Digital Commons Network^™

The Biologics Price Competition And Innovation Act: Potential Problems In The Biologic-Drug Regulatory Scheme, Ryan Timmis

Northwestern Journal of Technology and Intellectual Property

In 2010, Congress passed the Patient Protection and Affordable Care Act, often referred to as “Obamacare.” Though little noticed in the fanfare surrounding this event, Title VII, the Biologic Price Competition and Innovation Act (BPCIA), was arguably one of the most important provisions. The BPCIA represents one of the more significant overhauls to the pharmaceutical industry in recent decades. For the first time, federal law established a pathway for the creation of generic versions of drugs produced by biotechnological means. Congress hoped by legalizing the production of generic biological drugs, generally known as “biosimilars,” that consumer prices for a variety …

An Invasive Grass And A Desert Adapted Rodent: Is There An Effect On Locomotory Performance And Is It Modified By Prior Experience Or Familiarization?, Camille D. Boag

Master's Theses

Kangaroo rats (Dipodomys spp.) are frequently characterized as keystone species for their role in altering soil characteristics, changing habitat structure through seed consumption and dispersal, and being important primary consumers in their ecosystem. They are arid adapted and known to forage in areas with sparse vegetation. Studies suggests densely vegetated habitat to be unsuitable for kangaroo rats because plants are an impediment to their locomotion and predator avoidance behaviors. This study focuses on an invasive grass, South African Veldt (Ehrharta calycina), that converts landscapes with sparse vegetation into dense grassland habitats, and the Lompoc kangaroo rat …

Effects Of Supplemental Hydration On Physiology And Behavior Of Northern Pacific Rattlesnakes (Crotalus Oreganus Oreganus), Griffin D. Capehart

Master's Theses

Hydration is a critical element for many physiological processes in vertebrates, such as protein production, innate immunity, and behavioral processes such as daily activity and thermoregulation. Few studies have directly assessed the effect of hydration on these animals in nature. While it seems intuitive that drought is stressful to animals, studies examining drought are typically observational and fail to assess how the hydration state of these animals influences their physiology and behavior. We tested for an effect of hydration on several physiological and behavioral parameters in Northern Pacific rattlesnakes (Crotalus oreganus oreganus) by experimentally manipulating hydration levels in …

Fact Book 2015, Planning, Research, And Policy Analysis

Fact Book (1988-2019)

Fact Book 2015 for Illinois State University

Enrollment Report, Fall 2015, Planning, Research, And Policy Analysis

Enrollment Reports (2004-2019)

Enrollment Report for Fall 2015 for Illinois State University

The Impact Of The Queensland Shark Control Program On Local Populations Of Threatened Shark Species, 1962-2014, Carolyn Pushaw

Independent Study Project (ISP) Collection

Since 1962, the Queensland government has employed a shark control program consisting of shark nets and drum lines off the coast of popular beaches. This program is intended to protect beachgoers from shark interactions by fishing down local shark populations, reasoning that the fewer “large sharks that are present, all things being equal, the less chance of an attack occurring” (McPhee, 2012). In the current study, trends in Queensland Shark Control Program (QSCP) catch between 1962-2014 are examined for select threatened shark species; namely, Carcharodon carcharias, Carcharias taurus, and Sphyrna spp. For all focus species, significant and consistent …

Child Nutrition And Fitness In Switzerland And The United Kingdom: Analyzing Preventative Solutions For The Developing Obesity And Diabetes Crises, Nicolas Selemon

Independent Study Project (ISP) Collection

The current study takes a novel approach to analyzing how child nutrition and fitness can be used as preventative measures to solve the ongoing crises of obesity and diabetes. A comparison case-study between two stereotypically different European nations, Switzerland and the United Kingdom, was utilized to address how nutrition and fitness education, policy, culture and programs affect the health of the country. Each nation was analyzed comprehensively, accounting for dietary and exercise practices from infant stages to adolescence. Personal interviews with experts in the fields of breastfeeding, nutrition and fitness provided the main sources of information. Primary research was supplemented …

Bleaching, Disease, And Colonization: The Ecology Of Coral Health In Southeastern Nosy Be, Madagascar, Luella Allen-Waller

