association. The purpose of this pilot study is to first examine the feasibility and …

Successes, Challenges And Needs Regarding Rural Health Medical Education In Continental Central America: A Literature Review And Narrative Synthesis, Maria C. Colon-Gonzalez, F. El Rayess, S. Guevara, G. Anandarajah

School of Medicine Publications

Introduction: Central American countries, like many others, face a shortage of rural health physicians. Most medical schools in this region are located in urban areas and focus on tertiary care training rather than on community health or primary care, which are better suited for rural practice. However, many countries require young physicians to do community service in rural communities to address healthcare provider shortages. This study aimed to: (a) synthesize what is known about the current state of medical education preparing physicians for rural practice in this region, and (b) identify common needs, challenges and opportunities for improving medical education …

What Can Jesus Teach Us About Student Engagement?, Glenn James, Elda Martinez, Sherry Herbers

Journal of Catholic Education

This article examines Jesus’s teaching methods as described in the four Gospels, highlighting the ways in which He led listeners to participate actively in their learning. We identify similarities between many of Jesus’s techniques and current practices in the field of student engagement, with a focus on applications for instructors in higher education. Several of His approaches, most notably storytelling and the use of analogies, point to recommendations for improving teaching practice by increasing student engagement in the learning process.

Qu'est-ce que Jésus peut nous apprendre sur l'engagement des élèves?

Cet article examine la manière dont les méthodes d'enseignement de …

School Science Capacity: A Study Of Four Urban Catholic Grade Schools, Lara K. Smetana, Elizabeth R. Coleman

Journal of Catholic Education

Working from the view of schools as a system, and of school improvement as an ongoing journey (Hallinger & Heck, 2011; Jackson, 2000), this study investigated the perspectives of teacher leaders and principals from four metropolitan Catholic grade schools engaged in efforts to improve their school science programs. Built upon existing conceptualizations of school capacity, a model of school science capacity is presented and used as a framework for the development of four case studies. Findings gleaned from collecting and analyzing reports of teacher leaders’ and principals’ interpretations of their school systems illustrate how elements of the school science capacity …

When Did It Begin? Catholic And Public School Classroom Commonalities, Richard T. Ognibene

Journal of Catholic Education

Catholic educational historians note that although preserving Catholic identity has been a constant in the mission of Catholic schools, their curriculum and instructional practices evolved in ways that were similar to public schools, thus enabling Catholic parents to select schools that were both faith based and modern. Since there is an absence of information about when and how this change in Catholic education began, this article documents its origin in the 1940s when Catholic educators joined a public school reform movement called Life Adjustment Education. Once begun, there was no turning back, and Catholic educators participated in the major reforms …

Methane Generation From Livestock Waste, Don D. Jones, John C. Nye, Alvin C. Dale

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

Solar Heat For Grain Drying --Selection, Performance, Management, George H. Foster, Bruce A. Mckenzie, Sherwood S. Deforest

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

Diseases Of Soybean, Andreas Westphal, T Scott Abney, Gregory Shaner

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

Tomato Fungicide Guide For Indiana 2012, Dan Egel

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

What Landowners Should Know About Biological Diversity In Indiana, Brian K. Miller, Scott D. Roberts

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

Are Constructed Wetlands A Viable Option For Your Waste Management System?, Brian K. Miller, Brian J. Macgowan, Richard P. Reaves

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

Agricultural Biotechnology: Before You Judge, Marshall A. Martin, Jean R. Riepe, April C. Mason, Peter E. Dunn

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

Second Reaction: The Transforming Power Of Hope, Camea Davis

First Opinions, Second Reactions

No abstract provided.

