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Baby Mama: Appellate Court Declares Sherri Shepherd Is The Legal Mother Of A Child Born To Her Via Surrogate, Joanna L. Grossman Dec 2015

Baby Mama: Appellate Court Declares Sherri Shepherd Is The Legal Mother Of A Child Born To Her Via Surrogate, Joanna L. Grossman

Hofstra Law Faculty Scholarship

Although surrogacy ostensibly dates to biblical days—Abraham and Sarah’s handmaiden, Hagar, for example—it is quintessentially a modern path to parenthood. In its initial iteration, so-called traditional surrogacy, the arrangement called for artificial insemination of the surrogate carrier with sperm from the intended father, whose wife provided no genetic material but was the intended mother and a party to the contract. As reproductive technology advanced, and in vitro fertilization was first developed and then improved, a new type of surrogacy became the norm. With gestational surrogacy, the carrier provides only the womb, while both egg and sperm come from the intended …


Predicting Intraday Financial Market Dynamics Using Takens' Vectors; Incorporating Causality Testing And Machine Learning Techniques, Abubakar-Sadiq Bouda Abdulai Dec 2015

Predicting Intraday Financial Market Dynamics Using Takens' Vectors; Incorporating Causality Testing And Machine Learning Techniques, Abubakar-Sadiq Bouda Abdulai

Electronic Theses and Dissertations

Traditional approaches to predicting financial market dynamics tend to be linear and stationary, whereas financial time series data is increasingly nonlinear and non-stationary. Lately, advances in dynamical systems theory have enabled the extraction of complex dynamics from time series data. These developments include theory of time delay embedding and phase space reconstruction of dynamical systems from a scalar time series. In this thesis, a time delay embedding approach for predicting intraday stock or stock index movement is developed. The approach combines methods of nonlinear time series analysis with those of causality testing, theory of dynamical systems and machine learning (artificial …


Role Of The Orphan Crispr 2 In Enterococcus Faecalis, Andriy Barchuk Dec 2015

Role Of The Orphan Crispr 2 In Enterococcus Faecalis, Andriy Barchuk

Honors College Theses

Enterococcus faecalis is a Gram-positive aerotolerant anaerobic bacterium primarily found as a member of the human and animal intestinal flora. Enterococcus faecalis along with 27 other species comprise the genus Enterococcus. Out of the whole genus E. faecalis and E. faecium are the second most common nosocomial cause for urinary tract and wound infections. The treatment of the infections is made even more complex due to E. faecalis resistance to last-resort drugs like vancomycin. An inverse relationship has been observed in the species between antibiotic resistance and presence of the CRISPR-cas locus. CRISPR-Cas (clustered, regularly interspaced short palindromic repeats and …


A Manipulation Study: The Effect Of Predation Risk On The Space Use Of The Chilean Rodent, Octodon Degus, Erin D. Myers Dec 2015

A Manipulation Study: The Effect Of Predation Risk On The Space Use Of The Chilean Rodent, Octodon Degus, Erin D. Myers

Honors Theses

Predation has significant effects on animal behavior and space use across species. In small mammals, the home range areas are shown to be influenced by predation risk. This project incorporates trapping data to analyze how predation risk influences the space use of Octodon degus, a social rodent endemic to Chile. We compared range size of degus living in four predator exclusion enclosures versus four control, non-predator exclusion enclosures in Parque Nacional Bosque de Fray Jorge, Chile through grid trapping methods. For each enclosure (NP and P) 95% MCP, 95% Kernal, 95% Distance Interval, and average captures was measured. There were …


Optimizing A Luciferase-Based Tool For Studying The Effects Of Fatty Acid Desaturase 7 On Singlet Oxygen Accumulation In Arabidopsis Thaliana, Abeer Muhammedali Alnasrawi Dec 2015

Optimizing A Luciferase-Based Tool For Studying The Effects Of Fatty Acid Desaturase 7 On Singlet Oxygen Accumulation In Arabidopsis Thaliana, Abeer Muhammedali Alnasrawi

Graduate Theses and Dissertations

In plants, reactive oxygen species (ROS) are generated as a byproduct of normal metabolism, as well as in response to adverse conditions such as light stress, extreme temperatures, and exposure to pests and pathogens. Singlet oxygen (1O2) is a ROS that is formed during photosynthesis in photosystem II (PSII) of the chloroplasts. Levels of 1O2 and other ROS are tightly controlled in healthy plants, but some studies suggest that levels of fatty acid desaturase (FAD) activity in Arabidopsis thaliana can influence constitutive and/or stress-responsive ROS accumulation. In this study, a luciferase-based reporter gene that is selectively stimulated by 1O2 (AAA-ATPase: …


