Digital Commons Network^™

Role Of Lectins Receptors In Development Of Sepsis During Pulmonary Bacterial Infection, Anthony Lee Steichen

Theses and Dissertations

A major focus of my work has been to understand the mechanism/s of sepsis development during respiratory bacterial infections with the goal of identifying novel alarmins/alarmin receptors. Specifically, I have analyzed the role of C-type lectins as novel alarmin/alarmin receptors likely involved in the development of sepsis resulting from acute pulmonary infection with Gram negative bacteria Francisella novicida and Klebsiella pneumonia (Kpn). In that regard, the first project was built upon a previous observation, made by Dr. Sharma, that two soluble lectins galectin-3 and -9 were upregulated and released in extracellular milieu in lungs of mice upon pulmonary infection with …

Gvsu Undergraduate And Graduate Catalog, 2015-2016, Grand Valley State University

Course Catalogs, 1963 - Current

Grand Valley State University 2015-2016 undergraduate and/or graduate course catalog published annually to provide students with information and guidance for enrollment.

What Dna Can And Cannot Say: Perspectives Of Immigrant Families About The Use Of Genetic Testing In Immigration, Llilida P. Barata, Helene Starks, Patricia Kuszler, Wylie Burke

Articles

Genetic technologies are being implemented in areas that extend beyond the field of medicine to address social and legal problems. An emerging example is the implementation of genetic testing in the family petitioning process in immigration policy. This use of genetic testing offers the potential benefits of reducing immigration fraud and making the process more efficient and accessible for immigrants, especially those without documentation. However, little is known about the positive or negative impacts of such testing on immigrant families and their communities.

This study collected empirical data through family interviews to understand the experiences and attitudes of individuals who …

"Lead In The Far North" By Acceding To The Law Of The Sea Convention, Craig H. Allen

Articles

The theme for the 2015 Arctic Encounter Symposium was “Charting a Path to U.S. Leadership in the Far North.” I would like to begin my comments regarding U.S. leadership by reminding the audience that the Arctic is primarily a maritime domain and the fundamental rule set for international relations in the Arctic’s maritime domain is the 1982 U.N. Convention on the Law of the Sea (LOS Convention), a convention to which the United States remains the most conspicuous non-party.

Economic Efficiency Of Fuel Reduction Treatments In The Home Ignition Zone To Mitigate Wildfire Risk In Montana, Usa, Howard L. Williams

Graduate Student Theses, Dissertations, & Professional Papers

Wildland-urban interface growth and factors increasing the probability of wildfire suggest that annual spending on wildfire risk mitigation and suppression will continue to increase. With limited information about the benefits and costs of risk mitigation, land managers and homeowners may under- or over-invest in risk mitigation, where costs are disproportionate to the expected benefits of the strategy. This study accounted for expected increases in wildfire risk (due to growth of the WUI, climate change and vegetation growth) over time in Flathead County, Montana, and estimated the expected avoided loss in structure values associated with three treatment levels that would require …

Consequences Of Biomass Harvesting On Forest Condition And Productivity In The Northern Rocky Mountains, Woongsoon Jang

Graduate Student Theses, Dissertations, & Professional Papers

Emerging public interests to utilize forest woody biomass as an alternative feedstock accompanies a concern about potential nutrient depletion by increased woody biomass extraction. This study was conducted to investigate the long-term impact of intensive biomass utilization on site productivity and forest condition in the northern Rockies. The 1974 Forest Residues Utilization Research and Development Program site at Coram Experimental Forest of western Montana were revisited, and responses from individual tree to ecosystem level were measured. The experiment was designed to address the effect of biomass utilization intensity (high, medium and low) combined with prescribed broadcast burning treatment following conventional …

Trait Hope As A Moderator Of The Effects Of Hassles And Uplifts On Depressive Symtpoms In College Students, Leslie C. Croot

