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Articles 1411 - 1440 of 27530
Full-Text Articles in Entire DC Network
Grandiose And Vulnerable Narcissism: Where Do The Emotional Differences Lie?, Katherine E. Wolven
Grandiose And Vulnerable Narcissism: Where Do The Emotional Differences Lie?, Katherine E. Wolven
USC Aiken Psychology Theses
Narcissism can be conceptualized as existing on a continuum between grandiose and vulnerable phenotypes (Pincus & Lukowitsky, 2010). Previous studies found differences between narcissistic phenotypes in terms of behavioral task performance (Wallace & Baumeister, 2002) and emotional reactions to threatening conditions (Besser & Priel, 2010; Zeigler-Hill, Clark, & Pickard, 2008); however, research on emotion dysregulation was lacking in narcissistic populations. Thus, the purpose of the present study was to explore the subjective and objective emotional differences between the grandiose and vulnerable phenotypes of narcissism. In a laboratory manipulation, participants (N=63) completed self-report questionnaires, read emotionally-evocative vignettes describing achievement failure and …
Effects Of Amphetamine On Striatal Dopamine Release, Open-Field Activity, And Play In Fischer 344 And Sprague–Dawley Rats, Stephen M. Siviy, Lana S. Mcdowell, Samantha R. Eck, Alexandra Turano, Garnik Akopian, John P. Walsh
Effects Of Amphetamine On Striatal Dopamine Release, Open-Field Activity, And Play In Fischer 344 And Sprague–Dawley Rats, Stephen M. Siviy, Lana S. Mcdowell, Samantha R. Eck, Alexandra Turano, Garnik Akopian, John P. Walsh
Psychology Faculty Publications
Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning. To determine whether the dysfunctional play in this strain is associated with deficits in the handling and delivery of vesicular DA, the following experiments assessed the extent to which F344 rats are differentially sensitive to the effects of amphetamine. When exposed to amphetamine, striatal slices obtained from F344 rats showed a small increase in unstimulated DA release when compared with slices from Sprague–Dawley rats; they also showed a more rapid high …
Databasing Delinquency, Kevin Lapp
Databasing Delinquency, Kevin Lapp
UC Law Journal
Technological advances in recent decades have enabled an unprecedented level of surveillance by the government and permitted law enforcement to gather, store, and retrieve in real time enormous amounts of data. After nearly a century of limited record-making and enhanced confidentiality regarding juveniles, these data collection practices have quickly expanded to include youth. This Article uncovers the vast extent of modern data collection and distribution about juveniles by the criminal justice system from juvenile sex offender registration and their inclusion in gang and DNA databases, to schools turned into mandated law enforcement informants, to police and courts increasingly sharing juvenile …
Whaling In Circles: The Makahs, The International Whaling Commission, And Aboriginal Subsistence Whaling, Monder Khoury
Whaling In Circles: The Makahs, The International Whaling Commission, And Aboriginal Subsistence Whaling, Monder Khoury
UC Law Journal
In Anderson v. Evans, the Ninth Circuit held that the International Whaling Commission (“IWC”) Schedule’s approval of a quota to hunt whales for the Native American Makah Tribe (“Makahs”) violated the Marine Mammal Protection Act. The implications of this holding were troubling: despite the U.S. government and the IWC approving, on domestic and international levels, the Makahs’ whaling proposal in the 1990s, the Makahs were still unable to hunt whales legally. The Makahs’ right to whale stemmed from the 1855 Neah Bay Treaty, an agreement between the Makahs and the U.S. government in which the government promised the Makahs the …
Daily Eastern News: December 01, 2015, Eastern Illinois University
Daily Eastern News: December 01, 2015, Eastern Illinois University
December
No abstract provided.
