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2015

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Situating Contraceptive Practices And Public Health Strategy In The Bronx: Perspectives From Female Youth, Healthcare Workers, And Reproductive Health Leaders, Hannah Louise Helmy Jan 2015

Situating Contraceptive Practices And Public Health Strategy In The Bronx: Perspectives From Female Youth, Healthcare Workers, And Reproductive Health Leaders, Hannah Louise Helmy

USF Tampa Graduate Theses and Dissertations

In the United States, concerns about adolescent childbearing and its perceived corollaries – negative health outcomes for mother and child, the disintegration of the nuclear family, and “over-dependence” on public resources – began to circulate widely in policy spheres and popular media in the 1970’s, resulting in a proliferation of policies, programs, and services designed to address its prevention. Although national birth rates among adolescents are currently at their lowest since peaking in the early 1990’s, this decline masks persistent and significant disparities between groups of young people by race, ethnicity, geography, and poverty level. The concomitant existence of social …


Tampa Electric Company's Big Bend Utility Plant In Hillsborough County, Florida: A Case Study, Lynne M. Hodalski-Champagne Jan 2015

Tampa Electric Company's Big Bend Utility Plant In Hillsborough County, Florida: A Case Study, Lynne M. Hodalski-Champagne

USF Tampa Graduate Theses and Dissertations

This is an in-depth analysis of coal fire burning power plants, their effects on human health and the environment. It also employed case study data from Tampa Electric Company’s Big Bend facility to examine environmental infractions at that facility. Tampa Electric Company’s Big Bend Utility Plant, violated the Clean Air Act, which led to a lawsuit filed by the Department of Justice on behalf of the United States Environmental Protection Agency and the Florida Department of Environmental Protection in 1997. This case study details the lawsuit, and subsequent settlement as well as Tampa Electric Company’s record of compliance since 2000. …


Comparison Of Isotope-Based Biomass Pathways With Groundfish Community Structure In The Eastern Gulf Of Mexico, Sheri Ann Huelster Jan 2015

Comparison Of Isotope-Based Biomass Pathways With Groundfish Community Structure In The Eastern Gulf Of Mexico, Sheri Ann Huelster

USF Tampa Graduate Theses and Dissertations

This study compared traditional community analysis with stable-isotope trophic analysis to define process-based trophic elements of community structure in the eastern Gulf of Mexico, and developed a predictive capability regarding changes to fish community structure that would be expected from increasing eutrophication. Specifically, it used an existing trawl survey program (SEAMAP) to compare invertebrate herbivore (sponge and sea urchin) isotopes with groundfish isotopes, and then compared the resulting spatial patterns with spatial variation in community structure, as identified by cluster analysis. The comparison was applied to seven NMFS survey zones that extended offshore from the Caloosahatchee River, FL northwest to …


Equifinality And Multifinality In Psychopathology: Can Cognitive And Emotional Processes Differentiate Internalizing, Externalizing, And Co-Occurring Psychopathology, Brittany Jordan-Arthur Jan 2015

Equifinality And Multifinality In Psychopathology: Can Cognitive And Emotional Processes Differentiate Internalizing, Externalizing, And Co-Occurring Psychopathology, Brittany Jordan-Arthur

USF Tampa Graduate Theses and Dissertations

Despite our knowledge of environmental risk factors for psychopathology, the equifinality and multifinality observed in the extant literature reveals how little is known about the role of these risk factors in the development of psychopathology. The purpose of this study was to identify processes that differentiate internalizing, externalizing and co-occurring psychopathology. Specifically, emotion identification skill and cognitive appraisal style were examined as processes where individual differences may contribute to the development of mental illness. To date no study has been conducted to examine whether emotion identification and appraisal style may differentiate forms of internalizing, externalizing and co-occurring psychopathology and lack …


Structure-Function Analysis Of The Dna Damage Repair Complex Str In Saccharomyces Cerevisiae, Jessica Ashley Kennedy Jan 2015

Structure-Function Analysis Of The Dna Damage Repair Complex Str In Saccharomyces Cerevisiae, Jessica Ashley Kennedy