Modeling Wood Fibre Length In Black Spruce (Picea Mariana (Mill.) Bsp) Based On Ecological Land Classification, Elisha Townshend, Bharat Pokharel, Art Groot, Doug Pitt, Jeffery P. Dech

Agricultural and Environmental Sciences Faculty Research

Effective planning to optimize the forest value chain requires accurate and detailed information about the resource; however, estimates of the distribution of fibre properties on the landscape are largely unavailable prior to harvest. Our objective was to fit a model of the tree-level average fibre length related to ecosite classification and other forest inventory variables depicted at the landscape scale. A series of black spruce increment cores were collected at breast height from trees in nine different ecosite groups within the boreal forest of northeastern Ontario, and processed using standard techniques for maceration and fibre length measurement. Regression tree analysis …

Theory And Simulations Of Macromolecular Soft Materials: Linking Molecular Design To Macroscale Morphology And Function, Arthi Jayaraman

Amgen Seminar Series in Chemical Engineering

We use theory and simulation techniques to connect molecular features of macromolecular materials, specifically polymers, to their morphology and macroscopic properties, thereby guiding synthesis of materials for various applications in the energy and biomedical fields.

In the first part of my talk I will present our recent theory and simulation studies of polymer functionalized nanoparticles in polymer nanocomposites. The goal of this work is to control spatial arrangement of nanoparticles in a polymer nanocomposite so as to engineer materials with target mechanical or optical properties. One can tailor the inter-particle interactions and precisely control the assembly of the particles in …

Clusterin Seals The Ocular Surface Barrier In Mouse Dry Eye, Aditi Bauskar, Wendy J. Mack, Jerome Mauris, Pablo Argüeso, Martin Heur, Barbara A. Nagel, Grant R. Kolar, Martin E. Gleave, Takahiro Nakamura, Shigeru Kinoshita, Janet Moradian-Oldak, Noorjahan Panjwani, Stephen C. Pflugfelder, Mark R. Wilson

Biological Sciences Faculty Research & Creative Works

Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating stress that mimics dry eye. Using this mouse model, we show here that CLU prevents and ameliorates ocular surface barrier disruption by a remarkable sealing mechanism dependent on attainment of a critical all-or-none concentration. When the CLU level …

Ua12/2/1 College Heights Herald, Vol. 91, No. 10, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Hederson, Andrew & Samantha Wright. Gary Ransdell Offers Insight Into Confucius Institute
• Sullivan, Tommy. Pearce-Ford Tower Loses Nine Resident Assistants – Housing & Residence Life
• Wright, Samantha. Faculty, Staff Salaries Could See A Boost Soon – Budget
• Mayo, Marcel. Student Government Association Disapproves Confucius Institute Building Process
• Henderson, Andrew. U.S. Bancorp CEO Lectures Students on Leadership – Richard Davis
• Henderson, Andrew. Housing & Residence Life Director Steve Briggs Resigns
• Pettway, Shantel. Student Presents Research at Atlanta Conference – Marcus Stubbs, Association for the Study of African American Life & …

September 24, 2015, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Tiger Vol. 109 Issue 36 2015-09-24, Clemson University

Tiger Newspapers 2015

No abstract provided.

The Murray Ledger And Times, September 24, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Expert And Crowd-Sourced Validation Of An Individualized Sleep Spindle Detection Method Employing Complex Demodulation And Individualized Normalization, Laura B. Ray, Stephane Sockeel, Melissa Soon, Arnaud Bore, Ayako Myhr, Bobby Stojanoski, Rhodri Cusack, Adrian M. Owen, Julien Doyon, Stuart M. Fogel

Anatomy and Cell Biology Publications

A spindle detection method was developed that: (1) extracts the signal of interest (i.e., spindle-related phasic changes in sigma) relative to ongoing "background" sigma activity using complex demodulation, (2) accounts for variations of spindle characteristics across the night, scalp derivations and between individuals, and (3) employs a minimum number of sometimes arbitrary, user-defined parameters. Complex demodulation was used to extract instantaneous power in the spindle band. To account for intra- and inter individual differences, the signal was z-score transformed using a 60 s sliding window, per channel, over the course of the recording. Spindle events were detected with a z-score …