Sex-Specific Changes In Walleye Abundance, Size Structure And Harvest Following Implementation Of Regulation To Protect Broodstock, Keith D. Koupal, Jordan D. Katt, Casey W. Schoenebeck, Brad E. Eifert
Sex-Specific Changes In Walleye Abundance, Size Structure And Harvest Following Implementation Of Regulation To Protect Broodstock, Keith D. Koupal, Jordan D. Katt, Casey W. Schoenebeck, Brad E. Eifert
Nebraska Game and Parks Commission: Staff Research Publications
The popularity of walleye Sander vitreus fishing has resulted in the development of specialized regulations that are designed to protect these fisheries. In the case of Sherman Reservoir, Sherman County, Nebraska, the walleye population provides a sportfishing opportunity and serves as broodstock for the state. In 2009, for the primary purpose of protecting female broodstock, the regulation changed from a harvest limit of four walleye with 457-mm minimum length to allowing a reduced harvest limit of two walleye within a harvest slot (381–508 mm) and one walleye more than 711 mm. This study examined existing data sets to assess the …
Population And Ecosystem Attribute Trends Of Aquatic Macroinvertebrates, Alyssabeth Beadle
Population And Ecosystem Attribute Trends Of Aquatic Macroinvertebrates, Alyssabeth Beadle
Honors Projects
For the past ten years Professor Keith Piccard of the Grand Valley Biology department has been collecting data on aquatic macroinvertebrates in Allendale Middle School’s Sevey drain. He has been studying how precipitation effects aquatic macroinvertebrate population numbers, diversity, and ecosystem attributes. Aquatic macroinvertebrates are defined as organisms without backbones that live on, under, or around rocks and sediment on the bottom of lakes, rivers, and streams. Aquatic macroinvertebrates must be able to be observed by the human eye without the aid of a microscope. The two most common aquatic macroinvertebrates are Scuds and Caddisfly Larvae which are displayed below …
Doctors Of The Holocaust: An Examination Of Both Ss And Prisoner Doctors, Amanda Kronemeyer
Doctors Of The Holocaust: An Examination Of Both Ss And Prisoner Doctors, Amanda Kronemeyer
Honors Projects
When examining the Holocaust, there are a great number of different facets and ways to go about learning about that part of history. One aspect of the Holocaust that has a great deal of information to look at is the medical implications. This could be looking at the actual medicine that occurred in the concentration camps, including medical experiments, to the SS men and prisoners that were appointed as doctors in the camps, to so much more. This paper will focus on the doctors that worked in the concentration camps, both SS men and prisoners. First, SS doctors will be …
Analysis Of An Electrospun Nanofiber Device Applicable To Limb Salvage: Mass Loss, Morphological Changes, And Quantification Of Antibiotic Release, Caitlin Quinn
Honors Theses
The creation of an electrospun nanofiber embedded with two antibiotics that will be used to prevent infection while also stimulating bone regeneration will be explored. The nanofiber will contain an aminoglycoside and a glycopeptide, and it is sought to deliver a sustained release of antibiotics for up to 12 weeks. To determine release rate, nanofiber samples are immersed in 10.0 mL of MiliQ water (MQ), incubated at 37°C, assayed at specific time intervals, and then analyzed using ultra performance liquid chromatography in tandem with mass spectrometry. A hydrophilic interaction liquid chromatography (HILIC) method utilizing ultra-performance liquid chromatography (UPLC) in tandem …
The Neurochemistry Of Group Singing: Bonding And Oxytocin, Jason Keeler
The Neurochemistry Of Group Singing: Bonding And Oxytocin, Jason Keeler
Masters Theses
The purpose of this study was to examine the neurochemical correlates of group vocal improvisation and to determine the feasibility of the research methods. One group of four participants sang together in two conditions: pre-composed and improvised. Concentrations of plasma oxytocin and adrenocorticotropic hormone (ACTH) were measured before and after each singing condition to assess levels of hormones associated with social affiliation, engagement and arousal. Successful implementation of the methodology, including recruitment, data collection, and sample analysis, served as the primary outcome of this study. ACTH concentrations decreased in both conditions, and significantly so in the pre-composed singing condition. Mean …
A High Performance Architecture For An Exact Match Short-Read Aligner Using Burrows-Wheeler Aligner On Fpgas, Dana Abdul Qader
A High Performance Architecture For An Exact Match Short-Read Aligner Using Burrows-Wheeler Aligner On Fpgas, Dana Abdul Qader
Masters Theses
Due to modern DNA sequencing technologies vast amount of short DNA sequences known as short-reads is generated. Biologists need to be able to align the short-reads to a reference genome to be able to make scientific use of the data. Fast and accurate short-read aligner programs are needed to keep up with the pace at which this data is generated. Field Programmable Gate Arrays have been widely used to accelerate many data-intensive bioinformatics applications.
