Digital Commons Network^™

Inhibition Of Toxic Iapp Amyloid By Extracts Of Common Fruits, David Moffet

Chemistry and Biochemistry Faculty Works

The aggregation of the 37-amino acid polypeptide islet amyloid polypeptide (IAPP, amylin), as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of pancreatic β-islet cells in type 2 diabetes. It is believed that inhibiting the aggregation of IAPP may slow down, if not prevent entirely, the progression of this disease. Extracts of 13 different common fruits were analyzed for their ability to prevent the aggregation of amyloidogenic IAPP. Thioflavin T binding, immuno-detection and circular dichroism assays were performed to test the in vitro inhibitory potential of each extract. Atomic force microscopy was …

Inhibition Of Toxic Iapp Amyloid By Extracts Of Common Fruits, David A. Moffet, Pei-Yu Kao, Evangeline Green, Catalina Pereirab, Shauna Ekimura, Dennis Juarez, Travis Whyte, Taylor Arhar, Bianca Malaspina, Luiza A. Nogaj

Chemistry and Biochemistry Faculty Works

The aggregation of the 37-amino acid polypeptide islet amyloid polypeptide (IAPP, amylin), as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of pancreatic β-islet cells in type 2 diabetes. It is believed that inhibiting the aggregation of IAPP may slow down, if not prevent entirely, the progression of this disease. Extracts of thirteen different common fruits were analyzed for their ability to prevent the aggregation of amyloidogenic IAPP. Thioflavin T binding, immuno-detection and circular dichroism assays were performed to test the in vitro inhibitory potential of each extract. Atomic force microscopy was …

Dynamic Motions Of The Hiv-1 Frameshift Site Rna, Kathryn Mouzakis

Chemistry and Biochemistry Faculty Works

The HIV-1 frameshift site (FS) plays a critical role in viral replication. During translation, the HIV-1 FS transitions from a 3-helix to a 2-helix junction RNA secondary structure. The 2-helix junction structure contains a GGA bulge, and purine-rich bulges are common motifs in RNA secondary structure. Here, we investigate the dynamics of the HIV-1 FS 2-helix junction RNA. Interhelical motions were studied under different ionic conditions using NMR order tensor analysis of residual dipolar couplings. In 150 mM potassium, the RNA adopts a 43°(±4°) interhelical bend angle (β) and displays large amplitude, anisotropic interhelical motions characterized by a 0.52(±0.04) internal …

Global Shape Mimicry Of Trna Within A Viral Internal Ribosome Entry Site Mediates Translational Reading Frame Selection, Kathryn Mouzakis

Chemistry and Biochemistry Faculty Works

The dicistrovirus intergenic region internal ribosome entry site (IRES) adopts a triple-pseudoknotted RNA structure and occupies the core ribosomal E, P, and A sites to directly recruit the ribosome and initiate translation at a non-AUG codon. A subset of dicistrovirus IRESs directs translation in the 0 and +1 frames to produce the viral structural proteins and a +1 overlapping open reading frame called ORFx, respectively. Here we show that specific mutations of two unpaired adenosines located at the core of the threehelical junction of the honey bee dicistrovirus Israeli acute paralysis virus (IAPV) IRES PKI domain can uncouple 0 and …

Increasing Retention In Stem: Results From A Stem Talent Expansion Program At The University Of Memphis, Alistair Windsor, Anna E. Bargagliotti, Rachel Best, Donald Franceschetti, John Haddock, Stephanie Ivey, David Russomanno

Mathematics, Statistics and Data Science Faculty Works

MemphiSTEP is a five-year STEM Talent Expansion Program at the University of Memphis sponsored by the National Science Foundation. The project focuses on retention and persistence to graduation to increase the number of STEM majors and graduates. The project includes a range of student retention programs, including a Summer Mathematics Bridge Bootcamp, Networking Program, Research Award Program, Travel Award program and STEM Learning Communities; Results from the first four years of the project suggest that MemphiSTEP is making a positive impact on student retention and performance in STEM fields. Our data indicate that even after controlling for gender, race, and …

Philosophy And Theology: Reflections On Dignity, Christopher Kaczor

Philosophy Faculty Works

The article discusses the human dignity of a person. The meaning of human dignity in the philosophy of religion means each and every person value or worth of great respect. In Catholic teachings it believes that human being are created in the image and likeness of God has had the dignity of a person.