Modulation Of Valve Interstitial Cell Function Through Cell Shape And Phenotype, Atefeh Razavi Dec 2015

Modulation Of Valve Interstitial Cell Function Through Cell Shape And Phenotype, Atefeh Razavi

Graduate Theses and Dissertations

The aortic valve is a highly dynamic structure responding to actively to the chemical, mechanical and physical cues of the valve microenvironment. Valve interstitial cells are dispersed throughout the valve tissue and play an important role in maintaining the integrity and optimum function of the valve. They are a heterogeneous population composed of various phenotype. These phenotypes have specific functions characteristic of valve physiological and pathological conditions. The effect of mechanical loading and chemical modulators on the behavior of the valve interstitial cells have largely been studied. However the role of valve interstitial cell shape as an intrinsic physical cue …


Perceptions Of Agricultural Leadership Academic Programs At 1862 Land-Grant Universities, Jackson Cole Alexander Dec 2015

Perceptions Of Agricultural Leadership Academic Programs At 1862 Land-Grant Universities, Jackson Cole Alexander

Graduate Theses and Dissertations

This study sought to characterize perceptions of agricultural leadership programs in colleges of agriculture, food, life, human, or environmental sciences at 1862 land-grant institutions. Twenty-six academic programs were identified with a major, minor, graduate degree, specialization, concentration, or certificate in agricultural leadership. Programs were identified through analyzing the APLU and USDA NIFA websites, searching academic college websites, and contacting deans and departments heads. Objectives included identifying programs, describing the need for programs, describing evolution that has taken place within the discipline, describing faculty recommendations for future development and growth in the field, and examining why faculty believe programs are relevant. …


Chinese Tallow Invasion In Maritime Forests: Understand Invasion Mechanism And Develop Ecologically-Based Management, Lauren Susan Pile Dec 2015

Chinese Tallow Invasion In Maritime Forests: Understand Invasion Mechanism And Develop Ecologically-Based Management, Lauren Susan Pile

All Dissertations

Invasion by highly aggressive, non-native, invasive plants is a significant threat to management and conservation priorities as these plants can transform ecosystem functions and processes. In this study, I investigated the non-native, invasive tree, Chinese tallow (Triadica sebifera (L.) Small) in the maritime forests of Parris Island, South Carolina. I studied the role of land-use history and modern forest disturbance in facilitating the invasion of Chinese tallow. I found that stands previously cleared for agriculture and reforested with slash pine (Pinus elliottii Englem.) since the 1970s had significantly more Chinese tallow stems than stands that remained forested since …


Picosecond Time-Resolved Studies Of Multiple Energy Transfer In Conjugated Polymer Nanoparticles, Louis Charles Groff Ii Dec 2015

Picosecond Time-Resolved Studies Of Multiple Energy Transfer In Conjugated Polymer Nanoparticles, Louis Charles Groff Ii

All Dissertations

Conjugated polymer nanoparticles (CPNs) are a model system for the study of complex, nanoscale, multichromophoric interactions. In this dissertation, we are focused on furthering our understanding of the physical picture, processes, length scales, and time scales of energy transport in conjugated polymers. In particular, we are interested in determining how parameters related to the nanoscale structure and composition of CPs affect energy transport, which is investigated using steady-state and time-resolved fluorescence spectroscopy in conjunction with Monte Carlo simulation methods. Such information could prove useful for optimizing the structure and composition of device layers (e.g., in photovoltaic devices). We additionally seek …


Modeling Arbitrarily Interval-Censored Survival Data With External Time-Dependent Covariates, Wei Fang Dec 2015

Modeling Arbitrarily Interval-Censored Survival Data With External Time-Dependent Covariates, Wei Fang

Dissertations

Arbitrarily interval-censored survival data refer to the situation where the exact time of the occurrence of an event of interest is only known to have occurred within some two consecutive examinations. External time-dependent covariates refer to those whose values change during the periodic follow-up, and whose value at a particular time does not require individuals to be under direct observation. Regression modeling of survival data usually either handles arbitrarily interval-censored data alone (Farrington, 1996) or external time-dependent covariates alone (Cox, 1972; Therneau & Grambsch, 2000). In the current research, an adjustment has been made to the data augmentation used in …