Graduate Student Theses, Dissertations, & Professional Papers

Major Depression is the leading cause of disability in the United States and has been studied for decades. Research suggests that daily hassles may increase the likelihood of depressive symptoms while daily uplifts may help protect against depressive symptoms (Mayberry & Graham, 2001). Snyder's hope theory (Snyder et al., 1991) provides an avenue for understanding how hope can protect against symptoms of depression. Hope, hassles, uplifts, and depressive symptoms were assessed at three time points with one-month intervals in a sample of 186 undergraduate students via self-report measures. Results, analyzed using a Generalized Estimating Equation, were threefold: there was (1) …

Cultural And Ecological Relationship Between The Nisqually Indian Tribe And Plants Of Mount Rainier National Park, David Alan Hooper

Graduate Student Theses, Dissertations, & Professional Papers

Throughout the history of the National Park Service, the question of whether Native AmericanÆs still have rights to traditionally used natural resources found within park lands has been debated. This debate is largely held in political, legal, and philosophical arenas, but there are ethnographic and ecological questions that need to be addressed in order for policy makers to make informed decisions. Addressing these questions also provides insight into how cultures develop sustainable harvesting practices. One of the parks that has been addressing traditional plant harvesting is Mount Rainier National Park, which has been working with the Nisqually Indian Tribe to …

The Use Of Three-Dimensional Gps Observations For Tectonics And Hydrology In Northeast Africa, Yelebe Birhanu Amere

Graduate Student Theses, Dissertations, & Professional Papers

1. 27 campaign and 17 continuous GPS sites spanning the Ethiopian Highlands, Main Ethiopian Rift (MER), and Somali Platform in Ethiopia and Eritrea were measured for varying durations between 1995 and 2014. Velocities at these sites show that present day finite strain rates in NE Africa can be approximated at the continent scale by opening on a simple tectonic boundary within the Ethiopian Rift. Observations from the Somali Platform require relative velocities within the Somali plate to be less than 1 mm/yr. Observations from the Ethiopian Highlands allow relative velocities no greater than 1-2 mm/yr within the Nubia plate; statistically …

A Coxiella-Like Endosymbiont Is A Potential Vitamin Source For The Lone Star Tick, Todd A. Smith, Timothy Driscoll, Joseph J. Gillespie, Rahul Raghavan

Biology Faculty Publications and Presentations

Amblyomma americanum (Lone star tick) is an important disease vector in the United States. It transmits several human pathogens, including the agents of human monocytic ehrlichiosis, tularemia, and southern tick-associated rash illness. Blood-feeding insects (Class Insecta) depend on bacterial endosymbionts to provide vitamins and cofactors that are scarce in blood. It is unclear how this deficiency is compensated in ticks (Class Arachnida) that feed exclusively on mammalian blood. A bacterium related to Coxiella burnetii, the agent of human Q fever, has been observed previously within cells of A. americanum. Eliminating this bacterium (CLEAA, Coxiella-like endosymbiont of A. americanum) with antibiotics …

Critical Controlled Branching Processes And Their Relatives, George Yanev

School of Mathematical & Statistical Sciences Faculty Publications

This survey aims at collecting and presenting results for one-type, discrete time branching processes with random control functions. In particular, the subclass of critical migration processes with different regimes of immigration and emigration is reviewed in detail. Critical controlled branching processes with continuous state space are also discussed.

Beyond Instrumentalism: A Relational Approach To Negotiation, Marc-Charles Ingerson, Kristen Bell Detienne, Katie A. Liljenquist

Faculty Publications

Instrumentalism, the philosophy that rational people will behave in ways that promote self-interest, is often the default assumption that scholars and practitioners rely upon when interpreting and predicting human behavior in negotiations. Instrumentalism, however, need not be the only lens through which negotiators and negotiations are viewed. In this article, we discuss some of the problems associated with too heavy a reliance on instrumentalism and propose an alternative relational approach, one in which negotiators see themselves as agents embedded in a system of relationships, who are motivated to understand and advance the welfare of others. We discuss some of the …

Foreword

Tigra scientifica

No abstract provided.

