Digital Commons Network^™

Soziale Kompetenz: A Comparative Examination Of The Social-Cognitive Processes That Underlie Legal Definitions Of Mental Competency In The United States, Germany, And Japan, Joseph Alan Wszalek

Fordham International Law Journal

Part I of this Article will examine plain-text selections of legal language concerning mental competency from the constitutions, codes, or relevant decisions by the highest national courts, of three countries: the United States, Germany, and Japan. As three of the biggest economic powers on the planet, these countries merit consideration not just for their contrasting cultural and legal frameworks but also for their relative influence within the international arena during the latter half of the twentieth century. Part I’s examination will focus on constitutional and code language for two important reasons: (1) these sources of law form the basis of …

Fsd-C10: A More Promising Novel Rock Inhibitor Than Fasudil For Treatment Of Cns Autoimmunity., Yan-Le Xin, Jie-Zhong Yu, Xin-Wang Yang, Chun-Yun Liu, Yan-Hua Li, Ling Feng, Zhi Chai, Wan-Fang Yang, Qing Wang, Wei-Jia Jiang, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen Ma

Department of Neurology Faculty Papers

Rho-Rho kinase (Rho-ROCK) triggers an intracellular signalling cascade that regulates cell survival, death, adhesion, migration, neurite outgrowth and retraction and influences the generation and development of several neurological disorders. Although Fasudil, a ROCK inhibitor, effectively suppressed encephalomyelitis (EAE), certain side effects may limit its clinical use. A novel and efficient ROCK inhibitor, FSD-C10, has been explored. In the present study, we present chemical synthesis and structure of FSD-C10, as well as the relationship between compound concentration and ROCK inhibition. We compared the inhibitory efficiency of ROCKI and ROCK II, the cell cytotoxicity, neurite outgrowth and dendritic formation, neurotrophic factors and …

Making Do With Media: Teachers, Technology, And Tactics Of Media Use In American Classrooms, 1919–1946, Katie Day Good

University Faculty Publications and Creative Works

In the last century, teachers have come under pressure to incorporate new media technologies into their lessons. Comparing educational research, press coverage, and teachers' firsthand accounts of mediated instruction between 1919 and 1946, this article highlights a historic discrepancy between anticipated and actual uses of media in classrooms. Drawing on de Certeau's theory of “making do,” the author argues that teachers' efforts to balance high technologies with simpler, more do-it-yourself varieties of media in their lessons constituted critical forms of participation in educational media culture and small acts of resistance against industrial, top-down efforts to streamline, modernize, and technologize their …

Criminal Law And Common Sense: An Essay On The Perils And Promise Of Neuroscience, Stephen J. Morse

Marquette Law Review

None

Queering Indigenous Legal Studies, Emily Snyder

Dalhousie Law Journal

A handful of scholars have examined sex, gender, and sexuality in relation to Indigenous laws; yet their work is infrequently taken up in the field, and there is a broader need for conversations about what it means to "queer" Indigenous legal studies. In this paper, I centre and examine work that contributes to this queering so as to promote inclusive critical legal education and engagement. I also discuss the implications of not attending to sexuality and develop preliminary propositions for queering Indigenous legal studies.

Characterization Of Inhibitors Of Fatty Acid Transport Protein-2 In Cell And Animal Models, Nipun Saini

Department of Biochemistry: Dissertations, Theses, and Student Research

Obesity is correlated with insulin resistance and elevated levels of glucose, triglycerides and free fatty acids in blood. This affects overall metabolism and leads to disease. In the obese state, fat also accumulates in non-adipose tissue including liver, muscle and pancreas, where it can lead to cellular dysfunction and death. Currently, only a limited number of drugs are available to combat obesity and it is clear that new drugs, which more narrowly target the metabolic pathways involved, are required. Fatty Acid Transport Proteins (FATPs) are bifunctional proteins involved in the uptake and activation of fatty acids by esterification with coenzyme …

Acquisitions Unit Annual Report 2014-2015, Andrée J. Rathemacher

Technical Services Reports and Statistics

Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY15. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.

