Digital Commons Network^™

Street Code Adherence, Callous-Unemotional Traits And The Capacity Of Violent Offending Versus Non-Offending Urban Youth To Mentalize About Disrespect Murder, Zoe A. Berko

Dissertations, Theses, and Capstone Projects

National statistics are not available on the proportion of violent juvenile offenses driven by the experience of being disrespected. However, the New York Police Department estimates that about 40% of the city's shootings involve members of violent crews of 12 to 20 year olds with most of this gun violence driven by incidents of disrespect. Mentalization, defined as the ability to envision mental states (i.e., feelings, beliefs and intentions) in oneself and others, is viewed as underlying affect regulation, impulse control, self-monitoring, and the experience of self-agency, all of which are implicated in interpersonal violence (Fonagy, Gergely, Jurist, & Target, …

The Sadistic Reader: Gender And The Pleasures Of Violence In The Novel, Pamela Burger

Dissertations, Theses, and Capstone Projects

This project seeks to explain the prevalence of narratives that feature sexual violence against women in the tradition of the Anglophone novel. To this end, it posits the existence of a sadistic reading practice that coincides with readers' sympathetic identification. A sadistic reader takes pleasure in the bodily violation of the woman at the center of a novel; such a reader enters the text expecting violence, and experiences a sense of narrative gratification when the inevitable violation plays out. These expectations emerge from repeated interactions with a literary tradition in which victimized heroines are routine. To explore such sadism, I …

Theory Development And Pilot Testing Of A New Survey Instrument On Usability By Older Adults, Meriam Caboral-Stevens

Dissertations, Theses, and Capstone Projects

An aging population and the use of technology are two pervasive phenomena that are burgeoning simultaneously. The confluence of these phenomena may present challenges for the older adults that could prevent a successful interface. Barriers and challenges can be addressed by examining the interface between older adults and technology. Usability is described as how well and how easily a user without formal training can interact effectively with the system. A review of the literature shows paucity in nursing theories on usability and the use of technology among older adults. This paper describes the development of a conceptual model - Use …

Tonic And Phasic Inhibitory Mechanisms Mediating Sensorimotor Decision-Making In The Goldfish Auditory Startle Circuit, Paul C.P. Curtin

Dissertations, Theses, and Capstone Projects

This work describes related studies of cellular and synaptic signaling mechanisms involved in the balance of excitation and inhibition in the goldfish auditory startle circuit. The general purpose of these experiments was to identify novel mechanisms that contribute to action selection at different stages of the motor control hierarchy. The methods applied to achieve this goal tested the effects of selective antagonists for target receptor systems on sound-evoked excitation and inhibition of startle.

Chapter 2 describes a study of a poorly-understood serotonergic mechanism, the 5-HT_5A receptor, that was not previously functionally characterized in native tissues or associated with neural …

Integrating Phylogenomics, Biogeography And Systematics To Explore The Taxonomy And The Rise Of The Ratsnakes, Xin Chen

Dissertations, Theses, and Capstone Projects

Understanding the evolutionary processes that create the spectacular diversity of organisms, both in species numbers and form, is a primary goal for biologists. Global ratsnakes are a species-rich assemblage with high morphological and ecological diversity and a distribution that encompasses both the Old World (OW) and the New World (NW). To explore the mechanism leading to the divergence of the ratsnakes, I tested the hypotheses regarding the area of origin and global dispersal, and examined the patterns of diversification and trait evolution. Given adaptive radiation via ecological opportunity, a diversity-dependent diversification pattern and an early burst trait evolutionary pattern are …

Consuming Poverty: The Unexpected Politics Of Food Aid In An Era Of Austerity, Maggie Dickinson

Dissertations, Theses, and Capstone Projects

This dissertation tracks the remarkable growth of food assistance in the U.S. over the past fifteen years and asks what this expansion of food aid means for poor people living in New York City. Much of the scholarly literature on welfare policy in the U.S argues that social programs have become more stingy and punitive, particularly since the passage of welfare reform in 1996. On the surface, this does not seem to be the case for the food stamp program or for emergency food providers like soup kitchens and food pantries. Since 2001 food stamp rolls have risen 120% in …

Voices From On High: Rhetorical Education In A Jewish Women's Writing Center, Andrea Rosso Efthymiou

