Digital Commons Network^™

Developing An Integrative Glycobiology Workflow For The Identification Of Disease Markers For Pancreatic Cancer, Thomas Wesley Powers

MUSC Theses and Dissertations

A deeper understanding of dysregulated glycosylation in pancreatic cancer can provide insights into disease mechanisms and the identification of novel disease markers. Recent improvements in mass spectrometry techniques have been instrumental in profiling biologically relevant tissue sections in order to identify disease marker candidates, but have either not yet been adopted for studying glycosylation or applied directly to pancreatic cancer. In the dissertation herein, new methods have been developed and adapted to the study of aberrant glycosylation in pancreatic cancer, with the ultimate goal of identifying novel disease marker candidates. For the first time, we describe a mass spectrometry imaging …

Doctoral Program In School Psychology Policies And Procedures Handbook 2015-2016, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Master's Programs In Counseling Policies And Procedures Handbook 2015-2016, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

College Of Psychology 2015-2016 Catalog, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Master's Program In General Psychology Policies And Procedures Handbook, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

"Born There": Faulkner, Oxford, And Lafayette County, Philip M. Weinstein

English Literature Faculty Works

No abstract provided.

Adolescent Girls Initiative-Kenya: Health And Life Skills Curriculum, Wajir, Population Council

Poverty, Gender, and Youth

The Adolescent Girls Initiative–Kenya builds the social, health, and economic assets of adolescent girls in urban slums and Northeastern Kenya. This collection of learning sessions was designed to increase adolescent girls’ knowledge of reproductive health and sexuality; reinforce and promote attitudes and behaviors that will lead to a better quality of life; and instill skills among adolescents to enable them to overcome the challenges of growing up and becoming responsible adults including communication skills, decision-making, assertiveness, setting goals and resisting peer pressure. The sessions were developed to be delivered without a lot of resources or materials, with limited time available …

Baseline Survey Instruments: Adolescent Girls Initiative–Kenya, Population Council

Poverty, Gender, and Youth

This document contains various AGI-K survey instruments, including: Household Characteristics Survey (English), Respondent’s Schooling History (English), Respondent’s Work in Last Year (English), Respondent’s Spending in Last Year (English), Respondent’s Savings in Last Year (Kiswahili), Respondent’s Savings in Last Year (English).

Building Assets Toolkit: Developing Positive Benchmarks For Adolescent Girls—Resource Manual, Judith Bruce, Sarah Engebretsen, Kimberly Glazer

Poverty, Gender, and Youth

This document contains the Building Assets Toolkit’s Resource Manual, which includes valuable information about building meaningful program content as well as detailed notes on each asset for use in the toolkit’s “Asset Building Exercise.” This exercise is designed to involve multiple stakeholders in determining what assets girls need in order to survive and thrive. The Building Assets Toolkit is an approach for developing programs for specific segments of girls that will prepare them to better face the challenges of growing up. It will help program managers understand the needs of the girls in their community, engage stakeholders at different levels …

Understanding Factors Influencing Adverse Sex Ratios At Birth And Exploring What Works To Achieve Balance: The Situation In Selected Districts Of Nepal, Mahesh Puri, Anand Tamang

Poverty, Gender, and Youth

The goal of this study is to identify programs and sociocultural factors underlying disparities in sex ratios at birth in some parts of Nepal, by comparing the situation in districts with high and normal sex ratios at birth and among under-5 children. Findings are expected to inform the design of programs intended to raise the value of girls in general and counter the practice of gender-biased sex selection in particular. The study was conducted in two adjoining hill districts of the western development region of Nepal, namely Kaski (where sex ratios are adverse) and Tanhaun (where sex ratios are normal). …

Building Assets Toolkit: Developing Positive Benchmarks For Adolescent Girls, Judith Bruce, Sarah Engebretsen, Kimberly Glazer

Poverty, Gender, and Youth

The Building Assets Toolkit is an approach for developing programs for specific segments of girls that will prepare them to better face the challenges of growing up. It will help program managers understand the needs of the girls in their community, engage stakeholders at different levels and with different viewpoints, and build concrete and meaningful programming for adolescent girls. This document contains the complete toolkit in English (resource manual, instruction guide, and asset cards)

See Comments section below for individual links to each section of the toolkit and to the resources in other languages.