Non-Specific Blocking Of Mir-17-5p Guide Strand In Triple Negative Breast Cancer Cells By Amplifying Passenger Strand Activity., Yuan-Yuan Jin, Jade Andrade, Eric Wickstrom Dec 2015

Non-Specific Blocking Of Mir-17-5p Guide Strand In Triple Negative Breast Cancer Cells By Amplifying Passenger Strand Activity., Yuan-Yuan Jin, Jade Andrade, Eric Wickstrom

Department of Biochemistry and Molecular Biology Faculty Papers

Conventional wisdom holds that only one of the two strands in a micro ribonucleic acid (miRNA) precursor duplex is selected as the active miRNA guide strand. The complementary miRNA passenger strand, however, is thought to be inactive. High levels of the oncogenic miRNA (oncomiR) guide strand called miR-17-5p is overexpressed in triple negative breast cancer (TNBC) and can inhibit ribosomal translation of tumor suppressor gene mRNAs, such as programmed cell death 4 (PDCD4) or phosphatase and tensin homolog (PTEN). We hypothesized that knocking down the oncogenic microRNA (oncomiR) miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor …


The Role Of Valproic Acid, A Histone Deacetylase Inhibitor, In Reducing Anxiety Levels In Rats: An Epigenetics Study, Juliet Buteme Dec 2015

The Role Of Valproic Acid, A Histone Deacetylase Inhibitor, In Reducing Anxiety Levels In Rats: An Epigenetics Study, Juliet Buteme

Honors College Theses

Rats, like humans, show personality traits: they are born with different anxiety levels (i.e., high (HAn) or low anxiety (LAn) levels). In this study, we investigated (1) if treatment with valproic acid (VPA) can lower anxiety level in trait anxiety rats and (2) how VPA may interact with environment (e.g., enriched (EE), standard (SE) and isolated environments (IE)). VPA is a deacetylase inhibitor that increases Histone 3 acetylation, a known epigenetic mechanism that interacts with stress response proteins, and treats epilepsy and mood disorders. Since rats reared in IE exhibit heightened anxiety levels as compared to those in EE, we …


Animal Politics: Money, Power, And The Endangered Species Act, Edward J. Armellino Dec 2015

Animal Politics: Money, Power, And The Endangered Species Act, Edward J. Armellino

Seton Hall Journal of Legislation and Public Policy

No abstract provided.


The Effects Of Foliar Nutrient Applications On Split, Yield, And Internal Fruit Quality Of 'Wonderful' Pomegranate (Punica Granatum L.), John Matthew Chater Dec 2015

The Effects Of Foliar Nutrient Applications On Split, Yield, And Internal Fruit Quality Of 'Wonderful' Pomegranate (Punica Granatum L.), John Matthew Chater

Master's Theses

Fruit split is the most important physiological disorder in pomegranate production, causing devastating crop losses worldwide. Foliar nutrient applications have been used experimentally to mitigate pomegranate fruit split but none have been conducted using the industry standard cultivar, Wonderful, and little is known about the effects of foliar nutrient applications on pomegranate. Additionally, investigations into putative health benefits of pomegranate fruit have increased interest in its production but limited evidence exists regarding effects of agricultural practices such as foliar fertilizer applications on internal fruit quality. ‘Wonderful’ pomegranate trees at 2 commercial orchards were treated with foliar applications of ZnSO4 …


Performance, Body Temperature And Blood Metabolites Of Feedlot Steers As Influenced By Environmental Conditions And Supplementation Of Zilpaterol Hydrochloride, Bradley M. Boyd Dec 2015

Performance, Body Temperature And Blood Metabolites Of Feedlot Steers As Influenced By Environmental Conditions And Supplementation Of Zilpaterol Hydrochloride, Bradley M. Boyd

Department of Animal Science: Dissertations, Theses, and Student Research

Trial one was conducted at the United States Meat Animal Research Center (MARC) near clay center, NE during the summer of 2014. The objective of this trial was to measure the effects of supplementing zilpaterol hydrochloride (ZH) for the final 21 days of the finishing period, and shade, on performance, body temperature, respiration rate, and mobility of finishing beef steers. Feeding ZH increased hot carcass weight, dressing percent, longissimus muscle area, and reduce USDA yield grade. Shade did not affect steer performance and did not reduce body temperature. Zilpaterol hydrochloride increased respiration rate when compared to control cattle and had …


Genomic Analysis Of Sow Reproductive Traits: Identification Of Selective Sweeps, Major Genes, And Genotype By Diet Interactions, Melanie D. Trenhaile Dec 2015

Genomic Analysis Of Sow Reproductive Traits: Identification Of Selective Sweeps, Major Genes, And Genotype By Diet Interactions, Melanie D. Trenhaile

Department of Animal Science: Dissertations, Theses, and Student Research

Reproductive traits, such as litter size and reproductive longevity, are economically important. However, selection for these traits is difficult due to low heritability, polygenic nature, sex-limited expression, and expression late in life. Marker-assisted selection may provide an alternative to increase genetic progress.

