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2015

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Introduction To Amici Curiae Brief In Young V. United Parcel Service, Inc., Joanna L. Grossman, Deborah L. Brake Jan 2015

Introduction To Amici Curiae Brief In Young V. United Parcel Service, Inc., Joanna L. Grossman, Deborah L. Brake

Faculty Journal Articles and Book Chapters

On March 25, 2015, the U.S. Supreme Court issued its decision in Young v. United Parcel Service, Inc., the most important pregnancy discrimination case before the Court in nearly a quarter century. The Court ruled for Peggy Young in a decision that will chart the path of pregnancy discrimination litigation for years to come. Our brief, published here with a short introduction, lays out our theory for why an employer’s refusal to accommodate pregnancy with light-duty assignments on the same terms as other medical conditions similarly affecting work violates Title VII and the Pregnancy Discrimination Act. The brief was …


Przedsiębiorczość: Jednostka, Organizacja, Kontekst, Agnieszka Postuła, Julita Majczyk, Marcin Darecki Jan 2015

Przedsiębiorczość: Jednostka, Organizacja, Kontekst, Agnieszka Postuła, Julita Majczyk, Marcin Darecki

Monografie/Monographs

Pojęcie przedsiębiorczości, rozumiane nie tylko w kontekście osób prowadzących własną działalność gospodarczą i ich kompetencji, przywoływane jest coraz częściej zarówno przez środowisko naukowe, organy władzy państwowej, organizacje pozarządowe, instytucje finansowe, jak i osoby prywatne. Przyczyną wzrostu popularności przedsiębiorczości jest stopniowo pogłębiające się zrozumienie samego pojęcia.

Opracowana monografia skierowana jest nie tylko do badaczy, wykładowców czy też studentów zainteresowanych tematyką przedsiębiorczości. Wieloaspektowość zawartych publikacji nadaje jej charakter uniwersalny, przez co – na co mamy nadzieję – może być wykorzystywana przez wszystkich, w tym także samych przedsiębiorców.


Electron- And Photon-Impact Ionization Of Furfural, D. B. Jones, E. Ali, K. L. Nixon, P. Limão-Vieira, M.-J. Hubin-Franskin, J. Delwiche, C. G. Ning, J. Colgan, Andrew J. Murray, Don H. Madison, M .J. Brunger Jan 2015

Electron- And Photon-Impact Ionization Of Furfural, D. B. Jones, E. Ali, K. L. Nixon, P. Limão-Vieira, M.-J. Hubin-Franskin, J. Delwiche, C. G. Ning, J. Colgan, Andrew J. Murray, Don H. Madison, M .J. Brunger

Physics Faculty Research & Creative Works

The He(i) photoelectron spectrum of furfural has been investigated, with its vibrational structure assigned for the first time. The ground and excited ionized states are assigned through ab initio calculations performed at the outer-valence Green's function level. Triple differential cross sections (TDCSs) for electron-impact ionization of the unresolved combination of the 4a" + 21a' highest and next-highest occupied molecular orbitals have also been obtained. Experimental TDCSs are recorded in a combination of asymmetric coplanar and doubly symmetric coplanar kinematics. The experimental TDCSs are compared to theoretical calculations, obtained within a molecular 3-body distorted wave framework that employed either an orientation …


One-Loop Dominance In The Imaginary Part Of The Polarizability: Application To Blackbody And Noncontact Van Der Waals Friction, Ulrich D. Jentschura, Grzegorz Lach, Maarten Dekieviet, Krzysztof Pachucki Jan 2015

One-Loop Dominance In The Imaginary Part Of The Polarizability: Application To Blackbody And Noncontact Van Der Waals Friction, Ulrich D. Jentschura, Grzegorz Lach, Maarten Dekieviet, Krzysztof Pachucki

Physics Faculty Research & Creative Works

Phenomenologically important quantum dissipative processes include blackbody friction (an atom absorbs counterpropagating blueshifted photons and spontaneously emits them in all directions, losing kinetic energy) and noncontact van der Waals friction (in the vicinity of a dielectric surface, the mirror charges of the constituent particles inside the surface experience drag, slowing the atom). The theoretical predictions for these processes are modified upon a rigorous quantum electrodynamic treatment, which shows that the one-loop "correction" yields the dominant contribution to the off-resonant, gauge-invariant, imaginary part of the atom's polarizability at room temperature, for typical atom-surface interactions. The tree-level contribution to the polarizability dominates …


