Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2015

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 25531 - 25560 of 27534

Full-Text Articles in Entire DC Network

Fibrin Gel As An Injectable Biodegradable Scaffold And Cell Carrier For Tissue Engineering, Yuting Li, Hao Meng, Yuan Liu, Bruce P. Lee Jan 2015

Fibrin Gel As An Injectable Biodegradable Scaffold And Cell Carrier For Tissue Engineering, Yuting Li, Hao Meng, Yuan Liu, Bruce P. Lee

Department of Biomedical Engineering Publications

Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural …


The European Union’S Potential Contribution To Protect Marine Biodiversity In The Changing Arctic: A Roadmap, Nengye Liu, Elizabeth Kirk Jan 2015

The European Union’S Potential Contribution To Protect Marine Biodiversity In The Changing Arctic: A Roadmap, Nengye Liu, Elizabeth Kirk

Research Collection Yong Pung How School Of Law

This article provides a roadmap for possible European Union (eu) action in the protection of marine biodiversity in the changing Arctic. First the eu’s competence in the Arctic is briefly introduced. Then the discussion turns to the eu’s potential external and internal actions in shipping, fisheries and offshore oil and gas operations that could possibly enhance the international legal regime for the protection of marine biodiversity in the Arctic. The eu’s role vis-à-vis the global biodiversity regime and cross-cutting measures under the United Nations Convention on the Law of the Sea are discussed together in the final part.


Undergraduate Catholic Lesbians: The Intersection Of Religious And Sexual Aspects Of Identity, Christina Marie Chestna Jan 2015

Undergraduate Catholic Lesbians: The Intersection Of Religious And Sexual Aspects Of Identity, Christina Marie Chestna

Antioch University Dissertations & Theses

The following is a qualitative study designed to shed light on the experiences of undergraduate Catholic lesbians. The study focused on the unique ways in which these women negotiate the intersection of the religious and sexual aspects of their identities. Research shows that religious and sexual aspects of identity often conflict. In-depth research aimed specifically at the negotiation of religious and sexual identity dimensions is needed. In this study, semi-structured interviews were conducted with undergraduate Catholic lesbians who had the opportunity to speak about the ways in which they negotiate the potentially conflicting religious and sexual aspects of their identities. …


Personhood & Parenthood: An Experiential Account Of Balance & Well-Being, Venice Bruno Jan 2015

Personhood & Parenthood: An Experiential Account Of Balance & Well-Being, Venice Bruno

Antioch University Dissertations & Theses

Parents are constantly engaging in a balancing act, weighing their own needs with those of their children and family. Helping parents navigate the role of parenthood can promote optimal development in the child, parent, couple and family. Parents engage in various roles and responsibilities essential for family and individual well-being that require balance in order to be effective. Past research on balance has indicated that people are more satisfied with life when they are active in multiple life domains rather than in a single one. This study is interested in two specific life domains: personhood and parenthood, and how parents …


Fostering Connections: Group Therapy For Young Women Aging Out Of Foster Care, Meaghan Elizabeth Pilling Jan 2015

Fostering Connections: Group Therapy For Young Women Aging Out Of Foster Care, Meaghan Elizabeth Pilling

Antioch University Dissertations & Theses

The following dissertation outlines a group intervention designed to improve the relational and mental health of female emerging adults who have aged out of foster care. It is argued through review of the literature that emerging adulthood is a unique developmental phase in which relational connections are vital to successful transition to adulthood. Female emerging adults who have aged out of foster care frequently lack these social supports; their isolation renders them particularly vulnerable to psychological and interpersonal problems. Therefore, a mentoring component might be valuable to this population and is included in the current intervention. Included in the following …


Women Between The Ages Of 65 And 75: What Is Their Subjective Experience Of How Their Sexuality Is Portrayed In American Society?, Rebecca E. Gilda Jan 2015

Women Between The Ages Of 65 And 75: What Is Their Subjective Experience Of How Their Sexuality Is Portrayed In American Society?, Rebecca E. Gilda

Antioch University Dissertations & Theses

This dissertation focused on capturing and describing the experience of sexuality for women between the ages of 65 and 75 as they live in American society. The main research question asks how these women gain awareness, perceive, and react to the stereotypes, assumptions, expectations, and negative images associated with their sexuality. The participants completed a questionnaire and a semi-structured interview with the principal researcher. Information was gathered about age, relationships, family history, employment, and sexuality. In the interview general and specific questions were asked relating to sexuality in order to answer the research questions. The data from these was analyzed …