Integrating Meal And Exercise Into Personalized Glucoregulation Models: Metabolic Dynamics And Diabetic Athletes, Sofie Schunk

Master's Theses (2009 -)

Diabetes affects nearly 26 million Americans, according to the American Diabetes Association, with as many as three million Americans who have Type 1 Diabetes (ADA, 2015). Type 1 Diabetes (T1D) is autoimmune and characterized by little to no insulin production whereas Type 2 Diabetes (T2D) concerns insulin resistance and inability to use produced insulin. Factors contributing to current diabetes management and regulation include exercise type, daily movement activities, and distinct tissue compartment metabolism, each challenging to model in a robust and comprehensive manner. Past models are highly limited in regard to exercise and varying glucose fluctuations dependent on type, intensity, …

The Effectiveness Of Background Noise During A Sleep Deprived Eeg: A Randomised Control Trial, Louise Grant

Masters

Introduction Sleep Deprived Electroencephalogram’s (EEG’s) are usually carried out routinely in dedicated children’s Hospitals as they have been shown to increase the yield of the study. However, despite sleep deprivation being successfully carried out prior to the EEG the patient may fail to fall asleep. Various techniques have been developed to enhance sleep, such as the use of “white or background noise”. This study examined the use of background noise during the sleep portion of the EEG in comparison with a control group. Methodology This was a randomised control trial with two interventions (two different types of background noise) and …

Lifelines Fall 2015, Southern Adventist University

Lifelines - Biology Department Newsletter

The Fall 2015 issue of Lifelines features articles on undergraduate research on dinosaurs and spiders, an alumni spotlight, student missions to Bolivia, and updates on department happenings.

Columns Fall 2015, Southern Adventist University

Alumni Newsletter

Features the article "Fostering the Curious Mind". Academic risk-takers find a home in the Southern Scholars program, where students embrace an honors curriculum and creative off-campus activities in pursuit of the ultimate interdisciplinary experience.

A Novel C-Terminal Cib2 (Calcium And Integrin Binding Protein 2) Mutation Associated With Non-Syndromic Hearing Loss In A Hispanic Family, Kunjan Patel, Arnaud P. Giese, J. M. Grossheim, Rashima S. Hegde, Maria Delio, Joy Samanich, Saima Riazuddin, Gregory I. Frolenkov, Jinlu Cai, Zubair M. Ahmed, Bernice E. Morrow

Physiology Faculty Publications

Hearing loss is a complex disorder caused by both genetic and environmental factors. Previously, mutations in CIB2 have been identified as a common cause of genetic hearing loss in Pakistani and Turkish populations. Here we report a novel (c.556C>T; p.(Arg186Trp)) transition mutation in the CIB2 gene identified through whole exome sequencing (WES) in a Caribbean Hispanic family with non-syndromic hearing loss. CIB2 belongs to the family of calcium-and integrin-binding (CIB) proteins. The carboxy-termini of CIB proteins are associated with calcium binding and intracellular signaling. The p.(Arg186Trp) mutation is localized within predicted type II PDZ binding ligand at the carboxy …

Short Term Outcome And Predictors Of Response To Neoadjuvant Treatment In Rectal Cancer, Rizwan Sultan, Tabish Chawla, Mirza Mirza Aman Beg

Department of Surgery Docs

Abstract

OBJECTIVE:

To evaluate response to neoadjuvant chemoradiation in the treatment of rectal cancer and to see if it can be predicted whether a particular patient will benefit from such treatment.

METHODS:

The retrospective case series was done at the Aga Khan University Hospital, Karachi, and comprised data related to period from January 2005 to December 2014 of patients with rectal cancer who had received neoadjuvant treatment. They were divided into responders and non-responders on the basis of imaging. Pre-treatment factors were compared to identify differences in the two groups. SPSS 19 was used for statistical analysis.