Brief For Amici Curiae Scholars Of The Constitutional Rights Of Children In Support Of Respondent Edith Windsor Addressing The Merits And Supporting Affirmance, J. Robert Brown Jr., Catherine E. Smith, Kyle C. Velte, Susannah William Pollvogt, Tanya Washington

Sturm College of Law: Faculty Scholarship

This amicus brief filed by Scholars of the Constitutional Rights of Children turns the spotlight on children in same-sex families. The brief enumerates the ways Section 3 of DOMA impairs children's interests by denying federal recognition of their parents' marriages.

Brief Of Amici Curiae Scholars Of The Constitutional Rights Of Children In Support Of Petitioners In Obergefell V. Hodges, Catherine E. Smith, Lauren Fontana, Susannah William Pollvogt, Tanya Washington

Sturm College of Law: Faculty Scholarship

Supreme Court precedent establishes that the government may not punish children for matters beyond their control. Same-sex marriage bans and non-recognition laws (“marriage bans”) do precisely this. The states argue that marriage is good for children, yet marriage bans categorically exclude an entire class of children – children of same-sex couples – from the legal, economic and social benefits of marriage.

This amicus brief recounts a powerful body of equal protection jurisprudence that prohibits punishing children to reflect moral disapproval of parental conduct or to incentivize adult behavior. We then explain that marriage bans punish children of same-sex couples because …

Georgia Southern University Fact Book, Georgia Southern University

Georgia Southern Fact Books (1976-2022)

No abstract provided.

2015 Georgia Southern Football Full Media Guide, Georgia Southern University

Men's Football Records

• 2015 Georgia Southern Football Media Guide

Targeting The Tight Junction Protein, Zonula Occludens-1, With The Connexin 43 Mimetic Peptide, Αct-1 Reduces Vegf-Dependent Rpe Pathophysiology, Elizabeth Christa Obert

MUSC Theses and Dissertations

Age-related macular degeneration (AMD) is a multifactorial disease and is regarded as the predominant cause of central vision loss in the elderly in industrialized countries. A critical target tissue in AMD is the retinal pigment epithelium (RPE), which together with Bruch’s membrane forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction in AMD might result from attenuation and disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1) is a major structural protein of intercellular junctions. A connexin-based peptide mimetic, αCT-1 (Alpha Connexin carboxy-Terminal 1), was developed which competitively inhibits ZO-1 interaction with its binding partners. We hypothesized that targeting ZO-1 signaling using …

Mechanisms Of Mitochondrial Dysfunction In Sepsis-Induced Kidney Injury, Joshua Andrew Smith

MUSC Theses and Dissertations

Mitochondrial dysfunction is a well-characterized pathophysiological feature of acute kidney injury (AKI). Our laboratory has previously implicated suppression of mitochondrial biogenesis, the process by which cells generate new and functional mitochondria, as an important contributor to development of mitochondrial dysfunction in multiple experimental models of AKI. However, relatively little is known about the molecular mechanisms responsible for disruption of biogenesis in renal cells. The primary goals of this project were to define signaling pathways mediating acute suppression of renal cortical mitochondrial biogenesis and to characterize changes in glycolytic metabolism that might support both cellular and organ function following sepsis-induced AKI. …

The Role Of The Complement System In Cigarette Smoke Induced Emphysema Development And Progression, Sarah E. Stephenson

MUSC Theses and Dissertations

Emphysema is a complex inflammatory condition of the respiratory tract with an incompletely elucidated pathogenesis. Due to the complexity of the disease, treatment options are limited for patients and have poor efficacy. Therefore a greater understanding of disease pathogenesis is imperative to expand therapeutic strategies. Central to disease development is the activation of the innate and adaptive immune system, however, targeting blockade of only one side of the immune response, has shown little clinical benefit. The complement system, while regarded as an innate immune mechanism, can modulate both innate and adaptive immune responses. Given these dual modulatory effects, the complement …

The Alternative Complement Pathway Mediates Chronic Smoke-Induced Functional And Morphological Ocular Injury, Alex Stephen Woodell