Biographies

Tigra scientifica

No abstract provided.

Man's New Best Friend, Charles Simmons

Tigra scientifica

No abstract provided.

Tigra Scientifica Volume Ii, Issue 1

Tigra scientifica

It is our pleasure to welcome readers to the Fall 2015 issue of Tigra scientifica Science News Magazine. This is the 10th issue in this series of exemplary writings by students enrolled in Clemson University’s Creative Inquiry (CI) course, Popular Science Journalism. Science and technology have an enormous impact on society. Thus, science journalists shoulder the responsibility of transmitting accurate, comprehensible, and timely information to bridge the gap between scientists and the general public. A talented group of Clemson University undergraduate students has embraced this responsibility to produce this magazine.

A Path To Cure Neurological Disorders?, Alex Villano

Tigra scientifica

No abstract provided.

This Digital Life: A Neighborhood-Based Study Of Adolescents' Lives Online, Jessica Pater Phd, Andrew D. Miller, Elizabeth Mynatt

Health Services and Informatics Research

In Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems.

In this paper, we present the results of a multi-year study of the social computing practices of 179 adolescents (Mage=12.4 years, SD=1.3; range: 10-14) living in a majority-minority lower-income urban neighborhood in the Southeast U.S. We investigate shifting social media practices using annual surveys and focus groups. We describe participants’ social media use and motivations and show how that use has shifted over time. We show how participants identify social pressures and influences as well as specific behaviors including computer-mediated risky behaviors and self-harm. We discuss …

Consanguinity And Pregnancy Outcomes In A Multi-Ethnic, Metropolitan European Population, Rolf Becker, Thomas Keller, Rolf-Dieter Wegner, Heidemarie Neitzel, Markus Stumm, Ute Knoll, Markus Stärk, Heiner Fangerau, Alan Bittles

Research outputs 2014 to 2021

Objective: The aim of the present study was to assess the risk of major anomalies in the offspring of consanguineous couples, including data on the prenatal situation. Methods: Over 20years (1993-2012), 35391 fetuses were examined by prenatal sonography. In 675 cases (1.9%), parents were consanguineous, with 307 couples (45.5%) related as first cousins, 368 couples (54.5%) beyond first cousins. Detailed information was retrieved on 31710 (89.6%) fetuses, (consanguineous 568: 1.8%). Results: Overall prevalence of major anomalies among fetuses with non-consanguineous parents was 2.9% (consanguineous, 10.9%; first cousins, 12.4%; beyond first cousins, 6.5%). Adjusting the overall numbers for cases having been …

Rapid Recovery Of An Urban Remnant Reptile Community Following Summer Wildfire, Robert A. Davis, Tim S. Doherty

Research outputs 2014 to 2021

Reptiles in urban remnants are threatened with extinction by increased fire frequency, habitat fragmentation caused by urban development, and competition and predation from exotic species. Understanding how urban reptiles respond to and recover from such disturbances is key to their conservation. We monitored the recovery of an urban reptile community for five years following a summer wildfire at Kings Park in Perth, Western Australia, using pitfall trapping at five burnt and five unburnt sites. The reptile community recovered rapidly following the fire. Unburnt sites initially had higher species richness and total abundance, but burnt sites rapidly converged, recording a similar …

Multiple Drivers Of Decline In The Global Status Of Freshwater Crayfish (Decapoda: Astacidea), Nadia I. Richman, Monika Bohm, Susan Adams, Fernando Alvarez, Elizabeth A. Bergey, John J.S. Bunn, Quinton Burnham, Jay Cordeiro, Jason Coughran, Keith A. Crandall, Kathryn L. Dawkins, Robert J. Distefano, Niall E. Doran, Lennart Edsman, Arnold G. Eversole, Leopold Fureder, James M. Furse, Francessa Gherardi, Premek Hamr, David M. Holdich, Pierre Horwitz, Kerrylyn Johnston, Clive M. Jones, Julia P.G. Jones, Robert L. Jones, Thomas G. Jones, Tadashi Kawai, Susan Lawler, Marilu Lopez-Mejia, Rebecca M. Miller, Carlos Pedraza-Lara, Julian D. Reynolds, Alastair M.M. Richardson, Mark B. Schiltz, Guenter A. Schuster, Peter J. Sibley, Catherine Souty-Grosset, Christopher A. Taylor, Roger F. Thoma, Jerry Walls, Todd S. Walsh, Ben Collen

