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2015

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David B. Fluri (May 1949-August 2012): Life After West Chester University, Wayne Fluri Jan 2015

David B. Fluri (May 1949-August 2012): Life After West Chester University, Wayne Fluri

Gordon Natural Area History & Strategic Plan Documents

No abstract provided.

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Quality Of Minority Health Communication: An Analysis Of Hispanic-Targeted Health Websites., Emma K. Wertz, Sora Kim Jan 2015

Quality Of Minority Health Communication: An Analysis Of Hispanic-Targeted Health Websites., Emma K. Wertz, Sora Kim

Faculty Articles

The Internet has become one of the most used forms of health communication media. Using the Health on the Net code of conduct, this study examined the quality of health information available on the Internet for one of the United State's fastest growing minorities, Hispanics. When comparing Hispanic-targeted websites with those that target the majority population, this study found significant differences with respect to quality. Specifically, sites targeting Hispanics had a lower level of quality than those that targeted the majority population. [ABSTRACT FROM AUTHOR]

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Using Interpersonal Process Recall (Ipr) To Examine The Effects Of Equine Assisted Activities On The Personal And Professional Development Of Student Therapists, Dianna Isabel Giraldez Jan 2015

Using Interpersonal Process Recall (Ipr) To Examine The Effects Of Equine Assisted Activities On The Personal And Professional Development Of Student Therapists, Dianna Isabel Giraldez

Department of Family Therapy Dissertations and Applied Clinical Projects

The Introduction to Equine Assisted Family Therapy course offered at Nova Southeastern University (NSU) provides Master’s and Doctoral level student therapists the opportunity to learn how to conduct an equine session and how to utilize horses as part of the therapeutic process. Students learn about the underlying theories and framework behind the equine activities and methodology, as well as participate in the equine activities themselves. For the purpose of this study, classroom discussions centered around processing the students’ experiences and were further enriched by viewing photographs and videos that had been taken of the students conducting the equine activities. The …

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Respiratory Particle Deposition Probability Due To Sedimentation With Variable Gravity And Electrostatic Forces, Ioannis Haranas, Ioannis Gkigkitzis, George D. Zouganelis, Maria K. Haranas, Samantha Kirk Jan 2015

Respiratory Particle Deposition Probability Due To Sedimentation With Variable Gravity And Electrostatic Forces, Ioannis Haranas, Ioannis Gkigkitzis, George D. Zouganelis, Maria K. Haranas, Samantha Kirk

Physics and Computer Science Faculty Publications

In this paper, we study the effects of the acceleration gravity on the sedimentation deposition probability, as well as the aerosol deposition rate on the surface of the Earth and Mars, but also aboard a spacecraft in orbit around Earth and Mars as well for particles with density ρp = 1300 kg/m3, diameters dp = 1, 3, 5 µm and residence times t = 0.0272, 0.2 s respectively. For particles of diameter 1 µm we find that, on the surface of Earth and Mars the deposition probabilities are higher at the poles when compared to the …

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Heterozygosity For A Hypomorphic Polβ Mutation Reduces The Expansion Frequency In A Mouse Model Of The Fragile X-Related Disorders, Rachel Adihe Lokanga, Ali Senejani, Joann B. Sweasy, Karen Usdin Jan 2015

Heterozygosity For A Hypomorphic Polβ Mutation Reduces The Expansion Frequency In A Mouse Model Of The Fragile X-Related Disorders, Rachel Adihe Lokanga, Ali Senejani, Joann B. Sweasy, Karen Usdin

Biology and Environmental Science Faculty Publications

The Fragile X-related disorders (FXDs) are members of the Repeat Expansion Diseases, a group of human genetic conditions resulting from expansion of a specific tandem repeat. The FXDs result from expansion of a CGG/CCG repeat tract in the 5’ UTR of the FMR1 gene. While expansion in a FXD mouse model is known to require some mismatch repair (MMR) proteins, our previous work and work in mouse models of another Repeat Expansion Disease show that early events in the base excision repair (BER) pathway play a role in the expansion process. One model for repeat expansion proposes that a non-canonical …