RESULTS:

The median …

Repeated Trait Evolution Driven By Divergent Natural Selection At Early And Late Stages Of Speciation, Spencer J. Ingley

Theses and Dissertations

Speciation – the process by which new species arise – is of fundamental importance in the biological sciences. The means by which new species arise, and the relationship among living species, has been a topic that has captivated both lay and scientific observers for centuries. In recent years, the study of speciation has enjoyed increased attention, resulting in significant advances in our understanding of how species form. Although our understanding of the processes that contribute to speciation has increased dramatically in recent years, our knowledge of how reproductive barriers accumulate as speciation proceeds is still limited. Thus, studies that evaluate …

Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response To Beta-Adrenergic Stimulation., Guijun Yan, Ni Zhu, Shengdong Huang, Bing Yi, Xiying Shang, Ming Chen, Nadan Wang, Guan-Xin Zhang, Jennifer A Talarico, Douglas G Tilley, Erhe Gao, Jianxin Sun

Center for Translational Medicine Faculty Papers

The orphan nuclear receptor Nur77 plays critical roles in cardiovascular diseases, and its expression is markedly induced in the heart after beta-adrenergic receptor (β-AR) activation. However, the functional significance of Nur77 in β-AR signaling in the heart remains unclear. By using Northern blot, Western blot, and immunofluorescent staining assays, we showed that Nur77 expression was markedly upregulated in cardiomyocytes in response to multiple hypertrophic stimuli, including isoproterenol (ISO), phenylephrine (PE), and endothelin-1 (ET-1). In a time- and dose-dependent manner, ISO increases Nur77 expression in the nuclei of cardiomyocytes. Overexpression of Nur77 markedly inhibited ISO-induced cardiac hypertrophy by inducing nuclear translocation …

Akt Kinase C-Terminal Modifications Control Activation Loop Dephosphorylation And Enhance Insulin Response., Tung O. Chan, Jin Zhang, Brian C. Tiegs, Brian Blumhof, Linda Yan, Nikhil Keny, Morgan Penny, Xue Li, John M. Pascal, Roger S. Armen, Ulrich Rodeck, Raymond B. Penn

Center for Translational Medicine Faculty Papers

The Akt protein kinase, also known as protein kinase B, plays key roles in insulin receptor signalling and regulates cell growth, survival and metabolism. Recently, we described a mechanism to enhance Akt phosphorylation that restricts access of cellular phosphatases to the Akt activation loop (Thr(308) in Akt1 or protein kinase B isoform alpha) in an ATP-dependent manner. In the present paper, we describe a distinct mechanism to control Thr(308) dephosphorylation and thus Akt deactivation that depends on intramolecular interactions of Akt C-terminal sequences with its kinase domain. Modifications of amino acids surrounding the Akt1 C-terminal mTORC2 (mammalian target of rapamycin …

A Visualization And Characterization Of Microstructures Of Cohesive Powders, Vineeth R. Patil

Theses

In this work, a framework for the determination of the particle positions in a fluorescent powder structure was created. The feasibility of imaging and quantifying sedimented particulate samples in air was demonstrated by using micron-sized poly-dispersed electrophotographic printing particles. Particle positions were determined by a Confocal Laser Scanning Microscope (CLSM) to capture a stack of cross-sectional images of fluorescent particle clusters. The resulting images were analyzed using Matlab image processing tools. The XYZ coordinates and radii for these particles (assumed spherical) were calculated in several selected sampling volumes, and the packing fractions were calculated. A three-dimensional visualization of the particle …

Development Of Material Characterization Techniques Using Novel Nanoindentation Approaches On Hard And Soft Materials Used In Mems, Eyup Cinar

Theses

Investigating and modeling the mechanical properties of materials is important for many applications. The most common technique used for mechanical characterization of materials is called nanoindentation. The currently available tools utilized in order to perform nanoindentation have their limitations in terms of sensitivities in force and displacement for a broad range of material properties. When it comes to investigation of soft materials, these limitations might be more detrimental. In this dissertation work, novel nanoindentation techniques have been developed with a multi-probe scanning force microscopy (SPM) system in order to ease the major problems encountered with standard Atomic Force Microscopy (AFM) …

Cryptanalysis Of The Purple Cipher Using Random Restarts, Aparna Shikhare

Master's Projects

Cryptanalysis is the process of trying to analyze ciphers, cipher text, and crypto systems, which may exploit any loopholes or weaknesses in the systems, leading us to an understanding of the key used to encrypt the data. This project uses Expectation Maximization (EM) approach using numerous restarts to attack decipherment problems such as the Purple Cipher. In this research, we perform cryptanalysis of the Purple cipher using genetic algorithms and hidden Markov models (HMM). If the Purple cipher has a fixed plugboard, we show that genetic algorithms are successful in retrieving the plaintext from cipher text with high accuracy. On …

