Digital Commons Network^™

Ballard V. Kerr Respondent's Brief Dckt. 42611

Idaho Supreme Court Records & Briefs, All

No abstract provided.

October 5, 2015, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Crow's Nest, October 5, 2015, Crow's Nest Staff

Crow's Nest

The October 5, 2015, issue of the Crow's Nest.

Relation Between Parental Divorce And Adjustment In College Students, Breanna Connel

Honors Theses

No abstract provided.

Genome-Wide Detection And Analysis Of Multifunctional Genes, Yuri Pritykin, Dario Ghersi, Mona Singh

Interdisciplinary Informatics Faculty Publications

Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular functioning, thereby leading to a better understanding of the functional landscape of the cell. However, to date, genome-wide analysis of multifunctional genes (and the proteins they encode) has been limited. Here we introduce a computational approach that uses known functional annotations to extract genes playing a role in at least two distinct biological processes. We leverage functional genomics data sets for three organisms—H. sapiens, …

Genetics Ignite Focus On Microglial Inflammation In Alzheimer's Disease, Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo Ladu, David W. Fardo, G. William Rebeck, Steven Estus

Physiology Faculty Publications

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how …

An Analysis In Empathy: Why Compassion Need Not Be Exiled From The Province Of Judging Same-Gender Marriage Cases, Kacie Gray

Journal of Civil Law Studies

No abstract provided.

Costanza And Brewer V. Caldwell, Tiffany Bush

Journal of Civil Law Studies

No abstract provided.

Library News

The Southeastern Librarian

Recent developments from SELA member institutions.

Concentrations, Trends, And Air-Water Exchange Of Pahs And Pbdes Derived From Passive Samplers In Lake Superior In 2011, Zoe Ruge, Derek Muir, Paul Helm, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Polycyclic aromatic hydrocarbons (PAHs) and polybrominated diphenylethers (PBDEs) are both currently released into the environment from anthropogenic activity. Both are hence primarily associated with populated or industrial areas, although wildfires can be an important source of PAHs, too. Polyethylene passive samplers (PEs) were simultaneously deployed in surface water and near surface atmosphere to determine spatial trends and air-water gaseous exchange of 22 PAHs and 11 PBDEs at 19 sites across Lake Superior in 2011. Surface water and atmospheric PAH concentrations were greatest at urban sites (up to 65 ng L-1 and 140 ng m-3, respectively, averaged from June to October). …

Pat4 Levels Control Amino-Acid Sensitivity Of Rapamycin-Resistant Mtorc1 From The Golgi And Affect Clinical Outcome In Colorectal Cancer, S-J Fan, C Snell, H Turley, J-L Li, Et Al

Peninsula Medical School

Tumour cells can use strategies that make them resistant to nutrient deprivation to outcompete their neighbours. A key integrator of the cell's responses to starvation and other stresses is amino-acid-dependent mechanistic target of rapamycin complex 1 (mTORC1). Activation of mTORC1 on late endosomes and lysosomes is facilitated by amino-acid transporters within the solute-linked carrier 36 (SLC36) and SLC38 families. Here, we analyse the functions of SLC36 family member, SLC36A4, otherwise known as proton-assisted amino-acid transporter 4 (PAT4), in colorectal cancer. We show that independent of other major pathological factors, high PAT4 expression is associated with reduced relapse-free survival after colorectal …

Guest Recital, October 4, 2015, Lawrence University

Conservatory of Music Concert Programs

Harper Hall

Breast Cancer-Derived Extracellular Vesicles: Characterization And Contribution To The Metastatic Phenotype, Toni M. Green, Mary L. Alpaugh, Sanford H. Barsky, Germana Rappa, Aurelio Lorico

College of Science & Mathematics Departmental Research

The study of extracellular vesicles (EVs) in cancer progression is a complex and rapidly evolving field. Whole categories of cellular interactions in cancer which were originally presumed to be due solely to soluble secreted molecules have now evolved to include membrane-enclosed extracellular vesicles (EVs), which include both exosomes and shed microvesicles (MVs), and can contain many of the same molecules as those secreted in soluble form but many different molecules as well. EVs released by cancer cells can transfer mRNA, miRNA, and proteins to different recipient cells within the tumor microenvironment, in both an autocrine and paracrine manner, causing a …

Using An Agent-Based Model To Study The Effect Of Reproductive Skew On Mongoose Populations, Stacy Lee Mowry