Nebraska Index Line (NIL) has been selected for litter size related traits since 1981. It is one of the main contributing lines to the UNL reproductive longevity resource population (n > 1,500), which was genotyped for 60,000 SNPs, phenotyped for age at puberty (AP), lifetime number of parities (LTNP), litter size traits, and other reproductive traits, and fed …


Specification Of V2b And Ka Neurons In The Zebrafish Spinal Cord., Liwia Anna Andrzejczuk Dec 2015

Specification Of V2b And Ka Neurons In The Zebrafish Spinal Cord., Liwia Anna Andrzejczuk

Dissertations - ALL

Spinal cord contains different types of neurons. A vast majority of these neurons are interneurons. Therefore, a better understanding of how interneurons in the spinal cord develop is particularly important, as it will hopefully enable researchers to establish better treatments for spinal cord injury patients. In this thesis, I used zebrafish to study development of two classes of spinal cord neurons - KA cells (which correspond to cerebrospinal fluid-contacting neurons, CSF-cNs) and V2b cells. Both KA and V2b neurons are functionally important in vertebrate locomotor circuitry.

Development of functional neurons involves progression of genetic cascades that lead to correct cell …


Dancing With Gender: A Reception Analysis Of Chinese Women's Viewing Experiences Of Ann Hui's The Golden Era, Li Chen Dec 2015

Dancing With Gender: A Reception Analysis Of Chinese Women's Viewing Experiences Of Ann Hui's The Golden Era, Li Chen

Dissertations - ALL

The issue that this study addressed was the unprivileged status of women audience members and women directors in the male dominated Chinese film industry. To investigate this problem, the purpose of this study was to explore how Chinese women audience members produce different meanings in terms of gender identity and gender relations through viewing The Golden Era (2014), directed by a female filmmaker Ann Hui. To deeply understand the viewing experiences of Chinese women audience members, this qualitative research project was designed as a reception analysis. To gather data, interviews with 18 Chinese women with viewing experiences of this film …


Permitting Joint-Control In Asymmetric Dependence Relationships: Investigating A Strategy For Increasing Trust, Michael Ioerger Dec 2015

Permitting Joint-Control In Asymmetric Dependence Relationships: Investigating A Strategy For Increasing Trust, Michael Ioerger

Dissertations - ALL

Most work related to trust in dyadic interactions has focused on the establishment and development of trust in situations where partners are of relatively equal status and have the ability to impact each other's outcomes (Rempel, Holmes, & Zanna, 1985; for a review Simpson, 2007a; 2007b). However, many social interactions can be characterized as asymmetric dependence situations where the outcomes of one partner (i.e., the dependent partner) are completely controlled by another (i.e., the controlling partner). The current work investigated trust in the context of one-off asymmetric dependence interactions, and experimentally explored one strategy for increasing trust in these exchanges. …


Label Free Analysis Of Native Planktonic P. Aeruginosa Cells And Growth Media By Near Infrared (Nir) Binary Spectronephelometry (Bsn), Steven Ortiz Dec 2015

Label Free Analysis Of Native Planktonic P. Aeruginosa Cells And Growth Media By Near Infrared (Nir) Binary Spectronephelometry (Bsn), Steven Ortiz

Dissertations - ALL

Current noninvasive methods are unable to continuously and simultaneously monitor the concentration of cells and chemical components that define the state of native bacterial cultures because of the changing turbidity. We seek to solve this problem without subjecting the growing culture to the risk of contamination afforded by physical sampling. The Binary Spectronephelometry (BSN) algorithm uses laser induced emission to probe mildly turbid media. A training set spanning the linear range of elastic emission (EE) i.e. physical scattering and inelastic emission (IE) i.e. fluorescence and Raman emission was produced with varying concentrations of bacteria and standard media using a modified …


The Relationship Of Spirituality And Depression On The Subjective Well-Being Of Jamaican College Students: A Cross Sectional Study Of Teacher Training Institutions In Jamaica, Claudette A. Brown-Smythe Dec 2015