Proteomic Analysis Of Cardiac Response To Thermal Acclimation In The Eurythermal Goby Fish Gillichthys Mirabilis, W. Wesley Dowd, Nishad Jayasundara, Lars Tomanek, George N. Somero

Biology Faculty Works

Cardiac function is thought to play a central role in determining thermal optima and tolerance limits in teleost fishes. Investigating proteomic responses to temperature in cardiac tissues may provide insights into mechanisms supporting the thermal plasticity of cardiac function. Here, we utilized a global proteomic analysis to investigate changes in cardiac protein abundance in response to temperature acclimation (transfer from 13°C to 9, 19 and 26°C) in a eurythermal goby, Gillichthys mirabilis. Proteomic data revealed 122 differentially expressed proteins across acclimation groups, 37 of which were identified using tandem mass-spectrometry. These 37 proteins are involved in energy metabolism, mitochondrial regulation, …

Mining The Phytomicrobiome To Understand How Bacterial Coinoculations Enhance Plant Growth, Nancy Fujishige

Biology Faculty Works

In previous work, we showed that coinoculating Rhizobium leguminosarum bv. viciae 128C53 and Bacillus simplex 30N-5 onto Pisum sativum L. roots resulted in better nodulation and increased plant growth. We now expand this research to include another alpha-rhizobial species as well as a beta-rhizobium, Burkholderia tuberum STM678. We first determined whether the rhizobia were compatible with B. simplex 30N-5 by cross-streaking experiments, and then Medicago truncatula and Melilotus alba were coinoculated with B. simplex 30N-5 and Sinorhizobium (Ensifer) meliloti to determine the effects on plant growth. Similarly, B. simplex 30N-5 and Bu. tuberum STM678 were coinoculated onto Macroptilium atropurpureum. The …

Getting Even Less Than What They Paid For: The Plight Of Generic Drug Consumers Under The Levine-Mensing Dichotomy, Vikrama Chandrashekar

University of Colorado Law Review

The Drug Price Competition and Patent Restoration Act of 1984, known as the Hatch-Waxman Amendments, allows manufacturers to begin developing generic versions of patented, brand-name pharmaceuticals while the patent terms are in force, and to bring those generic versions to market as soon as the patent terms expire. The generic versions are to mimic the brand-name drug in every respect; thus, they are produced at a significantly reduced cost, and those savings are passed on to generic drug consumers. Under federal regulations, a generic drug's label must also mimic that of the brand-name drug, and generic drug manufacturers may not …

How National Park Law Really Works, John Copeland Nagle

University of Colorado Law Review

This Article provides the first explanation of the relationship between three overlapping sources of national park law. It first explains how the Organic Act affords the National Park Service substantial discretion to manage the national parks, including deciding the proper balance between enjoyment and conservation in particular instances. It next shows how federal environmental statutes push national park management toward preservation rather than enjoyment. Finally, the Article explains that Congress often intervenes to mandate particular management outcomes at individual parks, typically but not always toward enjoyment rather than preservation. The result is that the National Park Service has substantial discretion …

Human Anatomy And Physiology Preparatory Course (1st Edition), Carlos Liachovitzky

Open Educational Resources

The overall purpose of this preparatory course textbook is to help students familiarize with some terms and some basic concepts they will find later in the Human Anatomy and Physiology I course.

The organization and functioning of the human organism generally is discussed in terms of different levels of increasing complexity, from the smallest building blocks to the entire body. This Anatomy and Physiology preparatory course covers the foundations on the chemical level, and a basic introduction to cellular level, organ level, and organ system levels. There is also an introduction to homeostasis at the beginning.

Panel 4: Translational Expectations And Issues: Making It Work In Practice, Stacey A. Tovino

Other Faculty Publications

No abstract provided.

Space Use And Habitat Affinities Of The Singing Vole On The Northern Foothills Of The Brooks Range, Alaska, Andrew Maguire

Master's Theses and Capstones

Arctic tundra is being affected by a rapidly warming climate, which is accompanied by shifts in plant community composition and structure. Shrub expansion, a predominant consequence of this warming, is linked with changes in nutrient cycling and has direct implications to global change biology. Habitats are being altered across the landscape, with subsequent changes to arctic faunal communities. While herbivory has been noted as important in contributing to plant community composition in the arctic, with the potential to both exacerbate and mitigate shifts toward shrub-dominated tundra landscapes, little research has been conducted on herbivore dynamics. Microtine rodents (i.e., voles and …

Parameterization Of Transient Storage And Nutrient Retention In Coastal New England Wetlands, Sophie Wilderotter

Master's Theses and Capstones

Wetlands may play an important role in the removal of nutrients from river networks. In order to better understand this process, field observations for eight wetland-dominated reaches in coastal Massachusetts and New Hampshire were parameterized for transient storage and nutrient uptake rate constants. Transient storage was observed in all study wetlands, but the amount of storage and how connected the storage areas were to the wetland channel were not easily related to wetland physical characteristics: including wetland length, wetland width, wetland area, sinuosity, and length-to-width ratios, depth of the off-channel area, width of the off-channel area, cross-sectional area of the …