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Effect Of Bay (Laurus Nobilis) Essential Oil On Physicochemical Properties Of Alaska Pollock (Theragra Chalgoramma) Surimi Nutrified With Salmon And Flaxseed Oils Under Refrigerated Storage, Ugochukwu C. Anyanwu Jan 2015

Effect Of Bay (Laurus Nobilis) Essential Oil On Physicochemical Properties Of Alaska Pollock (Theragra Chalgoramma) Surimi Nutrified With Salmon And Flaxseed Oils Under Refrigerated Storage, Ugochukwu C. Anyanwu

Theses

Surimi seafood products are widely accepted and consumed in the U.S. and other parts of the world. In recent time, there has been increased demand for surimi seafood products nutrified with ω-3 polyunsaturated fatty acids (PUFAs) as a result of their reported health benefits, but this may have a negative effect on the storage time of the product due to lipid oxidation of fatty acids (FA). Bay (Laurus nobilis) essential oil (BEO) which has demonstrated antioxidant properties was incorporated to the surimi seafood to reduce lipid oxidation thereby extending storage time. The objectives of this study were to (1) evaluate …

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Teaching The Digital Caveman: Rethinking The Use Of Classroom Technology In Law School, James B. Levy Jan 2015

Teaching The Digital Caveman: Rethinking The Use Of Classroom Technology In Law School, James B. Levy

Chapman Law Review

No abstract provided.

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Mechanisms Of Pluripotency And Epigenetic Reprogramming In Primordial Germ Cells: Lessons For The Conversion Of Other Cell Types Into The Stem Cell Lineage, Suresh Palamadai Krishnan Jan 2015

Mechanisms Of Pluripotency And Epigenetic Reprogramming In Primordial Germ Cells: Lessons For The Conversion Of Other Cell Types Into The Stem Cell Lineage, Suresh Palamadai Krishnan

Turkish Journal of Biology

Primordial germ cells (PGCs) provide an excellent tool to better understand ancestor?descendent relationships as well as the efficiency and molecular mechanisms governing pluripotency in the reprogramming of somatic cells, since the latter type of cells have a relatively lower efficiency of conversion to pluripotent cells. This kind of comparison has gained credence from the commonalities regarding the expression of key transcription factors such as octamer-binding transcriptionhttp://en.wikipedia.org/wiki/Transcription_factor factor-4 (Oct3/4), SRY-related HMG box (Sox2), myelocytomatosis (c-Myc), and Nanog, as well as redundancy in terms of Kruppel-like factor 2 (Klf2), Kruppel-like factor 5 (Klf5), estrogen-related receptor beta (Esrrb), and estrogen-related receptor gamma (Esrrg) …

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Organ-Specific Antioxidant Defenses And Ft-Ir Spectroscopy Of Muscles In Crucian Carp (Carassius Auratus Gibelio) Exposed To Environmental Pb2+, Sher Ali Khan, Xiaoyu Liu, Hong Li, Wenting Fan, Bakht Ramin Shah, Jingna Li, Lu Zhang, Suyan Chen, Sher Bahadar Khan Jan 2015

Organ-Specific Antioxidant Defenses And Ft-Ir Spectroscopy Of Muscles In Crucian Carp (Carassius Auratus Gibelio) Exposed To Environmental Pb2+, Sher Ali Khan, Xiaoyu Liu, Hong Li, Wenting Fan, Bakht Ramin Shah, Jingna Li, Lu Zhang, Suyan Chen, Sher Bahadar Khan

Turkish Journal of Biology

Being a nonessential element, lead (Pb2+) can be toxic in trace amounts for freshwater fish. The present study was designed to evaluate the induction of oxidative stress, tissue-specific antioxidant response, acetyl cholinesterase (AchE) activities, and biochemical content of muscle in Crucian carp (Carassius auratus gibelio) after 96 h of acute exposure and 21 days of chronic exposure to various environmental concentrations (5, 10, and 30 µg L-1) of waterborne Pb2+. The results indicated that exposure to 10 and 30 µg L-1 Pb2+ significantly altered the activities of catalase, superoxide dismutase, and glutathione peroxidase in different tissues, while malondialdehyde content increased …