Dissertations, Theses, and Capstone Projects

This ethnographic dissertation looks at how the mission statement at one institution of higher education--Yeshiva University (YU)--establishes rhetorical education for its undergraduate students. The research site for this study of rhetorical education and institutional mission is the college writing center at YU's women's campus, Stern College for Women. This study defines rhetorical education as the way an institution authorizes written, spoken, and behavioral communication, with the goal of developing its students as civic beings, through its institutional mission. My findings demonstrate how undergraduate writing tutors disidentify with institutional rhetorical education to subvert, resist, and revise institutional rhetorical education, offering alternatives …

De Novo Design And Engineering Of Functional Metal And Porphyrin-Binding Protein Domains, Bernard Howard Everson

Dissertations, Theses, and Capstone Projects

In this work, I describe an approach to the rational, iterative design and characterization of two functional cofactor-binding protein domains. First, a hybrid computational/experimental method was developed with the aim of algorithmically generating a suite of porphyrin-binding protein sequences with minimal mutual sequence information. This method was explored by generating libraries of sequences, which were then expressed and evaluated for function. One successful sequence is shown to bind a variety of porphyrin-like cofactors, and exhibits light- activated electron transfer in mixed hemin:chlorin e6 and hemin:Zn(II)-protoporphyrin IX complexes. These results imply that many sophisticated functions such as cofactor binding and electron …

Towards The Total Synthesis Of (+/-)-Gephyrotoxin 287c, Maciej E. Domaradzki

Dissertations, Theses, and Capstone Projects

Studies directed toward the total synthesis of (+/-)-Gephyrotoxin 287C are described herein. Even though the target alkaloid has been synthesized four times to date, it still presents an interesting synthetic challenge. Our ultimate goal is to develop an efficient enantioselective synthetic route utilizing oxazolone chemistry in order to demonstrate its utility as a dienophilic component in intramolecular Diels-Alder reactions. This is part of a greater ongoing study aimed at a range of suitable alkaloid targets.

Chapter 1 provides introduction to frog toxins as secondary metabolites and subsequently shifts to the target alkaloid. (+/-)-Gephyrotoxin 287C was originally described by Daly and …

Held And Dropped: A Study Of Metaphor And Subjective Experience In A Psychoanalytic Treatment, Alison Michele Ferst

Dissertations, Theses, and Capstone Projects

This study explores particular patterns of change that might unfold over the course of an intensive psychoanalytic treatment by mapping the forms of change that might take place in terms of a patient's subjective experience and the meaning that the patient attributes to it as reflected in the effort to express that experience in figurative language (i.e., metaphors). The data set was treatment session transcripts provided by P. A. Dewald over a period of 2 years and is partitioned by Dewald into three sequential phases.

Figurative language in general and metaphor in particular consists of essential forms of representation of …

The Effects Of Morpho-Phonemic And Whole Word Instruction On The Literacy Skills Of Adult Struggling Readers, Susan Gray

Dissertations, Theses, and Capstone Projects

This study investigated the effects of two kinds of word study on the literacy skills of 34 adult struggling readers. Young adults seeking high school equivalency diplomas were randomly assigned to intensive individual tutoring, two hours once a week for four weeks, in either morpho-phonemic or whole word study to learn academic vocabulary from a civics curriculum. Participants were African American and Latino adults in secondary education who had learned English either as their native language or as their second language in early childhood. Those given morpho-phonemic instruction analyzed Latin and Greek word origins, parsed morpheme and syllable structures, and …

The Ties That Bind: Gender, Race, And Empire In Caribbean Indenture Narratives, Alison Joan Klein

Dissertations, Theses, and Capstone Projects

This dissertation traces the ways that oppressive gender roles and racial tensions in the Caribbean today developed out of the British imperial system of indentured labor. Between 1837 and 1920, after slavery was abolished in the British colonies and before most colonies achieved independence, approximately 750,000 laborers, primarily from India and China, traveled to the Caribbean under indenture. This is a critical but under-explored aspect of colonial history, as this immigration dramatically altered the ethnic make up of the Caribbean, the cultural norms and traditions of those who migrated, and the structure of British imperialism. I focus on depictions of …

Tcr Alpha Lcr And Non-Lcr Cis-Elements Contributing To Tissue Specific Expression Of The Tcr Alpha Gene In Thymic And Peripheral T Cells, Martina Kucerova-Levisohn