Smart Distributed Generation Systems Using Improved Islanding Detection And Event Classification, Bikiran Guha Jan 2015

Smart Distributed Generation Systems Using Improved Islanding Detection And Event Classification, Bikiran Guha

College of Graduate Studies: Theses & Dissertations

Distributed Generation (DG) sources have become an integral part of modern decentralized power systems. However, the interconnection of DG systems to the power grid can present several operational challenges. One such major challenge is islanding detection. Islanding occurs when a DG system is disconnected from the rest of the power grid. Islanding can present serious safety hazards and therefore an accurate and fast islanding detection technique is mandated by DG interconnection standards such as IEEE 1547 and UL 1741. Conventional islanding detection techniques passively monitor the local power system parameters such as voltage and frequency to detect islanding. These techniques …


Evaluation Of Linear And Nonlinear Postural Stability Measurements Following Concussion, Kelsey Evans Jan 2015

Evaluation Of Linear And Nonlinear Postural Stability Measurements Following Concussion, Kelsey Evans

College of Graduate Studies: Theses & Dissertations

Sport related concussions affect nearly 1.6 to 3.8 million athletes annually in the United States. A large number of these athletes suffer from postural instability following concussion. Postural control assessment has become a recommended tool to determine readiness to return to play. Measurement of postural control through the use of center of pressure (CoP) variables may provide a sensitive evaluation following concussion and throughout recovery. Purpose: To evaluate a unipedal and bipedal quiet stance protocol consisting of linear and nonlinear CoP measurements with varying durations in a concussed population throughout recovery. Methods: Thirteen NCAA Division I Collegiate Football players (age: …


Skins As Garments In The Book Of Mormon: A Textual Exegesis, Ethan Sproat Jan 2015

Skins As Garments In The Book Of Mormon: A Textual Exegesis, Ethan Sproat

Journal of Book of Mormon Studies

No abstract provided.


Religion Matters: A Conversation With President Kevin J. Worthen, Thomas A. Wayment Jan 2015

Religion Matters: A Conversation With President Kevin J. Worthen, Thomas A. Wayment

Religious Educator: Perspectives on the Restored Gospel

No abstract provided.


Morphology And Phylogeny Of The Sea Anemone Stichodactyla Haddoni(Cnidaria: Anthozoa: Actiniaria) From Chabahar Bay, Iran, Gilan Attaran Fariman, Pegah Javid, Arash Shakouri Jan 2015

Morphology And Phylogeny Of The Sea Anemone Stichodactyla Haddoni(Cnidaria: Anthozoa: Actiniaria) From Chabahar Bay, Iran, Gilan Attaran Fariman, Pegah Javid, Arash Shakouri

Turkish Journal of Zoology

????Carpet anemones of the genus Stichodactyla are characterized by having no calcium carbonate skeleton, being flattened with rather short tentacles, being exclusively tropical, and being hosts for clown fish species. Most of the species belonging to this genus, however, are often very similar morphologically; thus, identification by external features is rather difficult. In this study, we have described the morphology and phylogenetic affinities of a carpet anemone species collected from Chabahar Bay. Although the Iranian species showed different coloration patterns within the same geographical area, they strongly resemble Stichodactyla haddoni Saville-Kent, 1893 in having short tentacles densely covering the undulated …


Prozercon Banazensis Sp. Nov. (Acari: Mesostigmata: Zerconidae),A New Species Of Zerconid Mite From Turkey, With A New Record, Raşi̇t Urhan, Mehmet Karaca, Eli̇f Hi̇lal Duran Jan 2015

Prozercon Banazensis Sp. Nov. (Acari: Mesostigmata: Zerconidae),A New Species Of Zerconid Mite From Turkey, With A New Record, Raşi̇t Urhan, Mehmet Karaca, Eli̇f Hi̇lal Duran

Turkish Journal of Zoology

In this study, Prozercon banazensis sp. Nov. İs described and illustrated from female and deutonymph specimens collected in Kütahya and Uşak provinces (Turkey). Morphological features of P. Morazae Ujvári, 2011, which is a new record for the Turkish fauna, are also given with drawings. Information on habitat and distribution for each species is also provided.