Independent Study Project (ISP) Collection

Coral reefs constitute irreplaceable networks of marine biodiversity as well as an important economic resource to many coastal communities in the tropics. Many factors threaten these fragile ecosystems worldwide: overfishing, pollution, ocean acidification, and increasing sea temperatures all interact to diminish reef-building coral health in a variety of ways. This study aims to characterize the taxonomic and spatial patterns of several acute negative health conditions affecting hard corals in and near Lokobe National Park, Nosy Be, Madagascar. Bleaching, coral disease, filamentous algal overgrowth, and soft coral colonization were surveyed at six fringing reef sites representing different ecological zones. While Acropora …

By Any Other Name: Image Advertising And The Commercial Speech Doctrine In Jordan V. Jewel, Kelly Miller

Loyola of Los Angeles Entertainment Law Review

This Comment focuses on the commercial speech doctrine as applied to modern advertising strategies, specifically, corporate image advertising. It centers on the recent litigation between basketball superstar Michael Jordan and a Chicago-area grocery chain, Jewel-Osco. When Michael Jordan was inducted into the Basketball Hall of Fame, Jewel-Osco was invited to submit a congratulatory ad for a commemorative issue of Sports Illustrated devoted exclusively to Jordan’s career and accomplishments. Because Jordan had spent the bulk of his storied professional basketball career with the Chicago Bulls, the ad seemed a natural fit. Jordan, who did not give permission for his name to …

Characterization Of 1577 Primary Prostate Cancers Reveals Novel Biological And Clinicopathologic Insights Into Molecular Subtypes., Scott A. Tomlins, Mohammed Alshalalfa, Elai Davicioni, Nicholas Erho, Kasra Yousefi, Shuang Zhao, Zaid Haddad, Robert B. Den, Adam P. Dicker, Bruce J. Trock, Angelo M. Demarzo, Ashley E. Ross, Edward M. Schaeffer, Eric A. Klein, Cristina Magi-Galluzzi, R. Jeffrey Karnes, Robert B. Jenkins, Felix Y. Feng

Department of Radiation Oncology Faculty Papers

BACKGROUND: Prostate cancer (PCa) molecular subtypes have been defined by essentially mutually exclusive events, including ETS gene fusions (most commonly involving ERG) and SPINK1 overexpression. Clinical assessment may aid in disease stratification, complementing available prognostic tests.

OBJECTIVE: To determine the analytical validity and clinicopatholgic associations of microarray-based molecular subtyping.

DESIGN, SETTING, AND PARTICIPANTS: We analyzed Affymetrix GeneChip expression profiles for 1577 patients from eight radical prostatectomy cohorts, including 1351 cases assessed using the Decipher prognostic assay (GenomeDx Biosciences, San Diego, CA, USA) performed in a laboratory with Clinical Laboratory Improvements Amendment certification. A microarray-based (m-) random forest ERG classification model …

A Forecasting Tool For Predicting Australia's Domestic Airline Passenger Demand Using A Genetic Algorithm, Panarat Srisaeng, Glenn Baxter, Steven Richardson, Graham Wild

Research outputs 2014 to 2021

This study has proposed and empirically tested for the first time genetic algorithm optimization models for modelling Australia’s domestic airline passenger demand, as measured by enplaned passengers (GAPAXDE model) and revenue passenger kilometres performed (GARPKSDE model). Data was divided into training and testing datasets; 74 training datasets were used to estimate the weighting factors of the genetic algorithm models and 13 out-of-sample datasets were used for testing the robustness of the genetic algorithm models. The genetic algorithm parameters used in this study comprised population size (n): 200; the generation number: 1,000; and mutation rate: 0.01. The modelling results have shown …

Molecular Phylogeny And Systematics Of Spider Wasps (Hymenoptera: Pompilidae): Redefining Subfamily Boundaries And The Origin Of The Family, Caleb T. Walker, J. Rodriguez, M. S. Wasbauer, Carol D. Von Dohlen, James P. Pitts