Interactive Phishing Filter, Rushikesh Joshi

Master's Projects

Phishing is one of the prevalent techniques used by attackers to breach security and steal private and confidential information. It has compromised millions of users’ data. Blacklisting websites and heuristic-based methods are common approaches to detect a phishing website. The blacklist method suffers from a window of vulnerability. Many heuristics were proposed in the past. Some of them have better accuracy but a lower performance. A phishing filter should have better accuracy and peformance. It should be able to detect fresh phishing websites. Jo et al. [2] present a list of attributes of the web page to find the disparity …

Neural Network Captcha Cracker, Geetika Garg

Master's Projects

NEURAL NETWORK CAPTCHA CRACKER A CAPTCHA (acronym for "Completely Automated Public Turing test to tell Computers and Humans Apart") is a type of challenge-response test used to determine whether or not a user providing the response is human. In this project, we used a deep neural network framework for CAPTCHA recognition. The core idea of the project is to learn a model that breaks image-based CAPTCHAs. We used convolutional neural networks and recurrent neural networks instead of the conventional methods of CAPTCHA breaking based on segmenting and recognizing a CAPTCHA. Our models consist of two convolutional layers to learn image …

Janus Kinase 2/Signal Transducer And Activator Of Transcription 3 Inhibitors Attenuate The Effect Of Cardiotrophin-Like Cytokine Factor 1 And Human Focal Segmental Glomerulosclerosis Serum On Glomerular Filtration Barrier., Mukut Sharma, Jianping Zhou, Jean-François Gauchat, Ram Sharma, Ellen T. Mccarthy, Tarak Srivastava, Virginia J. Savin

Manuscripts, Articles, Book Chapters and Other Papers

Recurrence of idiopathic focal segmental glomerulosclerosis (FSGS) after renal transplantation is believed to be caused by a circulating factor(s). We detected cardiotrophin-like cytokine factor 1 (CLCF1), a member of the interleukin 6 family, in the plasma from patients with recurrent FSGS. We hypothesized that CLCF1 contributes to the effect of FSGS serum on the glomerular filtration barrier in vitro. Presently, we studied the effect of CLCF1 on isolated rat glomeruli using an in vitro assay of albumin permeability (P(alb)). CLCF1 (0.05-100 ng/mL) increased P(alb) and caused maximal effect at 5-10 ng/mL (P < 0.001). The increase in Palb was analogous to the effect of FSGS serum. Anti-CLCF1 monoclonal antibody blocked the CLCF1-induced increase in P(alb) and significantly attenuated the effect of FSGS serum (P < 0.001). The heterodimer composed of CLCF1 and cosecreted molecule cytokine receptor-like factor 1 (CRLF1) attenuated the increase in P(alb) caused by CLCF1 or FSGS serum. Western blot analysis showed that CLCF1 upregulated phosphorylation of signal transducer and activator of transcription 3 (STAT3) (Tyr705) in glomeruli. This effect was diminished by the heterodimer CLCF1-CRLF1. Janus kinase 2 (JAK2) inhibitor BMS-1119543 or STAT3 inhibitor Stattic significantly blocked the effect of CLCF1 or FSGS serum on P(alb) (P < 0.001). These novel findings suggest that when monomeric CLCF1 increases P(alb), the heterodimer CLCF1-CRLF1 may protect the glomerular filtration barrier. We speculate that albuminuria in FSGS is related to qualitative or quantitative changes in the CLCF1-CRLF1 complex, and that JAK2 or STAT3 inhibitors may be novel therapeutic agents to treat FSGS.

Diabetes Status, Predisposing, Enabling, And Oral Health Illness Level Variables As Predictors Of Preventive And Emergency Dental Service Use, Sabha Alshatrat

Health Services Research Dissertations

The purpose of this study was to clarify the relationship between diabetes and dental service use. This study addressed the question of whether individuals with diabetes are more or less likely to utilize dental services, measured in terms of preventive and emergency services during the past year. A cross-sectional study was conducted to assess the contributions of diabetes status to dental service use, relative to the contributions of Andersen and Newman Framework of Health Services Utilization dimensions (predisposing, enabling, and illness variables) in predicting dental service utilization during the past year using a nationally representative sample from a 2001-2002 National …

State Of Tennessee Treasurer's Report For The Fiscal Year Ended June 30, 2015, Tennessee. Department Of Treasury.