Research outputs 2014 to 2021

Rates of biodiversity loss are higher in freshwater ecosystems than in most terrestrial or marine ecosystems, making freshwater conservation a priority. However, prioritization methods are impeded by insufficient knowledge on the distribution and conservation status of freshwater taxa, particularly invertebrates. We evaluated the extinction risk of the world's 590 freshwater crayfish species using the IUCN Categories and Criteria and found 32% of all species are threatened with extinction. The level of extinction risk differed between families, with proportionally more threatened species in the Parastacidae and Astacidae than in the Cambaridae. Four described species were Extinct and 21% were assessed as …

Obesity As A Disease: Effects On Weight-Biased Attitudes And Beliefs, Rheanna Nichole Ata

USF Tampa Graduate Theses and Dissertations

In June 2013, the American Medical Association (AMA) made the highly controversial decision to designate obesity a disease. Proponents predicted the decision would lead to reduced weight-related stigma, whereas opponents predicted designating a third of the population as “diseased” would exacerbate stigma. To determine the effects of defining obesity as a disease on explicit and implicit weight-biased attitudes and explicit weight-biased beliefs, female undergraduate students (N = 146) were randomly assigned to one of two groups: disease or lifestyle. Participants in the disease group (n = 71) were asked to read an article describing obesity as a disease caused by …

Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster

USF Tampa Graduate Theses and Dissertations

Caregivers of persons with dementia, who are often older adults, report sleep disturbance, high rates of depressive symptoms and may be at risk for impaired cognition. This dissertation examined sleep, depressive symptoms, and cognition in older adults and caregivers of persons with dementia. The aims of the review of literature were to understand, in community dwelling adults 60 years and older, the relationships among sleep parameters (sleep onset latency, wake after sleep onset, sleep efficiency, total sleep time, and general sleep complaints), and the domains of cognition (Executive Function, Attention, Episodic Memory, Working Memory, Processing Speed), and global cognition. Based …

Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck

USF Tampa Graduate Theses and Dissertations

Evidence suggests comorbidity of ADHD and eating disorders (EDs) among females. Capitalizing on the comorbidity of ADHD and EDs and subsequent obesity could lead to improved prevention and treatment of all three conditions. However, additional information regarding the comorbidity is necessary to develop such interventions, as little is known about how or why this co-occurrence exists. A comprehensive model of the underlying mechanisms associated with comorbid ADHD and EDs is needed to improve understanding of the development of the comorbidity. Moreover, while there are gender differences within each disorder, literature is limited regarding to the comorbidity among males, leading to …

Straight Benevolence: Preserving Heterosexual Authority And White Privilege, Robb James Bruce

USF Tampa Graduate Theses and Dissertations

This thesis analyzes three current and popular media sites, exploring a term I coin “straight benevolence.” An ostensibly supportive and progressive attitude adopted by heterosexuals and expressed toward gay men in the United States, straight benevolence surreptitiously subordinates gayness and further entrenches white masculine heterosexual privilege. In my examination of hip-hop artist Macklemore’s “Same Love,” seven Major League Baseball “It Gets Better” gay-advocacy videos, and the “Suddenly, Last Summer” episode of ABC’s primetime U.S. television series Modern Family, I take an intersectional approach to address the interanimation of sexuality, gender, and race. I ask: In what ways is gay male …

Regulation And Targeting Of The Fancd2 Activation In Dna Repair, Valentina Celeste Caceres