USF Tampa Graduate Theses and Dissertations

The RecQ family of helicases has been termed the “Caretakers of the Genome,” and rightfully so. These proteins are highly conserved from bacteria to humans and have been implicated in functions from homologous recombinatorial repair to damage checkpoint response to telomere maintenance and more. Mutant genes of three of the human RecQ helicases lead to syndromes characterized by a high incidence of cancer, premature aging and early death. Despite their implications in several biological functions and importance to the integrity of the human genome and suppression of cancer, many aspects of the RecQ family structure and function remain unknown. To …


The Role Of Anxiety Sensitivity In The Relationship Between Posttraumatic Stress Symptoms And Negative Outcomes In Trauma-Exposed Adults, Brittany Belle Kugler Jan 2015

The Role Of Anxiety Sensitivity In The Relationship Between Posttraumatic Stress Symptoms And Negative Outcomes In Trauma-Exposed Adults, Brittany Belle Kugler

USF Tampa Graduate Theses and Dissertations

Background: The development of posttraumatic stress symptoms (PTS) following a traumatic event is related to significant functional impairment, diminished quality of life, and physical health issues. Yet it is not entirely clear why some traumatized individuals experience negative outcomes while others do not. The purpose of this study is to determine the role of several influential factors related to PTS severity and negative outcomes, such as diminished quality of life and physical health issues, following traumatic events. Method: One hundred and twenty-two trauma-exposed adults were recruited through the University of South Florida’s SONA system and through flyers on campus. Subjects …


Investigation Of Post-Translational Modifications In Staphylococcus Aureus, Christina Nadia Krute Jan 2015

Investigation Of Post-Translational Modifications In Staphylococcus Aureus, Christina Nadia Krute

USF Tampa Graduate Theses and Dissertations

The work presented herein details post-translational modifications (PTMs) in Staphylococcus aureus that are involved in mediating the stress response and normal cellular processes. The first PTM that was investigated is regulated intramembrane proteolysis (RIP) for the activation of the ECF sigma factor σS. We achieved this by analyzing the role of the site-1 protease, which we termed “putative regulator of sigmaS” (PrsS), as it is predicted to be the first enzyme in the RIP cascade, leading to the activation of σS. It was determined that the putative site-1 protease, prsS, mimics transcriptional profiles of sigS; with expression low in all …


System Threats And Gender Differences In Sexism And Gender Stereotypes, Sophie Lois Kuchynka Jan 2015

System Threats And Gender Differences In Sexism And Gender Stereotypes, Sophie Lois Kuchynka

USF Tampa Graduate Theses and Dissertations

In the United States, women’s persistent gains in structural power may cause backlash among those motivated to preserve the status quo. The proposed study examines the conditions that prompt men and women to endorse sexism and promote gender stereotypes. System justification theory proposes that people are motivated to justify the socio-political system that governs them and threats to the stability of their system can increase individual’s motivated defenses. I expect men to show the strongest motivated defenses when the hierarchy is threatened or viewed as unstable, because to protect group-based interests men will reinforce the legitimacy of the system through …


Schreibersite: Synthesis, Characterization And Corrosion And Possible Implications For Origin Of Life, Nikita Latesha La Cruz Jan 2015

Schreibersite: Synthesis, Characterization And Corrosion And Possible Implications For Origin Of Life, Nikita Latesha La Cruz

USF Tampa Graduate Theses and Dissertations

We present study of the synthesis and reactions of an analog of the meteoritic mineral schreibersite with formula (Fe,Ni)3P, believed to be a prebiotic source of reactive phosphorus that may have prompted the formation of phosphorylated biomolecules near the time of the origin of life (Pasek and Lauretta, 2005). The mineral was synthesized by mixing stoichiometric proportions of elemental iron, nickel and phosphorus and heating in a tube furnace at 820°C for approximately 235 hours under argon or under vacuum, a modification of the method of Skála and Drábek (2002). The mineral was characterized using X-ray diffractometry (XRD), X-ray photoelectron …