Burrows-Wheeler Transform has been used in the theory of string matching which has led to the development of many short-read alignment programs. This thesis presents a …
Depositional Facies And Sequence Stratigraphy Of Niagaran-Lower Salina Reef Complex Reservoirs Of The Guelph Formation, Michigan Basin, Matthew J. Rine
Depositional Facies And Sequence Stratigraphy Of Niagaran-Lower Salina Reef Complex Reservoirs Of The Guelph Formation, Michigan Basin, Matthew J. Rine
Masters Theses
Hydrocarbon reservoirs in the Niagara-Lower Salina Reef Complex in the Michigan Basin have been extensively studied since the early 1960’s. These reservoirs host an immense hydrocarbon resource, existing as closely-spaced, highly-compartmentalized reservoirs that have produced >500 million barrels of oil and 2.9 trillion cubic feet of natural gas. Previous studies depict these “pinnacle reefs” as tall, symmetrical towers with a random distribution of facies. This study utilizes abundant core data (32 cores, 20-acre spacing), thin-section petrography, and petrophysical wire-line logs to reconstruct the geometry, facies distributions, depositional history, and sequence stratigraphy of the Columbus III Reef Complex within the Southern …
Retinal Architecture In Rgs9- And R9ap-Associated Retinal Dysfunction (Bradyopsia), Rupert W. Strauss, Adam M. Dubis, Robert F. Cooper, Rola Ba-Abbad, Anthony T. Moore, Andrew R. Webster, Alfredo Dubra, Joseph Carroll, Michel Michaelides
Retinal Architecture In Rgs9- And R9ap-Associated Retinal Dysfunction (Bradyopsia), Rupert W. Strauss, Adam M. Dubis, Robert F. Cooper, Rola Ba-Abbad, Anthony T. Moore, Andrew R. Webster, Alfredo Dubra, Joseph Carroll, Michel Michaelides
Biomedical Engineering Faculty Research and Publications
Purpose
To characterize photoreceptor structure and mosaic integrity in subjects with RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy.
Design
Observational case series.
Methods
setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy.
Results
Cone density at 100 μm from foveal center ranged from 123 132 cones/mm2to 140 013 cones/mm2 …
Co-Design Of Dynamic Real-Time Scheduling And Cooperative Control For Human-Agent Collaboration Systems Based On Mutual Trust, Xiaotian Wang
Co-Design Of Dynamic Real-Time Scheduling And Cooperative Control For Human-Agent Collaboration Systems Based On Mutual Trust, Xiaotian Wang
All Theses
Mutual trust is a key factor in human-human collaboration. Inspired by this social interaction, we analyze human-agent mutual trust in the collaboration of one human and (semi)autonomous multi-agent systems. In the thesis, we derive time-series human-agent mutual trust models based on results from human factors engineering. To avoid both over- trust and under-trust, we set up dynamic timing models for the multi-agent scheduling problem and develop necessary and sufficient conditions to test the schedulability of the human multi-agent collaborative task. Furthermore, we extend the collaboration between one human and multiple agents into the collaboration between multi-human network and swarm-based agents …
Influence Of Exurban Neighborhoods On Riparian Vegetation And Stream Salamanders In The Southern Appalachian Mountains, Nathaniel Weaver
Influence Of Exurban Neighborhoods On Riparian Vegetation And Stream Salamanders In The Southern Appalachian Mountains, Nathaniel Weaver
All Theses
The southern Appalachian Mountains have experienced large population growth and a change in land use in the past 30 years. The majority of development has been low density, suburban land, known as exurban development. Lotic Systems and riparian areas are severely degraded by conversion from urban to rural land uses. The long-term effects of exurbanization on riparian vegetative communities and stream salamanders in the southern Appalachian Mountains are not well known. We sought to determine if vegetative community composition and structure change with time since neighborhood development or with the amount of impervious surface within the watershed. In order to …
A Predictive Correlation Study: What Human Capital And Demographic Factors Relate To Credential Completion For Stem Students?, Rick Jenkins
A Predictive Correlation Study: What Human Capital And Demographic Factors Relate To Credential Completion For Stem Students?, Rick Jenkins
Doctoral Dissertations and Projects
This dissertation examines the educational attainment of college STEM (Science, Technology, Engineering, and Mathematics) students in Arkansas in an attempt to identify the human capital factors that predict completion of a STEM degree or certificate. Students seeking STEM credentials (having STEM majors) were identified using the state higher education database from the state of Arkansas, including public four-year universities and two-year colleges. STEM students from 32 colleges and universities were included from three cohorts and tracked for six academic years. The criterion variable was STEM credential earned, whether or not the student earned any STEM undergraduate credentials. The predictor human …