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Marker-Assisted Selection For Rice Brown Planthopper (Nilaparvata Lugens)Resistance Using Linked Ssr Markers, Mahmoodreza Shabanimofrad, Mohd Rafii Yusop, Sadegh Ashkani, Mohamed Hanafi Musa, Nur Azura Adam, Iffah Haifa, Abdul Rahim Harun, Mohammad Abdul Latif Jan 2015

Marker-Assisted Selection For Rice Brown Planthopper (Nilaparvata Lugens)Resistance Using Linked Ssr Markers, Mahmoodreza Shabanimofrad, Mohd Rafii Yusop, Sadegh Ashkani, Mohamed Hanafi Musa, Nur Azura Adam, Iffah Haifa, Abdul Rahim Harun, Mohammad Abdul Latif

Turkish Journal of Biology

No abstract provided.

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Functional Nano/Microcapsules: Synthesis And Characterization, Gbewonyo Spero Jan 2015

Functional Nano/Microcapsules: Synthesis And Characterization, Gbewonyo Spero

Theses

Microencapsulation is a technique by which solid, liquid or gaseous active ingredients are enclosed within a shell material for the purpose of shielding the active ingredient from surrounding environment. The product therefrom is valuable as an active ingredient carrier and controlled release vehicle. In this research, polymer micro/nanocapsules with enclosed aqueous solution were synthesized through O/W emulsion-solvent evaporation technique. Specifically a commercial textile dye was encapsulated in poly (methyl methacrylate) (PMMA) micro/nanocapsules for an innovation of textile dyeing. A variety of synthesis parameters were studied including concentration of polymer, amount of dye, amount of surfactant, volume of surfactant aqueous solution, …

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Micrornas In Triple-Negative Breast Cancer: A Potential Biomarker, S. Godfrey Sherette Jan 2015

Micrornas In Triple-Negative Breast Cancer: A Potential Biomarker, S. Godfrey Sherette

Theses

Purpose: The Triple-Negative Breast Cancer (TNBC) subtype accounts for 15 percent of all breast cancers. It is characterized by cancer cells that lack estrogen, progesterone, and HER2/Neu receptors. TNBC is highly aggressive and deadly, and primarily affects younger African-American women. Identification of microRNAs that can be used as biomarkers for diagnosis, prognosis, and provide drug-able targets is the long-term goal of this study. The objective of this study is to compare and contrast microRNA expression level profiles from microarray (Partek Genomic Suite) and qPCR analysis performed on triple-negative breast cancer versus normal breast tissue cell line in order to find …

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Mu-Opioid Receptor Gene A118 G Variants And Persistent Pain Symptoms Among Men And Women Experiencing Motor Vehicle Collision, S. D. Linnstaedt, J. M. Hu, A. V. Bortsov, A. C. Soward, R. Swor, J. Jones, D. Lee, R. Domeier, P. Hendry, S. A. Mclean, +2 Additional Authors Jan 2015

Mu-Opioid Receptor Gene A118 G Variants And Persistent Pain Symptoms Among Men And Women Experiencing Motor Vehicle Collision, S. D. Linnstaedt, J. M. Hu, A. V. Bortsov, A. C. Soward, R. Swor, J. Jones, D. Lee, R. Domeier, P. Hendry, S. A. Mclean, +2 Additional Authors

Journal Articles

The mu-opioid receptor 1 (OPRM1) binds endogenous opioids. Increasing evidence suggests that endogenous OPRM1 agonists released at the time of trauma may contribute to the development of posttraumatic musculoskeletal pain (MSP). In this prospective observational study, we evaluated the hypothesis that individuals with an AG or GG genotype at the OPRM1 A118 G allele, which results in a reduced response to opioids, would have less severe MSP 6 weeks after motor vehicle collision (MVC). Based on previous evidence, we hypothesized that this effect would be sex-dependent and most pronounced among women with substantial peritraumatic distress. European American men and women …

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Genetic Polymorphisms In The Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision, Y. J. Qadri, A. V. Bortsov, D. C. Orrey, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, P. L. Hendry, S. A. Mclean, +1 Additional Author Jan 2015

