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Articles 23251 - 23280 of 27530
Full-Text Articles in Entire DC Network
Faith, Learning, And Success In Mennonite High Schools: What’S Working At Eastern Mennonite High School?, Ginny Birky
Faith, Learning, And Success In Mennonite High Schools: What’S Working At Eastern Mennonite High School?, Ginny Birky
Faculty Publications - College of Education
The story about Eastern Mennonite was written based on the perceptions and representations of what the participants said related to what was working and why. Every effort was made to portray the perspectives of those interviewed to get an accurate picture of what Eastern Mennonite was doing to help students be successful, engaged in school, and develop a faith.
Faith, Learning, And Success In Mennonite High Schools: What’S Working At Western Mennonite High School?, Ginny Birky
Faith, Learning, And Success In Mennonite High Schools: What’S Working At Western Mennonite High School?, Ginny Birky
Faculty Publications - College of Education
The story about Western Mennonite was written based on the perceptions and representations of what the participants said related to what was working and why. Every effort was made to portray the perspectives of those interviewed to get an accurate picture of what Western Mennonite was doing to help students be successful, engaged in school, and develop a faith.
Taxonomic Biases Of Seven Methods Used To Survey A Diverse Herpetofaunal Community, Donald T. Mcknight, Joshua R. Harmon, Jennifer L. Mcknight, Day B. Ligon
Taxonomic Biases Of Seven Methods Used To Survey A Diverse Herpetofaunal Community, Donald T. Mcknight, Joshua R. Harmon, Jennifer L. Mcknight, Day B. Ligon
College of Natural and Applied Sciences
We conducted a survey of a diverse herpetological community in southeastern Oklahoma from 2012-2013, with the goals of examining its composition and comparing the results of several commonly used survey methods. We used pitfall traps and funnel traps positioned along drift fences, funnel traps placed along logs, various aquatic turtle traps (hoop nets, crawfish traps, and minnow traps), artificial cover objects, and automated recording systems. We also recorded all incidental encounters. We documented 53 reptile and amphibian species. Incidental encounters, funnel traps along drift fences, and pitfall traps documented more species than any of the other methods. Incidental encounters, funnel …
Eggshell Membrane Hydrolyzates Activate Nf-Κb In Vitro: Possible Implications For In Vivo Efficacy., Kevin J. Ruff, Paul L. Durham, Austin O'Reilly, F. Daniel Long
Eggshell Membrane Hydrolyzates Activate Nf-Κb In Vitro: Possible Implications For In Vivo Efficacy., Kevin J. Ruff, Paul L. Durham, Austin O'Reilly, F. Daniel Long
College of Natural and Applied Sciences
Purpose: Eggshell membrane (ESM) has been shown to contain naturally occurring bioactive components, and biological activities such as reducing proinflammatory cytokines, liver fibrosis, and joint pain in osteoarthritis sufferers have also been reported for ESM matrix as a whole. Nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) is a signaling protein found in the cytoplasm of nearly all human and animal cell types and is a primary regulator of immune function. The studies reported herein were designed to investigate the possible role that NF-κB activity might play in the reported biological activities of ESM. Methods: Three ESM hydrolyzates produced via fermentation, …
Lynn - 2015 Annual Edition, Lynn University
Lynn - 2015 Annual Edition, Lynn University
Lynn Magazine / LYNN
Main Stories:
- College reimagined
- A sanctuary for all
- Perpers help Lynn stay focused on the future
Exploring Hierarchical Visualization Designs Using Phylogenetic Trees, Shaomeng Li, R. Jordan Crouser, Garth Griffin, Connor Gramazio, Hans-Jörg Schulz, Hank Childs, Remco Chang
Exploring Hierarchical Visualization Designs Using Phylogenetic Trees, Shaomeng Li, R. Jordan Crouser, Garth Griffin, Connor Gramazio, Hans-Jörg Schulz, Hank Childs, Remco Chang
