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2015

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Immunological Function Of Blimp-1 In Dendritic Cells And Relevance To Autoimmune Diseases, S. J. Kim Jan 2015

Immunological Function Of Blimp-1 In Dendritic Cells And Relevance To Autoimmune Diseases, S. J. Kim

Journal Articles

Previous studies have identified the immunological functions of transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) in various adaptive immune cell types such as T and B lymphocytes. More recently, it has been shown that Blimp-1 extends its functional roles to dendritic cells (DCs) and macrophages, two cell types belonging to the innate immune system. The protein acts as a direct and indirect regulator of target genes by recruiting chromatin modification factors and by regulating microRNA expression, respectively. In DCs, Blimp-1 has been identified as one of the components involved in antigen presentation. Genome-wide association studies identified polymorphisms associated with multiple …

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A Stationary Wavelet Entropy-Based Clustering Approach Accurately Predicts Gene Expression, N. Nguyen, A. Vo, I. Choi, K. J. Won Jan 2015

A Stationary Wavelet Entropy-Based Clustering Approach Accurately Predicts Gene Expression, N. Nguyen, A. Vo, I. Choi, K. J. Won

Journal Articles

Studying epigenetic landscapes is important to understand the condition for gene regulation. Clustering is a useful approach to study epigenetic landscapes by grouping genes based on their epigenetic conditions. However, classical clustering approaches that often use a representative value of the signals in a fixed-sized window do not fully use the information written in the epigenetic landscapes. Clustering approaches to maximize the information of the epigenetic signals are necessary for better understanding gene regulatory environments. For effective clustering of multidimensional epigenetic signals, we developed a method called Dewer, which uses the entropy of stationary wavelet of epigenetic signals inside enriched …

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Studies On Ageing And The Severity Of Radiographic Joint Damage In Rheumatoid Arthritis, L. Mangnus, H. W. Van Steenbergen, E. Lindqvist, E. Brouwer, M. Reijnierse, T. W. Huizinga, P. K. Gregersen, E. Berglin, S. Rantapaa-Dahlqvist, A. H. Van Der Helm-Van Mil, +1 Additional Author Jan 2015

Studies On Ageing And The Severity Of Radiographic Joint Damage In Rheumatoid Arthritis, L. Mangnus, H. W. Van Steenbergen, E. Lindqvist, E. Brouwer, M. Reijnierse, T. W. Huizinga, P. K. Gregersen, E. Berglin, S. Rantapaa-Dahlqvist, A. H. Van Der Helm-Van Mil, +1 Additional Author

Journal Articles

INTRODUCTION: The western population is ageing. It is unknown whether age at diagnosis affects the severity of Rheumatoid Arthritis (RA), we therefore performed the present study. METHOD: 1,875 RA-patients (7,219 radiographs) included in five European and North-American cohorts (Leiden-EAC, Wichita, Umea, Groningen and Lund) were studied on associations between age at diagnosis and joint damage severity. In 698 Leiden RA-patients with 7-years follow-up it was explored if symptom duration, anti-citrullinated-peptide-antibodies (ACPA), swollen joint count (SJC) and C-reactive-protein (CRP) mediated the association of age with joint damage. Fifty-six other RA-patients of the EAC-cohort underwent baseline MRIs of wrist, MCP and MTP-joints; …

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Notch Receptor Expression In Human Brain Arteriovenous Malformations, S. Hill-Felberg, H. H. Wu, S. A. Toms, A. R. Dehdashti Jan 2015

Notch Receptor Expression In Human Brain Arteriovenous Malformations, S. Hill-Felberg, H. H. Wu, S. A. Toms, A. R. Dehdashti