Genetic Polymorphisms In The Dopamine Receptor 2 Predict Acute Pain Severity After Motor Vehicle Collision, Y. J. Qadri, A. V. Bortsov, D. C. Orrey, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, P. L. Hendry, S. A. Mclean, +1 Additional Author

Journal Articles

Objectives:Dopaminergic signaling is implicated in nociceptive pathways. These effects are mediated largely through dopamine receptors and modulated in part by dopamine transporters. This study tested the hypothesis that genetic variants in the genes encoding dopamine receptor 2 (DRD2) and the dopamine active transporter (SLC6A3) influence acute pain severity after motor vehicle collision.Materials and Methods:European Americans presenting to the emergency department after motor vehicle collision were recruited. Overall pain intensity in emergency department was assessed using a 0 to 10 numeric rating scale. DNA was extracted from blood samples and genotyping of single-nucleotide polymorphisms (SNPs) in the DRD2 and SLC6A3 gene …

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Humoral Immune Response Against Nontargeted Tumor Antigens After Treatment With Sipuleucel-T And Its Association With Improved Clinical Outcome, D. Guhathakurta, N. A. Sheikh, L. Q. Fan, H. Kandadi, T. C. Meagher, S. J. Hall, J. B. Whitmore, M. W. Frohlich, J. B. Trager, C. G. Drake, +7 Additional Authors Jan 2015

Humoral Immune Response Against Nontargeted Tumor Antigens After Treatment With Sipuleucel-T And Its Association With Improved Clinical Outcome, D. Guhathakurta, N. A. Sheikh, L. Q. Fan, H. Kandadi, T. C. Meagher, S. J. Hall, J. B. Whitmore, M. W. Frohlich, J. B. Trager, C. G. Drake, +7 Additional Authors

Journal Articles

PURPOSE: Antitumor activity of cancer immunotherapies may elicit immune responses to nontargeted (secondary) tumor antigens, or antigen spread. We evaluated humoral antigen spread after treatment with sipuleucel-T, an immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC), designed to target prostatic acid phosphatase (PAP; primary antigen). EXPERIMENTAL DESIGN: Serum samples from patients with mCRPC enrolled in the placebo-controlled phase III IMPACT study (evaluable n = 142) were used to assess humoral antigen spread after treatment with sipuleucel-T. Immunoglobulin G (IgG) responses to self-antigens (including tumor antigens) were surveyed using protein microarrays and confirmed using Luminex xMAP. IgG responses …

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Pathological And Molecular Evaluation Of Pancreatic Neoplasms, A. Rishi, M. Goggins, L. D. Wood, R. H. Hruban Jan 2015

Pathological And Molecular Evaluation Of Pancreatic Neoplasms, A. Rishi, M. Goggins, L. D. Wood, R. H. Hruban

Journal Articles

Pancreatic neoplasms are morphologically and genetically heterogeneous and include a wide variety of tumors ranging from benign to malignant with an extremely poor clinical outcome. Our understanding of these pancreatic neoplasms has improved significantly with recent advances in cancer sequencing. Awareness of molecular pathogenesis brings new opportunities for early detection, improved prognostication, and personalized gene-specific therapies. Here we review the pathological classification of pancreatic neoplasms from the molecular and genetic perspectives.

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Antipsychotic Treatment And Functional Connectivity Of The Striatum In First-Episode Schizophrenia, D. K. Sarpal, D. G. Robinson, T. Lencz, M. Argyelan, T. Ikuta, K. Karlsgodt, J. Gallego, J. M. Kane, P. R. Szeszko, A. K. Malhotra Jan 2015

Antipsychotic Treatment And Functional Connectivity Of The Striatum In First-Episode Schizophrenia, D. K. Sarpal, D. G. Robinson, T. Lencz, M. Argyelan, T. Ikuta, K. Karlsgodt, J. Gallego, J. M. Kane, P. R. Szeszko, A. K. Malhotra

