Digital Commons Network^™

Pathological Complete Response In Breast Cancer Patients Following Neoadjuvant Chemotherapy At A Comprehensive Cancer Center: The Natural History Of An Elusive Prognosticator, Oluwadamilola M. Fayanju, Iheoma Nwaogu, Donna B. Jeffe, Julie A. Margenthaler

Open Access Publications

No abstract provided.

Neuronal-Targeted Tfeb Accelerates Lysosomal Degradation Of App, Reducing Aβ Generation And Amyloid Plaque Pathogenesis, Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L. Tripoli, Leah Czerniewski, Andrea Ballabio, John R. Cirrito, Abhinav Diwan, Jin-Moo Lee

Open Access Publications

No abstract provided.

Inflammatory Pain Promotes Increased Opioid Self-Administration: Role Of Dysregulated Ventral Tegmental Area Μ Opioid Receptors, Lucia Hipolito, Adrianne Wilson-Poe, Yolanda Campos-Jurado, Elaine Zhong, Jose Gonzalez-Romero, Laszlo Virag, Robert Whittington, Sandra D. Comer, Susan M. Carlton, Brendan M. Walker, Michael R. Bruchas, Jose A. Moron

Open Access Publications

No abstract provided.

Three-Dimensional Matrix Fiber Alignment Modulates Cell Migration And Mt1-Mmp Utility By Spatially And Temporally Directing Protrusions, Stephanie I. Fraley, Pei-Hsun Wu, Lijuan He, Yunfeng Feng, Ranjini Krisnamurthy, Gregory D. Longmore, Denis Wirtz

Open Access Publications

No abstract provided.

Satb2 Is A Sensitive Marker For Lower Gastrointestinal Well-Differentiated Neuroendocrine Tumors, Zhongwu Li, Jing Yuan, Lixin Wei, Kaiyong Mei, Junqiu Yue, Hongwen Gao, Miao Zhang, Ling Jia, Qiang Kang, Xiaozheng Huang, Dengfeng Cao

Open Access Publications

No abstract provided.

Unique And Redundant Functions Of Nkp46+ Ilc3s In Models Of Intestinal Inflammation, Christina Song, Jacob S. Lee, Susan Gilfillan, Michelle L. Robinette, Rodney D. Newberry, Thaddeus S. Stappenbeck, Matthias Mack, Marina Cella, Marco Colonna

Open Access Publications

No abstract provided.

Inhibition Of P-Selectin And Psgl-1 Using Humanized Monoclonal Antibodies Increases The Sensitivity Of Multiple Myeloma Cells To Bortezomib, Barbara Muz, Feda Azab, Pilar De La Puente, Scott Rollins, Richard Alvarez, Ziad Kawar, Abdel Kareem Azab

Open Access Publications

No abstract provided.

Impaired Fas-Fas Ligand Interactions Result In Greater Recurrent Herpetic Stromal Keratitis In Mice, Xiao-Tang Yin, Tammie L. Keadle, Jessicah Hard, John Herndon, Chelsea R. Del Rosso, Thomas A. Ferguson, Patrick M. Stuart

Open Access Publications

No abstract provided.

Seminoma Presenting As Renal Mass, Inferior Vena Caval Thrombus, And Regressed Testicular Mass, Valary T. Raup, Michael H. Johnson, Jonathan R. Weese, Ian S. Hagemann, Stephen D. Marshall, Steven B. Brandes

Open Access Publications

No abstract provided.

Targeting Cd226/Dnax Accessory Molecule-1 (Dnam-1) In Collagen-Induced Arthritis Mouse Models, Muriel Elhai, Gilles Chiocchia, Carmen Marchiol, Franck Lager, Gilles Renault, Marco Colonna, Guenter Bernhardt, Yannick Allanore, Jerome Avouac

Open Access Publications

No abstract provided.

Adrenocortical Zonation, Renewal, And Remodeling, Marjut Pihlajoki, Julia Dorner, Rebecca S. Cochran, Markku Heikinheimo, David B. Wilson

Open Access Publications

No abstract provided.

Extending Injury- And Disease-Resistant Cns Phenotypes By Repetitive Epigenetic Conditioning, Jeffrey M. Gidday

Open Access Publications

No abstract provided.

Toxoplasma Actin Is Required For Efficient Host Cell Invasion, Lisa L. Drewry, L. David Sibley

Open Access Publications

No abstract provided.

Macrophage Recruitment And Epithelial Repair Following Hair Cell Injury In The Mouse Utricle, Tejbeer Kaur, Keiko Hirose, Edwin W. Rubel, Mark E. Warchol

Open Access Publications

No abstract provided.