Journal Articles

The roles of the Notch pathway proteins in normal adult vascular physiology and the pathogenesis of brain arteriovenous malformations are not well-understood. Notch 1 and 4 have been detected in human and mutant mice vascular malformations respectively. Although mutations in the human Notch 3 gene caused a genetic form of vascular stroke and dementia, its role in arteriovenous malformations development has been unknown. In this study, we performed immunohistochemistry screening on tissue microarrays containing eight surgically resected human brain arteriovenous malformations and 10 control surgical epilepsy samples. The tissue microarrays were evaluated for Notch 1-4 expression. We have found that …

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Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction And Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders, Y. Chung, A. Jacobson, G. He, T. G. Van Erp, S. Mcewen, J. Addington, C. E. Bearden, K. Cadenhead, B. A. Cornblatt, T. D. Cannon, +8 Additional Authors Jan 2015

Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction And Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders, Y. Chung, A. Jacobson, G. He, T. G. Van Erp, S. Mcewen, J. Addington, C. E. Bearden, K. Cadenhead, B. A. Cornblatt, T. D. Cannon, +8 Additional Authors

Journal Articles

A recent prospective longitudinal neuroimaging study of 274 prodromal risk syndrome subjects revealed that those who later developed full-blown psychotic symptoms exhibited accelerated gray matter loss and third ventricle expansion around the time of onset of psychosis. Previous studies also indicate that higher levels of unusual thought content during prodromal states are a significant predictor of psychosis in clinically high-risk youth (CHR). However, the relationship between clinical symptoms and changes in neuroanatomical structure has not been previously examined in the North American Prodrome Longitudinal Study (NAPLS) sample at the atlas level. In this report, we investigated whether symptom severity as …

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Dissecting The Heterogeneity Of Treatment Response In First-Episode Schizophrenia, A. K. Malhotra Jan 2015

Dissecting The Heterogeneity Of Treatment Response In First-Episode Schizophrenia, A. K. Malhotra

Journal Articles

The Mental Health Centers for Intervention Development and Applied Research (CIDAR) program prioritized research to provide an evidence base for biomarker development. At the Zucker Hillside Hospital (ZHH), our CIDAR grant supported research on a comprehensive investigation of treatment response and outcome in first episode schizophrenia. Results provide evidence that baseline neuroimaging, neurocognitive, and genetic measures are significantly associated with clinical response to treatment, and that our currently available interventions can effectively treat aspects of psychotic illness, as well as potentially reduce comorbidity associated with illness. Future research may include combining modalities to more robustly predict response and identify treatment …

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Targeting Mutant Braf In Relapsed Or Refractory Hairy-Cell Leukemia, E. Tiacci, J. H. Park, L. De Carolis, S. S. Chung, A. Broccoli, S. Scott, F. Zaja, S. Devlin, K. R. Rai, M. S. Tallman, +31 Additional Authors Jan 2015

Targeting Mutant Braf In Relapsed Or Refractory Hairy-Cell Leukemia, E. Tiacci, J. H. Park, L. De Carolis, S. S. Chung, A. Broccoli, S. Scott, F. Zaja, S. Devlin, K. R. Rai, M. S. Tallman, +31 Additional Authors

Journal Articles

Background BRAF V600E is the genetic lesion underlying hairy-cell leukemia. We assessed the safety and activity of the oral BRAF inhibitor vemurafenib in patients with hairy-cell leukemia that had relapsed after treatment with a purine analogue or who had disease that was refractory to purine analogues. Methods We conducted two phase 2, single-group, multicenter studies of vemurafenib (at a dose of 960 mg twice daily) - one in Italy and one in the United States. The therapy was administered for a median of 16 weeks in the Italian study and 18 weeks in the U.S. STUDY: Primary end points were …

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Egfr And Her2: Is There A Role In Ovarian Cancer?, E. Teplinsky, F. Muggia Jan 2015