Establishment Of The Multicolored Asian Lady Beetle, Harmonia Axyridis, As A Model System For The Evolution Of Phenotypic Variation, Lindsay Havens

Master's Theses and Capstones

The mechanisms behind the evolution and maintenance of striking visual phenotypes are as varied as the species that display these phenotypes. Multiple study systems have been well characterized and provide critical information about the evolution of these traits. However, new study systems in which the phenotype of interest can be easily manipulated and quantified are essential to answer many questions about the functionality of core evolutionary processes. One such model is elytral spot number of the multicolored Asian lady beetle, Harmonia axyridis (Chapter 1). I describe Harmonia axyridis as a potential novel model species for examining extreme phenotypic evolution. To …

Rice Blast Disease Forecasting For Northern Philippines, Proceso L. Fernandez Jr, Alvin R. Malicdem

Department of Information Systems & Computer Science Faculty Publications

Rice blast disease has become an enigmatic problem in several rice growing ecosystems of both tropical and temperate regions of the world. In this study, we develop models for predicting the occurrence and severity of rice blast disease, with the aim of helping to prevent or at least mitigate the spread of such disease. Data from 2 government agencies in selected provinces from northern Philippines were gathered, cleaned and synchronized for the purpose of building the predictive models. After the data synchronization, dimensionality reduction of the feature space was done, using Principal Component Analysis (PCA), to determine the most important …

Ang Konsepto Ng Planetisasyon Ni Teilhard De Chardin: Isang Pagsusumubok Bigkasin Ang Meron, Wilhelm Patrick Joseph S. Strebel

Philosophy Department Faculty Publications

In his book Pambungad sa Metapisika, Roque J. Ferriols, SJ, stresses that metaphysics is a practicum. Metaphysics makes one aware of reality, and this awareness drives the person to affirm, respect, and work and move in accord to and within it. This response to reality is what Ferriols calls “pagbigkas sa meron.” Ferriols also devotes a chapter of his book to the thought of the French paleontologist, Pierre Teilhard de Chardin, SJ. The paper explores how this understanding of Teilhard’s thought leads to the practicum identified above as “pagbigkas sa meron.” The paper begins with an exposition of the key …

Experimental Evolution And Economics, Terence C. Burnham, Aimee Dunlap, David W. Stephens

ESI Publications

This is a theory paper that advocates experimental evolution as a novel approach to study economic preferences. Economics could benefit because preferences are exogenous, axiomatic, and contentious. Experimental evolution allows the empirical study of preferences by placing organisms in designed environments and studying their genotype and phenotype over multiple generations. We describe a number of empirical studies on different aspects of preferences. We argue that experimental evolution has the potential to improve economics.

Compassion Development In Higher Education, Roxanne Rashedi, Thomas G. Plante, Erin S. Callister

Psychology

Many schools of psychology and religious studies intend to promote the cultivation of compassion. Compassion is currently an integral area of study in psychology, religious studies, and higher education, specifically in faith-based higher education. While secular universities in the United States strive to generate disciplinary-based knowledge through scholarship, their ability to promote students' use of the information they are learning to create positive social change has typically lagged. Conscious of the magnitude of today's global issues and dissatisfied with the current disparity between the world's reality and university curricula, scholars have begun to re-imagine the role of higher education in …

An Analysis Of Evapotranspiration In The Southeastern United States : Its Role In The Climatology And Hydrology Of The Region, Walter Lee Ellenburg Ii

Dissertations

As a major term in both the energy and water budgets, evapotranspiration (ET) has the potential to exert significant impacts on both climate and hydrology, from the basin, regional and global scales. This dissertation will examine of the impacts of ET on climatology and hydrology in the Southeastern (SE) region of the United States. It is presented in two complementary narratives throughout this document; an analysis of climatological impacts of ET due to land use change and a hydrological analysis, examining the spatial and temporal roles of ET with respect to streamflow. The climatological analysis investigates a regional climate anomaly …

Observation Of The Catfish Chaetostoma Microps Climbing In A Cave In Tena, Ecuador, Geoffrey Hoese, Aaron Addison, Theofilos Toulkeridis

KIP Articles

As part of a mapping and preliminary flora and fauna inventory of hypogean life in caves, developed in Cretaceous limestones in the sub-andean zone of Ecuador, we were able to observe a number of catfish climbing a steep flowstone waterfall in the dark zone of a cave. The waterfall was a minor infeeder to the small stream that flowed through the cave. On investigation the fish were determined to be Chaetostoma microps Günther, 1864 (Siluriformes Loricariidae), a detritivorous–herbivorous neotropical freshwater catfish, endemic to the upper reaches of the Amazon basin in Ecuador. We document the observation of this species exhibiting …

Context-Dependent Conservation Responses To Emerging Wildlife Diseases, Kate E. Langwig

KIP Articles

No abstract provided.