Moving Beyond Cardio: The Value Of Resistance Training, Balance Training, And Other Forms Of Exercise In The Management Of Diabetes, Marni J. Armstrong, Sheri R. Colberg, Ronald J. Sigal Jan 2015

Moving Beyond Cardio: The Value Of Resistance Training, Balance Training, And Other Forms Of Exercise In The Management Of Diabetes, Marni J. Armstrong, Sheri R. Colberg, Ronald J. Sigal

Human Movement Studies & Special Education Faculty Publications

Traditionally, aerobic training has been a central focus of exercise promotion for diabetes management. However, people with diabetes have much to gain from other forms of exercise. This article reviews the evidence and recommendations on resistance, balance, and flexibility training, as well as other, less traditional, forms of exercise such as yoga and Tai Chi.


Drought Resistance And Resilience Of Non-Native Vs. Native Grasses In The Northern Tallgrass Prairie, Wyatt Kirwan Jan 2015

Drought Resistance And Resilience Of Non-Native Vs. Native Grasses In The Northern Tallgrass Prairie, Wyatt Kirwan

Electronic Theses and Dissertations

Drought can have major impacts on rangeland productivity and remains highly unpredictable. Like many other rangelands in the US, the Tallgrass Prairie of eastern South Dakota contains native prairie where the plant composition includes mostly native species as well as pasture that has been converted to or invaded by cool-season introduced species. So how are these two plant communities impacted by drought? The specific objective of this study was to compare drought resistance and drought resilience of native prairie to introduced cool-season pasture (Smooth brome - Bromus inermis and Kentucky bluegrass - Poa pratensis). Our Hypothesis was that native prairie …


Population Ecology Of Rocky Mountain Elk In The Black Hills, South Dakota And Wyoming, Benjamin D. Simpson Jan 2015

Population Ecology Of Rocky Mountain Elk In The Black Hills, South Dakota And Wyoming, Benjamin D. Simpson

Electronic Theses and Dissertations

We conducted a 2-year (2012–2013) study of survival and cause–specific mortality using individually marked adult cow and neonate elk (Cervus elaphus) occupying the southwestern region of the Black Hills. We used known-fate analysis in Program MARK for survival analysis of adult cows and calves. We estimated survival and cause-specific mortality of 49 adult female elk over the 2 years of the study. Annual adult cow survival was 0.85 (95% CI = 0.72–0.87). We documented 12 mortalities with harvest (58.3%) and predation (16.6%) accounting for the majority of known mortalities. We captured and fit 71 neonates < 10 days of age with expandable Very High Frequency (VHF) radiocollars during summer 2012 (n = 37) and 2013 (n = 34). Annual (12 month) survival of elk calves was 0.75 (95% CI = 0.61–0.84) while summer (20 weeks; 15 May–25 September) survival was 0.79 (95% CI = 0.68–0.88). Predation accounted for 87.5% of mortalities; remaining mortalities were from starvation (6.3%) and unknown (6. 3%) causes. We used Global Positioning System (GPS) collars to collect 167,707 locations to determine home range, movement ecology, and macroscale resource selection of 48 adult cow elk. We documented elk using a variety of migration strategies (obligate migrator, resident, conditional migrator, disperser); the majority of the population (58%) was migratory. Spring migration distance travelled ranged from 2.45 km – 74.44 km (n = 42); fall migration distances ranged from 6.41km – 153.95 km (n = 46). We used 99% Brownian Bridge Movement Models to create seasonal and overall home ranges of adult cow elk. Mean overall home range size for conditional migrators was 249.28 km2 (SE = 28.60, n = 7, range = 233.75), for obligate migrant elk it was 227.18 km2 (SE = 13.94, n = 29, range = 346.83), and for resident elk it was 175.65 km2 (SE = 22.75, n = 11, range = 216.04). We used discrete choice models to determine resource selection at the macro-habitat scale of collared adult elk using ArcMap 10.1 data. Adult cow elk selected for open grassland/herbaceous areas and early successional forest areas close to forested edges at higher elevations. Our study showed that elk populations have the ability to thrive within an ecosystem with healthy predator populations.