Biology Faculty Publications

Spider wasps (Hymenoptera: Pompilidae) constitute a monophyletic family supported by numerous morphological and behavioural traits. The subfamilial and tribal classifications, however, have a history of conflicting and confusing designations and nomenclature. Here, we reconstruct a molecular phylogeny of Pompilidae from Bayesian and maximum-likelihood analyses of four nuclear molecular markers (elongation factor-1 ë± F2 copy, long-wavelength rhodopsin, RNA polymerase II, and 28S ribosomal RNA). A Bayesian divergence-time estimation analysis was performed using four calibration points and an ancestral-area reconstruction was performed with a Bayesian binary Markov chain Monte Carlo method. New relationships are recovered, and new subfamilial delimitations are proposed and …

Examining Unmanned Aerial System Threats & Defenses: A Conceptual Analysis, Ryan J. Wallace, Jon M. Loffi

International Journal of Aviation, Aeronautics, and Aerospace

The integration of unmanned aerial systems (UAS) into the already complex global aviation system presents new and unique hazards. While many studies have addressed the potential safety concerns of UAS integration, little research has been dedicated to the potential security implications. This study sought to identify potential uses and adaptations of civil UAS systems as weapons of terrorism or crime and potential UAS defenses. Researchers examined 68 academic studies, unclassified government reports, and news articles using Conceptual Analysis to systematically capture and categorize various threats. Using the collected data, researchers developed a UAS threat model for categorically evaluating potential threats. …

The Inkwell, Armstrong State University

The Inkwell

No abstract provided.

A Randomized Controlled Behavioral Intervention Trial To Improve Medication Adherence In Adult Stroke Patients With Prescription Tailored Short Messaging Service (Sms)-Sms4stroke Study., Ayeesha Kamran Kamal, Quratulain Shaikh,, Omrana Pasha, Iqbal Azam Syed, Muhammad Islam,, Adeel Ali Memon, Hasan Rehman, Masood Ahmed Akram,, Muhammad Affan, Sumaira Nazir, Salman Aziz, Muhammad Jan, Anita Andani, Abdul Muqeet, Bilal Ahmed, Shariq Khoja

Department of Medicine

Background: The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial to test the effectiveness of SMS on improving medication adherence in stroke survivors in Pakistan.

Methods: This was a parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally randomized in fixed block sizes. Adult participants on multiple medications with access to a cell phone and stroke at least 4 weeks from onset (Onset as defined by last seen normal) were eligible. The intervention group, in addition …

The Contribution Of Syntrophic Fatty-Acid Degrading Microbial Communities To Anaerobic Digester Function And Stability, Prince Peter Mathai

Dissertations (1934 -)

Anaerobic digestion (AD), the conversion of complex organic matter to methane, occurs through a series of reactions mediated by different guilds of microorganisms. AD process imbalances, such as organic overload or high organic loading rates (OLR), can result in the accumulation of volatile fatty acids (VFA) e.g., propionate, which must be degraded to maintain stable reactor function. VFAs are metabolized by syntrophic fatty-acid degrading bacteria (SFAB) in association with methanogenic archaea (collectively, syntrophic microbial communities, SMC). Despite their indispensable role in AD, little is known about the ecology of SFAB, especially under stressed conditions. To facilitate ecological studies, four quantitative …

Abstractionsinmetal, Michael Lacien

All Student Theses and Dissertations

My work has been rooted in the philosophy of Existentialism. Especially in the belief that individuality is crucial in finding happiness and that we are not preprogrammed prior to birth but are provided some basics but we are the sum of our own experiences and personal choices. Society can compartmentalize humans for its benefit in many ways but this is not beneficial to our personal humanity. What I make are reflections and commentary to how I see these effects and how I choose to try and rebel. Abstract metal weapons, black and pointed, made to covey a battle against conformity, …

Analysis Of Persistent Marking Techniques Using Passive Integrated Transponders And Visible Implant Elastomer Through Metamorphosis In Ambystoma Mavortium, Brooke Welsh-Appleby