Every Day Counts: Proposals To Reform Idea's Due Process Structure, Elizabeth A. Shaver

Case Western Reserve Law Review

It is a core principle of special education legislation that the parents of children with disabilities can challenge the child's educational programming through an administrative due process hearing. Yet for years the special education due process structure has been criticized as inefficient, anticollaborative, and prohibitively expensive. Those criticisms have given rise to widely varying proposals to reform special education due process, proposals that range from adding certain alternative dispute resolution mechanisms to a wholesale replacement of the due process structure.

This article provides a comprehensive analysis of special education dispute resolution. The article first examines the lively debate among scholars …

President’S Annual Report, Jean E. Bartels

Office of the President: Annual Report (Archived)

No abstract provided.

Strengthening The Role Of Universities In Addressing Sustainability Challenges: The Mitchell Center For Sustainability Solutions As An Institutional Experiment, David D. Hart, Kathleen P. Bell, Laura A. Lindenfeld, Shaleen Jain, Teresa R. Johnson, Darren Ranco, Brain Mcgill

New Hampshire EPSCoR

As the magnitude, complexity, and urgency of many sustainability problems increase, there is a growing need for universities to contribute more effectively to problem solving. Drawing upon prior research on social-ecological systems, knowledge-action connections, and organizational innovation, we developed an integrated conceptual framework for strengthening the capacity of universities to help society understand and respond to a wide range of sustainability challenges. Based on experiences gained in creating the Senator George J. Mitchell Center for Sustainability Solutions (Mitchell Center), we tested this framework by evaluating the experiences of interdisciplinary research teams involved in place-based, solutions-oriented research projects at the scale …

Northeastern Illinois University, 2015-2016, Northeastern Illinois University

Course Catalogs

No abstract provided.

Gene Expression In The Choanoderm, Jesús Federico Peña

Electronic Theses and Dissertations

The body plan of sponges (phylum Porifera) is an outlier among modern animals and is thought to have special evolutionary significance. Sponges lack muscles, nerves and a gut. Instead, they are composed of few cell types and simple tissues that function to pump water through an internal canal network where bacterial prey are filtered by a specialized tissue called the choanoderm. The choanoderm is composed of cells with striking similarity to choanoflagellates, the unicellular relatives of animals. Thus, the traditional view is that the sponge choanoderm is a useful model of the first animal epithelial tissues. Using the freshwater sponge …

Choice Of Human–Computer Interaction Mode In Stroke Rehabilitation, Hossein Mousavi Hondori, Maryam Khademi, Lucy Dodakian, Alison Mackenzie, Cristina V. Lopes, Steven C. Cramer

Physical Therapy Faculty Articles and Research

Background and Objective. Advances in technology are providing new forms of human–computer interaction. The current study examined one form of human–computer interaction, augmented reality (AR), whereby subjects train in the real-world workspace with virtual objects projected by the computer. Motor performances were compared with those obtained while subjects used a traditional human–computer interaction, that is, a personal computer (PC) with a mouse. Methods. Patients used goal-directed arm movements to play AR and PC versions of the Fruit Ninja video game. The 2 versions required the same arm movements to control the game but had different cognitive demands. With …

Transcending Thresholds: A Phenomenological Study Of How African American Women Working In The Federal Government Experience Professional Development, Betsy A. Kelly Bell

Department of Conflict Resolution Studies Theses and Dissertations

The purpose of this qualitative study was to explore the professional development experiences of federally employed African American women and to discover whether and how they perceive race and gender as informing their professional development. The researcher used an existential phenomenological approach, guided by the following research questions: what are the professional development experiences of African American women working in the federal government?; what, if any, challenges to professional development have been experienced by this population, and what meaning do they find in those experiences?; and what are the perceptions of this population regarding how social-organizational constructs inform their professional …

Thematic Categories & Associated Metrics To Develop An Indian River Lagoon Report Card, Kait Wood, Melissa Pumphrey

Ocean Engineering and Marine Sciences Student Publications

The Indian River Lagoon (IRL) is a 156 mile estuary system that extends from Ponce De Leon Inlet to Jupiter Inlet (Busby, 1993). The IRL is home to over 3,500 species and promotes an industry of over 3.7 billion dollars a year (Garland, 2013). The lagoon provides more than 15,000 full or part time jobs, and 11 million people use the lagoon for recreational purposes annually (Garland, 2013). The Marine Resource Council (MRC) is a charitable organization whose mission to protect and restore the IRL is accomplished through collaborative problem solving. In May 2014, the MRC organized the Lagoon Action …