A Strategy Of Ministry For Small Korean-American Church Growth: Centered On Tallahassee Korean Community Presbyterian Church, Ju Yang
Doctoral Dissertations and Projects
Many small Korean-American churches have difficulties. The small number of members causes financial problem and causes member burn out. Also a lot of church members have difficulty which comes from the difference of language and culture in America. The purpose of this thesis project is to provide a strategy to help small Korean-American churches to grow and be more effective. Tallahassee Korean Community Presbyterian Church will be used as a model. Even though this is not an exceptionally successful church, it has potential for growth. First, literature research about church growth, worship, homiletics, leadership, and discipleship will be processed based …
A Retrospective Study Of The Motivations And Perceptions Of Industry Sponsors And Academia Regarding Mechanical Engineering Capstone Design Program, Varun Rawal
All Theses
The overall goal of this research is to understand and explore the motivation andvalue that industry gains from sponsoring senior year capstone design projects in theDepartment of Mechanical Engineering at Clemson University. Further, this researchcompares the true value as defined by the sponsoring companies against the perceivedvalue of the faculty recruiting these projects. It compares the thoughts between the facultymembers of the capstone program for the Department of Mechanical Engineering atClemson University and the company sponsoring those projects. This can help the facultyin dealing with the company sponsors when soliciting new projects.Capstone design program is a bridge that improves the …
Finite Element Analysis Of The Effect Of Acoustic Wavelength To Hierarchical Side Length And Facet Area For Elastic Scattering From Polygonal Rings And Geodesic Spheres, Ankit Kumar
All Theses
In this work, the frequency response from two-dimensional polygon and three-dimensional geodesic spheres is numerically simulated using a coupled structural acoustic finite element model. The model is composed of a submerged thin-walled elastic shell structure surrounded by an infinite acoustic air domain. Infinite elements are used to simulate the far-field acoustic radiation condition. Results for the faceted polygon and geodesic sphere are compared to their canonical counterpart viz. a circle/ring and a spherical shell. A unique feature of this study is to compare results as the number of facets in the polygon or geodesic is increased, such that the surface …
Use Of Electrochemistry To Monitor The Growth And Activity Of Clostridium Phytofermentans, Ariane Laurence Martin
Use Of Electrochemistry To Monitor The Growth And Activity Of Clostridium Phytofermentans, Ariane Laurence Martin
All Theses
Microbes have a wide range of metabolic capabilities available that make them industrially useful organisms. Monitoring these metabolic processes is a crucial component in efficient industrial application. Unfortunately, monitoring these metabolic processes is often invasive and time consuming especially within an anaerobic environment. Electrochemical techniques, such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) offer a non-invasive approach to monitor microbial activity and growth. We hypothesized that EIS and CV could be used to monitor Clostridium phytofermentans, an anaerobic and endospore-forming bacterium. C. phytofermentans ferments a wide range of sugars into hydrogen, acetate, and ethanol as fermentation by-products and …
Title Ix Giveth And The Religious Exemption Taketh Away: How The Religious Exemption Eviscerates The Protection Afforded Transgender Students Under Title Ix, Amanda Bryk
Cardozo Law Review
No abstract provided.
Socioeconomic Status And Study Abroad: Participation, Academic Performance, And Graduation, Steven Douglas Bell
Socioeconomic Status And Study Abroad: Participation, Academic Performance, And Graduation, Steven Douglas Bell
Educational Leadership & Workforce Development Theses & Dissertations
Research into retention, academic performance, and degree completion of study abroad program participants positively correlates with the assertion of Kuh, Kinzie, Schuh, Whitt, and Associates (2005) that study abroad is a high-impact educational activity. Literature on study abroad participation, academic performance, and graduation status is limited. This quantitative study adds to the literature on study abroad, and specifically examines to what extent participation, academic performance, and graduation at four and six years for study abroad students differ by socioeconomic status.
