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Sexual Dysfunctions In Psoriatic Patients, Maria Isabela Sarbu, Mircea Tampa, Alexandra Elenda Sarbu, Simona Roxana Georgescu

Journal of Mind and Medical Sciences

Psoriasis is a chronic, immune-mediated disorder with a worldwide occurrence characterized by well-defined infiltrated erythematous papules and plaques, covered by silvery white or yellowish scales. It is a physically, socially and emotionally invalidating disorder that affects 1-2% of the population. Sexual health is an important part of general health and sexual dysfunctions can negatively affect self-esteem, confidence, interpersonal relationships and the quality of life. Dermatology Life Quality Index (DLQI), Psoriasis Disability Index (PDI) and the Impact of Psoriasis on Quality of Life (IPSO) questionnaire are all questionnaires used to assess the quality of life of patients with psoriasis and each …

Mental And Medical Sciences Today, David L. Rowland, Ion G. Motofei

Journal of Mind and Medical Sciences

Journal of Mind and Medical Sciences is designed as a free online, open access, interdisciplinary and peer-reviewed journal. The JMMS mission is to address ideas and issues related to mind and medicine, publishing scientific review and empirical papers regarding mental and medical health and disease. Our goal is to stimulate constructive debates among scholars, researchers, physicians, scientists and health professionals with respect to the latest discoveries and trends in the field. The journal pays special attention to interdisciplinary and integrative perspectives, focusing primarily on papers approaching mind and body as a unitary domain of study.

Our supposition is that the …

A New Foundation For Sexual Social Justice: The World Health Organization’S Report On Sexual Health, Human Rights, And The Law, Nikki L. Rogers, Cristina Redko

Breaking Silences, Demanding Crip Justice: Sex, Sexuality, and Disability

Social justice benefits from a unified foundation of shared basic beliefs. There are still too few global, evidence-based documents that provide standardized language and vision through which social justice standards, policy and legal actions can be created, compared and amended.

This is a broad, evidence-based public health report on best practices to foster “achievement of the highest attainable standard of sexual health”. It frames this goal as intimately related to the protection of human rights, the right to non-discrimination and to health information and services.

While other reports link laws impacting human rights and health, this specific focus on laws …

The Problem Of Global Economic Inequity: Legal Structures And Some Thoughts On The Next 40 Years, Inamul Haq

Georgia Journal of International & Comparative Law

No abstract provided.

Understanding Acceptable Level Of Risk: Incorporating The Economic Cost Of Under-Managing Invasive Species, Alisha D. Davidson, Chad L. Hewitt, Donna R. Kashian

Environmental Science and Geology Faculty Research Publications

Management of nonindigenous species includes prevention, early detection and rapid response and control. Early detection and rapid response depend on prioritizing and monitoring sites at risk for arrival or secondary spread of nonindigenous species. Such monitoring efforts require sufficient biosecurity budgets to be effective and meet management or policy directives for reduced risk of introduction. Such consideration of risk reduction is rarely considered, however. Here, we review the concepts of acceptable level of risk (ALOR) and associated costs with respect to nonindigenous species and present a framework for aligning risk reduction priorities with available biosecurity resources. We conclude that available …

Weekly News Digest 11/04/2015, Jenna Ray

Weekly Bulletin Archive

In This Issue:

● 5th Celebration of Scholarly Accomplishments Opens

● Morris Leads the State in Effectiveness and Efficiency

● Three Cougar Teams Make It to UMAC Semi-Finals

● Cyrus Bina Interviewed by The Real News Network

Cder's Emerging Technology Team, Kurt Brorson, Sau Lee

Integrated Continuous Biomanufacturing II

The newly formed Emerging Technology Team (ETT) draws membership from all CDER quality review, research and inspection functions, including Office of Biotechnology Products. The goal of the ETT is provide a primary point of contact for external inquiries regarding emerging technology in pharmaceutical and biotechnology manufacturing and quality control. The ETT will partner with review offices in a cross-functional manner and identify regulatory strategy and resolve roadblocks to new technologies relating to existing guidance, policy or practices related to review or inspection. The ETT’s initial focus will be innovation on novel products, manufacturing processes, or testing technologies or processes to …

Exploring Continuous And Integrated Strategies For The Up- And Downstream Processing Of Human Mesenchymal Stem Cells, Barbara Cunha, Tiago Aguiar, Ricardo Silva, Cristina Peixoto, Manuel Carrondo, Margarida Serra, Paula Alves

Integrated Continuous Biomanufacturing II

The integration of up- and downstream unit operations can result in the elimination of hold steps, thus decreasing the footprint, and ultimately can create robust closed system operations. This type of design is desirable for the bioprocess of human mesenchymal stem cells (hMSC), where high numbers of pure cells, at low volumes, need to be delivered for therapy applications. The aim of this work is to perform a proof of concept of the integration of a continuous perfusion culture in bioreactors with a tangential flow filtration (TFF) system for the concentration and washing of hMSC. In particular, we have evaluated …