Dissertations, Theses, and Capstone Projects

Orchestrated expression of multiple genes residing in the complex TCRα/δ/Dad1 locus requires tight control from multiple cis-acting elements. The TCRα locus control region (LCR), is positioned between TCRα and Dad1 gene, and has been implicated in the differential expression of both genes. In this study, we focus our work on the hypersensitive site (HS)1 prime (HS1'), located 3' of the classical Eα enhancer, within the TCRα LCR. We investigated its non- redundant role in TCRα expression in thymic and peripheral T cells as assayed by in vivo and in vitro studies. Furthermore, formation of HS1' in both lymphoid and …

`We Are All Stories In The End, I Want Mine To Be A Good One': College Students' Work-Family Expectations And The Role Of Educational Experiences, Chandra D. Mason

Dissertations, Theses, and Capstone Projects

While researchers have long been interested in the experiences of people who combine paid work with non-work roles (e.g., spouse, parent, eldercare provider), relatively little attention has been given to the expectations that people hold prior to occupying these roles, such as the amount of role conflict or fulfillment anticipated as a result of participating in both work and non-work roles. Even less is known about the factors that shape these expectations. For college students, these factors may include experiences of a college education (e.g., coursework that addresses gender roles, interacting with successful role models), yet, ironically, few studies have …

Opportunities For Play-Based Experiences In Post "No Child Left Behind" Kindergarten Classrooms: The Role Of Training, Resources, And Accountability Pressures In Meeting Best Practices, Cristina Medellin

Dissertations, Theses, and Capstone Projects

In response to No Child Left Behind (NCLB), opportunities for play-based experiences in classrooms have been challenged over the past decade. Despite research demonstrating the educational benefits of child driven play, teachers and schools have been pressured to focus on improving children's success on standardized assessments which may not relate to the developmental achievements expected from activity based experiences. To explore teachers' response to the tension between assessment driven mandates and best early childhood practices, this study investigated which factors influence teacher practices and values. Specifically, how do teacher training and classroom resources influence teachers' values about the appropriateness of …

The Neurophysiology Of Intersensory Selective Attention And Task Switching, Jeremy W. Murphy

Dissertations, Theses, and Capstone Projects

Our ability to selectively attend to certain aspects of the world and ignore others is fundamental to our day-to-day lives. The need for selective attention stems from capacity limitations inherent in our perceptual and cognitive processing architecture. Because not every elemental piece of our environment can be fully processed in parallel, the nervous system must prioritize processing. This prioritization is generally referred to as selective attention. Meanwhile, we are faced with a world that is constantly in flux, such that we have to frequently shift our attention from one piece of the environment to another and from one task to …

Estimation Of Outer-Middle Ear Transmission Using Dpoaes And Fractional-Order Modeling Of Human Middle Ear, Maryam Naghibolhosseini

Dissertations, Theses, and Capstone Projects

Our ability to hear depends primarily on sound waves traveling through the outer and middle ear toward the inner ear. Hence, the characteristics of the outer and middle ear affect sound transmission to/from the inner ear. The role of the middle and outer ear in sound transmission is particularly important for otoacoustic emissions (OAEs), which are sound signals generated in a healthy cochlea, and recorded by a sensitive microphone placed in the ear canal. OAEs are used to evaluate the health and function of the cochlea; however, they are also affected by outer and middle ear characteristics. To …

The Mechanisms Of Transmission: Examining The Effects Of Childhood Interpersonal Violence Across Generations, Amber Nemeth

Dissertations, Theses, and Capstone Projects

This study examined the direct relationship between maternal exposure to childhood interpersonal violence (sexual and/or physical abuse) and behavioral problems in her pre- to early-adolescent children. It also examined whether maternal aggression (psychological and physical aggression) and emotion dysregulation (lifetime PTSD diagnosis and alexithymia) exerted a significant indirect effect on this relationship. This study was a secondary analysis of data collected from a cross-sectional and cross-generational study designed to examine associations among maternal impairments (substance abuse, general psychopathology, neuropychological functioning), child-rearing deficits (parenting deficits, child neglect, child physical/ sexual abuse), and adverse child outcomes (self-regulation deficits, aggressive behavior, and substance …

Cationic Amphiphilic Synthetic Macromolecules With Superior Antibacterial Activity, Ashish Punia