The Relationship Of Spirituality And Depression On The Subjective Well-Being Of Jamaican College Students: A Cross Sectional Study Of Teacher Training Institutions In Jamaica, Claudette A. Brown-Smythe

Dissertations - ALL

Abstract

Spiritual is an integral component of one’s well-being and can serve as a barrier to our wellness as well as a protective factor from ill health. Spirituality helps one to make meaning of life’s circumstances and can be an intrinsic motivator helping to regain balance in our world. This study examined the relationship between spirituality, depression, and subjective well-being in 214 students enrolled in teachers’ colleges in Jamaica. Researchers (Campbell, Roberti, Maynard & Emmanuel, 2009; Kameel & Kamal, 2011; Lipps, Lowe & Gibbons, 2004; Lowe, Lipps & Young, 2009) have documented depression as an issue for college students in …


A Qualitative Approach To Studying The Lived Experiences Of High School Aged Sexual Minority And Gender Nonconforming Youth Across Relationships And Contexts., Michael Calloway Dec 2015

A Qualitative Approach To Studying The Lived Experiences Of High School Aged Sexual Minority And Gender Nonconforming Youth Across Relationships And Contexts., Michael Calloway

Dissertations - ALL

Four youth who identified as sexual or gender minorities were recruited from a high school in Upstate New York for a study designed to investigate the experiences that facilitate or hinder their ability to fully question and explore their identities between and across relationships and contexts. This current investigation utilized Bronfenbrenner’s Bioecological Theory as a means with which to structure both the interviews with the informants as well as the findings. I also utilized Interpretive Phenomenological Analysis as the means of gathering, interpreting, and presenting the data in a meaningful way. The participants engaged in a range of interpersonal and …


Assessing The Quantified Impact Of A Hybrid Pogil Methodology On Student Averages In A Forensic Science Survey Course, Tyna Lynn Meeks Dec 2015

Assessing The Quantified Impact Of A Hybrid Pogil Methodology On Student Averages In A Forensic Science Survey Course, Tyna Lynn Meeks

Dissertations - ALL

A causal-comparative/quasi experimental study examined the effect of incorporating a hybrid teaching methodology that blended lecture with Process Oriented Guided Inquiry Lessons (POGILs) on the overall academic achievement of a diverse student body in a large lecture setting. Additional considerations included student gender, ethnicity, declared major (STEM or non-STEM), and SAT scores. An evaluation of the effect that these characteristics had on student achievement due to differentiating import placed on the use of POGILs as a learning tool was included. This study used data obtained from a longitudinal examination of eight years of student data from an introductory forensic science …


Teacher Implementation And Impact Of Academic Vocabulary Instructional Protocols For Long Term English Learners, Rosa I. Isiah Dec 2015

Teacher Implementation And Impact Of Academic Vocabulary Instructional Protocols For Long Term English Learners, Rosa I. Isiah

LMU Theses and Dissertations

English learners are expected to acquire academic language and content simultaneously. Long Term English Learners (LTELs), a growing English Learner subgroup, struggle academically and do not have the necessary academic vocabulary proficiency to achieve academic success in our current educational system.

This mixed-methods study examined the implementation of Academic Vocabulary Instructional protocols in the upper grades in a small urban elementary school district. Semistructured interviews, focus group, observation protocol, and data analysis methods were used as primary methods for data collection. Overall, four key themes emerged in this study. First, all 4th- and 5th-grade teachers implemented the new Academic Vocabulary …


Diurnal Variation Of Testosterone In Beluga Whale Blow, Renee Bakker Dec 2015

Diurnal Variation Of Testosterone In Beluga Whale Blow, Renee Bakker

Senior Honors Projects

Studies on the concentrations of certain hormones in cetaceans and their effects on cetacean biology are useful to determining physical conditions such as age, sex, and reproductive status of individuals. Hormone concentrations can be determined through blood samples, but collection of blow (exhaled respiratory vapor) has proven to be a noninvasive method of obtaining samples that can be analyzed for hormone concentrations. The existence of diurnal variation in hormone concentrations greatly affects the value of what time of day samples are collected. Previous studies have found that other mammalian species exhibit diurnal variation of testosterone and that for many species …


Black And White Advertising In Fashion Magazines, Lauren E. Necaise Dec 2015

Black And White Advertising In Fashion Magazines, Lauren E. Necaise

Honors Theses

This thesis consists of a quantitative analysis with respect to black and white advertising in select women’s fashion magazines. There were five research questions outlined.