Journal Articles

IMPORTANCE Previous evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the relationship between its functional connectivity and symptomatic reduction remains unknown. OBJECTIVE To explore the longitudinal effect of treatment with second-generation antipsychotics on functional connectivity of the striatum during the resting state in patients experiencing a first episode of psychosis. DESIGN, SETTING, AND PARTICIPANTS This prospective controlled study took place at a clinical research center and included 24 patients with first-episode psychosis and 24 healthy participants matched for age, sex, education, and handedness. Medications were administered in …

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Applying Cognitive Load Theory To Medical Education: Construct And Measurement Challenges, John Young, J. L. Sewell Jan 2015

Applying Cognitive Load Theory To Medical Education: Construct And Measurement Challenges, John Young, J. L. Sewell

Journal Articles

No abstract provided.

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Progressive Reduction In Cortical Thickness As Psychosis Develops: A Multisite Longitudinal Neuroimaging Study Of Youth At Elevated Clinical Risk, T. D. Cannon, Y. Chung, G. He, D. Sun, K. Cadenhead, B. A. Cornblatt, M. Tsuang, E. Walker, S. W. Woods, R. Heinssen, +10 Additional Authors Jan 2015

Progressive Reduction In Cortical Thickness As Psychosis Develops: A Multisite Longitudinal Neuroimaging Study Of Youth At Elevated Clinical Risk, T. D. Cannon, Y. Chung, G. He, D. Sun, K. Cadenhead, B. A. Cornblatt, M. Tsuang, E. Walker, S. W. Woods, R. Heinssen, +10 Additional Authors

Journal Articles

BACKGROUND: Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with individuals without symptomatic progression and with healthy control subjects. Whether such changes reflect processes associated with the pathophysiology of schizophrenia or exposure to antipsychotic drugs is unknown. METHODS: In this multisite study, 274 CHR cases, including 35 individuals who converted to psychosis, and 135 healthy comparison subjects were scanned with magnetic resonance imaging at baseline, 12-month follow-up, or the point of conversion for the subjects who developed fully psychotic symptoms. RESULTS: In …

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Prognostic Significance Of Lymph Node Metastases In Small Intestinal Neuroendocrine Tumors, M. K. Kim, R. R. P. Warner, S. C. Ward, N. Harpaz, S. Roayaie, M. E. Schwartz, S. Itzkowitz, J. Wisnivesky Jan 2015

Prognostic Significance Of Lymph Node Metastases In Small Intestinal Neuroendocrine Tumors, M. K. Kim, R. R. P. Warner, S. C. Ward, N. Harpaz, S. Roayaie, M. E. Schwartz, S. Itzkowitz, J. Wisnivesky

Journal Articles

Background/Aims: Current staging guidelines for small intestinal neuroendocrine tumors (SI-NETs) differentiate between the presence (N1) and absence (N0) of lymph node (LN) metastases. However, the prognostic significance of the extent of LN involvement remains unknown. In this study, we used data from a population-based cancer registry to examine whether involvement of a higher number of LNs is associated with worse survival. Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to identify patients with histologically confirmed, surgically resected SI-NETS diagnosed between 1988 and 2010. Patients were classified into three groups by the LN ratio (number of positive LNs/number …

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Hypothesis: Neuroendocrine Mechanisms (Hypothalamus-Growth Hormone-Stat5 Axis) Contribute To Sex Bias In Pulmonary Hypertension, P. B. Sehgal, Y. M. Yang, E. J. Miller Jan 2015

Hypothesis: Neuroendocrine Mechanisms (Hypothalamus-Growth Hormone-Stat5 Axis) Contribute To Sex Bias In Pulmonary Hypertension, P. B. Sehgal, Y. M. Yang, E. J. Miller

Journal Articles

Pulmonary hypertension (PH) is a disease with high morbidity and mortality. The prevalence of idiopathic pulmonary arterial hypertension (IPAH) and hereditary pulmonary arterial hypertension (HPAH) is approximately 2-4-fold higher in women than in men. Paradoxically, there is an opposite male bias in typical rodent models of PH (chronic hypoxia or monocrotaline); in these models administration of estrogenic compounds [e.g. estradiol-17beta (E2)] is protective. Further complexities are observed in humans ingesting anorexigens (female bias), and in rodent models such as after hypoxia plus SU5416/Sugen (little sex bias) or involving serotonin transporter overexpression or dexfenfluramine administration (female bias). These complexities in sex …