Abrolophus Balkanicus Sp. Nov. From Montenegro, With Redescriptions Of A. Stanislavae (Haitlinger, 1986) And A. Wratislaviensis (Haitlinger, 1986) And Notes On A. Podorasensis (Haitlinger, 2007) (Acari: Erythraeidae), Ryszard Haitlinger, Miloje Sundic Jan 2015

Abrolophus Balkanicus Sp. Nov. From Montenegro, With Redescriptions Of A. Stanislavae (Haitlinger, 1986) And A. Wratislaviensis (Haitlinger, 1986) And Notes On A. Podorasensis (Haitlinger, 2007) (Acari: Erythraeidae), Ryszard Haitlinger, Miloje Sundic

Turkish Journal of Zoology

Abrolophus balkanicus sp. Nov. İs described and illustrated from larvae collected in Montenegro. Abrolophus stanislavae (Haitlinger) and A. Wratislaviensis (Haitlinger) are redescribed. New metric data for A. Podorasensis (Haitlinger) are given. A. Podorasensis is new to the fauna of Montenegro and A. Stanislavae is new to the fauna of Bosnia and Herzegovina.


Description Of The Previously Unknown Female Of Drassodes Bifidus Kovblyuk & Seyyar, 2009 (Araneae: Gnaphosidae) From Turkey, Osman Seyyar, Hakan Demi̇r, Tuncay Türkeş Jan 2015

Description Of The Previously Unknown Female Of Drassodes Bifidus Kovblyuk & Seyyar, 2009 (Araneae: Gnaphosidae) From Turkey, Osman Seyyar, Hakan Demi̇r, Tuncay Türkeş

Turkish Journal of Zoology

Drassodes bifidus Kovblyuk and Seyyar, 2009, previously known only from one male from southern Turkey (Alanya District, Antalya Province), is redescribed on the basis of newly collected materials. The female of Drassodes bifidus is described for the first time. Illustrations, description, and distribution are presented.


Taxonomic Study Of Subfamily Scymninae (Coleoptera: Coccinellidae)With One New Record From Gilgit-Baltistan, Pakistan, Muhammad Ashfaque, Farman Ullah, Muhammad Ather Rafi, Falak Naz Jan 2015

Taxonomic Study Of Subfamily Scymninae (Coleoptera: Coccinellidae)With One New Record From Gilgit-Baltistan, Pakistan, Muhammad Ashfaque, Farman Ullah, Muhammad Ather Rafi, Falak Naz

Turkish Journal of Zoology

The fauna of the subfamily Scymninae (Coccinellidae: Coleoptera) of Gilgit-Baltistan was explored and studied. This study confirmed the occurrence of 4 species in 2 genera of Scymninae. These include 2 species in genus Scymnus (S. Posticalis Sicard, 1913 and S. Nubilus Mulstant, 1850), and 2 species in genus Stethorus (Stethorus gilvifrons (Mulstant, 1850) and S. Pauperculus (Weise, 1895)). Among these 4 species, S. Posticalis Sicard is reported here as a new record from the study area. A description of each species is given, along with color plates of adult specimens and genitalia. Remarks pertaining to taxonomic discussion, history, taxon status, …


A First Overview Of The Fauna Of Chloropidae Of Iran (Diptera, Acalyptratae), Zeinab Bazyar, Abu Fazel Dousti, Michael Von Tschirnhaus, Majid Fallahzadeh Jan 2015

A First Overview Of The Fauna Of Chloropidae Of Iran (Diptera, Acalyptratae), Zeinab Bazyar, Abu Fazel Dousti, Michael Von Tschirnhaus, Majid Fallahzadeh

Turkish Journal of Zoology

We present recent findings of Chloropidae in Iran and a first list of the Iranian species of this family. It includes 20 genera and 50 species (39 identified to species level), recorded up until 2014. Some European distribution records not included in Fauna Europaea are added. The courtship behavior of Polyodaspis sulcicollis is described for the first time.