USF Tampa Graduate Theses and Dissertations

Fanconi anemia (FA) is a genome instability syndrome that is clinically manifested by bone marrow failure, congenital defects, and elevated cancer susceptibility. The FA pathway is known to regulate the repair of DNA interstrand crosslinks in part through DNA homologous recombination (HR) repair. Up to today 16 FA proteins have been discovered that may participate in the common pathway. Cells that have mutations in the FA genes are hypersensitive to DNA damaging agents and display chromosome instability. A key regulatory event in the FA pathway is monoubiquitination of FANCD2-FANCI heterodimer that is mediated by a multi-component E3 ubiquitin ligase complex …

Functional Analysis Of The Ovarian Cancer Susceptibility Locus At 9p22.2 Reveals A Transcription Regulatory Network Mediated By Bnc2 In Ovarian Cells, Melissa Buckley

USF Tampa Graduate Theses and Dissertations

GWAS have identified several chromosomal loci associated with ovarian cancer risk. However, the mechanism underlying these associations remains elusive. We identify candidate functional Single Nucleotide Polymorphisms (SNPs) at the 9p22.2 ovarian cancer susceptibility locus, several of which map to transcriptional regulatory elements active in ovarian cells identified by FAIRE-seq (Formaldehyde assisted isolation of regulatory elements followed by sequencing) and ChIP-seq (Chromatin Immunoprecipitation followed by sequencing) in relevant cell types. Reporter and electrophoretic mobility shift assays (EMSA) determined the extent to which candidate SNPs had allele specific effects. Chromosome conformation capture (3C) reveals a physical association between Basonuclin 2 (BNC2) and …

The Relation Between Adiposity And Anxiety In Youth: Analysis Of Peer Victimization, Teasing, Sociocultural Influences, And Internalization Of Appearance Ideals As Explanatory Variables, Natasha L. Burke

USF Tampa Graduate Theses and Dissertations

The purpose of the current study was to examine putative mediators and moderators in the association between adiposity and anxiety in a sample of overweight and obese youth. In addition, anxiety was examined as a potential moderator between adiposity and health-related quality of life (HRQOL). Participants were youth (N = 137) between 8 and 17 years old (M = 13.09, SD = 2.61) and their legal caregivers recruited from four medical clinics affiliated with the University of South Florida. Youth were primarily overweight (28.5%) or obese (64.2%) and ethnically diverse. Data were analyzed by path analysis. Weight-related teasing significantly mediated …

Exploring The Pathogenic And Drug Resistance Mechanisms Of Staphylococcus Aureus, Whittney Burda

USF Tampa Graduate Theses and Dissertations

We have previously identified σS, an ECF sigma factor that is important in the virulence and stress response of S. aureus. Transcriptional profiling of sigS revealed that it is differentially regulated in a variety of laboratory and clinical strains of S. aureus, suggesting that there exists a regulatory network that modulates its expression. In order to identify direct regulators of sigS expression, we performed a biotin pull down assay in tandem with mass spectrometry. We identified CymR as a direct regulator and observed that sigS expression is increased in cells lacking cymR. In addition, transposon mutagenesis was performed to identify …

Genome-Wide Scans Detect Adaptation To Aridity In A Widespread Forest Tree Species, Dorothy A. Steane, Brad M. Potts, Elizabeth Mcclean, Suzanne M. Prober, William D. Stock, René E. Vaillancourt, Margaret Byrne

Research Datasets

Patterns of adaptive variation within plant species are best studied through common garden experiments, but these are costly and time-consuming, especially for trees that have long generation times. We explored whether genome-wide scanning technology combined with outlier marker detection could be used to detect adaptation to climate and provide an alternative to common garden experiments. As a case study, we sampled nine provenances of the widespread forest tree species, Eucalyptus tricarpa, across an aridity gradient in southeastern Australia. Using a Bayesian analysis we identified a suite of 94 putatively adaptive (outlying) sequence-tagged markers across the genome. Population-level allele frequencies of …