Egfr And Her2: Is There A Role In Ovarian Cancer?, E. Teplinsky, F. Muggia

Journal Articles

Advanced ovarian cancer carries a grim prognosis and development of targeted therapies to improve outcomes has become an active area of research in this disease. The epidermal growth factor receptor (EGFR) and HER2/neu have shown to be overexpressed in ovarian cancer and there have been several clinical trials evaluating anti-EGFR and HER2 therapies in ovarian cancer. Unfortunately, the drugs have shown minimal efficacy and more recent work has now focused on identifying mechanisms of resistance and alternative ways of targeting these pathways. This review will discuss the currently published trials with anti-EGFR and HER2 agents in ovarian cancer and the …

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Exon 4-Encoded Sequence Is A Major Determinant Of Cytotoxicity Of Apolipoprotein L1, A. K. Khatua, A. M. Cheatham, E. D. Kruzel, P. C. Singhal, K. Skorecki, W. Popik Jan 2015

Exon 4-Encoded Sequence Is A Major Determinant Of Cytotoxicity Of Apolipoprotein L1, A. K. Khatua, A. M. Cheatham, E. D. Kruzel, P. C. Singhal, K. Skorecki, W. Popik

Journal Articles

The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors that trigger or modify the progression of disease. In this regard, the effect of alternative splicing in the absence or presence of G1 or G2 alleles is unknown. In this study we investigated whether alternative splicing of non-G1, non-G2 APOL1 (APOL1 G0) affects its biological activity. Among seven APOL1 exons, exons 2 and 4 …

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In Support Of A Patient-Driven Initiative And Petition To Lower The High Price Of Cancer Drugs, A. Tefferi, K. Rai, A. I. Schafer, C. Schiffer, M. A. Sekeres, L. L. Siu, F. M. Stewart, M. Thompson, J. M. Vose, P. H. Wiernik, +109 Additional Authors Jan 2015

In Support Of A Patient-Driven Initiative And Petition To Lower The High Price Of Cancer Drugs, A. Tefferi, K. Rai, A. I. Schafer, C. Schiffer, M. A. Sekeres, L. L. Siu, F. M. Stewart, M. Thompson, J. M. Vose, P. H. Wiernik, +109 Additional Authors

Journal Articles

No abstract provided.

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Biologics In Achilles Tendon Healing And Repair: A Review, E. Shapiro, D. Grande, M. Drakos Jan 2015

Biologics In Achilles Tendon Healing And Repair: A Review, E. Shapiro, D. Grande, M. Drakos

Journal Articles

Injuries of the Achilles tendon are relatively common with potentially devastating outcomes. Healing Achilles tendons form a fibrovascular scar resulting in a tendon which may be mechanically weaker than the native tendon. The resulting strength deficit causes a high risk for reinjury and other complications. Treatments using biologics aim to restore the normal properties of the native tendon and reduce the risk of rerupture and maximize tendon function. The purpose of this review was to summarize the current findings of various therapies using biologics in an attempt to improve the prognosis of Achilles tendon ruptures and tendinopathies. A PubMed search …

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Objective Identification And Analysis Of Physiological And Behavioral Signs Of Schizophrenia, M. Osipov, Y. Behzadi, J. M. Kane, G. Petrides, G. D. Clifford Jan 2015

Objective Identification And Analysis Of Physiological And Behavioral Signs Of Schizophrenia, M. Osipov, Y. Behzadi, J. M. Kane, G. Petrides, G. D. Clifford

Journal Articles

BACKGROUND: A patient's physical activity is often used by psychiatrists to contribute to the diagnostic process for mental disorders. Typically, it is based mostly on self-reports or observations, and hardly ever upon actigraphy. Other signals related to physiology are rarely used, despite the fact that the autonomic nervous system is often affected by mental disorders. AIM: This study attempted to fuse physiological and physical activity data and discover features that are predictive for schizophrenia. METHOD: Continuous simultaneous heart rate (HR) and physical activity recordings were made on 16 individuals with schizophrenia and 19 healthy controls. Statistical characteristics of the recorded …