Tachinidae (Diptera) Species Of Sakarya Province (Turkey), With 2 New Recordstarık Balkan, Kenan Kara, Turgut Atay* Department Of Plant Protection, Faculty Of Agriculture, Gaziosmanpaşa University, Tokat, Turkey, Tarik Balkan, Kenan Kara, Turgut Atay Jan 2015

Tachinidae (Diptera) Species Of Sakarya Province (Turkey), With 2 New Recordstarık Balkan, Kenan Kara, Turgut Atay* Department Of Plant Protection, Faculty Of Agriculture, Gaziosmanpaşa University, Tokat, Turkey, Tarik Balkan, Kenan Kara, Turgut Atay

Turkish Journal of Zoology

This study was carried out to determinate the Tachinidae fauna of Sakarya Province in 2012 and 2013. Tachinids were collected in the region by sweeping with nets from various plants. As a result of this study, 7 genera and 8 species belonging to the subfamily of Exoristinae, 5 genera and 5 species belonging to the subfamily of Tachininae, 2 genera and 2 species belonging to the subfamily of Dexiinae, and 4 genera and 6 species belonging to the subfamily of Phasiinae were found. Two species among them, Meigenia incana (Fallen, 1810) and Exorista civilis (Rondani, 1859), were recorded for the …


Two New Records Of Fruit Flies (Diptera: Tephritidae) For The Fauna Ofaksaray And Mersin Provinces, Mehmet Yaran, Murat Kütük Jan 2015

Two New Records Of Fruit Flies (Diptera: Tephritidae) For The Fauna Ofaksaray And Mersin Provinces, Mehmet Yaran, Murat Kütük

Turkish Journal of Zoology

This study was based on fruit flies collected from Aksaray and Mersin provinces in spring and summer of 2012-2013. During the study, samples were collected from host plants randomly or systematically by using an insect net. In the study, 62 species belonging to 21 genera from 5 subfamilies have been determined, and Dioxyna sororcula and Terellia ivannikovi have been recorded for the first time in Turkey. In addition, adult figures of new records and wing figures of all species are given.


Contributions To Subfamily Otitinae (Diptera: Ulidiidae) Fauna Ofturkey With Four New Recordsseda Mesci̇*, Abdullah Hasbenli̇department Of Biology, Faculty Of Science, Gazi University, Teknikokullar, Ankara, Turkey, Seda Mesci̇, Abdullah Hasbenli̇ Jan 2015

Contributions To Subfamily Otitinae (Diptera: Ulidiidae) Fauna Ofturkey With Four New Recordsseda Mesci̇*, Abdullah Hasbenli̇department Of Biology, Faculty Of Science, Gazi University, Teknikokullar, Ankara, Turkey, Seda Mesci̇, Abdullah Hasbenli̇

Turkish Journal of Zoology

In this study, specimens were collected from different cities in Turkey during the years 1992-2006. Seven species of 4 genera belonging to Otitinae (Diptera: Ulidiidae) were identified. Four species [Dorycera caucasica Hendel, 1910; Ceroxys urticae (Linnaeus, 1758); Herina lugubris (Meigen, 1826); and Otites formosa (Panzer, 1798)] are new records for the Turkish fauna. The distributions of these species are mapped. In addition, wing photographs of species given in this study are provided.


A Contribution To The Kleptoparasitic Bees Of Turkey: Part I.,The Genus Sphecodes Latreille (Hymenoptera: Halictidae), Hi̇kmet Özbek, Petr Bogusch, Jakub Straka Jan 2015

A Contribution To The Kleptoparasitic Bees Of Turkey: Part I.,The Genus Sphecodes Latreille (Hymenoptera: Halictidae), Hi̇kmet Özbek, Petr Bogusch, Jakub Straka

Turkish Journal of Zoology

The present study was carried out to determine the occurrence and distribution of the kleptoparasitic bee genus Sphecodes Latreille (Hymenoptera: Halictidae) of Turkey. The material comprises samples collected from various parts of Turkey since the 1960s and certain private collections in Europe. The examination of the material and an overview of the published sources allowed us to reach the conclusion that Sphecodes of Turkey is represented by 33 species. Of these, Sphecodes crassanus Warncke, 1992 and S. Majalis Pérez, 1903 are new records for Turkey as well the Asian continent. Sphecodes alternatus Smith 1853, S. Ephippius (Linnaeus, 1767), S. Gibbus …


New Host And New Records Of Charipinae(Hymenoptera: Cynipoidea: Figitidae) From Iran, Mar Ferrer Suay, Jesus Selfa, Ehsan Rakhshani, Elham Nader, Juli Pujade Villar Jan 2015