Historical And Current Population Patterns Of The Staghorn Coral (_Acropora Cervicornis_) In Dry Tortugas National Park, Kaitlyn Lizza Jan 2015

Historical And Current Population Patterns Of The Staghorn Coral (_Acropora Cervicornis_) In Dry Tortugas National Park, Kaitlyn Lizza

USF Tampa Graduate Theses and Dissertations

Acropora cervicornis was once one of the dominant reef building corals of the Caribbean, Florida Keys, and Dry Tortugas (DRTO), but since the 1970’s populations have been decimated throughout their geographic range. Recently, a repopulation was documented through detailed benthic surveys conducted by the U.S. Geological Survey at three locations (Pulaski Shoal, East Key, and Loggerhead Key) within DRTO. Benthic surveys using the U.S Geological Survey’s Along-Track Reef Imaging System (ATRIS) revealed hundreds of previously undocumented colonies.

These discoveries have provided a unique data-set, allowing a comparison between the historical (1883, 1976) and contemporary distributions (2009, 2011) of A. cervicornis. …


Effects Of Solids Retention Time And Feeding Frequency On Performance And Pathogen Fate In Semi-Continuous Mesophilic Anaerobic Digesters, Nathan Daniel Manser Jan 2015

Effects Of Solids Retention Time And Feeding Frequency On Performance And Pathogen Fate In Semi-Continuous Mesophilic Anaerobic Digesters, Nathan Daniel Manser

USF Tampa Graduate Theses and Dissertations

Anaerobic digestion is a biochemical process in which organic carbon is biodegraded in an oxygen free environment through a microbial consortium. Engineered biological systems used for resource recovery often utilize anaerobic digestion to treat anthropogenic organic wastes by reclaiming the carbon as energy (methane gas) and a soil amendment (biosolids). Small-scale, or household, semi-continuous anaerobic digesters have been used in developed and developing countries for many decades to produce biogas from human and livestock waste, which is used for heating, lighting, and cooking. This application has been shown to improve the quality of life of the user. Although there is …


Rapid Root Elongation By Phreatophyte Seedlings Does Not Imply Tolerance Of Water Table Decline, Caroline A. Canham, Raymond H. Froend, William D. Stock Jan 2015

Rapid Root Elongation By Phreatophyte Seedlings Does Not Imply Tolerance Of Water Table Decline, Caroline A. Canham, Raymond H. Froend, William D. Stock

Research outputs 2014 to 2021

Key message Despite high rates of root elongation during phreatophyte establishment once connection to groundwater has occurred and leaf area develops, seedlings demonstrate limited capacity for root elongation in response to groundwater decline.

Abstract In a water-limited environment, rapid root elongation immediately after germination can be critical for a plant to reach deeper water sources such as a water table to avoid water deficit stress. However, once plants have accessed a water table, their continued survival may depend on their ability to adapt their root distribution to changes in the depth to a water table. In glasshouse experiments using two …


The Role Of Apoe-Ε4 And Beta Amyloid In The Differential Rate Of Recovery From Ect : A Review, T. A. Sutton, Hamid R. Sohrabi, Stephanie Rainey-Smith, S. M. Bird, M. Weinborn, Ralph Martins Jan 2015

The Role Of Apoe-Ε4 And Beta Amyloid In The Differential Rate Of Recovery From Ect : A Review, T. A. Sutton, Hamid R. Sohrabi, Stephanie Rainey-Smith, S. M. Bird, M. Weinborn, Ralph Martins

Research outputs 2014 to 2021

Individual biological differences may contribute to the variability of outcomes, including cognitive effects, observed following electroconvulsive treatment (ECT). A narrative review of the research literature on carriage of the apolipoprotein E ε4 allele (APOE-ε4) and the protein biomarker beta amyloid (Aβ) with ECT cognitive outcome was undertaken. ECT induces repeated brain seizures and there is debate as to whether this causes brain injury and long-term cognitive disruption. The majority of ECT is administered to the elderly (over age 65 years) with drug-resistant depression. Depression in the elderly may be a symptom of the prodromal stage of Alzheimer’s disease …