The Dsm-5: Implications For Health Law, Stacey A. Tovino Jan 2015

The Dsm-5: Implications For Health Law, Stacey A. Tovino

Faculty Articles

In May 2013, the American Psychiatric Association released the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders ("DSM-5"). Among other changes, the DSM-5 includes new entries for hoarding disorder and premenstrual dysphoric disorder as well as a reclassified entry for gambling disorder. Using these changes as examples, this Article examines the implications of the DSM-5 for key issues in health law, including health insurance coverage, public and private disability benefit eligibility, and disability discrimination protection. As a descriptive matter, this Article illustrates how the addition of new disorders and the reclassification of existing disorders in the DSM-5 …


Tort As Democracy: Lessons From The Food Wars, Melissa Mortazavi Jan 2015

Tort As Democracy: Lessons From The Food Wars, Melissa Mortazavi

Faculty Articles

This Article develops alternative emerging theories regarding the function of tort in American civil society. Often, scholars and policymakers evaluate the tort system in terms of compensation, loss allocation, and risk management. This focus overlooks an important modern function of tort; in the context of the modern administrative state, tort is a vital player in the democratic deliberative process. Tort suits bring forth new ideas, force fact-finding, and increase communication amongst public and private institutional actors to develop sound and legitimate law and policy. Perhaps nowhere is this more obvious today than with the current boom of food litigation. Lawsuits …


Honorslink, Issue 2015.1, University Of Dayton. Honors Program Jan 2015

Honorslink, Issue 2015.1, University Of Dayton. Honors Program

HonorsLINK Newsletter

News and notes from the University of Dayton Honors Program. Featured articles include stories about the Honors cohorts and the Berry connection.


Sca-1+ Cells From Fetal Heart With High Aldehyde Dehydrogenase Activity Exhibit Enhanced Gene Expression For Self-Renewal, Proliferation, And Survival, Devaveena Dey, Guodong Pan, Nadimpalli R. S. Varma, Suresh S. Palaniyandi Jan 2015

Sca-1+ Cells From Fetal Heart With High Aldehyde Dehydrogenase Activity Exhibit Enhanced Gene Expression For Self-Renewal, Proliferation, And Survival, Devaveena Dey, Guodong Pan, Nadimpalli R. S. Varma, Suresh S. Palaniyandi

Hypertension and Vascular Research Articles

Stem/progenitor cells from multiple tissues have been isolated based on enhanced activity of cytosolic aldehyde dehydrogenase (ALDH) enzyme. ALDH activity has emerged as a reliable marker for stem/progenitor cells, such that ALDH(bright/high) cells from multiple tissues have been shown to possess enhanced stemness properties (self-renewal and multipotency). So far though, not much is known about ALDH activity in specific fetal organs. In this study, we sought to analyze the presence and activity of the ALDH enzyme in the stem cell antigen-1-positive (Sca-1+) cells of fetal human heart. Biochemical assays showed that a subpopulation of Sca-1+ cells (15%) possess significantly high …


Bryant University Undergraduate Course Catalog 2015-2016 Jan 2015

Bryant University Undergraduate Course Catalog 2015-2016

Bryant University Undergraduate Course Catalog

No abstract provided.


America The Eusocial, 49 New Eng. L. Rev. On Remand 71 (2015), Timothy P. O'Neill Jan 2015

America The Eusocial, 49 New Eng. L. Rev. On Remand 71 (2015), Timothy P. O'Neill

UIC Law Open Access Faculty Scholarship

No abstract provided.


Am Ceremonial Script, April 26, 2015, Eastern Michigan University Jan 2015

Am Ceremonial Script, April 26, 2015, Eastern Michigan University

Commencement Programs and Materials

No abstract provided.


Systematics Of The Tribe Hippotragini (Cetartiodactyla: Bovidae), Wesley Holland Jan 2015

Systematics Of The Tribe Hippotragini (Cetartiodactyla: Bovidae), Wesley Holland

2015

The tribe Hippotragini consists of the so-called “Horse-like” antelopes, a specious group of large grazing antelopes characterized by striking facial coloration, thick tapering necks, erect manes, and highly specialized for arid regions of Africa and the Arabian Peninsula. Hippotragini consists of three genera: Addax+Oryx, and Hippotragus and currently includes eleven species although that number might increase as more molecular studies are undertaken. The taxonomic history of this group is ongoing as phylogenetic and comparative analyses and techniques continue to improve.