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Robust Low-Dose Ct Perfusion Deconvolution Via Tensor Total-Variation Regularization, R. G. Fang, S. T. Zhang, T. H. Chen, P. C. Sanelli Jan 2015

Robust Low-Dose Ct Perfusion Deconvolution Via Tensor Total-Variation Regularization, R. G. Fang, S. T. Zhang, T. H. Chen, P. C. Sanelli

Journal Articles

Acute brain diseases such as acute strokes and transit ischemic attacks are the leading causes of mortality and morbidity worldwide, responsible for 9% of total death every year. "Time is brain" is a widely accepted concept in acute cerebrovascular disease treatment. Efficient and accurate computational framework for hemodynamic parameters estimation can save critical time for thrombolytic therapy. Meanwhile the high level of accumulated radiation dosage due to continuous image acquisition in CT perfusion (CTP) raised concerns on patient safety and public health. However, low-radiation leads to increased noise and artifacts which require more sophisticated and time-consuming algorithms for robust estimation. …

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Tamibarotene In Patients With Acute Promyelocytic Leukaemia Relapsing After Treatment With All-Trans Retinoic Acid And Arsenic Trioxide, D. Sanford, F. Lo-Coco, M. A. Sanz, E. Di Bona, S. Coutre, J. K. Altman, M. Wetzler, S. L. Allen, F. Ravandi, H. Kantarjian, J. E. Cortes Jan 2015

Tamibarotene In Patients With Acute Promyelocytic Leukaemia Relapsing After Treatment With All-Trans Retinoic Acid And Arsenic Trioxide, D. Sanford, F. Lo-Coco, M. A. Sanz, E. Di Bona, S. Coutre, J. K. Altman, M. Wetzler, S. L. Allen, F. Ravandi, H. Kantarjian, J. E. Cortes

Journal Articles

Treatment of acute promyelocytic leukaemia (APL) with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is highly effective first-line therapy, although approximately 5-10% of patients relapse. Tamibarotene is a synthetic retinoid with activity in APL patients who relapse after chemotherapy and ATRA, but has not been studied in relapse after treatment with ATO and ATRA. We report on a phase II study of tamibarotene in adult patients with relapsed or refractory APL after treatment with ATRA and ATO (n = 14). Participants were treated with tamibarotene (6 mg/m2 /d) during induction and for up to six cycles of consolidation. The …

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Management Of Chronic Lymphocytic Leukemia In The Elderly, J. C. Barrientos Jan 2015

Management Of Chronic Lymphocytic Leukemia In The Elderly, J. C. Barrientos

Journal Articles

No abstract provided.

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A Novel Engineered Vegf Blocker With An Excellent Pharmacokinetic Profile And Robust Anti-Tumor Activity, L. Liu, H. Yu, X. Huang, H. Tan, S. Li, Y. Luo, L. Zhang, S. Jiang, C. C. Chu, W. Tian, +4 Additional Authors Jan 2015

A Novel Engineered Vegf Blocker With An Excellent Pharmacokinetic Profile And Robust Anti-Tumor Activity, L. Liu, H. Yu, X. Huang, H. Tan, S. Li, Y. Luo, L. Zhang, S. Jiang, C. C. Chu, W. Tian, +4 Additional Authors

Journal Articles

BACKGROUND: Relatively poor penetration and retention in tumor tissue has been documented for large molecule drugs including therapeutic antibodies and recombinant immunoglobulin constant region (Fc)-fusion proteins due to their large size, positive charge, and strong target binding affinity. Therefore, when designing a large molecular drug candidate, smaller size, neutral charge, and optimal affinity should be considered. METHODS: We engineered a recombinant protein by molecular engineering the second domain of VEGFR1 and a few flanking residues fused with the Fc fragment of human IgG1, which we named HB-002.1. This recombinant protein was extensively characterized both in vitro and in vivo for …

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Optical Microfibre Based Photonic Components And Their Applications In Label-Free Biosensing, Pengfei Wang, Lin Bo, Yuliya Semenova, Gerald Farrell, Gilberto Bramilla Jan 2015