Quality Systems For Continuous Manufacturing, Ron Branning

Integrated Continuous Biomanufacturing II

Continuous manufacturing is a familiar concept in large volume commercial commodity operations such as glass and plastic production. In the wake of the Tylenol cyanide poison scare in the 1970’s, pharmaceutical production at the J&J subsidiary McNeil converted to virtually closed, continuous manufacturing. Several Biotech firms tried to develop fermentation unit operations in the 1990’s that were based on the continuous manufacturing concept. Today there are a number of initiatives to update and realize the concept from bench top, such as MIT and Novartis’ sponsorship of start up firm Continuus’ production of solid dosage forms in Boston, to biodefense tractor-trailer …

Dynamic Oncolytic Measles Virus Production, Tanja Grein, Denise Salzig, Michael Muehlebach, Peter Czermak

Integrated Continuous Biomanufacturing II

Oncolytic viruses can be effective weapons against cancer with few treatment options. For example the tissue culture–adapted Edmonston strains of measles virus (MV) have altered its receptor specificity and became selectively oncolytic with attenuated pathogenicity. Russel et al. showed in 2014 full remission in an advanced stage multiple myeloma patient after systemic application of genetically modified MV. In this clinical trial, the patient was treated by intravenous infusion of 10¹¹ TCID₅₀ (50% tissue culture infectious dose) - of an engineered MV encoding human sodium iodide symporter. Appropriate medical treatment with oncolytic viruses calls for high concentrations and absolute …

Transforming The Present Into The Future With Uncertainty And Imprecision, Chales Cooney

Integrated Continuous Biomanufacturing II

No abstract provided.

Advanced Computational Tools To Enhance Continuous Monoclonal Antibody Production, Maria M. Papathanasiou, Ana Quiroga, Athanasios Mantalaris, Efstratios Pistikopoulos

Integrated Continuous Biomanufacturing II

Leading pharmaceutical companies invest high percentage of their revenue in the improvement of existing technologies used for the production of monoclonal antibodies (mAbs). Recently, there has been a paradigm shift towards the development of continuous/quasi-continuous purification operations, aiming to reduce capital and operational costs [1]. At the moment, however, there are no standardized methods and/or tools that can be used for global control and monitoring of integrated processes.

Mathematical models and advanced computational tools can be the key for the development of robust, integrated processes, as they can provide valuable insight in the process dynamics and ensure optimal operation [2]. …

Small-Scale Platform For Rapid On-Demand Manufacturing Of Recombinant Proteins, J. Christopher Love

Integrated Continuous Biomanufacturing II

The current timeline for manufacturing high-quality recombinant proteins used for therapeutics and vaccines, and delivering them to patients, typically requires many months. There are many circumstances, however, where the rapid production, release, and delivery of these biologics could address unmet medical needs, including shortages, emergency situations, and pandemics. This talk will present a new platform developed to produce biologic medicines on demand called Integrated and Scalable Cyto-Technology (InSCyT). This platform comprises an integrated, subliter-scale portable system for the (semi)continuous operation of fermentation, filtration of cell debris from secreted product, innovative affinity-based purification, polishing, and finishing. This program also emphasizes integrated …

Regulatory Challenges Of Continuous Biomanufacturing, Andy Papas

Integrated Continuous Biomanufacturing II

The interaction with regulatory agencies on the biomanufacturing of therapeutic proteins, mAbs, or other large molecules occurs throughout the drug development of the biologic; it begins with the original IND, accelerates at the licensing phase and continues throughout the product’s life cycle. There are many regulatory challenges along this journey.

Because of uniqueness of continuous biomanufacturing, one challenge that occurs throughout the product’s lifecycle is the inevitable change in Agency product reviewers who many times need to be educated on the nuances of your process or have a different opinion or expectation on how things should be done. As such, …

Fizzy: Feature Subset Selection For Metagenomics., Gregory Ditzler, J Calvin Morrison, Yemin Lan, Gail L Rosen

Henry M. Rowan College of Engineering Departmental Research

BACKGROUND: Some of the current software tools for comparative metagenomics provide ecologists with the ability to investigate and explore bacterial communities using α- & β-diversity. Feature subset selection--a sub-field of machine learning--can also provide a unique insight into the differences between metagenomic or 16S phenotypes. In particular, feature subset selection methods can obtain the operational taxonomic units (OTUs), or functional features, that have a high-level of influence on the condition being studied. For example, in a previous study we have used information-theoretic feature selection to understand the differences between protein family abundances that best discriminate between age groups in the …

Senate Meeting, November 4, 2015, Academic Senate

Academic Senate Minutes

No abstract provided.

Rosenthal Coauthors Rapid Purging Of Genetic Load In Metapopulation Consequences For Range Expansion In Invasive Plant, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

11/04/2015 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 11/04/2015. Scroll down to see the names and obituary description.