Apoe Ε4 Moderates Abnormal Csf-Abeta-42 Levels, While Neurocognitive Impairment Is Associated With Abnormal Csf Tau Levels In Hiv+ Individuals - A Cross-Sectional Observational Study, Cysique A. Lucette, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph Martins, Constance S. Chew, Nicholas N. Davies, Patricia J. Price, Bruce J. Brew Jan 2015

Apoe Ε4 Moderates Abnormal Csf-Abeta-42 Levels, While Neurocognitive Impairment Is Associated With Abnormal Csf Tau Levels In Hiv+ Individuals - A Cross-Sectional Observational Study, Cysique A. Lucette, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph Martins, Constance S. Chew, Nicholas N. Davies, Patricia J. Price, Bruce J. Brew

Research outputs 2014 to 2021

Background: Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. Methods: Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median HIV duration 20 years, >95% plasma and CSF HIV RNA /mL, on cART for a median 24 months). All underwent standard neuropsychological testing (61% had HAND), APOE genotyping (30.9% carried APOE ε4 and 7.1% were ε4 homozygotes) and a lumbar puncture. Concentrations of Aβ1-42, t-tau and p-tau were assessed in the CSF using commercial …


Diagnostic Value Of Subjective Memory Complaints Assessed With A Single Item In Dominantly Inherited Alzheimer's Disease: Results Of The Dian Study, Christoph Laske, Hamid R. Sohrabi, Mateusz S. Jasielec, Stephan A. Müller, Niklas K. Koehler, Susanne Gräber, Stefan L. Förster, Alexander E. Drzezga, Felix Mueller-Sarnowski, Adrian Danek, Mathias Jucker, Randall J. Bateman, Virginia D. Buckles, Andrew J. Saykin, Ralph Martins, John C. Morris Jan 2015

Diagnostic Value Of Subjective Memory Complaints Assessed With A Single Item In Dominantly Inherited Alzheimer's Disease: Results Of The Dian Study, Christoph Laske, Hamid R. Sohrabi, Mateusz S. Jasielec, Stephan A. Müller, Niklas K. Koehler, Susanne Gräber, Stefan L. Förster, Alexander E. Drzezga, Felix Mueller-Sarnowski, Adrian Danek, Mathias Jucker, Randall J. Bateman, Virginia D. Buckles, Andrew J. Saykin, Ralph Martins, John C. Morris

Research outputs 2014 to 2021

Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). Methods. The baseline sample of 183 mutation carriers (MCs) and 117 noncarriers (NCs) was divided according to Clinical Dementia Rating (CDR) scale into preclinical (CDR 0; MCs: n = 107; NCs: n = 109), early symptomatic (CDR 0.5; MCs: n = 48; NCs: n = 8), and dementia stage (CDR ≥ 1; MCs: n = 28; NCs: n = 0). These groups …


Failure Of Science, Death Of Nature, H.F. Recher Jan 2015

Failure Of Science, Death Of Nature, H.F. Recher

Research outputs 2014 to 2021

As a people, Australians have lost contact with the world of nature, Risking the collapse of civilization. One factor in the alienation of nature in Australia is the failure of the scientific community to take responsibility for the technology created by the knowledge generated from scientific research. Science has failed to protect Australia's flora and fauna. Scientists must communicate more widely with society, but need to be educated on how to communicate and on their ethical responsibilities to others and other species. Government needs to show leadership in environmental management and nature conservation, while conservationists need to 'invert the paradigm', …


Increasing Sediment Accumulation Rates In La Fonera (Palamós) Submarine Canyon Axis And Their Relationship With Bottom Trawling Activities, P. Puig, J. Martin, P. Masque, A. Palanques Jan 2015

Increasing Sediment Accumulation Rates In La Fonera (Palamós) Submarine Canyon Axis And Their Relationship With Bottom Trawling Activities, P. Puig, J. Martin, P. Masque, A. Palanques