Department of Environmental Studies: Undergraduate Student Theses

Salamander species are a key component of monitoring ecosystem integrity and health as indicator species. Being able to monitor growth and development from larval to adult forms can provide important descriptive data such as growth, development, and survivorship. Passive integrated transponders (PIT) and visible implant elastomer (VIE) are two methods of permanent tagging through metamorphosis in salamander species. We were interested in what the retention rate of tags using PIT versus VIE through metamorphosis in Ambystoma mavortium. We hypothesized intramuscular PIT tags would be most successful compared to sub-cutaneous PIT tags and VIE injection. In our experiment, PIT tags retention …

Men’S Perinatal Mental Health In The Transition To Fatherhood, Daniel B. Singley, Lisa M. Edwards

College of Education Faculty Research and Publications

While fathers have come to be more involved with their partners and infants throughout the perinatal period, recent research has shown that roughly 10% of new dads experience mental health difficulties including depression and anxiety. Unfortunately, few psychologists receive focused training regarding conceptualizing, assessing, or treating common men’s issues in the period spanning from conception through a year post-partum. Because men tend not to seek mental health services during this period, the lack of scholarly attention to this vulnerable group reflects a commonly overlooked public mental health disparity. This article provides an overview of the key factors which research and …

Quaker Campus, October 1, 2015 (Vol. 102, Issue 4), Whittier College

Quaker Campus

No abstract provided.

Wildlife Crime And Other Challenges To Resource System Resilience, Patricia Anne Raxter

Graduate Program in International Studies Theses & Dissertations

Although wildlife crime has exploded in Africa over the past decade —“commercial poaching” now kills an estimated eight percent of the continent’s elephant population each year—some governments have proven more successful than others at protecting wildlife and preserving habitats. To explain this variation, this study examines how the policies of three states (Kenya, Tanzania, and Botswana) have enhanced or undermined the resilience of the continent’s elephant ecosystem. Using the social-ecological system framework, the study illustrates how each state’s changing practices have either exacerbated the stresses wrought by wildlife crime or successfully protected local populations from poaching. The study finds that …

Learning Opportunities 2015/2016, Illinois Mathematics And Science Academy

Course Catalogs

The graduation requirements of the Illinois Mathematics and Science Academy are in concert with those maintained by the State of Illinois with additional requirements as established by the IMSA Board of Trustees. Each semester students must take a minimum of 5 academic courses (2.5 credits) for a grade (not Pass/Fail). Fine Arts, Wellness, and Independent Study courses, or any course taken on a Pass/Fail basis do not count towards the 5 course (2.5 credits) minimum. Most students will take between 5 (2.5 credits) and 7 (3.5 credits) academic courses per semester. Only courses taken for a letter grade will count …

Mattrack: A Matlab-Based Quantitative Image Analysis Platform For Investigating Real-Time Photo-Converted Fluorescent Signals In Live Cells, Jane Courtney, Elena Woods, Dimitri Scholz, William Hall, Virginie Gautier

Articles

We introduce here MATtrack, an open source MATLAB-based computational platform developed to process multi-Tiff files produced by a photo-conversion time lapse protocol for live cell fluorescent microscopy. MATtrack automatically performs a series of steps required for image processing, including extraction and import of numerical values from Multi-Tiff files, red/green image classification using gating parameters, noise filtering, background extraction, contrast stretching and temporal smoothing. MATtrack also integrates a series of algorithms for quantitative image analysis enabling the construction of mean and standard deviation images, clustering and classification of subcellular regions and injection point approximation. In addition, MATtrack features a simple user …

Exposure To Elemental Carbon, Organic Carbon, Nitrate, And Sulfate Fractions Of Fine Particulate Matter And Risk Of Preterm Birth In New Jersey, Ohio, And Pennsylvania (2000–2005), Kristen M. Rappazzo, Julie L. Daniels, Lynne C. Messer, Charles Poole, Danelle T. Lobdell

Community Health Faculty Publications and Presentations

Background: Particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) has been consistently associated with preterm birth (PTB) to varying degrees, but roles of PM2.5 species have been less studied.

Objective: We estimated risk differences (RD) of PTB (reported per 106 pregnancies) associated with change in ambient concentrations of elemental carbon (EC), organic carbon (OC), nitrates (NO3), and sulfates (SO4).