MUSC Theses and Dissertations

BACKGROUND: Age-related macular degeneration (AMD), a complex disease involving genetic variants and environmental insults, is among the leading causes of blindness in Western populations. Genetic and histologic evidence implicate the complement system in AMD pathogenesis, and smoking is the major environmental risk factor associated with increased disease risk. Although previous studies have demonstrated that cigarette smoke exposure (CE) causes retinal pigment epithelium (RPE) defects in mice and smoking leads to complement activation in patients, it is unknown whether complement activation is causative in the development of CE pathology; and if so, which complement pathway is required. METHODS: Mice were exposed …

Sleeve Gastrectomy And Roux-En-Y Gastric Bypass Alter The Gut-Brain Communication, Lindsey Ballsmider, Alexandra Vaughn, Michelle David, Andras Hajnal, Patricia Di Lorenzo, Krzysztof Czaja

Psychology Faculty Scholarship

This study investigated the anatomical integrity of vagal innervation of the gastrointestinal tract following vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) operations. The retrograde tracer fast blue (FB) was injected into the stomach to label vagal neurons originating from nodose ganglion (NG) and dorsal motor nucleus of the vagus (DMV). Microglia activation was determined by quantifying changes in the fluorescent staining of hindbrain sections against an ionizing calcium adapter binding molecule 1 (Iba1). Reorganization of vagal afferents in the hindbrain was studied by fluorescent staining against isolectin 4 (IB4). The density of Iba1-and IB4-immunoreactivity was analyzed using Nikon …

Food Of Bobcats And Coyotes From Cumberland Island, Camden County, Georgia, John O. Whitaker Jr., Carol Ruckdeschel, Angela Chamberlain, Lauren Bakken

Georgia Journal of Science

Fifty scats of bobcats and 105 scats of coyotes from Cumberland Island, Camden County, Georgia, were examined during this study. Major foods of bobcats were mammals (81.8% volume), followed by birds (13.8%) and vegetation (4.2%), with only 0.2% invertebrates. Major foods of coyotes were plant materials (46.6% volume), mammals (43.8%), and invertebrates (6.0%). This is apparently the first report of coyote foods from Cumberland Island.

Scholarship Against Desire, Shari Motro

Law Faculty Publications

This article uses my own experience navigating the law review placement process to reflect on the dynamics that shape intellectual life at American law schools. My recent work focuses on the legal relationship between unmarried lovers who conceive. At its heart, it is about the law’s role in shaping the precursor to pregnancy—heterosexual sex. When I began researching this topic what I was most curious about was how law and culture might conspire to foster connections that are more loving and less violent, more authentic and less alienated. Pursuing this topic—which would entail exploring big existential questions to which I …

Fp-15-02 Multiple Partner Fertility Among White Married Couples In The U.S., 1955, Sara R. Zobl, Pamela J. Smock

National Center for Family and Marriage Research Family Profiles

No abstract provided.

Living On The Edge: Rethinking Pueblo Period: (Ad 700 – Ad 1225) Indigenous Settlement Patterns Within Grand Canyon National Park, Northern Arizona, Philip B. Mink Ii

Theses and Dissertations--Anthropology

This dissertation challenges traditional interpretations that indigenous groups who settled the Grand Canyon during the Pueblo Period (AD 700 -1225) relied heavily on maize to meet their subsistence needs. Instead they are viewed as dynamic ecosystem engineers who employed fire and natural plant succession to engage in a wild plant subsistence strategy that was supplemented to varying degrees by maize. By examining the relationship between archaeological sites and the natural environment throughout the Canyon, new settlement pattern models were developed. These models attempt to account for the spatial distribution of Virgin people, as represented by Virgin Gray Ware ceramics, Kayenta …

How Medicare Part D, Medicaid, Electronic Prescribing, And Icd-10 Could Improve Public Health (But Only If Cms Lets Them), Jennifer L. Herbst

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Volume 25 (2015), Case Western Reserve Health Matrix: Journal Of Law-Medicine

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Understanding And Addressing The Common Roots Of Racial Health Disparities: The Case Of Cardiovascular Disease And Hiv/Aids In African Americans, Matha E. Lang, Chloe E. Bird

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Biologic Drugs, Biosimilars, And Barriers To Entry, Joanna M. Shepherd

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Defining Compensable Injury In Biomedical Research, Megan E. Larkin

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Medicaid And Migrant Farmworkers: Why The State Residency Requirement Presents A Significant Access Barrier And What States Should Do About It, Malea Hetrick

Health Matrix: The Journal of Law-Medicine

No abstract provided.