A code sheet was created to obtain data with regard to factors including: number of black and white and total advertisements, product/service category, setting, advertisement size, percent of black and white of the ad, position, product/user, black and white visual and verbal (words/ information), emotional/intellectual appeal. This allowed the research questions to be answered. A qualitative analysis was also performed on repeat advertisements for products that used both color and black and white advertising with …


Physical Activity: A Tool For Improving Health (Part 1—Biological Health Benefits, Patrick J. Gallaway, Nobuko Hongu Dec 2015

Physical Activity: A Tool For Improving Health (Part 1—Biological Health Benefits, Patrick J. Gallaway, Nobuko Hongu

Journal of Extension

Extension educators have been promoting and incorporating physical activities into their community-based programs and improving the health of individuals, particularly those with limited resources. This article is the first of a three-part series describing the benefits of physical activity for human health: 1) biological health benefits of physical activity, 2) mental health benefits of physical activity, and 3) recommended amounts of physical activity for optimal health. Each part of the series is designed to help Extension educators effectively integrate physical activity into community programs and motivate individuals to maintain an interest in being physically active during and after the program.


"Clickers" And Haccp: Educating A Diverse Food Industry Audience With Technology, Angela Shaw, Aubrey Mendonca, Aura Daraba Dec 2015

"Clickers" And Haccp: Educating A Diverse Food Industry Audience With Technology, Angela Shaw, Aubrey Mendonca, Aura Daraba

Journal of Extension

Hazard Analysis Critical Control Points (HACCP) is a systematic approach to food safety education for the food industry. To receive a HACCP certificate, participants must receive an 80% or higher on the final examination. Language barriers, educational levels, and age have been noted as primary reasoning's for not passing the final examination. Clicker technology has been shown to improve knowledge transfer to students in various classroom settings. Incorporation of mock final examination questions using Clickers into a traditional HACCP course has been shown in a small pilot study to increase the pass rate.


Perceptions Of Mattering In The Doctoral Student And Advisor Relationship, Holly Anne Schneider Dec 2015

Perceptions Of Mattering In The Doctoral Student And Advisor Relationship, Holly Anne Schneider

UNLV Theses, Dissertations, Professional Papers, and Capstones

The advising relationship has been acknowledged as one of the most important factors in doctoral student persistence and attrition. Less researched are psychosocial factors that contribute to doctoral student persistence and completion. Preliminary research including measures of psychosocial factors on doctoral student success found faculty-student relationships and collegial support contributed significantly to doctoral completion more so than individual factors including motivation, career goals, procrastination, financial security, and external demands such as family.

The current study draws on the psychosocial construct of mattering (Rosenberg &

McCullough, 1981) to examine doctoral students’ perceptions of mattering to their advisors and the influence on …


Safety And Immunogenicity Of Human Serum Albumin-Free Mmr Vaccine In Us Children Aged 12-15 Months., Maurice A. Mufson, Clemente Diaz, Michael Leonardi, Christopher J. Harrison, Stanley Grogg, Antonio Carbayo, Simon Carlo-Torres, Robert Jeanfreau, Ana Quintero-Del-Rio, Gisele Bautista, Michael Povey, Christopher Da Costa, Ouzama Nicholson, Bruce L. Innis Dec 2015

Safety And Immunogenicity Of Human Serum Albumin-Free Mmr Vaccine In Us Children Aged 12-15 Months., Maurice A. Mufson, Clemente Diaz, Michael Leonardi, Christopher J. Harrison, Stanley Grogg, Antonio Carbayo, Simon Carlo-Torres, Robert Jeanfreau, Ana Quintero-Del-Rio, Gisele Bautista, Michael Povey, Christopher Da Costa, Ouzama Nicholson, Bruce L. Innis

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: M-M-R(TM)II (MMRII; Merck & Co) is currently the only measles-mumps-rubella (MMR) vaccine licensed in the United States. Another licensed vaccine would reinforce MMR supply. This study assessed the immunogenicity of a candidate vaccine (Priorix(TM), GlaxoSmithKline Vaccines [MMR-RIT]) when used as a first dose among eligible children in the United States.

METHODS: In this exploratory Phase-2, multicenter, observer-blind study, 1220 healthy subjects aged 12-15 months were randomized (3:3:3:3) and received 1 dose of 1 of 3 MMR-RIT lots with differing mumps virus titers (MMR-RIT-1 [4.8 log10]; MMR-RIT-2 [4.1 log10]; MMR-RIT-3 [3.7 log10] CCID50) or MMRII co-administered with hepatitis A vaccine …