Methods: From live birth certificates from three states, we constructed a cohort of singleton pregnancies at or beyond 20 weeks of gestation from 2000 through 2005 (n = 1,771,225; 8% PTB). We estimated mean species exposures for each week of …

Severity Of Depression, Anxious Distress And The Risk Of Cardiovascular Disease In A Swedish Population-Based Cohort., Aysha Almas, Yvonne Forsell,, Romaina Iqbal, Imre Janszky,, Jette Moller

Department of Medicine

Background: Depression is known to be associated with cardiovascular diseases (CVD). This population-based cohort study aimed to determine the association between depression of varying severity and risk for CVD and to study the effect of concomitant anxious distress on this association.

Methods: We utilized data from a longitudinal cohort study of mental health, work and relations among adults (20–64 years), with a total of 10,443 individuals. Depression and anxious distress were assessed using psychiatric rating scales and defined according to DSM-5. Outcomes were register-based and self-reported cardiovascular diseases.

Findings: Overall increased odds ratios of 1.5 to 2.6 were seen …

University Of North Florida Journal Fall 2015, University Of North Florida

UNF Journal

A university periodical for alumni and friends of the University of North Florida. (UNF Journal)

The Effects Of Gender, Physical Attractiveness, And Socioeconomic Status On Initial Attraction, Sherrie Jagolino

Master's Theses

The tradeoff threshold model posits that in a heterosexual relationship, high socioeconomic status (SES) can compensate for physical unattractiveness in men, whereas physical attractiveness can compensate for low SES in women. In the present study, we attempted to provide evidence for the tradeoff threshold model. Ninety-six heterosexual participants viewed eight high and low attractive male or female stimuli photographs each attached with high or low SES descriptions. Average physical attractiveness ratings were analyzed in a 2 (physical attractiveness: high and low) x 2 (SES: high and low) repeated measures analysis of variance (ANOVA) for each gender. Women rated low SES …

Biv Tar Rna Binding Glycine Mutant Tat Peptides: An Integrated Modeling And Binding Assay Approach, Loc Tien Nguyen

Master's Theses

Interactions between viral encoded regulatory proteins and RNA target sequences control gene expression of Lentiviruses, including human immunodeficiency virus (HIV). Bovine immunodeficiency virus (BIV) provides a simpler model of interaction between the viral trans-activating protein (Tat) and trans-activation response RNA element (TAR), using Tat peptides binding to TAR RNA fragments. The resulting characterization of the hinge region of native BIV TAR-Tat complex was confirmed by more comprehensive calculations, involving an exhaustive generation of lattice chains. This modeled 2-residues per move of the native 11-mer Tat peptide and a 28-nucleotides TAR fragment. But these sorts of coarse-grained calculations, upon substitution of …

A Test Of Educational Methods To Reduce Boating Disturbance To Harbor Seals, Rachel Nicole Solvason

Master's Theses

Environmental education can affect attitudes and behaviors, but determining the most effective methods for protecting wildlife requires research. This study examined the effect of two modes of environmental education, one passive and one active, on the behaviors of boaters toward harbor seals (Phoca vitulina) at Corkscrew Slough in Redwood City, California, an area where harbor seals haul out and pup. Thirty-one boaters viewed an interpretive sign (passive environmental mode) and 30 experienced a docent talk (active) both designed to educate boaters on protecting harbor seals; 31 boaters received no environmental information (the control), therefore were not exposed to the interpretive …

Effects Of Particle Size And Particle Heterogeneity On Benthic Functional Guilds In Elkhorn Slough, Ca, Katherine Elizabeth Huotari

Master's Theses

Changes in particle size of sediment as a result of erosion can have potential impacts on benthic community structure. To examine the potential impacts, a 2x2 factorial design was used to evaluate the effects of particle size and particle heterogeneity on the intertidal community structure of Elkhorn Slough using data provided by Moss Landing Marine Laboratories. In this study, changes in functional guild roles with respect to particle size and particle heterogeneity were examined, rather than traditional biological measures, because functional guild roles are more directly related to physical changes in the environment. The results showed that particle size and …