Paleontological evidence suggests that Hippotragini evolved in Eurasia during the early Miocene but it was not until the Pliocene …


Biology, 2015-2016, University Of South Florida St. Petersburg Jan 2015

Biology, 2015-2016, University Of South Florida St. Petersburg

Academic Learning Compacts

The Academic Learning Compact for 2015-2016 for the Bachelor's of Science in Biology.


Environmental Science And Policy, 2015-2016, University Of South Florida St. Petersburg Jan 2015

Environmental Science And Policy, 2015-2016, University Of South Florida St. Petersburg

Academic Learning Compacts

The Academic Learning Compact for 2015-2016 for the Bachelor's of Arts in Environmental Science and Policy.


Health Science Professions, 2015-2016, University Of South Florida St. Petersburg Jan 2015

Health Science Professions, 2015-2016, University Of South Florida St. Petersburg

Academic Learning Compacts

The Academic Learning Compact for 2015-2016 for Health Science Professions.


Brca1 185delag Mutation Enhances Interleukin-1Β Expression In Ovarian Surface Epithelial Cells, Kamisha T. Woolery, Mai Mohamed, Rebecca J. Linger, Kimberly P. Dobrinski, Jesse Roman, Patricia A. Kruk Jan 2015

Brca1 185delag Mutation Enhances Interleukin-1Β Expression In Ovarian Surface Epithelial Cells, Kamisha T. Woolery, Mai Mohamed, Rebecca J. Linger, Kimberly P. Dobrinski, Jesse Roman, Patricia A. Kruk

Pathology and Cell Biology Faculty Publications

Familial history remains the strongest risk factor for developing ovarian cancer (OC) and is associated with germline BRCA1 mutations, such as the 185delAG founder mutation. We sought to determine whether normal human ovarian surface epithelial (OSE) cells expressing the BRCA1 185delAG mutant, BRAT, could promote an inflammatory phenotype by investigating its impact on expression of the proinflammatory cytokine, Interleukin-1β (IL-1β). Cultured OSE cells with and without BRAT were analyzed for differential target gene expression by real-time PCR, western blot, ELISA, luciferase reporter, and siRNA assays. We found that BRAT cells expressed increased cellular and secreted levels of …


Tp53 And Mdm2 Single Nucleotide Polymorphisms Influence Survival In Non-Del(5q) Myelodysplastic Syndromes, Kathy L. Mcgraw, Thomas Cluzeau, David A. Sallman, Ashley A. Basiorka, Brittany A. Irvine, Ling Zhang, P.K. Epling-Burnette, Dana E. Rollison, Mar Mallo, Lubomir Sokol, Francesc Solé, Jaroslaw Maciejewski, Alan F. List Jan 2015

Tp53 And Mdm2 Single Nucleotide Polymorphisms Influence Survival In Non-Del(5q) Myelodysplastic Syndromes, Kathy L. Mcgraw, Thomas Cluzeau, David A. Sallman, Ashley A. Basiorka, Brittany A. Irvine, Ling Zhang, P.K. Epling-Burnette, Dana E. Rollison, Mar Mallo, Lubomir Sokol, Francesc Solé, Jaroslaw Maciejewski, Alan F. List

Pathology and Cell Biology Faculty Publications

P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase. Single nucleotide polymorphisms (SNPs) of either gene alone, and in combination, are linked to cancer susceptibility, disease progression, and therapy response. We analyzed the interaction of TP53 R72P and MDM2 SNP309 SNPs in relationship to outcome in patients with myelodysplastic syndromes (MDS). Sanger sequencing was performed on DNA isolated from 208 MDS cases. Utilizing a novel functional SNP scoring system ranging from +2 to −2 based on predicted p53 activity, we found statistically significant differences …


Cancer Stem Cell Targeted Therapy: Progress Amid Controversies, Tao Wang, Sarah Shigdar, Michael P. Gantier, Yingchun Hou, Li Wang, Yong Li, Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao, Wei Duan Jan 2015

Cancer Stem Cell Targeted Therapy: Progress Amid Controversies, Tao Wang, Sarah Shigdar, Michael P. Gantier, Yingchun Hou, Li Wang, Yong Li, Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao, Wei Duan

Pharmacy Faculty Publications

Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.