Research outputs 2014 to 2021

Previous studies conducted in La Fonera (Palamós) submarine canyon (NW Mediterranean) found that trawling activities along the canyon flanks cause resuspension and transport of sediments toward the canyon axis. 210Pb chronology supported by 137Cs dating applied to a sediment core collected at 1750m in 2002 suggested a doubling of the sediment accumulation rate since the 1970s, coincident with the rapid industrialization of the local trawling fleet. The same canyon area has been revisited a decade later, and new data are consistent with a sedimentary regime shift during the 1970s and also suggest that the accumulation rate during the last decade …


A New Species Of Sphaerowithius (Pseudoscorpiones, Withiidae) From Namibia, Mark S. Harvey, V. Menhert Jan 2015

A New Species Of Sphaerowithius (Pseudoscorpiones, Withiidae) From Namibia, Mark S. Harvey, V. Menhert

Research outputs 2014 to 2021

A new species of Sphaerowithius Mahnert, 1988, S. ansieae sp. n., is described from specimens collected in caves in northern Namibia. The specimens show some slight modifications to an obligate cavernicolous existence including small eyes and long, slender pedipalps.


Postmitotic Expression Of Sod1g93a Gene Affects The Identity Of Myogenic Cells And Inhibits Myoblasts Differentiation, M. Martini, G. Dobrowolny, M. Aucello, Antonio Musaro Jan 2015

Postmitotic Expression Of Sod1g93a Gene Affects The Identity Of Myogenic Cells And Inhibits Myoblasts Differentiation, M. Martini, G. Dobrowolny, M. Aucello, Antonio Musaro

Research outputs 2014 to 2021

To determine the role of mutant SOD1 gene (SOD1G93A) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1G93A gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1G93A in C2C12 cells resulted in dramatic inhibition of myoblast differentiation. Transfected SOD1G93A gene expression in postmitotic skeletal myocytes downregulated the expression of relevant markers of committed and differentiated myoblasts such as MyoD, Myogenin, MRF4, and the muscle specific miRNA expression. The inhibitory effects of SOD1G93A gene on myogenic program perturbed Akt/p70 and MAPK signaling pathways which promote differentiation cascade. Of note, …


A Preliminary Investigation Into The Relationship Between Functional Movement Screen Scores And Athletic Physical Performance In Female Team Sport Athletes, R.G. Lockie, A.B. Schultz, Samuel J. Callaghan, C.A. Jordan, T.M. Luczo, M.D. Jeffriess Jan 2015

A Preliminary Investigation Into The Relationship Between Functional Movement Screen Scores And Athletic Physical Performance In Female Team Sport Athletes, R.G. Lockie, A.B. Schultz, Samuel J. Callaghan, C.A. Jordan, T.M. Luczo, M.D. Jeffriess

Research outputs 2014 to 2021

There is little research investigating relationships between the Functional Movement Screen (FMS) and athletic performance in female athletes. This study analyzed the relationships between FMS (deep squat; hurdle step [HS]; in-line lunge [ILL]; shoulder mobility; active straight-leg raise [ASLR]; trunk stability push-up; rotary stability) scores, and performance tests (bilateral and unilateral sit-and-reach [flexibility]; 20-m sprint [linear speed]; 505 with turns from each leg; modified T-test with movement to left and right [change-of-direction speed]; bilateral and unilateral vertical and standing broad jumps; lateral jumps [leg power]). Nine healthy female recreational team sport athletes (age = 22.67 ± 5.12 years; height = …


The Effect Of Multidisciplinary Rehabilitation On Brain Structure And Cognition In Huntington's Disease: An Exploratory Study, Travis M. Cruickshank, Jennifer A. Thompson, Juan F. Dominguez D, Alvaro P. Reyes, Mike Bynevelt, Nellie Georgiou-Karistianis, Roger A. Barker, Mel R. Ziman Jan 2015

The Effect Of Multidisciplinary Rehabilitation On Brain Structure And Cognition In Huntington's Disease: An Exploratory Study, Travis M. Cruickshank, Jennifer A. Thompson, Juan F. Dominguez D, Alvaro P. Reyes, Mike Bynevelt, Nellie Georgiou-Karistianis, Roger A. Barker, Mel R. Ziman