Regional Scale Cropland Carbon Budgets: Evaluating A Geospatial Agricultural Modeling System Using Inventory Data, Xuesong Zhang, Roberto C. Izaurralde, David H. Manowitz, Ritvik Sahajpal, Tristram O. West, Allison M. Thomson, Min Xu, Kaiguang Zhao, Stephen D. Leduc, Jimmy R. Williams

United States Environmental Protection Agency: Publications

Accurate quantification and clear understanding of regional scale cropland carbon (C) cycling is critical for designing effective policies and management practices that can contribute toward stabilizing atmospheric CO₂ concentrations. However, extrapolating site-scale observations to regional scales represents a major challenge confronting the agricultural modeling community. This study introduces a novel geospatial agricultural modeling system (GAMS) exploring the integration of the mechanistic Environmental Policy Integrated Climate model, spatially-resolved data, surveyed management data, and supercomputing functions for cropland C budgets estimates. This modeling system creates spatiallyexplicit modeling units at a spatial resolution consistent with remotely-sensed crop identification and assigns cropping systems …

Scientific And Regulatory Policy Committee (Srpc) Review*: Interpretation And Use Of Cell Proliferation Data In Cancer Risk Assessment, Charles E. Wood, Renee R. Hukkanen, Radhakrisha Sura, David Jacobson-Kram, Thomas Nolte, Marielle Odin, Samuel M. Cohen

United States Food and Drug Administration: Publications

Increased cell proliferation is a central key event in the mode of action for many non-genotoxic carcinogens, and quantitative cell proliferation data play an important role in the cancer risk assessment of many pharmaceutical and environmental compounds. Currently, there is limited unified information on assay standards, reference values, targeted applications, study design issues, and quality control considerations for proliferation data. Here, we review issues in measuring cell proliferation indices, considerations for targeted studies, and applications within current risk assessment frameworks. As the regulatory environment moves toward more prospective evaluations based on quantitative pathway-based models, standardiza- tion of proliferation assays will …

Estimation Of Potential Evapotranspiration From Extraterrestrial Radiation, Air Temperature And Humidity To Assess Future Climate Change Effects On The Vegetation Of The Northern Great Plains, Usa, David A. King, Dominique M. Bachelet, Amy J. Symstad, Ken Ferschweiler, Michael Hobbins

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

The potential evapotranspiration (PET) that would occur with unlimited plant access to water is a central driver of simulated plant growth in many ecological models. PET is influenced by solar and long wave radiation, temperature, wind speed, and humidity, but it is often modeled as a function of temperature alone. This approach can cause biases in projections of future climate impacts in part because it confounds the effects of warming due to increased greenhouse gases with that which would be caused by increased radiation from the sun. We developed an algorithm for linking PET to extraterrestrial solar radiation (incoming top-of …

At-Grade Stabilization Structure Impact On Surface Water Quality Of An Agricultural Watershed, Kyle R. Minks, Matthew D. Ruark, Birl Lowery, Fred W. Madison, Dennis Frame, Todd D. Stuntebeck, Matthew J. Komiskey, George J. Kraft

United States Geological Survey: Staff Publications

Decades of farming and fertilization of farm land in the unglaciated/Driftless Area (DA) of southwestern Wisconsin have resulted in the build-up of P and to some extent, N, in soils. This build-up, combined with steep topography and upper and lower elevation farming (tiered farming), exacerbates problems associated with runoff and nutrient transport in these landscapes. Use of an at-grade stabilization structure (AGSS) as an additional conservation practice to contour strip cropping and no-tillage, proved to be successful in reducing organic and sediment bound N and P within an agricultural watershed located in the DA. The research site was designed as …

Interactive Effects Of Climate Change With Nutrients, Mercury, And Freshwater Acidification On Key Taxa In The North Atlantic Landscape Conservation Cooperative Region, Alfred E. Pinkney, Charles T. Driscoll, David C. Evers, Michael J. Hooper, Jeffrey Horan, Jess W. Jones, Rebecca S. Lazarus, Harold G. Marshall, Andrew Milliken, Barnett A. Rattner, John Schmerfeld, Donald W. Sparling

United States Geological Survey: Staff Publications

The North Atlantic Landscape Conservation Cooperative LCC (NA LCC) is a public–private partnership that provides information to support conservation decisions that may be affected by global climate change (GCC) and other threats. The NA LCC region extends from southeast Virginia to the Canadian Maritime Provinces. Within this region, the US National Climate Assessment documented increases in air temperature, total precipitation, frequency of heavy precipitation events, and rising sea level, and predicted more drastic changes. Here, we synthesize literature on the effects of GCC interacting with selected contaminant, nutrient, and environmental processes to adversely affect natural resources within this region. Using …