Computer Science: Faculty Publications
Ongoing research on information visualization has produced an ever-increasing number of visualization designs. Despite this activity, limited progress has been made in categorizing this large number of information visualizations. This makes understanding their common design features challenging, and obscures the yet unexplored areas of novel designs. With this work, we provide categorization from an evolutionary perspective, leveraging a computational model to represent evolutionary processes, the phylogenetic tree. The result — a phylogenetic tree of a design corpus of hierarchical visualizations — enables better understanding of the various design features of hierarchical information visualizations, and further illuminates the space in which …
The Relationship Between Vagal Tone, A Marker Of Parasympathetic Activity, And Pro-Social Behavior, Emily A. Goodlin
The Relationship Between Vagal Tone, A Marker Of Parasympathetic Activity, And Pro-Social Behavior, Emily A. Goodlin
Scripps Senior Theses
Vagal tone, a measure of parasympathetic activity via the vagus nerve, is known to be associated with positive emotion because it promotes social engagement and self-soothing behavior. Heart rate variability (HRV), especially high frequency oscillation, is a direct measure of vagal tone, and has been used in previous studies to test the correlation between vagal tone and positive emotion. This study aims to determine if the two major oscillations of heart rate variability, high frequency (HF-HRV) and low frequency (LF-HRV) can predict pro-social behavior, which is classified as giving donations to charities. Baseline LF- and HF-HRV levels were recorded, and …
A Call For Bioregional Governance In Cascadia: Shaping An Ecological Identity In The Land Of Falling Waters, Molly D. Freed
A Call For Bioregional Governance In Cascadia: Shaping An Ecological Identity In The Land Of Falling Waters, Molly D. Freed
Scripps Senior Theses
In recent years, as globalization has taken a toll on North Americans’ “sense of place,” there has been a swelling interest in the identification of bioregions: spaces delineated by their natural borders and shaped by the cultures that arise within them. Bioregionalism, the movement that arose from this scalar shift, emphasizes the “reinhabitation” of bioregions through a deep understanding and attachment between residents and their watershed and habitat. This thesis argues for a shift to bioregional-scale environmental governance in the Cascadian bioregion (the Pacific Northwest) via an interstate compact. Using the Great Lakes bioregion as a comparable case …
Nerve Growth Factor Reduces Apoptotic Cell Death In Rat Facial Motor Neurons After Facial Nerve Injury, Lian Hui, Jing Yuan, Zhong Ren, Xuejun Jiang
Nerve Growth Factor Reduces Apoptotic Cell Death In Rat Facial Motor Neurons After Facial Nerve Injury, Lian Hui, Jing Yuan, Zhong Ren, Xuejun Jiang
Neurosciences
Objectives: To assess the effects of nerve growth factor (NGF) on motor neurons after induction of a facial nerve lesion, and to compare the effects of different routes of NGF injection on motor neuron survival. Methods: This study was carried out in the Department of Otolaryngology Head & Neck Surgery, China Medical University, Liaoning, China from October 2012 to March 2013. Male Wistar rats (n = 65) were randomly assigned into 4 groups: A) healthy controls; B) facial nerve lesion model + normal saline injection; C) facial nerve lesion model + NGF injection through the stylomastoid foramen; D) facial nerve …
Potential Neuroprotective Effect Of Anakinra In Spinal Cord Injury In An In Vivo Experimental Animal Model, Askin E. Hasturk, Erdal R. Yilmaz, Erhan Turkoglu, Murat Arikan, Guray Togral, Nazli Hayirli, Berrin I. Erguder, Oya Evirgen
Potential Neuroprotective Effect Of Anakinra In Spinal Cord Injury In An In Vivo Experimental Animal Model, Askin E. Hasturk, Erdal R. Yilmaz, Erhan Turkoglu, Murat Arikan, Guray Togral, Nazli Hayirli, Berrin I. Erguder, Oya Evirgen
