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Editors' Note, Laura B. Regassa, Delena Gatch

Biology: Faculty Publications

Dear colleagues,

The International Journal for the Scholarship of Teaching & Learning is undergoing some major changes.

• The layout of the journal has been overhauled, giving it a look that better aligns with the quality of the content. As we continue to struggle with SoTL “counting” as scholarship at some institutions, it is important to package our work in a way that reinforces its value. We hope you enjoy the new look!

• Articles are being assigned DOI (digital object identifier) numbers. All articles, past and present, will be tagged and linked to metadata as indexing is completed over the next …

Do Water Buffalo Facilitate Dispersal Of Invasive Alien Tree Species Acacia Nilotica In Bekol Savanna Baluran National Park?, Sutomo

Research outputs 2014 to 2021

Invasion of Acacia nilotica in Baluran National Park, East Java Province, Indonesia, has caused significant loss to savanna cover which is the main natural feature of the park. This study aimed to describe whether water buffalo may play a role in the dispersal of Acacia nilotica seed in Bekol Savanna usinganalysis of buffalo stools/scats, observations and seed experiments. In total there were 30 plots set up around the Bekol Savanna to collect buffalo stools. In addition,A. nilotica pods matured from its trees were collected, as controls. Germination tests were conducted on seeds that were extracted from the collected stools …

Teacher Emotion Research: Introducing A Conceptual Model To Guide Future Research, Leanne Fried, Caroline Mansfield, Eva Dobozy

Research outputs 2014 to 2021

This article reports on the development of a conceptual model of teacher emotion through a review of teacher emotion research published between 2003 and 2013. By examining 82 publications regarding teacher emotion, the main aim of the review was to identify how teacher emotion was conceptualised in the literature and develop a conceptual model to illustrate the findings. Interestingly, few papers explicitly defined ‘emotion’ or ‘teacher emotion’ but described the functions of emotion (such as providing information) and influences on emotion (such as personal characteristics), so these were also used to build the conceptual model. The literature also highlighted the …

Chasing The ‘Hounds Of Hell’: Howard Thurman’S Jesus And The Disinherited As A Curriculum For Racial Justice And Reconciliation, Sandra Richards Mayo

International Christian Community of Teacher Educators Journal

This essay explores the implications of the Trayvon Martin case for educators who must contend with the complexities of race in the context of schooling. With the assumption that race continues to function as an important category in social arrangements, this essay addresses the following questions: What is the role of race and racial stereotyping in educational disparities? How can educators work purposely toward a curriculum of racial justice and reconciliation? Drawing on the work of African American theologian and civil rights leader Howard Thurman, this essay argues that new approaches to social justice education should address both the extrapersonal …

Cortical Oscillatory Dynamics And Benzodiazepine-Site Modulation Of Tonic Inhibition In Fast Spiking Interneurons, Emma J. Prokic, Cathryn Weston, Naoki Yamawaki, Stephen D. Hall, Roland S.G. Jones, Ian M. Stanford, Graham Ladds, Gavin L. Woodhall

School of Psychology

No abstract provided.

The Uyghur Population And Genetic Susceptibility To Type 2 Diabetes: Potential Role For Variants In Cdkal1, Jazf1, And Igf1 Genes, Manshu Song, Feifei Zhao, Longjin Ran, Mamatyusupu Dolikun, Lijuan Wu, Lijuan Ge, Hao Dong, Qing Gao, Yanchun Zhai, Ling Zhang, Yuxiang Yan, Fen Liu, Xinghua Yang, Xiuhua Guo, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Substantial evidence suggests that type 2 diabetes mellitus (T2DM) is a multi-factorial disease with a strong genetic component. A list of genetic susceptibility loci in populations of European and Asian ancestry has been established in the literature. Little is known on the inter-ethnic contribution of such established functional polymorphic variants. We performed a case-control study to explore the genetic susceptibility of 16 selected T2DM-related SNPs in a cohort of 102 Uyghur objects (51 cases and 51 controls). Three of the 16 SNPs showed significant association with T2DM in the Uyghur population. There were significant differences between the T2DM and control …

Genome-Wide Scans Detect Adaptation To Aridity In A Widespread Forest Tree Species, Dorothy A. Steane, Brad M. Potts, Elizabeth Mcclean, Suzanne M. Prober, William D. Stock, René E. Vaillancourt, Margaret Byrne