New Host And New Records Of Charipinae(Hymenoptera: Cynipoidea: Figitidae) From Iran, Mar Ferrer Suay, Jesus Selfa, Ehsan Rakhshani, Elham Nader, Juli Pujade Villar

Turkish Journal of Zoology

Charipinae material collected from various localities in Iran was studied. A total of 712 specimens have been determined in 8 species: Alloxysta arcuata (Kieffer, 1902), A. Brevis (Thomson, 1862), A. Circumscripta (Hartig, 1841), A. Citripes (Thomson, 1862), A. Darci (Girault, 1933), A. Mullensis (Cameron, 1883), A. Pusilla (Kieffer, 1902), and Phaenoglyphis villosa (Hartig, 1841). Alloxysta circumscripta and A. Darci are cited for the first time from Iran. In total, 91 host associations (Charipinae-Aphidiinae-Aphid-host plant) are recorded, of which 23 are new to science. New trophic relationships are also recorded for Iran for A. Brevis, A. Mullensis, and P. Villosa. Diagnoses, …


Testing The Habitat Selectivity Of Bdelloid Rotifers In A Restricted Area, Murat Kaya, Sevi̇l Erdoğan Jan 2015

Testing The Habitat Selectivity Of Bdelloid Rotifers In A Restricted Area, Murat Kaya, Sevi̇l Erdoğan

Turkish Journal of Zoology

each habitat (ANOSIM: R = 0.40, P = 0.001).


Additional Evidence And New Records Of The Genus Bracon Fabricius,1804 (Hymenoptera: Braconidae) In Southern Iran, Ali Ameri, Ali Asghar Talebi, Ehsan Rakhshani, Ahmet Beyarslan, Karim Kamali Jan 2015

Additional Evidence And New Records Of The Genus Bracon Fabricius,1804 (Hymenoptera: Braconidae) In Southern Iran, Ali Ameri, Ali Asghar Talebi, Ehsan Rakhshani, Ahmet Beyarslan, Karim Kamali

Turkish Journal of Zoology

The present contribution is based on the genus Bracon Fabricius, 1804 collected from the southern part of Iran during 2010-2013. A total of 10 species belonging to 6 subgenera were collected and identified, of which 2 subgenera (Ophthalmobracon Tobias, 1957, and Osculobracon) and 6 species are recorded for the first time from Iran. The newly recorded species from Iran are as follows: Bracon (Glabrobracon) ahngeri Telenga, 1936; Bracon (Habrobracon) didemie (Beyarslan, 2002); Bracon (Ophthalmobracon) ophthalmicus Telenga, 1933; Bracon (Osculobracon) erzurumiensis Beyarslan, 2002; Bracon (Osculobracon) osculator Nees 1811; and Bracon (Glabrobracon) obscurator Nees, 1811. Geographical distributions of all species and diagnostic …


Intensity And Prevalence Of Some Crustacean Fish Parasites Inturkey And Their Molecular Identification, Aki̇f Er, Şevki̇ Kayiş Jan 2015

Intensity And Prevalence Of Some Crustacean Fish Parasites Inturkey And Their Molecular Identification, Aki̇f Er, Şevki̇ Kayiş

Turkish Journal of Zoology

In the present study, intensity, prevalence, and some pathologic effects of Caligus minimus, Nerocila spp., and Livoneca punctata on fishes extending from the eastern Black Sea coast of Turkey were determined. In addition, besides morphological characters of parasites, diagnosis of the species was carried out by using a molecular method (polymerase chain reaction) in characterization. Caligus minimus was isolated for the first time from wild sea bass (Dicentrarchus labrax) from the eastern Black Sea coast of Turkey. Seasonal distribution of Nerocila spp. Was determined. The highest prevalence rates of Nerocila were determined on snouted sole (Pegusa nasuta, syn. Solea nasuta) …


Factors Affecting The Diet Of The Red Fox (Vulpes Vulpes) In A Heterogeneousmediterranean Landscape, Dimitrios Bakaloudis, Vasileios Bontzorlos, Christos Vlachos, Malamati Papakosta, Evanggelos Chatzinikos, Sotirios Braziotis, Vasileios Kontsiotis Jan 2015