Neurosciences
Objective: To evaluate the therapeutic effects of inhibiting interleukin-1 beta (IL-1β) in vivo using Anakinra in an experimental model of spinal cord injury (SCI). Methods: All experimental procedures were performed in the animal laboratory of Ankara Education and Research Hospital, Ankara, Turkey between August 2012 and May 2014. The SCI was induced by applying vascular clips to the dura via a 4-level T5-T8 laminectomy. Fifty-four rats were randomized into the following groups: controls (n = 18), SCI + saline (n = 18), and SCI + Anakinra (n = 18). Spinal cord samples were obtained from animals in both SCI groups …
The Relationship Between Willis-Ekbom Disease And Serum Ferritin Levels Among Children In Northwestern Turkey, Gulistan Halac, Gulsen M. Sezer, Neslihan O. Saglam, Pinar Tekturk, Aysegul D. Demir, Saliha Demir, Faruk Akcay, Aysegul Uslu, Zuhal Yapıcı, Talip Asil
The Relationship Between Willis-Ekbom Disease And Serum Ferritin Levels Among Children In Northwestern Turkey, Gulistan Halac, Gulsen M. Sezer, Neslihan O. Saglam, Pinar Tekturk, Aysegul D. Demir, Saliha Demir, Faruk Akcay, Aysegul Uslu, Zuhal Yapıcı, Talip Asil
Neurosciences
Objective: To examine the incidence of restless legs syndrome (RLS) among children with iron deficiency, or iron deficiency anemia, or both, and the relationship between RLS prevalence and serum ferritin levels. Methods: This prospective, cross-sectional, case controlled study was carried out between January and June 2013, and included 98 iron deficiency and/or iron deficiency anemia, and 102 healthy children referred to the Neurology and Pediatric Departments of the Medical Faculty of Bezmialem Vakif University, Istanbul, Turkey. Both groups were evaluated according to the International Restless Legs Syndrome Study Group diagnostic criteria. Results: The range of ferritin levels was 0.01-12 mg/ml …
Fibrinolytic Changes In Pregnant Women On Highly Active Antiretroviral Therapy, Odaburhine E. Osime, Joseph U. Ese-Onakewhor, Samson O. Kolade
Fibrinolytic Changes In Pregnant Women On Highly Active Antiretroviral Therapy, Odaburhine E. Osime, Joseph U. Ese-Onakewhor, Samson O. Kolade
Saudi Medical Journal
Objectives: To report on the changes in fibrinolytic activity in human immunodeficiency virus (HIV) infected pregnant women who are undergoing highly active antiretroviral therapy (HAART). Methods: Blood was collected from 50 HIV positive women on HAART (test subjects), and 50 HIV positive women not on HAART (controls). These women were attending the prevention of mother to child clinic (PMTCT) of the University of Benin Teaching Hospital, Benin City, Nigeria from January to June 2014. Standard manual techniques were used to estimate plasma fibrinogen concentration (PFC), euglobulin lysis time (ELT), packed cell volume (PCV), and plasma viscosity (PV). Results: The mean …
Tardive Dyskinesia Occurring In A Young Woman After Withdrawal Of An Atypical Antipsychotic Drug, Mohammed A. Alblowi, Fahad D. Alosaimi
Tardive Dyskinesia Occurring In A Young Woman After Withdrawal Of An Atypical Antipsychotic Drug, Mohammed A. Alblowi, Fahad D. Alosaimi
Neurosciences
Tardive dyskinesia (TD) is one of the most serious and disturbing side-effects of dopamine receptor antagonists. It affects 20-50% of patients on long-term antipsychotic therapy. The pathophysiology of TD remains poorly understood, and treatment is often challenging. Here, we present a 32-year-old woman presenting with a 9-month history of TD occurring after risperidone withdrawal, and characterized almost exclusively by tongue protrusion. After being seen by different specialties and undergoing multiple investigations, she was eventually correctly diagnosed with TD by a specialist team and successfully treated with amantadine. Vigilance and awareness of this condition and its risk factors are required to …
Loving V. Virginia As A Civil Rights Decision, Dorothy E. Roberts
Loving V. Virginia As A Civil Rights Decision, Dorothy E. Roberts
NYLS Law Review
No abstract provided.