Research Datasets

Patterns of adaptive variation within plant species are best studied through common garden experiments, but these are costly and time-consuming, especially for trees that have long generation times. We explored whether genome-wide scanning technology combined with outlier marker detection could be used to detect adaptation to climate and provide an alternative to common garden experiments. As a case study, we sampled nine provenances of the widespread forest tree species, Eucalyptus tricarpa, across an aridity gradient in southeastern Australia. Using a Bayesian analysis we identified a suite of 94 putatively adaptive (outlying) sequence-tagged markers across the genome. Population-level allele frequencies of …

Follow-Up Plasma Apolipoprotein E Levels In The Australian Imaging, Biomarkers And Lifestyle Flagship Study Of Ageing (Aibl) Cohort, Veer B. Gupta, V.B, Andrea C. Wilson, Samantha Burnham, Eugene Hone, Steve Pedrini, Simon M. Laws, Wei L.F. Lim, Alan Rembach, Stephanie Rainey-Smith, David Ames, Lynne Cobiac, S L. Macaulay, Colin L. Masters, Christopher C. Rowe, Ashley I. Bush, Ralph Martins, Aibl Research Group

Research outputs 2014 to 2021

Introduction: Alzheimer's disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devastating disease have become a research priority. Consequently, the identification of clinically significant and sensitive blood biomarkers for its early detection is very important. Apolipoprotein E (APOE) is a well-known and established genetic risk factor for late-onset AD; however, the impact of the protein level on AD risk is unclear. We assessed the utility of plasma ApoE protein as a potential biomarker of AD in the large, well-characterised Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) cohort. Methods: Total plasma ApoE levels were …

Rapid Root Elongation By Phreatophyte Seedlings Does Not Imply Tolerance Of Water Table Decline, Caroline A. Canham, Raymond H. Froend, William D. Stock

Research outputs 2014 to 2021

Key message Despite high rates of root elongation during phreatophyte establishment once connection to groundwater has occurred and leaf area develops, seedlings demonstrate limited capacity for root elongation in response to groundwater decline.

Abstract In a water-limited environment, rapid root elongation immediately after germination can be critical for a plant to reach deeper water sources such as a water table to avoid water deficit stress. However, once plants have accessed a water table, their continued survival may depend on their ability to adapt their root distribution to changes in the depth to a water table. In glasshouse experiments using two …

Mechanisms Contributing To Differential Regulation Of Pax3 Downstream Target Genes In Normal Human Epidermal Melanocytes Versus Melanoma Cells, Danielle Bartlett, Glen M. Boyle, Mel Ziman, Sandra Medic

Research outputs 2014 to 2021

Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of these melanocytes is driven by the transcription factor PAX3 early during embryonic development. As a result of alternative splicing, the PAX3 gene gives rise to eight different transcripts which encode isoforms that have different structures and activate different downstream target genes involved in pathways of cell proliferation, migration, differentiation and survival. Furthermore, posttranslational modifications have also been shown to alter the functions of PAX3.We previously identified PAX3 downstream target genes in melanocytes and melanoma …

Strengthening Confidence In Climate Change Impact Science, Mary I. O'Connor, Johnna M. Holding, Carrie V. Kappel, Carlos M. Duarte, Keith Brander, Christopher J. Brown, John F. Bruno, Lauren Buckley, Michael T. Burrows, Benjamin S. Halpern, Wolfgang Kiessling, Pippa Moore, John M. Pandolfi, Camille Parmesan, Elvira S. Poloczanska, David S. Schoeman, William J. Sydeman, Anthony J. Richardson

Research outputs 2014 to 2021

Aim: To assess confidence in conclusions about climate-driven biological change through time, and identify approaches for strengthening confidence scientific conclusions about ecological impacts of climate change. Location: Global. Methods: We outlined a framework for strengthening confidence in inferences drawn from biological climate impact studies through the systematic integration of prior expectations, long-term data and quantitative statistical procedures. We then developed a numerical confidence index (Cindex) and used it to evaluate current practices in 208 studies of marine climate impacts comprising 1735 biological time series. Results: Confidence scores for inferred climate impacts varied widely from 1 to 16 (very low to …

Amyloid-Related Memory Decline In Preclinical Alzheimer's Disease In Dependent On Apoe Ε4 And Is Detectable Over 18-Months, Christine Thai, Yen Ying Lim, Victor L. Villemagne, Simon Laws, David Ames, Kathryn A. Ellis, Stephanie Rainey-Smith, Ralph Martins, Colin L. Masters, Christopher C. Rowe, Paul Maruff, Australian Imaging, Biomarkers And Lifestyle (Aibl) Research Group