Microrna Profiling Response To Acupuncture Therapy In Spontaneously Hypertensive Rats, Jia-You Wang, Hui Li, Chun-Mei Ma, Jia-Lu Wang, Xin-Sheng Lai, Shu-Feng Zhou Jan 2015

Microrna Profiling Response To Acupuncture Therapy In Spontaneously Hypertensive Rats, Jia-You Wang, Hui Li, Chun-Mei Ma, Jia-Lu Wang, Xin-Sheng Lai, Shu-Feng Zhou

Pharmacy Faculty Publications

MicroRNAs (miRNAs) are a group of endogenous noncoding RNAs that play important roles in many biological processes. This study aimed to check if miRNAs were involved in the response to acupuncture in rats. Microarray analysis was performed to compare the miRNA expression profiles of medulla in spontaneously hypertensive rats (SHRs) treated with or without acupuncture. Our microarray analysis identified 222 differentially expressed miRNAs in the medulla of SHRs treated with acupuncture at taichong acupoint. Among these miRNAs, 23 miRNAs with a significant difference were found in acupuncture-treated SHRs compared to untreated rats. These 23 miRNAs could regulate 2963 target genes …


Enhancing The Bonding Of Synthetic Polymers Mimicking Marine Bioadhesives, Heather Jean Meredith Jan 2015

Enhancing The Bonding Of Synthetic Polymers Mimicking Marine Bioadhesives, Heather Jean Meredith

Open Access Dissertations

Marine organisms, such as mussels, are giving inspiration to a new generation of adhesive materials. The adhesive plaques of these shellfish are made up of proteins that contain a high amount of the amino acid, 3,4-dihydroxyphenylalanine (DOPA). This catechol moiety provides cross-linking chemistry that allows these animals to bond tightly to rocks and each other, even when wet. In developing synthetic mimics of mussel adhesive proteins, we are incorporating simplified forms of cross-linkable monomers into synthetic polymer backbones. One such example is poly[(3,4-dihydroxystyrene)-co-styrene] in which 3,4-dihydroxystyrene can provide cross-linking analogous to DOPA. In order to enhance adhesive bonding of these …


Quantitative Safety Assessment Of Air Traffic Control Systems Through System Control Capacity, Jingjing Guo Jan 2015

Quantitative Safety Assessment Of Air Traffic Control Systems Through System Control Capacity, Jingjing Guo

Open Access Dissertations

Quantitative Safety Assessments (QSA) are essential to safety benefit verification and regulations of developmental changes in safety critical systems like the Air Traffic Control (ATC) systems. Effectiveness of the assessments is particularly desirable today in the safe implementations of revolutionary ATC overhauls like NextGen and SESAR. QSA of ATC systems are however challenged by system complexity and lack of accident data.


Itraq-Based Proteomic Analysis Of Visual Cycle-Associated Proteins In Rpe Of Rd12 Mice Before And After Rpe65 Gene Delivery, Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Shanshan Hua, Minghan Li, Jijing Pang, Jia Qu, Wensheng Li Jan 2015

Itraq-Based Proteomic Analysis Of Visual Cycle-Associated Proteins In Rpe Of Rd12 Mice Before And After Rpe65 Gene Delivery, Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Shanshan Hua, Minghan Li, Jijing Pang, Jia Qu, Wensheng Li

Ophthalmology Faculty Publications

Purpose. To investigate the iTRAQ-based proteomic changes of visual cycle-associated proteins in RPE of rd12 mice before and after RPE65 gene delivery. Mehtods. The right eyes of rd12 mice underwent RPE65 gene delivery by subretinal injection at P14, leaving the left eyes as control. C57BL/6J mice were served as a wide-type control group. ERGs were recorded at P42, and RPE-choroid-sclera complex was collected to evaluate the proteomic changes in visual cycle-associated proteins by iTRAQ-based analysis. Western blot was used to confirm the changes in the differentially expressed proteins of interest. Results. ERG parameters improved dramatically at P42 after …


Craniopharyngioma Causing Bilateral Vision Loss 4 Months After Unremarkable Magnetic Resonance Imaging Of The Brain, Rainy Betts, Curtis E. Margo, Mitchell Drucker Jan 2015

Craniopharyngioma Causing Bilateral Vision Loss 4 Months After Unremarkable Magnetic Resonance Imaging Of The Brain, Rainy Betts, Curtis E. Margo, Mitchell Drucker