Meeting Minutes For November 4, 2015, Rollins College Student Government Association

SGA Meeting Minutes

No abstract provided.

Molecular Network Control Through Boolean Canalization, David Murrugarra, Elena S. Dimitrova

Mathematics Faculty Publications

Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network modeling where each layer of canalization adds a degree of stability in the dynamics of the network. Recently, dynamic network control approaches have been used for the design of new therapeutic interventions and for other applications such as stem cell reprogramming. This work studies the role of canalization in the control of Boolean molecular networks. It provides a method for identifying the potential edges …

Obesity: A Persistent Global Health Problem, Linda Eanes

School of Nursing Faculty Publications

Despite extensive public attention given to diet and exercise as effective countermeasures to obesity and obesity-related problems, there has been no significant reduction in obesity rates in the United States and throughout the world. The author provides a brief update on obesity, dietary and physical activity guidelines, potential contributing factors to behavioral change and the role that nurses have in advancing health promoting activities that can reduce the health risks associated with obesity.

Spectator 2015-11-04, Editors Of The Spectator

The Spectator

No abstract provided.

Uab Researchers Seek Friedreich's Ataxia Biomarkers, Jeff Hansen

Browse All News

No abstract provided.

Volume 53, Number 12: November 04, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

Grove V. State Clerk's Record V. 1 Dckt. 43537

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Examining Temporal Sample Scale And Model Choice With Spatial Capture-Recapture Models In The Common Leopard Panthera Pardus, Joshua F. Goldberg, Tshering Tempa, Nawang Norbu, Mark Hebblewhite, L. Scott Mills, Tshewang R. Wangchuk, Paul Lukacs

Wildlife Biology Faculty Publications

Many large carnivores occupy a wide geographic distribution, and face treats from habitat loss and fragmentation, poaching, prey depletion, and human wildlife-conflicts. Conservation requires robust techniques for estimating population densities and trends, but the elusive nature and low densities of many large carnivores make them difficult to detect. Spatial capture-recapture (SCR) models provide a means for handling imperfect detectability, while linking population estimates to individual movement patterns to provide more accurate estimates than standard approaches. Within this framework, we investigate the effect of different sample interval lengths on density estimates, using simulations and a common leopard (Panthera pardus) …

Design And Synthesis Of Novel Chloroquine-Based Antimalarials, Kevin Vincent Murphy

Dissertations and Theses

Malaria is an infectious, often fatal disease that afflicts nearly 200 million people every year. The disease, characterized by recurring and extreme flu-like symptoms, is caused by the protozoan parasite Plasmodium falciparum. Victims usually contract the disease through a mosquito vector. Chloroquine is a chemotherapeutic that was introduced in the 1940s. For many years the drug was the foremost treatment of malaria, being effective and producing few side effects. Unfortunately, tolerance to chloroquine developed when the parasite evolved a resistance mechanism. Newer drugs have been developed and implemented, but these medicines also show a decreasing effect with continued administration. …

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Isolation Of Rhp-Psp, A Member Of Yer057c/Yjgf/Uk114 Protein Family With Antiviral Properties, From The Photosynthetic Bacterium Rhodopseudomonas Palustris Strain Jsc-3b, Pin Su, Tuizi Feng, Xuguo Zhou, Songbai Zhang, Yu Zhang, Ju'e Cheng, Yuanhua Luo, Jing Peng, Zhuo Zhang, Xiangyang Lu, Deyong Zhang, Yong Liu

Entomology Faculty Publications

Rhodopseudomonas palustris strain JSC-3b isolated from a water canal adjacent to a vegetable field produces a protein that was purified by bioactivity-guided fractionation based on ammonium sulfate precipitation, ion-exchange absorption and size exclusion. The protein was further identified as an endoribonuclease L-PSP (Liver-Perchloric acid-soluble protein) by shotgun mass spectrometry analysis and gene identification, and it is member of YER057c/YjgF/UK114 protein family. Herein, this protein is designated Rhp-PSP. Rhp-PSP exhibited significant inhibitory activities against tobacco mosaic virus (TMV) in vivo and in vitro. To our knowledge, this represents the first report on the antiviral activity of a protein of the …

Attractor-Based Obstructions To Growth In Homogeneous Cyclic Boolean Automata, Bilal Khan, Yuri Cantor, Kirk Dombrowski

Department of Sociology: Faculty Publications

We consider a synchronous Boolean organism consisting of N cells arranged in a circle, where each cell initially takes on an independently chosen Boolean value. During the lifetime of the organism, each cell updates its own value by responding to the presence (or absence) of diversity amongst its two neighbours’ values. We show that if all cells eventually take a value of 0 (irrespective of their initial values) then the organism necessarily has a cell count that is a power of 2. In addition, the converse is also proved: if the number of cells in the organism is a proper …