Research outputs 2014 to 2021

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE ε4 carrier status, and cognitive decline over 18 monthes, in 317 cognitively healthy (CN) older adults (47% males, 52.4% females) aged between 60 and 89 years (Mean = 69.9, SC = 6.8). Cognition was assessed using the Cogstate Brief Battery (CBB) and the California Verbal Learning Test, Second Edition (CVLT-II). Planned comparisons indicated that CN older adults …

Editorial: Neural Implementation Of Expertise, Merim Bilalic, Robert Langner, Guillermo J. Campitelli, Luca Turella, Wolfgang Grodd

Research outputs 2014 to 2021

How the brain enables humans to reach an outstanding level of performance typical of expertise is of great interest to cognitive neuroscience, as demonstrated by the number and diversity of the articles in this Research Topic (RT). The RT presents a collection of 23 articles written by 80 authors on traditional expertise topics such as sport, board games, and music, but also on the expertise aspects of everyday skills, such as language and the perception of faces and objects. Just as the topics in the RT are diverse, so are the neuroimaging techniques employed and the article formats. Here we …

Learning As It Goes Down The Line: Siblings And Family Networked In The Acquisition Of Online Skills, Kylie J. Stevenson, Lelia Green, Leslie Haddon

Research outputs 2014 to 2021

The Parents and Peers project set out to investigate key influences of peers and parents on the online experiences of young people aged 13 - 17. Specifically, the project sought to explore the family constructions of learning, support and management systems that operate in the informal context of the domestic space of the family home (Silverstone & Haddon 1996). It became apparent through interviewing several sets of older siblings that there was benefit in interviewing a wider age range of siblings who were engaged in online activity within individual families. Therefore, the interview participants’ age range was extended to age …

Propagating Precipitation Waves In Hydrogels, Darrell Collison

Graduate Theses, Dissertations, and Problem Reports (ETD)

In 1896, Raphael E. Liesegang discovered that precipitation reactions may produce striking precipi- tation rings and bands. More than a century later, propagating precipitation waves were discovered in similar reactions. The bands and rings discovered by Liesegang are static, but traveling precipitation waves exhibit complex spatiotemporal dynamics. Traveling waves are widespread and occur in both living and nonliving systems. Examples include calcium waves propagating through Xenopus laevis oocytes, cyclic AMP waves in colonies of Dictyostelium discordium cells, and spiral waves in propagating flames fronts. Recently, traveling waves were identified in a precipitation reaction involving AlCl3 and NaOH. The propagating precipitation …

Evaluation Of The Effects Of A Plasma Activated Medium On Cancer Cells, S. Mohades, M. Laroussi, J. Sears, N. Barekzi, H. Razavi

Electrical & Computer Engineering Faculty Publications

The interaction of low temperature plasma with liquids is a relevant topic of study to the field of plasma medicine. This is because cells and tissues are normally surrounded or covered by biological fluids. Therefore, the chemistry induced by the plasma in the aqueous state becomes crucial and usually dictates the biological outcomes. This process became even more important after the discovery that plasma activated media can be useful in killing various cancer cell lines. Here, we report on the measurements of concentrations of hydrogen peroxide, a species known to have strong biological effects, produced by application of plasma to …

Killing Adherent And Nonadherent Cancer Cells With The Plasma Pencil, Mounir Laroussi, Soheila Mohades, Nazir Barekzi

Electrical & Computer Engineering Faculty Publications

The application of low temperature plasmas in biology and medicine may lead to a paradigm shift in the way various diseases can be treated without serious side effects. Low temperature plasmas generated in gas mixtures that contain oxygen or air produce several chemically reactive species that have important biological implications when they interact with eukaryotic or prokaryotic cells. Here, a review of the effects of low temperature plasma generated by the plasma pencil on different cancerous cells is presented. Results indicate that plasma consistently shows a delayed killing effect that is dose dependent. In addition, there is some evidence that …

In Vivo Chemical And Structural Analysis Of Plant Cuticular Waxes Using Stimulated Raman Scattering Microscopy, George R. Littlejohn, Jessica C. Mansfield, David Parker, Rob Lind, Sarah Perfect, Mark Seymour, Nicholas Smirnoff, John Love, Julian Moger

School of Biological and Marine Sciences

No abstract provided.