Climatic Preferences And Distribution Of 6 Evolutionary Lineages Oftyphlops Vermicularis Merrem, 1820 In Turkey Using Ecological Niche Modeling, Serkan Gül, Yusuf Kumlutaş, Çeti̇n Ilgaz
Climatic Preferences And Distribution Of 6 Evolutionary Lineages Oftyphlops Vermicularis Merrem, 1820 In Turkey Using Ecological Niche Modeling, Serkan Gül, Yusuf Kumlutaş, Çeti̇n Ilgaz
Turkish Journal of Zoology
According to evolutionary biologists, ecology is a very important factor in speciation. Ecology may be effective at driving adaptive divergence between lineages in different environments and climatic conditions. Because Anatolia has major mountain belts, paleogeographic characteristics, and unique climatic traits, it plays an important role in speciation and shows a barrier effect for many terrestrial species. In this study, we investigated the climatic preferences of 6 isolated evolutionary lineages of Typhlops vermicularis in Anatolia using ecological niche modeling. Our results revealed that both glacial (Last Glacial Maximum) and interglacial (Last Interglacial) modeling, as well as current modeling, showed the most …
Distribution Of Hard Tick Species In Ankara, Turkey, Olcay Heki̇moğlu, Ayşe Nurdan Özer
Distribution Of Hard Tick Species In Ankara, Turkey, Olcay Heki̇moğlu, Ayşe Nurdan Özer
Turkish Journal of Zoology
A systematic study has been carried out on hard ticks from Ankara Province, Turkey. Between April 2010 and July 2012, 1800 tick specimens belonging to 9 species were identified at 31 locations in 9 districts. Tick species are listed as follows: Rhipicephalus sanguineus group (43.44%), Rhipicephalus bursa (36.67%), Hyalomma marginatum (8.83%), Haemaphysalis parva (6%), Hyalomma aegyptium (2.39%), Hyalomma excavatum (1.33%), Dermacentor marginatus (1.06%), Haemaphysalis punctata (0.22%), and Hyalomma detritum (0.06%). Ticks were collected from host animals and from vegetation via the flagging method. The species of the genus Rhipicephalus were present in most of the study areas, the most common …
Cryptinae (Hymenoptera: Ichneumonidae) Fauna Of Isfahan Province Of Central Iran, Hossein Barahoei, Elham Nader, Ehsan Rakhshani
Cryptinae (Hymenoptera: Ichneumonidae) Fauna Of Isfahan Province Of Central Iran, Hossein Barahoei, Elham Nader, Ehsan Rakhshani
Turkish Journal of Zoology
A survey on the fauna of the Cryptinae of Isfahan Province was carried out in the summer of 2012. Specimens were collected using Malaise traps and sweeping nets. Nine species belonging to 9 genera of Cryptinae occurring in Isfahan Province were collected and identified. Among them, 7 species have been recorded from Iran previously. These species are Cryptus inculcator (Linnaeus, 1758); Dichrogaster saharator (Aubert, 1964); Gelis areator (Panzer, 1804); Lysibia nana (Gravenhorst, 1829); Mesostenus transfuga Gravenhorst, 1829; Stilpnus gagates (Gravenhorst, 1807); and Trychosis priesneri Rossem, 1971. Mesoleptus laevigatus (Gravenhorst, 1820) and Zoophthorus plumbeus (Thomson, 1884) are new records for the …
First Larval Description Of The Genus Mirabilithrombium Gabry?, 1999(Acari, Microtrombidiidae) From Turkey, Sevgi̇ Sevsay, Sezai̇ Adi̇l
First Larval Description Of The Genus Mirabilithrombium Gabry?, 1999(Acari, Microtrombidiidae) From Turkey, Sevgi̇ Sevsay, Sezai̇ Adi̇l
Turkish Journal of Zoology
Mirabilithrombium turcicum sp. nov. is described based on both active postlarval forms and larvae. Larvae of Mirabilithrombium Gabrys, 1999 were obtained by experimental rearing from a field-collected female and are described for the first time. This is the third species described in the genus; a key to the active postlarval forms is provided. Data on the habitat specificity for the species are provided.
New Data On Distribution, Ecology, And Taxonomy Of Turkish Nitidulidae (Coleoptera), Saki̇ne Serap Avgin, Gloria Antonini, Andrzej Lason, Nicklas Jansson, Tuba Öncül Abacigi̇l, Saki̇n Vural Varli, Alessio De Biase, Paolo Audisio
New Data On Distribution, Ecology, And Taxonomy Of Turkish Nitidulidae (Coleoptera), Saki̇ne Serap Avgin, Gloria Antonini, Andrzej Lason, Nicklas Jansson, Tuba Öncül Abacigi̇l, Saki̇n Vural Varli, Alessio De Biase, Paolo Audisio
Turkish Journal of Zoology
This paper updates our present knowledge on the geographical distribution and host plant relationships of Turkish species of the sap- and pollen-beetle family Nitidulidae. Pria zenobia Jelínek, 1997 from eastern Mediterranean areas is synonymized with Pria angustula Cooper, 1982, from South Africa (syn. nov.). The unknown ovipositor of Xerogethes osellai Audisio & Jelínek, 2000, a species endemic to central Turkey, is described, and the first information on its biology is reported. Glischrochilus quadripunctatus (Linnaeus, 1758) (Tunceli Province) and Pityophagus quercus Reitter, 1877 (Balikesir Province) are first recorded for the Turkish fauna. The distributions of Glischrochilus hortensis (Geoffroy in Fourcroy, 1785), …
Longwood University Catalog 2015-2016, Longwood University
Longwood University Catalog 2015-2016, Longwood University
Undergraduate Catalogs
No abstract provided.