Optical Microfibre Based Photonic Components And Their Applications In Label-Free Biosensing, Pengfei Wang, Lin Bo, Yuliya Semenova, Gerald Farrell, Gilberto Bramilla

Articles

Optical microfibre photonic components offer a variety of enabling properties, including large evanescent fields, flexibility, configurability, high confinement, robustness and compactness. These unique features have been exploited in a range of applications such as telecommunication, sensing, optical manipulation and high Q resonators. Optical microfibre biosensors, as a class of fibre optic biosensors which rely on small geometries to expose the evanescent field to interact with samples, have been widely investigated. Due to their unique properties, such as fast response, functionalization, strong confinement, configurability, flexibility, compact size, low cost, robustness, ease of miniaturization, large evanescent field and label-free operation, optical microfibres …

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Long Reach Lane At Long Marsh, Harpswell, 2015 Post-Project Monitoring Report; Year 2 Of 5, Matt Craig Jan 2015

Long Reach Lane At Long Marsh, Harpswell, 2015 Post-Project Monitoring Report; Year 2 Of 5, Matt Craig

Publications

In 2012, the Maine Department of Transportation (MDOT) proposed a mitigation project at Long Reach Lane in Harpswell (Figure 1) to compensate for the functional impacts to marine wetlands associated with the construction of the Martin’s Point Bridge between Falmouth and Portland. The mitigation project took place in January and February 2014, and resulted in the successful replacement of a 36” (7.1 ft 2 flow area) round concrete pipe beneath Long Reach Lane with a larger 6’ x 12’ concrete box culvert (72 ft 2 flow area) in February 2014 (photo MDOT, below).

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Maine's Climate Future 2015 Update, University Of Maine Jan 2015

Maine's Climate Future 2015 Update, University Of Maine

Publications

No abstract provided.

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Developing, Using, And Interacting In The Flipped Learning Movement: Gaps Among Subject Areas, Hsin-Liang Chen, Kevin L. Summers Jan 2015

Developing, Using, And Interacting In The Flipped Learning Movement: Gaps Among Subject Areas, Hsin-Liang Chen, Kevin L. Summers

University Libraries Faculty Research & Creative Works

The purpose of this paper is to investigate the current video collection of an open-access video website (TED-Ed). The research questions focus on its content as evidence of development, its viewership as evidence of use, and flipping as evidence of interaction in informal learning. In late September 2013, 686 video lessons were posted on the TED-Ed website that spanned 12 academic subject categories and 60 academic subject subcategories, as labeled and sorted on the TED-Ed website itself. The findings of the analysis of the TED-Ed video collection indicate several gaps in the humanities, social science, and natural science academic areas …

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A-803467, A Tetrodotoxin-Resistant Sodium Channel Blocker, Modulates Abcg2-Mediated Mdr In Vitro And In Vivo, Nagaraju Anreddy, Atish Patel, Yun-Kai Zhang, Yi-Jun Wang, Suneet Shukla, Rishil J. Kathawala, Priyank Kumar Jan 2015

A-803467, A Tetrodotoxin-Resistant Sodium Channel Blocker, Modulates Abcg2-Mediated Mdr In Vitro And In Vivo, Nagaraju Anreddy, Atish Patel, Yun-Kai Zhang, Yi-Jun Wang, Suneet Shukla, Rishil J. Kathawala, Priyank Kumar

Touro College of Pharmacy (New York) Publications and Research

ATP-binding cassette subfamily G member 2 (ABCG2) is a member of the ABC transporter superfamily proteins, which has been implicated in the development of multidrug resistance (MDR) in cancer, apart from its physiological role to remove toxic substances out of the cells. The diverse range of substrates of ABCG2 includes many antineoplastic agents such as topotecan, doxorubicin and mitoxantrone. ABCG2 expression has been reported to be significantly increased in some solid tumors and hematologic malignancies, correlated to poor clinical outcomes. In addition, ABCG2 expression is a distinguishing feature of cancer stem cells, whereby this membrane transporter facilitates resistance to the …

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