Pre-Altitude Serum Ferritin Levels And Daily Oral Iron Supplement Dose Mediate Iron Parameter And Hemoglobin Mass Responses To Altitude Exposure, Daniel A. Galvao, Laura A. Garvican-Lewis,, Chris R. Abbiss, Peter Peeling, Christopher J. Gore

Research outputs 2014 to 2021

Purpose : To investigate the influence of daily oral iron supplementation on changes in hemoglobin mass (Hb_mass) and iron parameters after 2–4 weeks of moderate altitude exposure.Methods :Hematological data collected from 178 athletes (98 males, 80 females) exposed to moderate altitude (1,350–3,000 m) were analysed using linear regression to determine how altitude exposure combined with oral iron supplementation influenced Hb_mass, total iron incorporation (TII) and blood iron parameters [ferritin and transferrin saturation (TSAT)]. Results :Altitude exposure (mean ± s: 21 ± 3 days) increased Hb_mass by 1.1% [-0.4, 2.6], 3.3% [1.7, 4.8], and 4.0% …

Guidelines For The Standardization Of Preanalytic Variables For Blood-Based Biomarker Studies In Alzheimer's Disease Research, Sid O'Bryant, Veer Gupta, Kim Henriksen, Melissa Edwards, Andreas Jeromin, Simone Lista, Chantal Bazenet, Holly Soares, Simon Lovestone, Harald Hampel, Thomas Montine, Kaj Blennow, Tatiana Foroud, Maria Carrillo, Neill Graff-Radford, Christoph Laske, Monique Breteler, Leslie Shaw, John Q. Trojanowski, Nicole Schupf, Robert A. Rissman, Anne M. Fagan, Pankaj Oberoi, Robert Umek, Michael W. Weiner, Paula Grammas, Holly Posner, Ralph Martins

Research outputs 2014 to 2021

The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement …

Bone Mineral Density, Adiposity, And Cognitive Functions, Hamid R. Sohrabi, Kristyn A. Bates, Michael Weinborn, Romola S. Bucks, Stephanie R. Rainey-Smith, Mark A. Rodrigues, Sabine M. Bird, Belinda M. Brown, John Beilby, Matthew Howard, Arthur Criddle, Megan Wraith, Kevin Taddei, Georgia Martins, Athena Paton, Tejal Shah, Satvinder S. Dhaliwal, Pankaj D. Mehta, Jonathan K. Foster, Ian J. Martins, Nicola T. Lautenschlager, Francis Mastaglia, Simon Laws, Ralph Martins

Research outputs 2014 to 2021

Cognitive decline and dementia due to Alzheimer's disease (AD) have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34–87 years old (62.78 ± 9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after 3 years. Blood samples were collected for …

Abcb5 Identifies Immunoregulatory Dermal Cells, Tobias Schatton, Jun Yang, Sonja Kleffel, Mayuko Uehara, Steven R. Barthel, Christoph Schlapbach, Qian Zhan, Stephen Dudeney, Hansgeorg Mueller, Nayoung Lee, Juliane C. De Vries, Barbara Meier, Seppe Vander Beken, Mark M. Kluth, Christoph Ganss, Arlene H. Sharpe, Ana Maria Waaga-Gasser, Mohamed H. Sayegh, Reza Abdi, Karin Scharffetter-Kochanek, George F. Murphy, Thomas S. Kupper, Natasha Y. Frank, Markus H. Frank

Research outputs 2014 to 2021

Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells (DIRCs) capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1 (PD-1). Purified Abcb5+ DIRCs suppressed T cell proliferation, evaded immune rejection, homed to recipient immune tissues, and induced Tregs in vivo. In fully major-histocompatibility-complex-mismatched cardiac allotransplantation models, allogeneic DIRCs significantly prolonged allograft survival. Blockade of DIRC-expressed PD-1 reversed the inhibitory effects of …

Doctoral Students' Relational Communication With Their Advisors: A Dyadic Examination Using Chickering's Theory Of Psychosocial Development, Zachary W. Goldman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this dissertation was to explore how psychosocial development affects doctoral students' relationships with their advisor and their success in graduate school. Toward this goal, three objectives were identified. The first objective was to integrate Chickering and Reisser's (1993) vectors of psychosocial development into the doctoral education context to understand how mature students maintain their relationships and address conflict with their advisor. The second objective was to investigate the extent to which doctoral students' psychosocial development and communication behaviors affected satisfaction in the student-advisor relationship. The third objective was to examine the effect of psychosocial development on doctoral …

The Multimodal Brain Tumor Image Segmentation Benchmark (Brats), Bjoern H. Menze, Andras Jakab, Stefan Bauer, Jayashree Kalpathy-Cramer, Khan M. Iftekharuddin, Syed M.S. Reza

Electrical & Computer Engineering Faculty Publications

In this paper we report the set-up and results of the Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) organized in conjunction with the MICCAI 2012 and 2013 conferences. Twenty state-of-the-art tumor segmentation algorithms were applied to a set of 65 multi-contrast MR scans of low-and high-grade glioma patients-manually annotated by up to four raters-and to 65 comparable scans generated using tumor image simulation software. Quantitative evaluations revealed considerable disagreement between the human raters in segmenting various tumor sub-regions (Dice scores in the range 74%-85%), illustrating the difficulty of this task. We found that different algorithms worked best for different sub-regions …