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An Immunohistochemical Analysis Of Stathmin 1 Expression In Uterine Smooth Muscle Tumors: Differential Expression In Leiomyosarcomas And Leiomyomas, M. M. Allen, J. J. Douds, S. X. Liang, M. M. Desouki, V. Parkash, O. Fadare Jan 2015

An Immunohistochemical Analysis Of Stathmin 1 Expression In Uterine Smooth Muscle Tumors: Differential Expression In Leiomyosarcomas And Leiomyomas, M. M. Allen, J. J. Douds, S. X. Liang, M. M. Desouki, V. Parkash, O. Fadare

Journal Articles

The oncogenic phosphatidylinositol 3-kinase-AKT-mammlian target of rapamycin pathway (PI3K-AKT-mTOR) pathway is known to be activated in uterine smooth muscle tumors, and Stathmin 1 (STMN1) expression has been identified as a marker of PI3K-AKT-mTOR pathway activation. We hypothesized that STMN1 may have some diagnostic utility and explored how well STMN1 expression correlated with histologic classifications of uterine smooth muscle tumors into benign and malignant groupings. 84 smooth muscle tumors were assessed for STMN1 expression by immunohistochemistry. These included spindle cell leiomyosarcoma (n=32), conventional spindle cell leiomyomas (n=30), atypical (symplastic) leiomyoma (n=5), cellular leiomyoma (n=7), smooth muscle tumor of uncertain malignant potential …

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Exosomes In Cancer Research, S. R. Vaiselbuh Jan 2015

Exosomes In Cancer Research, S. R. Vaiselbuh

Journal Articles

No abstract provided.

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Early Toxicity In Patients Treated With Postoperative Proton Therapy For Locally Advanced Breast Cancer, J. J. Cuaron, B. Chon, H. Tsai, A. Goenka, D. Deblois, A. Ho, S. Powell, E. Hug, O. Cahlon Jan 2015

Early Toxicity In Patients Treated With Postoperative Proton Therapy For Locally Advanced Breast Cancer, J. J. Cuaron, B. Chon, H. Tsai, A. Goenka, D. Deblois, A. Ho, S. Powell, E. Hug, O. Cahlon

Journal Articles

PURPOSE: To report dosimetry and early toxicity data in breast cancer patients treated with postoperative proton radiation therapy. METHODS AND MATERIALS: From March 2013 to April 2014, 30 patients with nonmetastatic breast cancer and no history of prior radiation were treated with proton therapy at a single proton center. Patient characteristics and dosimetry were obtained through chart review. Patients were seen weekly while on treatment, at 1 month after radiation therapy completion, and at 3- to 6-month intervals thereafter. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4.0. Frequencies of toxicities were tabulated. RESULTS: Median dose delivered …

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Child And Adolescent Psychiatrists' Reported Monitoring Behaviors For Second-Generation Antipsychotics, A. M. Rodday, S. K. Parsons, C. Mankiw, C. U. Correll, A. S. Robb, B. T. Zima, T. S. Saunders, L. K. Leslie Jan 2015

Child And Adolescent Psychiatrists' Reported Monitoring Behaviors For Second-Generation Antipsychotics, A. M. Rodday, S. K. Parsons, C. Mankiw, C. U. Correll, A. S. Robb, B. T. Zima, T. S. Saunders, L. K. Leslie

Journal Articles

Objective: The number of children and adolescents (hereafter referred to as "children") who have been prescribed second-generation antipsychotics (SGAs) has increased over the last decade, but little is known about monitoring practices in pediatric patients who are vulnerable to adverse effects. We examined factors associated with psychiatrists' self-reported monitoring of children who were prescribed SGAs. Methods: A survey was mailed to a national, randomly selected sample of 1600 child and adolescent psychiatrists from the American Medical Association mailing list. Using logistic regression, we tested whether psychiatrist characteristics, attitudes, and practice characteristics were associated with monitoring (baseline and/or periodic) the following: …