Being Ready To Treat Ebola Virus Disease Patients, David Brett-Major, Shevin T. Jacob, Frederique A. Jacquerioz, George F. Risi, William A. Fischer, Yasuyuki Kato, Catherine F. Houlihan, Ian Crozier, Henry Kyobe Bosa, James V. Lawler, Takuya Adachi, Sara K. Hurley, Louise E. Berry, John C. Carlson, Thomas C. Button, Susan L. Mclellan, Barbara J. Shea, Gary G. Kuniyoshi, Mauricio Ferri, Srinivas G. Murthy, Nicola Petrosillo, Francois Lamontagne, David T. Porembka, John S. Schieffelin, Lewis Rubinson, Tim O'Dempsey, Suzanne M. Donovan, Daniel G. Bausch, Robert A. Fowler, Thomas E. Fletcher
Being Ready To Treat Ebola Virus Disease Patients, David Brett-Major, Shevin T. Jacob, Frederique A. Jacquerioz, George F. Risi, William A. Fischer, Yasuyuki Kato, Catherine F. Houlihan, Ian Crozier, Henry Kyobe Bosa, James V. Lawler, Takuya Adachi, Sara K. Hurley, Louise E. Berry, John C. Carlson, Thomas C. Button, Susan L. Mclellan, Barbara J. Shea, Gary G. Kuniyoshi, Mauricio Ferri, Srinivas G. Murthy, Nicola Petrosillo, Francois Lamontagne, David T. Porembka, John S. Schieffelin, Lewis Rubinson, Tim O'Dempsey, Suzanne M. Donovan, Daniel G. Bausch, Robert A. Fowler, Thomas E. Fletcher
Journal Articles: Epidemiology
As the outbreak of Ebola virus disease (EVD) in West Africa continues, clinical preparedness is needed in countries at risk for EVD (e.g., United States) and more fully equipped and supported clinical teams in those countries with epidemic spread of EVD in Africa. Clinical staff must approach the patient with a very deliberate focus on providing effective care while assuring personal safety. To do this, both individual health care providers and health systems must improve EVD care. Although formal guidance toward these goals exists from the World Health Organization, Medecin Sans Frontières, the Centers for Disease Control and Prevention, and …
Soil-Transmitted Helminth Infections And Associated Risk Factors Among Schoolchildren In Durbete Town, Northwestern Ethiopia, Tilahun Alelign, Abraham Degarege, Berhanu Erko
Soil-Transmitted Helminth Infections And Associated Risk Factors Among Schoolchildren In Durbete Town, Northwestern Ethiopia, Tilahun Alelign, Abraham Degarege, Berhanu Erko
Journal Articles: Epidemiology
Identifying determinants of soil transmitted helminth infection is vital to design control strategy for the disease. This study assessed the prevalence of STH infections and associated factors among schoolchildren in Durbete town, northwestern Ethiopia. Data about the sociodemographic and socioeconomic status of the children were collected using a questionnaire and stool samples were diagnosed using thick Kato-Katz smear. STH infection was more common among school-age children in Durbete town. Hookworm was the most frequent helminth species detected. The prevalence of STH infection was more in children who did not practice wearing shoes and washing hands before eating and in those …
Big Data -- A 21st Century Science Maginot Line? No-Boundary Thinking: Shifting From The Big Data Paradigm, Xiuzhen Huang, Steven F. Jennings, Barry Bruce, Alison Buchan, Liming Cai, Pengyin Chen, Carole Cramer, Weihua Guan, Uwe Kk Hilgert, Hongmei Jiang, Zenglu Li, Gail Mcclure, Donald F. Mcmullen, Bindu Nanduri, Andy Perkins, Bhanu Rekepalli, Saeed Salem, Jennifer Specker, Karl Walker, Donald C. Wunsch, Donghai Xiong, Shuzhong Zhang, Yu Zhang, Zhongming Zhao, Jason H. Moore
Big Data -- A 21st Century Science Maginot Line? No-Boundary Thinking: Shifting From The Big Data Paradigm, Xiuzhen Huang, Steven F. Jennings, Barry Bruce, Alison Buchan, Liming Cai, Pengyin Chen, Carole Cramer, Weihua Guan, Uwe Kk Hilgert, Hongmei Jiang, Zenglu Li, Gail Mcclure, Donald F. Mcmullen, Bindu Nanduri, Andy Perkins, Bhanu Rekepalli, Saeed Salem, Jennifer Specker, Karl Walker, Donald C. Wunsch, Donghai Xiong, Shuzhong Zhang, Yu Zhang, Zhongming Zhao, Jason H. Moore