Treasurer’s Report

No abstract provided.

Hsp31 Is A Stress Response Chaperone That Intervenes In The Protein Misfolding Process, Chai-Jui Tsai, Kiran Aslam, Holli M. Drendel, Josephat M. Asiago, Kourtney M. Goode, Lake N. Paul, Jean-Christophe Rochet, Tony R. Hazbun

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

The Saccharomyces cerevisiae heat shock protein Hsp31 is a stress-inducible homodimeric protein that is involved in diauxicshift reprogramming and has glyoxalase activity. We show thatsubstoichiometric concentrations of Hsp31 can abrogate aggrega-tion of a broad array of substrates in vitro. Hsp31 also modulates the aggregation of -synuclein ( Syn), a target of the chaperoneactivity of human DJ-1, an Hsp31 homolog. We demonstrate thatHsp31 is able to suppress the in vitro fibrillization or aggregation of Syn, citrate synthase and insulin. Chaperone activity was also observed in vivo because constitutive overexpression of Hsp31 reduced the incidence of Syn cytoplasmic foci, and yeast cells …

Scitech News Volume 69, No. 4

Sci-Tech News

Table of Contents:

Columns and Reports

From the Editor 5

SciTech News Call for Articles 5

Division News

Science-Technology Division 6

Preliminary Results from SciTech Survey 15

Chemistry Division 18

Membership Survey Report 19

Appendix: Summary of DCHE 2015 Membership Survey Result 20

Engineering Division 42

Engineering Division Executive Board Election Results 44

Aerospace Section of the Engineering Division 45

Call for Nominations & Applications

Engineering Division: First call - 2016 award nominations & applications 43

Reviews Sci-Tech Book News Reviews 46

Advertisements Annual Reviews 3

CRC Press 4

The Montclarion, October 01, 2015, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Parameter Estimation For Gene Regulatory Networks From Microarray Data: Cold Shock Response In Saccharomyces Cerevisiae, Kam D. Dahlquist, Ben G. Fitzpatrick, Erika T. Camacho, Stephanie D. Entzminger, Nathan C. Wanner

Biology Faculty Works

We investigated the dynamics of a gene regulatory network controlling the cold shock response in budding yeast, Saccharomyces cerevisiae. The medium-scale network, derived from published genome-wide location data, consists of 21 transcription factors that regulate one another through 31 directed edges. The expression levels of the individual transcription factors were modeled using mass balance ordinary differential equations with a sigmoidal production function. Each equation includes a production rate, a degradation rate, weights that denote the magnitude and type of influence of the connected transcription factors (activation or repression), and a threshold of expression. The inverse problem of determining model …

Dispredict: A Predictor Of Disordered Protein Using Optimized Rbf Kernel, Sumaiya Iqbal, Md Tamjidul Hoque

Computer Science Faculty Publications

Intrinsically disordered proteins or, regions perform important biological functions through their dynamic conformations during binding. Thus accurate identification of these disordered regions have significant implications in proper annotation of function, induced fold prediction and drug design to combat critical diseases. We introduce DisPredict, a disorder predictor that employs a single support vector machine with RBF kernel and novel features for reliable characterization of protein structure. DisPredict yields effective performance. In addition to 10-fold cross validation, training and testing of DisPredict was conducted with independent test datasets. The results were consistent with both the training and test error minimal. The use …

Cell Type–Dependent Mechanisms For Formin-Mediated Assembly Of Filopodia, Lorna E. Young, Ernest G. Heimsath, Henry N. Higgs

Dartmouth Scholarship

Filopodia are finger-like protrusions from the plasma membrane and are of fundamental importance to cellular physiology, but the mechanisms governing their assembly are still in question. One model, called convergent elongation, proposes that filopodia arise from Arp2/3 complex-nucleated dendritic actin networks, with factors such as formins elongating these filaments into filopodia. We test this model using constitutively active constructs of two formins, FMNL3 and mDia2. Surprisingly, filopodial assembly requirements differ between suspension and adherent cells. In suspension cells, Arp2/3 complex is required for filopodial assembly through either formin. In contrast, a subset of filopodia remains after Arp2/3 complex inhibition in …