Dissertations, Theses, and Capstone Projects

The increasing prevalence of antibiotic resistant bacteria (superbugs) has created a pressing need for new systems of antimicrobial agents. In this dissertation, I report on my extensive research on the design, synthesis, and development of synthetic amphiphilic macromolecules with antimicrobial activity and very low hemolytic impact. Synthetic amphiphilic polymers attack bacteria directly to rupture the cell membrane through electrostatic and hydrophobic interactions. However, the toxicity of such synthetic amphiphilic polymers against mammalian cells have impeded their therapeutic applications. We investigated the systematic structure/activities relationships for antibacterial and hemolytic activities of amphiphilic polyacrylates and poly(vinyl esters). Acrylate homopolymers with various lengths …

Development Of Functional Interactions Among Cortical And Trabecular Traits During Growth Of The Lumbar Vertebral Body, Melissa Ramcharan

Dissertations, Theses, and Capstone Projects

Variation in bone traits that contribute to increased fracture risk in the elderly is mainly established in adulthood. Previous studies have shown that in adults, cortical and trabecular traits are functionally related. How variations in traits develop to establish mechanical function in adult bone is not well understood. In this study, we examined temporal changes in the development of cortical and trabecular traits during growth in mouse lumbar vertebral body structures that have a wide range of genetic variants. We determined a sequence of events among traits that would suggest how functional bone structures developed. Examining bones in A/J, C57/BL6 …

Systematics And Biogeography Of Orthaea Kloztsch (Ericaceae: Vaccinieae), Nelson Salinas

Dissertations, Theses, and Capstone Projects

In the first chapter a study of the distribution patterns of the neotropical Vaccinieae (Ericaceae) is presented. Five areas of endemism were recovered: Central America, northern Chocó, southern Chocó, eastern Ecuador, and Yungas. Divergence times estimations indicate that the Andean clade of Vaccinieae migrated to South America during the Late Oligocene or Early Miocene (28.9-17.84 MA), and most of the subsequent diversification took place during the Tertiary. The Yungas was the first Andean area to be colonized, and several dispersals towards the north expanded their distribution range. Both areas of endemism and dispersal events were influenced by geological processes, such …

Biomolecule Mediating Synthesis Of Inorganic Nanoparticles And Their Applications, Zengyan Wei

Dissertations, Theses, and Capstone Projects

Project 1.

The conventional phage display technique focuses on screening peptide sequences that can bind on target substrates, however the selected peptides are not necessary to nucleate and mediate the growth of the target inorganic crystals, and in many cases they only show moderate affinity to the targets. Here we report a novel phage display approach that can directly screen peptides catalytically growing inorganic nanoparticles in aqueous solution at room temperature. In this study, the phage library is incubated with zinc precursor at room temperature. Among random peptide sequences displayed on phages, those phages that can grow zinc oxide (ZnO) …

Conformational Heterogeneity And Exchange Within The Junction Of The Human U2-U6 Snrna Complex Measured By 19f Nmr Spectroscopy, Caijie Zhao

Dissertations, Theses, and Capstone Projects

Pre-mRNA splicing, the process by which non-coding sequences are removed and coding sequences are ligated, plays an important role in the maturation of precursor messenger RNA molecules prior to their translation into proteins. In eukaryotes, splicing is catalyzed by the spliceosome, a large and dynamic nuclear macromolecular "machine" that comprises five small nuclear (sn)RNA molecules and more than one hundred proteins. Among the RNA components, the complex formed between the U2 and U6 snRNA molecules is implicated in catalytic activity. In this dissertation, I have used ¹⁹F NMR techniques to characterize the conformation ("fold") and dynamics of a protein-free …

Isolation Of Diverse Members Of The Aquificales From Geothermal Springs In Tengchong, China, Brian P. Hedlund, Anna-Louise Reysenbach, Liuquin Huang, John C. Ong, Zizhang Liu, Jeremy A. Dodsworth, Reham Ahmed, Amanda J. Williams, Brandon R. Briggs, Yitai Liu, Weiguo Hou, Hailiang Dong

Biology Faculty Publications and Presentations

The order Aquificales (phylum Aquificae) consists of thermophilic and hyperthermophilic bacteria that are prominent in many geothermal systems, including those in Tengchong, Yunnan Province, China. However, Aquificales have not previously been isolated from Tengchong. We isolated five strains of Aquificales from diverse springs (temperature 45.2–83.3°C and pH 2.6–9.1) in the Rehai Geothermal Field from sites in which Aquificales were abundant. Phylogenetic analysis showed that four of the strains belong to the genera Hydrogenobacter, Hydrogenobaculum, andSulfurihydrogenibium, including strains distant enough to likely justify new species ofHydrogenobacter and Hydrogenobaculum. The additional strain may represent a …