Electrical and Computer Engineering Faculty Research & Creative Works
Whether your interests lie in scientific arenas, the corporate world, or in government, you have certainly heard the praises of big data: Big data will give you new insights, allow you to become more efficient, and/or will solve your problems. While big data has had some outstanding successes, many are now beginning to see that it is not the Silver Bullet that it has been touted to be. Here our main concern is the overall impact of big data; the current manifestation of big data is constructing a Maginot Line in science in the 21st century. Big data is not …
Types Of Ampullariidae (Mollusca: Gastropoda) In The National Museum Of Natural History, Smithsonian Institution, With Lectotype Designations, Robert Cowie, Kenneth Hayes, Ellen Strong
Types Of Ampullariidae (Mollusca: Gastropoda) In The National Museum Of Natural History, Smithsonian Institution, With Lectotype Designations, Robert Cowie, Kenneth Hayes, Ellen Strong
Department of Biology Faculty Publications
Cowie, Robert H., Kenneth A. Hayes, and Ellen E. Strong. Types of Ampullariidae (Mollusca: Gastropoda) in the NationalMuseum of Natural History, Smithsonian Institution, with Lectotype Designations. Smithsonian Contributions to Zoology, number 645, iv + 13 pages, 1 figure, 2015.—The caenogastropod family Ampullariidae Gray, 1824, is a family of freshwater snails predominantly distributed in humid tropical and subtropical habitats in Africa, South and Central America, and Asia. The family includes the largest of all freshwater snails and frequently constitutes a major portion of the native freshwater malacofauna of these regions. Ampullariid taxonomy is confused primarily because most species were described on …
The Feasibility Of Implementing A Novel Electrical Stimulation Device In The Self-Management Of Hand Burn Pain, Katrina Liddiard
The Feasibility Of Implementing A Novel Electrical Stimulation Device In The Self-Management Of Hand Burn Pain, Katrina Liddiard
Theses : Honours
Burns are widely acknowledged as one of the most painful injuries experienced, and poorly controlled pain following burn injury has been linked to reduced psychological adjustment, lower quality of life, and increased risk of developing a chronic pain state. Transcutaneous electrical nerve stimulation has been used for pain relief in a range of medical conditions, and may have the potential to reduce pain and analgesic consumption for burns patients. The burn care environment presents unique challenges to the introduction of new interventions, and the feasibility of introducing a novel form of electrical stimulation into this environment has not been tested. …
A Report From The First Regional Pain Medicine Symposia In East, Central And Southern African Region. (Ecsa-R)-“The Rhino Model In Pain Education In Africa”, Thikra Sharif, John Bugo
A Report From The First Regional Pain Medicine Symposia In East, Central And Southern African Region. (Ecsa-R)-“The Rhino Model In Pain Education In Africa”, Thikra Sharif, John Bugo
Anaesthesiology, East Africa
The 1st Regional pain medicine symposia were held between the 14th and 18th of November 2011 in 3 cities (Nairobi, Mombasa and Dar-es-salaam), across 2 countries, Kenya and Tanzania. It was funded by the International Association for the Study of Pain (IASP), through the IASP developing country education grant for 2011 and The Aga Khan University Hospital Nairobi (AKUHN). It was organized by faculty from the Pain Management Unit (PMU) AKUHN. The Pain medicine educators were from PMU, AKUHN and from Specialists in Pain International Network (SPIN).