Global Change And Conservation Triage On National Wildlife Refuges, Fred Johnson, Mitchell J. Eaton, Gerard Mcmahon, Raye Nilius, Michael R. Bryant, Dave Case, Julien Martin, Nathan Wood, Laura Taylor

United States Geological Survey: Staff Publications

National Wildlife Refuges (NWRs) in the United States play an important role in the adaptation of social-ecological systems to climate change, land-use change, and other global-change processes. Coastal refuges are already experiencing threats from sea-level rise and other change processes that are largely beyond their ability to influence, while at the same time facing tighter budgets and reduced staff. We engaged in workshops with NWR managers along the U.S. Atlantic coast to understand the problems they face from global-change processes and began a multidisciplinary collaboration to use decision science to help address them. We are applying a values-focused approach to …

A Bird’S- Eye View Of The Usa National Phenology Network: An Off-The-Shelf Monitoring Program, Jherime Kellerman, Caroline A. F. Enquist, Diana L. Humple, Nathaniel E. Seavy, Alyssa Rosemartin, Renée L. Cormier, Lorianne Barnett

United States Geological Survey: Staff Publications

Phenology is central to the biology and ecology of organisms and highly sensitive to climate. Differential responses to climate change are impacting phenological synchrony of inter- acting species, which has been implicated in the decline of migratory birds that rely on seasonal resources. However, few studies explicitly measure phenology of seasonal habitat resources on the breeding and wintering grounds and at stopover sites. While avian monitoring methods are widely standardized, methods of monitoring resource phenology can be highly variable and difficult to integrate. The USA National Phenology Network (USA- NPN) has developed standardized plant and animal phenology protocols and a …

Relationship Between Heat-Labile Enterotoxin Secretion Capacity And Virulence In Wild Type Porcine-Origin Enterotoxigenic Escherichia Coli Strains, Prageeth Wijemanne, Jun Xing, Emil M. Berberov, David H. Francis, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

Heat-labile enterotoxin (LT) is an important virulence factor secreted by some strains of enterotoxigenic Escherichia coli (ETEC). The prototypic human-origin strain H10407 secretes LT via a type II secretion system(T2SS). We sought to determine the relationship between the capacity to secrete LT and virulence in porcine-origin wild type (WT) ETEC strains. Sixteen WT ETEC strains isolated from cases of severe diarrheal disease were analyzed by GM1ganglioside enzyme- linked immunosorbent assay tomeasure LT concentrations in culture supernatants. All strains had detectable LT in supernatants by 2 h of culture and 1 strain, which was particularly virulent in gnotobiotic piglets (3030-2), had …

Temperatures Of Storage Areas In Large Animal Veterinary Practice Vehicles In The Summer And Comparison With Drug Manufacturers’ Storage Recommendations, Jeff D. Ondrak, Meredyth L. Jones, Virginia R. Fajt

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: Large animal veterinarians carry drugs in their practice vehicles in storage areas that are not typically refrigerated. The most common upper limits of manufacturers’ storage temperatures for United States (U.S.)-approved non-refrigerated drugs are 25 or 30 °C. Because ambient temperatures in many locations in the U.S. exceed these temperatures during the summer, we measured storage area temperatures over 4 months in the summer of 2013 to evaluate the extent to which labeled storage temperatures are exceeded.

Methods: A convenience sample of 12 vehicles from 5 central Texas practices and 12 vehicles from 4 south central Nebraska practices was …

Whole-Genome Sequencing Of Kaposi’S Sarcoma-Associated Herpesvirus From Zambian Kaposi’S Sarcoma Biopsy Specimens Reveals Unique Viral Diversity, Landon Olp, Adrien Jeanniard, Clemence Marimo, Charles Wood

Nebraska Center for Virology: Faculty Publications

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent for Kaposi’s sarcoma (KS). Both KSHV and KS are endemic in sub-Saharan Africa where approximately 84% of global KS cases occur. Nevertheless, whole-genome sequencing of KSHV has only been completed using isolates from Western countries—where KS is not endemic. The lack of whole-genome KSHV sequence data from the most clinically important geographical region, sub-Saharan Africa, represents an important gap since it remains unclear whether genomic diversity has a role on KSHV pathogenesis. We hypothesized that distinct KSHV genotypes might be present in sub-Saharan Africa compared to Western countries. Using a KSHV-targeted enrichment …

Observed And Expected Incidence Of Cervical Cancer In Lusaka And The Southern And Western Provinces Of Zambia, 2007 - 2012, Mulele Kalima, Kennedy Lishimpi, Jane L. Meza, Shinobu Watanabe-Galloway, Susan C. Msadabwe, Catherine K. Mwaba, Aaron L. Shibemba, Lewis Banda, Charles Wood, Robert M. Chamberlain, Amr S. Soliman

Nebraska Center for Virology: Faculty Publications

Objectives—Cervical cancer is increasing but underestimated in developing countries. We calculated the observed and expected incidence of cervical cancer in Lusaka and Southern and Western provinces of Zambia.