A Robust Deep Model For Improved Classification Of Ad/Mci Patients, Feng Li, Loc Tran, Kim-Han Thung, Shuiwang Ji, Dinggang Shen, Jiang Li

Electrical & Computer Engineering Faculty Publications

Accurate classification of Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI), plays a critical role in possibly preventing progression of memory impairment and improving quality of life for AD patients. Among many research tasks, it is of a particular interest to identify noninvasive imaging biomarkers for AD diagnosis. In this paper, we present a robust deep learning system to identify different progression stages of AD patients based on MRI and PET scans. We utilized the dropout technique to improve classical deep learning by preventing its weight coadaptation, which is a typical cause of overfitting in deep learning. …

Plasma Processes And Cancer - Special Topical Cluster Of The 2nd Iwpct Meeting, Masaru Hori, Mounir Laroussi, Kai Masur, Yuzuru Ikehara

Electrical & Computer Engineering Faculty Publications

(First paragraph) Although the emerging multidisciplinary field of plasma medicine has been around for nearly two decades important advances have already taken place that could one day revolutionize healthcare and the way various challenging diseases can be treated.1-3Amongst these advances the effects of low temperature plasma (LTP) on cancer cells in vitro and in vivo stand out.4-13Current cancer treatment modalities, such as chemotherapy and radiation therapy, have serious side effects and tend to lose their benefits to the patients after a while. Therefore, novel and improved therapies that can be used alone …

The Environmental Effects Of Geologically Sequestered Carbon Dioxide Gas And The Enhanced Recovery Of Coal Bed Methane From An Unmineable Coal Seam, Brad David Hega

Graduate Theses, Dissertations, and Problem Reports (ETD)

The need to mitigate the alleged effects of anthropogenic carbon dioxide gas (CO2(g)) generation has led to the exploring of specific subsurface environments to house the gas. The geology of the subsurface underlying Marshall County West Virginia makes the area an ideal setting for use as a CO 2(g) repository. A cooperative, pilot study was undertaken by CONSOL Energy Inc., which owns and operates the selected CO2(g) sequestration site, along with personnel from West Virginia University (WVU) and other agencies under the United States Department of Energy (DOE) funded Zero Emissions Research Technology or ZERT program. The repository is an …

Justifying India's Patent Position To The United States International Trade Commission And Office Of The United States Trade Representative, Srividhya Ragavan, Sean Flynn, Brook Baker

Faculty Scholarship

The paper below largely is an extract of the testimonial filed by the authors to the Secretary of the ITC in response to the Notice on the Federal Register dated August 29, 2013 titled Trade, Investment, and Industrial Policies in India: Effects on the U.S. Economy. Where required, the paper also draws from the written submissions that the authors made to the United States Trade Representative’s (hereinafter, USTR) office on the related question of whether India deny adequate and effective protection of intellectual property rights or deny fair and equitable market access to U.S. persons who rely on intellectual property …

On The Roles Of Drosophila Notch Signaling And Atonal Autoregulation In The Specification Of R8 Photoreceptors, Adam T. Majot

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drosophila retinogenesis has long served as a paradigm of tissue patterning. Notch, an anciently conserved signaling pathway, is critical to both the formation of and proper spacing of founding R8 photoreceptors. Notch is intimately interwoven into the activity of Atonal (Ato), a proneural basic helix-loop-helix (bHLH) that is required for R8 specification. Ato is expressed through dual enhancers: ato-3' and 5'-ato. ato-3' is activated in response to Notch-independent signaling cues whereas 5'-ato exhibits complex dependence on Notch signaling. First, Notch is required for 5'-ato activation, eliciting formation of Ato intermediate groups (IGs, evenly spaced clusters of 10--20 cells). Subsequently, Notch …

Vulture Flight Behavior Driven By Uplift Availability At Local And Continental Scales, Julie Mallon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding how animals move in response to their environment is a fundamental question in ecology. Soaring species, which rely on environmentally generated uplift to forage and migrate, should be especially sensitive to changing weather and climatic conditions. Changes in uplift distribution or strength can have energetic implications and restrict movement capacity for soaring species. Poor weather conditions can shorten foraging time or slow migration progress. To increase mobility, birds can switch to flapping or soar using another uplift type. Use of uplift, however, is associated with certain flight altitudes and movement speeds. Switching uplift types will affect a bird's ecological …