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Risk Prediction For Chronic Kidney Disease Progression Using Heterogeneous Electronic Health Record Data And Time Series Analysis, A. Perotte, R. Ranganath, J. S. Hirsch, D. Blei, N. Elhadad Jan 2015

Risk Prediction For Chronic Kidney Disease Progression Using Heterogeneous Electronic Health Record Data And Time Series Analysis, A. Perotte, R. Ranganath, J. S. Hirsch, D. Blei, N. Elhadad

Journal Articles

BACKGROUND: As adoption of electronic health records continues to increase, there is an opportunity to incorporate clinical documentation as well as laboratory values and demographics into risk prediction modeling. OBJECTIVE: The authors develop a risk prediction model for chronic kidney disease (CKD) progression from stage III to stage IV that includes longitudinal data and features drawn from clinical documentation. METHODS: The study cohort consisted of 2908 primary-care clinic patients who had at least three visits prior to January 1, 2013 and developed CKD stage III during their documented history. Development and validation cohorts were randomly selected from this cohort and …

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Daily Soil Surface Co2 Flux During Non-Flooded Periods In Flood-Irrigated Rice Rotations, J. M. Motschenbacher, K. R. Brye, M. M. Anders, E. E. Gbur, N. A. Slaton, M. A. Evans-White Jan 2015

Daily Soil Surface Co2 Flux During Non-Flooded Periods In Flood-Irrigated Rice Rotations, J. M. Motschenbacher, K. R. Brye, M. M. Anders, E. E. Gbur, N. A. Slaton, M. A. Evans-White

School of Natural Resources: Faculty Publications

No abstract provided.

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2015 South Dakota Beef Report, Department Of Animal Sciences, South Dakota State University, Agricultural Experiment Station, South Dakota State University, Cooperative Extension Service, South Dakota State University Jan 2015

2015 South Dakota Beef Report, Department Of Animal Sciences, South Dakota State University, Agricultural Experiment Station, South Dakota State University, Cooperative Extension Service, South Dakota State University

South Dakota Beef Report, 2015

This is the 2015 South Dakota Beef Report produced by the SDSU Department of Animal Sciences in conjunction with the Agricultural Experiment Station, and the SDSU Cooperative Extension. The articles published in this report summarize many of the beef cattle research activities conducted at South Dakota State University during 2015. The articles in this report have many levels of application. Some information has immediate application for your farm, ranch, or agribusiness. The articles include information on nutrition,management, health, growth and development, and economics of the cattle and beef industry in South Dakota.

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Five Ways To Support Interdisciplinary Work Before Tenure, Barbara Cosens Jan 2015

Five Ways To Support Interdisciplinary Work Before Tenure, Barbara Cosens

Articles

Academic institutions often claim to promote interdisciplinary teaching and research. Prescriptions for successfully engaging in interdisciplinary efforts, however, are usually directed at the individuals doing the work rather than the institutions evaluating them for the purpose of tenure and promotion. Where institutional recommendations do exist, they are often general in nature and lacking concrete guidance. Here, we draw on our experiences as students and faculty participating in three interdisciplinary water resource management programs in the USA to propose five practices that academic institutions can adopt to effectively support interdisciplinary work. We focus on reforms that will support pre-tenure faculty because …

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Typeface Connotation, Matias Ferrari Jan 2015

Typeface Connotation, Matias Ferrari

Open Access Theses

Since the invention of movable type, letters and characters of the Western alphabet have worn many different typefaces. The same way clothing can suggest fragments of the persona of who wears them, it has been suggested that typefaces carry connotative value.