The aims of the symposia were to introduce the Rhino model concept, the …
Design Of Novel Histone Demethylase Inhibitors As Drug Candidates To Prevent Cardiac Ischemia-Reperfusion Injury, Craig Jerome Kutz
Design Of Novel Histone Demethylase Inhibitors As Drug Candidates To Prevent Cardiac Ischemia-Reperfusion Injury, Craig Jerome Kutz
MUSC Theses and Dissertations
Current therapies to assist short- and long-term outcomes after acute myocardial infarction (AMI) depend on primary percutaneous coronary intervention shortly after ischemic insult. Upon reperfusion, localized influx of oxidative stressors overwhelms the endogenous antioxidant systems and lead to contractile dysfunction and arrhythmias. The extent of irreversible myocyte damage during ischemia-reperfusion (IR) injury is a key determinant in patient outcomes and therefore, strategies to reduce oxidative damage are essential. In recent years, increasing evidence indicates that epigenetic enzymes such as the histone demethylases and deacetylases play crucial roles during cardiovascular disease (CVD). One such enzyme, lysine specific demethylase-1 (LSD1), is hypoxia-inducible …
Role Of 2,4-Dihydroxyquinoline (Dhq) In Pseudomonas Aeruginosa Pathogenicity, Jordan Dale Gruber
Role Of 2,4-Dihydroxyquinoline (Dhq) In Pseudomonas Aeruginosa Pathogenicity, Jordan Dale Gruber
MUSC Theses and Dissertations
Bacterial group behaviors are advantageous during an infection to thwart immune cell attack and resist deleterious changes in the environment. Bacteria use a chemical messaging system in order to coordinate the phenotypes in the environment. In Pseudomonas aeruginosa, the Pseudomonas quinolone signal (Pqs) quorum-sensing system produces alkylquinolones that regulate virulence factor production and also perform extracellular roles. Two alkylquinolones, 2-heptyl-4-quinolone (HHQ) and 2- heptyl-3-hydroxy-4-quinolone (PQS) activate transcriptional regulator PqsR for subsequent production of quinolones and phenazines, iron chelation, and autolysis. The most abundant quinolone produced from the Pqs system is 2,4-Dihydroxyquinoline (DHQ); however, DHQ has no known function. We demonstrated …
Developing A Heterotypic Cell Culture Model To Determine Vegf Action Of Neural Stem Cell Fate Choice, Stephanie Snyder
Developing A Heterotypic Cell Culture Model To Determine Vegf Action Of Neural Stem Cell Fate Choice, Stephanie Snyder
Theses and Dissertations
Brain development requires tight cell and molecular regulation for proper neural stem cell (NSC) proliferation and differentiation. Increasing interest in NSCs has arisen due to the flexibility inherent within their proliferative capacity and their ability to generate multiple neuronal cell types. Our main focus is on the cortex, the primary integrator for higher order brain function. Cortical NSC proliferation and differentiation occur in concert with blood vessel ingression into the primitive cortex to vascularize the neuroepithelium. One potential influence derived from vascular cells is Vascular endothelial growth factor A (Vegf). Vegf has the ability to regulate both neurogenesis and angiogenesis …
Syntheses And Characterization Of Bis(Amino)Cyclodiphosphazane Complexes Of Group 4- And -15 Elements, Mathew Etang Otang
Syntheses And Characterization Of Bis(Amino)Cyclodiphosphazane Complexes Of Group 4- And -15 Elements, Mathew Etang Otang
Theses and Dissertations
In the first part of this work, the interaction of sodium tert-butoxide and sulfur with Group 4 metal bis(tert-butylamido)cyclodiphosph(III)azanes dichlorides, {[tBuNP)2tBuN)2]MCl2}, where M is Zr or Hf, is reported. The reaction of two equivalents of NaOtBu with {[tBuNP)2tBuN)2]MCl2}, M = Zr, Hf, resulted in the isolation of the first metal alkoxide complexes {[tBuNP)2tBuN)2]M(OtBu)2}, 35 (M =Zr) and 36 (M = Hf) of cyclodiphosphazanes. The oxidation of compounds 35 and 36 with elemental sulfur yielded {[tBuNP=S)2tBuN)2]M(OtBu)2}, 37 (M = Zr) and 38 (M = Hf), respectively. Similarly, the oxidation of {[tBuNP)2tBuN)2]MCl2}, M = Zr, Hf, with elemental sulfur led to the …