Research outputs 2014 to 2021

Background: There is a wealth of evidence detailing gray matter degeneration and loss of cognitive function over time in individuals with Huntington's disease (HD). Efforts to attenuate disease-related brain and cognitive changes have been unsuccessful to date. Multidisciplinary rehabilitation, comprising motor and cognitive intervention, has been shown to positively impact on functional capacity, depression, quality of life and some aspects of cognition in individuals with HD. This exploratory study aimed to evaluate, for the first time, whether multidisciplinary rehabilitation can slow further deterioration of disease-related brain changes and related cognitive deficits in individuals with manifest HD. Methods: Fifteen participants who …


Deep Convolutional Neural Networks For Annotating Gene Expression Patterns In The Mouse Brain, Tao Zeng, Rongjian Li, Ravi Mukkamala, Jieping Ye, Shuiwang Ji Jan 2015

Deep Convolutional Neural Networks For Annotating Gene Expression Patterns In The Mouse Brain, Tao Zeng, Rongjian Li, Ravi Mukkamala, Jieping Ye, Shuiwang Ji

Computer Science Faculty Publications

Background: Profiling gene expression in brain structures at various spatial and temporal scales is essential to understanding how genes regulate the development of brain structures. The Allen Developing Mouse Brain Atlas provides high-resolution 3-D in situ hybridization (ISH) gene expression patterns in multiple developing stages of the mouse brain. Currently, the ISH images are annotated with anatomical terms manually. In this paper, we propose a computational approach to annotate gene expression pattern images in the mouse brain at various structural levels over the course of development.

Results: We applied deep convolutional neural network that was trained on a large set …


Altitude Exposure At 1800 M Increases Haemoglobin Mass In Distance Runners, Laura A. Gravican-Lewis, Iona Halliday, Chris R. Abbiss, Philo U. Saunders, Christopher P.J. Gore Jan 2015

Altitude Exposure At 1800 M Increases Haemoglobin Mass In Distance Runners, Laura A. Gravican-Lewis, Iona Halliday, Chris R. Abbiss, Philo U. Saunders, Christopher P.J. Gore

Research outputs 2014 to 2021

The influence of low natural altitudes (< 2000 m) on erythropoietic adaptation is currently unclear, with current recommendations indicating that such low altitudes may be insufficient to stimulate significant increases in haemoglobin mass (Hbmass). As such, the purpose of this study was to determine the influence of 3 weeks of live high, train high exposure (LHTH) at low natural altitude (i.e. 1800 m) on Hbmass, red blood cell count and iron profile. A total of 16 elite or well-trained runners were assigned into either a LHTH (n = 8) or CONTROL (n = 8) group. Venous blood samples were drawn prior to, at 2 weeks and at 3 weeks following exposure. Hbmass was measured in duplicate prior to exposure and at 2 …


A New Qualitative Typology To Classify Treading Water Movement Patterns, Christophe Schnitzler, Chris Button, James L. Croft, Ludovic Seifert Jan 2015

A New Qualitative Typology To Classify Treading Water Movement Patterns, Christophe Schnitzler, Chris Button, James L. Croft, Ludovic Seifert

Research outputs 2014 to 2021

This study proposes a new qualitative typology that can be used to classify learners treading water into different skill-based categories. To establish the typology, 38 participants were videotaped while treading water and their movement patterns were qualitatively analyzed by two experienced biomechanists. 13 sport science students were then asked to classify eight of the original participants after watching a brief tutorial video about how to use the typology. To examine intra-rater consistency, each participant was presented in a random order three times. Generalizability (G) and Decision (D) studies were performed to estimate the importance variance due to rater, occasion, video …


The Ph Sensing Properties Of Rf Sputtered Ruo2 Thin-Film Prepared Using Different Ar/O2 Flow Ratio, Ali Sardarinejad, Devendra Kumar Maurya, Kamal Alameh Jan 2015