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Quantitative Characterization Of Canopy Coverage In The Genetically Diverse Soynam Population, Benjamin P. Hall Jan 2015

Quantitative Characterization Of Canopy Coverage In The Genetically Diverse Soynam Population, Benjamin P. Hall

Open Access Theses

Despite estimates of annual on-farm soybean (Glycine max L. Merr.) grain yield gain ranging from 23-66 kg ha-1 yr-1, current trends show that the average decadal increase of soybean grain yield is declining in rate. It is suggested that a narrowing genetic diversity of cultivated soybean germplasm due to direct selection for grain yield, and insufficient knowledge of genetic influences underlying grain yield-associated physiological traits are contributing factors. Canopy development plays a critical role in the fraction of light intercepted by soybean crops throughout the growing season. Rapid canopy closure maximizes light interception and optimizes growth dynamic parameters, which ultimately …

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A New Historicist Analysis Of Education And Female-Life Factors In The 1926 Indiana Prairie Farmer Magazine Column "John Turnipseed", Jessica Ellen Mills Jan 2015

A New Historicist Analysis Of Education And Female-Life Factors In The 1926 Indiana Prairie Farmer Magazine Column "John Turnipseed", Jessica Ellen Mills

Open Access Theses

This research used a literary-theoretical approach to guide investigation of the once-popular column titled “John Turnipseed,” which was published for more than 60 years in the Indiana Prairie Farmer magazine. As the fictional author, Turnipseed entertained thousands of rural readers through his humorous first-person narration of interactions and adventures on and about his Indiana farm in the early twentieth century. The research focused specifically on the 51 Turnipseed columns published in the year 1926, a pivotal era in U.S. agriculture as well as American society. The literary theory of New Historicism was used to analyze two historical factors — education …

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Genomic Characterization Of Interspecific Hybrids And An Admixture Population Derived From Panicum Amarum × P. Virgatum, Christopher Heffelfinger, Adam P. Deresienski, Kimberly A. Nelson, Maria A. Moreno, Joel P. Hague, Stephen L. Dellaporta, Albert P. Kausch Jan 2015

Genomic Characterization Of Interspecific Hybrids And An Admixture Population Derived From Panicum Amarum × P. Virgatum, Christopher Heffelfinger, Adam P. Deresienski, Kimberly A. Nelson, Maria A. Moreno, Joel P. Hague, Stephen L. Dellaporta, Albert P. Kausch

Cell and Molecular Biology Faculty Publications

Switchgrass (Panicum virgatum L.) and its relatives are regarded as top bioenergy crop candidates; however, one critical barrier is the introduction of useful genetic diversity and the development of new cultivars and hybrids. Combining genomes from related cultivars and species provides an opportunity to introduce new traits. In switchgrass, a breeding advantage would be achieved by combining the genomes of intervarietal ecotypes or interspecific hybrids. The recovery of wide crosses, however, is often tedious and may involve complicated embryo rescue and numerous backcrosses. Here, we demonstrate a straightforward approach to wide crosses involving the use of a selectable transgene …

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Surface Enhanced Raman Spectroscopy Detection Of Biomolecules Using Ebl Fabricated Nanostructured Substrates, Robert F. Peters, Luis Gutierrez-Rivera, Steven K. Dew, Maria Stepanova Jan 2015

Surface Enhanced Raman Spectroscopy Detection Of Biomolecules Using Ebl Fabricated Nanostructured Substrates, Robert F. Peters, Luis Gutierrez-Rivera, Steven K. Dew, Maria Stepanova

College of Natural and Applied Sciences

Fabrication and characterization of conjugate nano-biological systems interfacing metallic nanostructures on solid supports with immobilized biomolecules is reported. The entire sequence of relevant experimental steps is described, involving the fabrication of nanostructured substrates using electron beam lithography, immobilization of biomolecules on the substrates, and their characterization utilizing surface-enhanced Raman spectroscopy (SERS). Three different designs of nano-biological systems are employed, including protein A, glucose binding protein, and a dopamine binding DNA aptamer. In the latter two cases, the binding of respective ligands, D-glucose and dopamine, is also included. The three kinds of biomolecules are immobilized on nanostructured substrates by different methods, …

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Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li Jan 2015