Mthfr C677t, Pt G20120a And Fv Leiden As Risk Factors For Thrombosis In Egyptian Pediatric All Patients, Mohamed Nagy Ahmed

Theses and Dissertations

Thrombosis is a well-known side effect associated with Acute Lymphoblastic Leukemia (ALL) treatment leading to significant morbidity rates. Thrombosis occurrence in ALL patients seems to be due to the interaction between the disease, the therapy and the possible inherited genetic defects affecting the hemostatic balance. In this study we aimed to assess the prevalence of prothrombotic defects- FV Leiden, MTHFR (Methylene Tetra Hydrofolate Reductase enzyme) C677T & prothrombin (PT) G20210A mutations in Egyptian pediatric ALL patients and its impact on the risk of thrombosis onset as well as to evaluate the impact of the presence of single versus multiple prothrombotic …

Development Of Real-Time Pcr Assay For Detection Of Total Bacteria In Beverage Emulsions, Essam Gamaleldin Elsisi

Theses and Dissertations

The rapid growth and expansion of the soft drinks market and the necessity to meet and maintain the consumers’ expectations of having high quality products safe for consumption, have both drawn the attention to the need for rapid and sensitive methods for the detection of potential microbial contaminations. This has made the current conventional culture-based methods inconvenient due to the relatively long periods of time they need to yield results, in addition to their relatively low sensitivity. In contrast, real-time PCR is a rapid and sensitive molecular detection technique, capable of providing quick detection and quantification methods of specific DNA …

The Role Of Ngos In Empowering Visually Impaired People To Access Education And Employment In Egypt, Nevine Sharaf

Theses and Dissertations

Disability is viewed as a developmental issue given that people with disability are usually excluded from mainstream economic and social opportunities. However, the attention given to the people with disability in Egypt is mostly confined to medical and scientific features. Local NGOs in Egypt have long been working with visually impaired people. However, there is limited literature and empirical research specifying the role of local NGOs in empowering the visually impaired people to access education and employability in Egypt. Thus the purpose of this study is to assess the role that local NGOs play in this regard. The methodology used …

Promising Antitumor Therapeutics Of Herbal Origin: Exploring Cytotoxic Activity Of Glycoalkaloids And Unraveling Underlying Mechanisms., Noha Nagdy Farrag

Theses and Dissertations

To evaluate the anticancer potential of the extracts of the two Solanaceae family plants: Solanum macrocarpon (African Eggplant) and Solanum seaforthianum (Brazilian Nightshade), cytotoxicity screening was performed. The extract exhibiting the most potent effect; Total glycoalkaloid extract of Solanum seaforthianum (TGASS) was then investigated further, through screening of individual compounds fractionated from it and comparing their cytotoxicity with each other and with other standard Solanum alkaloids. Further investigations were performed to define the underlying mechanisms by which each of the three most potent alkaloids function on hepatocellular carcinoma (HepG2) cell line. The hypothesis involves that alkaloids fractionated from the Solanaceae …

Recycling Of Waste Gypsum Boards To Produce New Drywalls And Non-Load Bearing Bricks, Nada Khaled Fathy Ragab

Theses and Dissertations

Recycling of gypsum boards wastes is attractive but challenging at the same time. The quality and quantity of the waste is quite important. The amount of gypsum board waste is on the rise. Millions of tons of gypsum board waste are produced annually and only a small percentage of gypsum board waste is recycled. This waste threatens the environment in three main ways: producing Hydrogen Sulfide gas when dumped in a moist environment, increasing the use of landfills and depleting natural resources. Consequently, the United States is considering the prohibition of gypsum board waste partial or full dumping in landfills …

Development Of Inhalable Microparticles For Drug Delivery To Deep Lung Tissues, Yasmine Houssam Eldin Abbas

Theses and Dissertations

Lung cancer is the deadliest solid tumor, leading to the deaths of more individuals than the combination of the three next most lethal cancers which are colon, prostate and breast cancer. According to the IARC, in 2012 lung cancer accounted for 13% (1.83 million) of cancer cases and caused 19% (1.56 million) of cancer deaths worldwide. Despite advances in surgery and drug discovery, lung cancer remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor diagnosis and the lack of targeted drug delivery platforms. The aim of this study was to develop a non-invasive, patient convenient …