Factors Affecting The Diet Of The Red Fox (Vulpes Vulpes) In A Heterogeneousmediterranean Landscape, Dimitrios Bakaloudis, Vasileios Bontzorlos, Christos Vlachos, Malamati Papakosta, Evanggelos Chatzinikos, Sotirios Braziotis, Vasileios Kontsiotis

Turkish Journal of Zoology

The diet of the red fox (Vulpes vulpes) has been well studied in Europe, but limited information exists about its feeding habits in Greece and in other Mediterranean landscapes. We studied the diet variation of the red fox by analyzing contents from 219 red fox stomachs in central Greece from 2003 to 2005. We used canonical correspondence analysis (CCA) and quasi-distribution generalized linear model (GLM) response curves to investigate whether the trophic groups of the red fox diet varied temporally and/or spatially with environmental factors. Mammals, arthropods, and plants were the most important trophic groups in the diet; in particular, …


An Observation Of Haversian Systems In Stellagama Stellio (Linnaeus, 1758)(Squamata: Sauria: Agamidae) In Barla/Isparta, Turkeymeltem Kumaş1,*, Dinçer Ayaz21department Of Histology And Embryology, Faculty Of Medicine, Bezmialem Vakıf University, İstanbul, Turkey2section Of Zoology, Department Of Biology, Faculty Of Science, Ege University, İzmir, Turkey, Meltem Kumaş, Di̇nçer Ayaz Jan 2015

An Observation Of Haversian Systems In Stellagama Stellio (Linnaeus, 1758)(Squamata: Sauria: Agamidae) In Barla/Isparta, Turkeymeltem Kumaş1,*, Dinçer Ayaz21department Of Histology And Embryology, Faculty Of Medicine, Bezmialem Vakıf University, İstanbul, Turkey2section Of Zoology, Department Of Biology, Faculty Of Science, Ege University, İzmir, Turkey, Meltem Kumaş, Di̇nçer Ayaz

Turkish Journal of Zoology

null


New Records For Turkish Tachinidae (Diptera) Fauna From Erciyes Mountain, Kayseri, Turgut Atay, Kenan Kara, Mustafa Özdemi̇r Jan 2015

New Records For Turkish Tachinidae (Diptera) Fauna From Erciyes Mountain, Kayseri, Turgut Atay, Kenan Kara, Mustafa Özdemi̇r

Turkish Journal of Zoology

Four Tachinidae species were recorded for the first time in Turkey. They are Aphria longirostris, Belida angelicae, Winthemia quadripustulata, and Nowickia rondanii.


Herpetofauna Of The Lake District Around Burdur, Oğuzhan Ege, Batuhan Yaman Yakin, Cemal Varol Tok Jan 2015

Herpetofauna Of The Lake District Around Burdur, Oğuzhan Ege, Batuhan Yaman Yakin, Cemal Varol Tok

Turkish Journal of Zoology

This study investigated the amphibian and reptilian fauna of the Lake District around Burdur, Turkey. A total of 21 amphibian and reptile species were identified, consisting of two anurans, two turtles, one tortoise, seven lizards, and nine snakes. A zoogeographical assessment was also carried out in which the chorotypes and the IUCN criteria of the species were added.


Cover And Contents Jan 2015

Cover And Contents

Turkish Journal of Zoology

No abstract provided.


Mitochondrial Involvement In Pancreatic Beta Cell Glucolipotoxicity, Jonathan Barlow Jan 2015

Mitochondrial Involvement In Pancreatic Beta Cell Glucolipotoxicity, Jonathan Barlow

School of Biomedical Sciences Theses

High circulating glucose and non-esterified free fatty acid (NEFA) levels can cause pancreatic β-cell failure. The molecular mechanisms of this β-cell glucolipotoxicity are yet to be established conclusively. In this thesis by exploring mitochondrial energy metabolism in INS-1E insulinoma cells and isolated pancreatic islets, a role of mitochondria in pancreatic β-cell glucolipotoxicity is uncovered. It is reported that prolonged palmitate exposure at high glucose attenuates glucose-stimulated mitochondrial respiration which is coupled to ADP phosphorylation. These mitochondrial defects coincide with an increased level of mitochondrial reactive oxygen species (ROS), impaired glucose-stimulated insulin secretion (GSIS) and decreased cell viability. Palmitoleate, on the …