Theses and Dissertations

Reproductive skew is the name given to the unequal partitioning of breeding

within social groups. Within these groups a mating hierarchy emerges wherein one dominant mating pair holds an unproportional majority of the group's reproductive benefit, while other members mate infrequently, yet allocate energy and resources toward the offspring of the dominant group members. In this paper, we use an agent-based model, which mimics dwarf and banded mongoose populations, to investigate how reproductive skew aftects the speed natural selection, and thus how reproductive skew affects fitness. The results of the model show that due to the geometric structure of skewed …

Mapping The Movement Of Overwintering Western Monarch Butterflies (Danaus Plexippus) At The Pismo Beach Monarch Butterfly Grove Using Arcgis Software, Brett Johnson, Jesse Wycko, Daniel Goldthwaite, Tyler Brown

Symposium

Dr. Villablanca of the Cal Poly Biology Department commissioned this project with the goal of tracking Monarch Butterfly spatial redistribution in anticipation of or response to severe weather events. We believe that Monarchs cluster non-preferentially on introduced Eucalyptus trees until midwinter when they begin to cluster preferentially on native conifers. Based on the efforts of a previous group of students, it has been deter- mined that, over a two-week time period in mid-winter, Monarchs spend the majority of their time on native conifers. We set out to clearly demonstrate Monarch Butterfly spatial redistribution in either anticipation of or response to …

Variation In Microbiome Composition And Stability For A Vancomycin Treated Primary Sclerosing Cholangitis Patient With Ulcerative Colitis Compared With Controls, Alanna Dubrovsky

Symposium

The bacterial composition of the human intestines contributes to much more than just digestion. In the inflammatory, autoimmune conditions primary sclerosing cholangitis (PSC) and ulcerative colitis (UC), the microbiome may be, in some cases, a factor. To gain a better understanding of the composition and stability of the microbiome in a patient treated with vancomycin for PSC, terminal restriction fragment (TRF) analysis was performed on 13 controls and 1 patient, and 16s rRNA microbiome composition analysis was performed on 1 patient and 3 controls. Results showed similar levels of stability, with surprising differences in composition.

The Influence Of Psychological Factors On Reducing Recovery Time From Total Knee Replacement Surgery, Melissa Geiger

Symposium

Osteoarthritis is the most common cause of physical disability that Americans face, leading to destruction of the joints of the body. The primary joint affected is the knee, and the leading treatment is total knee replacement. The incidence of total knee replacement surgery is rising–and will continue to rise–as a treatment for knee pain resulting from osteoarthritis (Mizner et al., 2005). Various psychological factors have been proven to influence a person’s well-being in general and, more specifically, with recovery from illness or surgery (Taylor, 2011). Pre- surgical psychological screenings are an important factor in determining how the patient will recover …

Observational Learning In Eusocial Insects: Chemical Transmission Of Information Between Rival Colonies Of Leafcutter Ants, Avity Norman

Symposium

Like other ants (Hymenoptera, Formicidae), leafcutter ants of the genus Atta use chemical signals, including airborne pheromones and cuticular hydrocarbons, to coordinate extraordinarily complex eusocial organization. This genus is ecologically and economically important because of its extreme impact on vegetation throughout the Neotropics, and also lends itself well to ethological research because of its easily observed and manipulated foraging behavior. Saverschek et al. (2010) used fungicide-treated leaves to induce an avoidance response to certain types of leaves, demonstrating that colonies of Atta columbica are capable of experiential learning and long-term memory. The proposed study will use similar methods to determine …

Protocols For Cleaning And Articulating Large Mammal Skeleton, Brandon Rowley

Symposium

This protocol will refer to Panthera tigris as an example for each cleaning method and articulation because that was the organism subject to this procedure. However, the processes and methods discussed here can be used as reference for any large mammal. The key is to make sure the skeleton is clean, which entails removing the meat from the bones, degreasing, and whitening. Once this is done, articulation can begin. The protocol is divided into three major sections: cleaning the skeleton, whitening and degreasing, and articulation. The cleaning section contains three contemporary methods for removing tissue. Each method can be performed …

Size And Abundance Of Pismo Clams In The Intertidal And Subtidal, Jenny Greene

Symposium

Pismo clams, Tivela stultorum, were observed at Rincon Beach, CA to find patterns of abundance and size distribution along a depth gradient from the intertidal, where recreational clammers have access on foot, to the subtidal, where clammers only have access with more specialized snorkeling or SCUBA equipment. Size and abundance patterns were compared between the intertidal and subtidal regions. A heuristic model was created to predict the effects of predation and wave action on clam density. Clam abundance was significantly greater in the intertidal than the subtidal and displayed a Gaussian distribution across the entire distance sampled. While Pismo clam …

Editor's Note, Wilson Shao

Symposium

Editor's Note for 2014-2015 Symposium

2015 Scas Annual Meeting Program

Journal of the South Carolina Academy of Science

No abstract provided.