Methods/Materials—Data for 2007-2012 was obtained for the 3 provinces. Data included age, residence, year of diagnosis, marital status, occupation, HIV, stage, radiotherapy and chemotherapy. Expected incidence in Southern and Western provinces was calculated based on observed incidence for Lusaka province, adjusting for HIV.

Results—Crude and age-standardized incidence rates (ASR) in Lusaka were 2-4 times higher than incidence in the other 2 provinces. Lusaka had a rate of 54.1/10⁵ and ASR of …

Crf07_Bc Strain Dominates The Hiv-1 Epidemic In Injection Drug Users In Liangshan Prefecture Of Sichuan, China, Lin Li, Daying Wei, Wan-Ling Hsu, Tianyi Li, Tao Gui, Charles Wood, Yongjian Liu, Hanping Li, Zuoyi Bao, Siyang Liu, Xiaolin Wang, Jingyun Li

Nebraska Center for Virology: Faculty Publications

The Liangshan prefecture in Sichuan province is an area in China severely affected by the HIV epidemic, with intravenous drug use (IDU) as the main risk factor. No reports on HIV subtypes prevalent in IDUs in Liangshan prefecture could be found. In this study, we have characterized the genotypes of HIV-1 in the IDU population in Liangshan prefecture and further determined the phylogenetic relationship of the CRF07_BC strains to HIV-1 sequences from the other regions of China, including Xinjiang and Yunnan provinces, to explore the pattern and possible diffusion pathway of HIV-1 in these regions. HIV-1-seropositive drug-naive IDUs identified in …

Relaxin Activates Peroxisome Proliferator-Activated Receptor Ƴ (PparƳ) Through A Pathway Involving Ppar Ƴ Coactivator 1Α (Pgc1Α), Sudhir K. Singh, Ronda L. Simpson, Robert G. Bennett

United States Department of Veterans Affairs: Publications

Background: Relaxin activates peroxisome proliferator-activated receptor_ƴ

(PPAR_ƴ) by an unknown PPAR_ƴ ligandindependent mechanism.

Results: Expression of PPAR_ƴ coactivator 1_α (PGC1_α) was increased by relaxin through distinct signaling pathways.

Conclusion: The mechanism for relaxin regulation of PPAR_ƴ is through increased PGC1_α levels.

Significance: Discovery of new targets of relaxin signaling may provide further understanding of its pleiotropic effects.

Airborne And Air Assault Operations, United States Army

United States Army: Field Manuals

Airborne and Air Assault Operations, United States Army Field Manual FM 3-99

University Of Nebraska- Lincoln: Fact Book

University of Nebraska-Lincoln Administration: Reports, Papers, Publications, and Presentations

Fact Book Table of Contents

Front Cover............................................................. 1

Introduction ........................................... 2

Table of Contents.................................................................. 4

General Information

University of Nebraska-Lincoln Core Values (LEADERS)................................... 7

The Role of the University of Nebraska-Lincoln ....................................... 8

The Missions of the University of Nebraska-Lincoln ......................................... 8

Teaching........................................................................................................... 9

Research.................................................................................................. 10

Service........................................................................................... 10

Institutional and Professional Accreditations................................................. 11

University of Nebraska-Lincoln Administrative Organization Chart .................. 14

Student Credit Hours (SCH)

Total SCH: Fall Semester Since 1979 ...................................................... 15

Total SCH: Spring Semester Since 1993 .......................................................... 16

SCH by College and Course Level, Fall and Spring Semester, 5 Year Trend ... 17

SCH by College and …

Detection, Occurrence And Fate Of Emerging Contaminants In Agricultural Environments, Daniel D. Snow, David A. Cassada, Shannon L. Bartelt-Hunt, Xu Li, Matteo D'Alessio, Rachel Levine, Yun Zhang, J. Brett Sallach

Nebraska Water Center: Faculty Publications

A total of 43 papers published in 2014 were reviewed ranging from detailed descriptions of analytical methods, to fate and occurrence studies, to measuring and predicting biological effects for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, natural and synthetics steroids, and antibiotic resistance genes in agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Occurrence and Fate, Antibiotic Resistance Genes, and Risk Assessment.