Repeated Effects Of The Neurotensin Receptor Agonist Pd149163 In Three Animal Tests Of Antipsychotic Activity: Assessing For Tolerance And Cross-Tolerance To Clozapine, Shinnyi Chou, Collin Davis, Sean Jones, Ming Li

Department of Psychology: Faculty Publications

Neurotensin is an endogenous neuropeptide closely associated with the mesolimbic dopaminergic system and shown to possess antipsychotic-like effects. In particular, acute neurotensin receptor activation can inhibit conditioned avoidance response (CAR), attenuate phencyclidine (PCP)-induced prepulse inhibition (PPI) disruptions, and reverse PCP-induced hyperlocomotion. However, few studies have examined the long term effects of repeated neurotensin receptor activation and results are inconsistent. Since clinical administration of antipsychotic therapy often requires a prolonged treatment schedule, here we assessed the effects of repeated activation of neurotensin receptors using an NTS1 receptor selective agonist, PD149163, in 3 behavioral tests of antipsychotic activity. We also investigated whether …

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Apoptotic Effect Of Cordycepin On A549 Human Lung Cancer Cell Line, Hardeep Singh Tuli, Gaurav Kumar, Sardul Singh Sandhu, Anil Kumar Sharma, Dharmbir Kashyap Jan 2015

Apoptotic Effect Of Cordycepin On A549 Human Lung Cancer Cell Line, Hardeep Singh Tuli, Gaurav Kumar, Sardul Singh Sandhu, Anil Kumar Sharma, Dharmbir Kashyap

Turkish Journal of Biology

Cordycepin, an active ingredient in the insect fungus Cordyceps militaris, is in a category of compounds that exhibit significant therapeutic activity. The aim of the present study was to investigate the effect of cordycepin on cell proliferation, apoptosis, and cell cycle in A549 human lung cancer cells. MTT assay was used to evaluate the cytotoxic effect of cordycepin on A549 cell growth. Apoptotic effect was observed using cell morphology, DAPI staining, and DNA fragmentation studies. Flow cytometry (FCM) analysis was used to analyze cell cycle status after cordycepin treatment. Furthermore, apoptosis was assayed using annexin V-Alexa Fluor 488. Results of …

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The Effect Of A Mushroom (Coriolus Versicolor) Based Probiotic On Innate Immunity In Goats Naturally Infected With Gastrointestinal Parasites, Kingsley Ekwemalor Jan 2015

The Effect Of A Mushroom (Coriolus Versicolor) Based Probiotic On Innate Immunity In Goats Naturally Infected With Gastrointestinal Parasites, Kingsley Ekwemalor

Theses

Gastrointestinal parasites such as the nematode Haemonchus contortus and protozoa Coccidia pose a serious threat to the global goat industry due to resistance of parasites to anthelmintic drugs. The objective of this study was to evaluate the effect of extracts of CorPet biomass, a mushroom (Coriolus versicolor) on gastrointestinal parasite infection and innate immunity in goats. Fifteen female SpanishXBoer goats were drenched with 10 ml of either a hot extract of CorPet (N=5), a cold extract (N=5), or with sterile water (control N=5) for eight weeks. Treatment groups were reversed after four weeks. Body weight, body condition and FAMACHA scores, …

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Do Female Guppies Prefer Orange-Tailed Males Over Yellow-Tailed Males During Mate Choice As A Result Of Sexual Selection, Ivy Bias, Henry Linford, Miles Brooks, Ian Gates Jan 2015

Do Female Guppies Prefer Orange-Tailed Males Over Yellow-Tailed Males During Mate Choice As A Result Of Sexual Selection, Ivy Bias, Henry Linford, Miles Brooks, Ian Gates

Biology Posters

No abstract provided.

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Production Of Phycocyanobilin From Spirulina, Matthew Argiro, Jon Takemoto, Dong Chen Jan 2015

Production Of Phycocyanobilin From Spirulina, Matthew Argiro, Jon Takemoto, Dong Chen

Biology Posters

No abstract provided.

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