Assessing The Synergistic Effect Of Caffeine And Sugar On Cognitive Performance In Undergraduate Students, Sandra P. Urquiza, Michelle Vieyra

Journal of the South Carolina Academy of Science

Working independently, both caffeine and sugar provide benefits to attention and memory. However, there is sparse literature on the synergistic effects on improved cognitive performance between caffeine and sugar when taken together. This study explored the dynamics between caffeine and sugar when consumed under ordinary conditions – as a cup of coffee. Twenty-four undergraduate students (15 women and 9 men) were asked to complete a baseline cognitive test, and one of the three variables was given at random in the form of a cup of coffee: decaffeinated with sugar, caffeinated with no sugar, and caffeinated with sugar. The remaining two …

Predicting Phase Resetting Due To Multiple Stimuli, Kelsey M. Vollmer, Davy C. Vanderweyen, Derek R. Tuck, Sorinel A. Oprisan

Journal of the South Carolina Academy of Science

We generalized the phase resetting curve (PRC) to a more realistic case of neural oscillators receiving two or more inputs per cycle. The PRC tabulates the transient change in the firing period of a neuron due to an external perturbation, such as a presynaptic stimulus. We used a conductance-based model neuron to estimate experimentally the two-stimulus PRC and compared the results against our mathematical prediction based on the assumption of instantaneous recurrent stimulation. Within the limits of the recurrent stimulation assumptions, we found that the newly introduced prediction for the two-stimulus PRC matched experimental measurements. Our new results open the …

Reactive Oxygen Species-Mediated Neurodegeneration Is Independent Of The Ryanodine Receptor In Caenorhabditis Elegans, Lyndsay E.A. Young, Daniel C. Williams

Journal of the South Carolina Academy of Science

Despite the significant impacts on human health caused by neurodegeneration, our understanding of the degeneration process is incomplete. The nematode Caenorhabditis elegans is emerging as a genetic model organism well suited for identification of conserved cellular mechanisms and molecular pathways of neurodegeneration. Studies in the worm have identified factors that contribute to neurodegeneration, including excitotoxicity and stress due to reactive oxygen species (ROS). Disruption of the gene unc-68, which encodes the ryanodine receptor, abolishes excitotoxic cell death, indicating a role for calcium (Ca²⁺) signaling in neurodegeneration. We tested the requirement for unc-68 in ROS-mediated neurodegeneration using the …

Resource Sharing Begins At Home: Opportunities For Library Partnerships On A University Campus, Robert A. Seal

University Libraries: Faculty Publications and Other Works

Typical discussions of academic library resource sharing focus on activities between and among institutions: interlibrary loan, reciprocal borrowing, document delivery, group acquisitions, etc. But there is another equally important type of cooperation, i.e. working with other campus units to provide better service, more convenience, and enhanced resources for library users. Sometimes referred to as campus collaboration or convergence, this activity also advances institutional priorities, in particular that of student success. Library partners include information technology services, student development, writing centers, academic departments, and centers for teaching excellence, among others. This paper explores these relationships, their advantages and disadvantages, goals, the …

The Sun Star Vol 35 No 10 ( November 3rd, 2015), N/A N/A

Sun Star

No abstract provided.

Spring, Summer, Fall 2015 Graduation Survey Responses Master File Without Identifiers, Uno Office Of Institutional Effectiveness

Graduation

Spring, Summer, Fall 2015 Graduation survey responses.

Presentation, Geographic And Numeric Updates To The Estimated Breeding Population Of Reddish Egret, October 3, 2015, Ann F. Paul, Jerome J. Lorenz, Ann B. Hodgson

Audubon Coastal Islands Sanctuaries - Records

A presentation examining the distribution, population status, and conservation of the Reddish Egret in Florida, including recent survey findings and management recommendations.

Summer Research And Creativity Grants, Uk Office Of Undergraduate Research

Kaleidoscope

No abstract provided.