The Ph Sensing Properties Of Rf Sputtered Ruo2 Thin-Film Prepared Using Different Ar/O2 Flow Ratio, Ali Sardarinejad, Devendra Kumar Maurya, Kamal Alameh

Research outputs 2014 to 2021

The influence of the Ar/O2 gas ratio during radio frequency (RF) sputtering of the RuO2 sensing electrode on the pH sensing performance is investigated. The developed pH sensor consists in an RF sputtered ruthenium oxide thin-film sensing electrode, in conjunction with an electroplated Ag/AgCl reference electrode. The performance and characterization of the developed pH sensors in terms of sensitivity, response time, stability, reversibility, and hysteresis are investigated. Experimental results show that the pH sensor exhibits super-Nernstian slopes in the range of 64.33-73.83 mV/pH for Ar/O2 gas ratio between 10/0-7/3. In particular, the best pH sensing performance, in …


Amyloid-Related Memory Decline In Preclinical Alzheimer's Disease In Dependent On Apoe Ε4 And Is Detectable Over 18-Months, Christine Thai, Yen Ying Lim, Victor L. Villemagne, Simon Laws, David Ames, Kathryn A. Ellis, Stephanie Rainey-Smith, Ralph Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff, Australian Imaging, Biomarkers And Lifestyle (Aibl) Research Group Jan 2015

Amyloid-Related Memory Decline In Preclinical Alzheimer's Disease In Dependent On Apoe Ε4 And Is Detectable Over 18-Months, Christine Thai, Yen Ying Lim, Victor L. Villemagne, Simon Laws, David Ames, Kathryn A. Ellis, Stephanie Rainey-Smith, Ralph Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff, Australian Imaging, Biomarkers And Lifestyle (Aibl) Research Group

Research outputs 2014 to 2021

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE ε4 carrier status, and cognitive decline over 18 monthes, in 317 cognitively healthy (CN) older adults (47% males, 52.4% females) aged between 60 and 89 years (Mean = 69.9, SC = 6.8). Cognition was assessed using the Cogstate Brief Battery (CBB) and the California Verbal Learning Test, Second Edition (CVLT-II). Planned comparisons indicated that CN older adults …


Association Of Systemic Lupus Erythematosus Associates With Decreased Immunosuppressive Potential Of The Igg Glycome, Franco Vukovic, Jasminka Krištić, Ivan Gudelj, Maria Teruel, Toma Keser, Marija Pezer, Maja Pučić-Baković, Jerko Štambuk, Irena Trbojević-Akmačić, Clara Barrios, Tamara Pavić, Cristina Menni, Youxin Wang, Yong Zhou, Liufu Cui, Haicheng Song, Qiang Zeng, Xiuhua Guo, Bernardo A. Pons-Estel, Paul Mckeigue, Alan Leslie Patrick, Olga Gornik, Tim D. Spector, Miroslav Harjaček, Marta Alarcon-Riquelme, Miriam Molokhia, Wei Wang, Gordan Lauc Jan 2015

Association Of Systemic Lupus Erythematosus Associates With Decreased Immunosuppressive Potential Of The Igg Glycome, Franco Vukovic, Jasminka Krištić, Ivan Gudelj, Maria Teruel, Toma Keser, Marija Pezer, Maja Pučić-Baković, Jerko Štambuk, Irena Trbojević-Akmačić, Clara Barrios, Tamara Pavić, Cristina Menni, Youxin Wang, Yong Zhou, Liufu Cui, Haicheng Song, Qiang Zeng, Xiuhua Guo, Bernardo A. Pons-Estel, Paul Mckeigue, Alan Leslie Patrick, Olga Gornik, Tim D. Spector, Miroslav Harjaček, Marta Alarcon-Riquelme, Miriam Molokhia, Wei Wang, Gordan Lauc