Ophthalmology Faculty Publications

A 65-year-old man developed bilateral vision loss 4 months after magnetic resonance imaging demonstrated no lesion in the vicinity of the optic chiasm, hypothalamus, and suprasellar tissues. Repeat computed tomography 3 months later showed a predominantly cystic mass of the suprasellar cistern with extension into the anterior third ventricle, which histologically was a craniopharyngioma. The clinical course of this case fuels the controversy whether craniopharyngiomas arise from embryonic rests or can be acquired. From a clinical perspective, it raises questions about when to obtain imaging studies dedicated to the chiasm and the appropriate interval in which a scan should be …


Frataxin Levels In Peripheral Tissue In Friedreich Ataxia, Michael Lazaropoulos, Yina Dong, Elisia Clark, Nathaniel R. Greeley, Lauren A. Seyer, Karlla W. Brigatti, Carlton Christie, Susan L. Perlman, George R. Wilmot, Christoper M. Gomez, Katherine D. Mathews, Grace Yoon, Theresa Zesiewicz, Chad Hoyle, Sub H. Subramony, Alicia F. Brocht, Jennifer M. Farmer, Robert B. Wilson, Eric C. Deutsch, David R. Lynch Jan 2015

Frataxin Levels In Peripheral Tissue In Friedreich Ataxia, Michael Lazaropoulos, Yina Dong, Elisia Clark, Nathaniel R. Greeley, Lauren A. Seyer, Karlla W. Brigatti, Carlton Christie, Susan L. Perlman, George R. Wilmot, Christoper M. Gomez, Katherine D. Mathews, Grace Yoon, Theresa Zesiewicz, Chad Hoyle, Sub H. Subramony, Alicia F. Brocht, Jennifer M. Farmer, Robert B. Wilson, Eric C. Deutsch, David R. Lynch

Neurology Faculty Publications

No abstract provided.


Some Ohio Observations By W. F. Henninger, Bill Whan Jan 2015

Some Ohio Observations By W. F. Henninger, Bill Whan

Ohio Cardinal

No abstract provided.


Applications Of Lidar And Field Reconnaissance In The Rapid Assessment Of Karst-Based Surface Morphology, Coconino National Forest, Arizona, Kyle Rowinski Jan 2015

Applications Of Lidar And Field Reconnaissance In The Rapid Assessment Of Karst-Based Surface Morphology, Coconino National Forest, Arizona, Kyle Rowinski

KIP Data Sets and Technical Reports

Kyle Rowinski, Geological Society of America GeoCorps Program, Summer 2015 Subsurface analysis using data obtained from an aerial platform may be regarded as impractical, however recent advancements in Very High Resolution (VHR) remote sensing have rendered the collection of terrain data with a vertical resolution of up to 30 cm highly feasible. Obtained via a process termed Light Detection and Ranging (LiDAR), data collected provides a 3-dimensional representation of surface morphology with high resolution. Input of LiDAR data into geospatial analysis software such as ArcMap or ArcScene allows for the identification of subtle topographic changes across a land surface. Considering …


Detection Of Canonical A-To-G Editing Events At 3’ Utrs And Microrna Target Sites In Human Lungs Using Next-Generation Sequencing, Ramani Soundararajan, Timothy M. Stearns, Anthony J. Griswold, Arpit Mehta, Alexander Czachor, Jutaro Fukumoto, Richard F. Lockey, Benjamin L. King, Narasaiah Kolliputi Jan 2015

Detection Of Canonical A-To-G Editing Events At 3’ Utrs And Microrna Target Sites In Human Lungs Using Next-Generation Sequencing, Ramani Soundararajan, Timothy M. Stearns, Anthony J. Griswold, Arpit Mehta, Alexander Czachor, Jutaro Fukumoto, Richard F. Lockey, Benjamin L. King, Narasaiah Kolliputi

Internal Medicine Faculty Publications

RNA editing is a post-transcriptional modification of RNA. The majority of these changes result from adenosine deaminase acting on RNA (ADARs) catalyzing the conversion of adenosine residues to inosine in double-stranded RNAs (dsRNAs). Massively parallel sequencing has enabled the identification of RNA editing sites in human transcriptomes. In this study, we sequenced DNA and RNA from human lungs and identified RNA editing sites with high confidence via a computational pipeline utilizing stringent analysis thresholds. We identified a total of 3,447 editing sites that overlapped in three human lung samples, and with 50% of these sites having canonical A-to-G base changes. …