Research outputs 2014 to 2021

Objective: Glycans attached to the Fc portion of IgG are important modulators of IgG effector functions. Interindividual differences in IgG glycome composition are large and they associate strongly with different inflammatory and autoimmune diseases. IKZF1, HLA–DQ2A/B, and BACH2 genetic loci that affect IgG glycome composition show pleiotropy with systemic lupus erythematosus (SLE), indicating a potentially causative role of aberrant IgG glycosylation in SLE. We undertook this large multicenter case–control study to determine whether SLE is associated with altered IgG glycosylation. Methods: Using ultra-performance liquid chromatography analysis of released glycans, we analyzed the composition of the IgG glycome in 261 SLE …


Butyrylated Starch Intake Can Prevent Red Meat-Induced O6-Methyl-2-Deoxyguanosine Adducts In Human Rectal Tissue: A Randomised Clinical Trial, Richard K. Le Leu, Jean M. Winter, Claus T. Christophersen, Graeme P. Young, Karen J. Humphreys, Ying Hu, Silvia W. Gratz, Rosalind B. Miller, David L. Topping, Anthony R. Bird, Michael A. Conlon Jan 2015

Butyrylated Starch Intake Can Prevent Red Meat-Induced O6-Methyl-2-Deoxyguanosine Adducts In Human Rectal Tissue: A Randomised Clinical Trial, Richard K. Le Leu, Jean M. Winter, Claus T. Christophersen, Graeme P. Young, Karen J. Humphreys, Ying Hu, Silvia W. Gratz, Rosalind B. Miller, David L. Topping, Anthony R. Bird, Michael A. Conlon

Research outputs 2014 to 2021

Epidemiological studies have identified increased colorectal cancer (CRC) risk with high red meat (HRM) intakes, whereas dietary fibre intake appears to be protective. In the present study, we examined whether a HRM diet increased rectal O6-methyl-2-deoxyguanosine (O6MeG) adduct levels in healthy human subjects, and whether butyrylated high-amylose maize starch (HAMSB) was protective. A group of twenty-three individuals consumed 300 g/d of cooked red meat without (HRM diet) or with 40 g/d of HAMSB (HRM+HAMSB diet) over 4-week periods separated by a 4-week washout in a randomised cross-over design. Stool and rectal biopsy samples were collected for …


Inflamation And Oxidative Stress : The Molecular Connectivity Between Insulin Resistance, Obesity And Alzheimer's Disease, Guiseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph Martins, Paul E. Fraser, Philip Newsholme Jan 2015

Inflamation And Oxidative Stress : The Molecular Connectivity Between Insulin Resistance, Obesity And Alzheimer's Disease, Guiseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph Martins, Paul E. Fraser, Philip Newsholme

Research outputs 2014 to 2021

Type 2 diabetes (T 2 DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders. Alzheimer’s disease (AD) is the most common subtype of dementia. Reduced release (for T 2 DM) and decreased action of insulin are central to the development and progression of both T 2 DM and AD. A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD. Insulin resistance …


Relationships Between Lower-Body Muscle Structure And, Lower-Body Strength, Explosiveness And Eccentric Leg Stiffness In Adolescent Athletes, Josh Secomb, Sophia Nimphius, Oliver R. Farley, Lina Lundgren, Tai T. Tran, Jeremy M. Sheppard Jan 2015

Relationships Between Lower-Body Muscle Structure And, Lower-Body Strength, Explosiveness And Eccentric Leg Stiffness In Adolescent Athletes, Josh Secomb, Sophia Nimphius, Oliver R. Farley, Lina Lundgren, Tai T. Tran, Jeremy M. Sheppard

Research outputs 2014 to 2021

The purpose of the present study was to determine whether any relationships were present between lower-body muscle structure and, lower-body strength, variables measured during a counter-movement jump (CMJ) and squat jump (SJ), and eccentric leg stiffness, in adolescent athletes. Thirty junior male (n = 23) and female (n = 7) surfing athletes (14.8 ± 1.7 y; 1.63 ± 0.09 m; 54.8 ± 12.1 kg) undertook lower-body muscle structure assessment with ultrasonography and performed a; CMJ, SJ and an isomet-ric mid-thigh pull (IMTP). In addition, eccentric leg stiffness was calculated from variables of the CMJ and IMTP. Moderate to very large …