Generalisation, Decision Making, And Embodiment Effects In Mental Rotation: A Neurorobotic Architecture Tested With A Humanoid Robot, K Seepanomwan, D Caligiore, A Cangelosi, G Baldassarre
Generalisation, Decision Making, And Embodiment Effects In Mental Rotation: A Neurorobotic Architecture Tested With A Humanoid Robot, K Seepanomwan, D Caligiore, A Cangelosi, G Baldassarre
School of Engineering, Computing and Mathematics
Mental rotation, a classic experimental paradigm of cognitive psychology, tests the capacity of humans to mentally rotate a seen object to decide if it matches a target object. In recent years, mental rotation has been investigated with brain imaging techniques to identify the brain areas involved. Mental rotation has also been investigated through the development of neural-network models, used to identify the specific mechanisms that underlie its process, and with neurorobotics models to investigate its embodied nature. Current models, however, have limited capacities to relate to neuro-scientific evidence, to generalise mental rotation to new objects, to suitably represent decision making …
Systematic Review Of The Global Epidemiology, Clinical And Laboratory Profile Of Enteric Fever, Asma Azmatullah, Farah Naz Qamar, Durrane Thaver, Anita Km Zaidi, Zulfiqar A. Bhutta
Systematic Review Of The Global Epidemiology, Clinical And Laboratory Profile Of Enteric Fever, Asma Azmatullah, Farah Naz Qamar, Durrane Thaver, Anita Km Zaidi, Zulfiqar A. Bhutta
Department of Paediatrics and Child Health
Background: Children suffer the highest burden of enteric fever among populations in South Asian countries. The clinical features are non-specific, vary in populations, and are often difficult to distinguish clinically from other febrile illnesses, leading to delayed or inappropriate diagnosis and treatment. We undertook a systematic review to assess the clinical profile and laboratory features of enteric fever across age groups, economic regions, level of care and antibiotic susceptibility patterns.
Methods: We searched PubMed (January 1964-December 2013) for studies describing clinical features in defined cohorts of patients over varying time periods. Studies with all culture-confirmed cases or those with at …
The Development And Initial Evaluation Of Katatagan: A Resilience Intervention For Filipino Disaster Survivors, Ma. Regina Hechanova, Lynn Waelde, Pierce S. Docena, Liane Peña Alampay, Arsenio S. Alianan, Mary Jane B. Flores, Pia Anna P. Ramos, Maria Isabel E. Melgar
The Development And Initial Evaluation Of Katatagan: A Resilience Intervention For Filipino Disaster Survivors, Ma. Regina Hechanova, Lynn Waelde, Pierce S. Docena, Liane Peña Alampay, Arsenio S. Alianan, Mary Jane B. Flores, Pia Anna P. Ramos, Maria Isabel E. Melgar
Psychology Department Faculty Publications
This paper documents the development, pilot, and initial evaluation of Katatagan, a group-based resilience program designed to hone coping skills of Filipino disaster survivors. The paper describes vulnerabilities and protective factors of Filipino survivors based on previous research and key informant interviews. It also explains how Luthar and Cicchetti’s (2000) resilience framework and guidelines for the development of interventions were incorporated in the objectives and the design of the resilience intervention. The intervention consists of six modules that aim to improve self-ecacy, adaptive coping skills, and well-being of Filipino survivors. The paper presents an initial evaluation of Katatagan among college …
Novel Methods For Identification Of Posttranslational Lipid Modified Proteins By Mass Spectrometry, Ruchika P. Bhawal
Novel Methods For Identification Of Posttranslational Lipid Modified Proteins By Mass Spectrometry, Ruchika P. Bhawal
Chemistry & Biochemistry Dissertations - Archive
Study of posttranslational modifications (PTMs) is very important for developing potential new drugs for the treatment of several diseases. Posttranslational lipid modifications are major PTMs which help proteins to anchor to cell membranes and facilitate protein-protein interactions. There are several kinds of lipid modifications of proteins. The major lipid modifications are palmitoylation, myristoylation and prenylation. Prenylation are of two types - farnesylation and geranylgeranylation. These modifications are involved with several human cancers and genetic diseases. Hutchinson-Gilford progeria syndrome (HGPS), a disease which causes premature aging for children is the product of prenylation. Understanding the mechanism of prenylation and their substrates …
Wills, Trusts, Guardianships, And Fiduciary Administration, Mary F. Radford
Wills, Trusts, Guardianships, And Fiduciary Administration, Mary F. Radford
Mercer Law Review
This Article describes selected cases and significant legislation from the period of June 1, 2014 through May 31, 2015 pertaining to Georgia fiduciary law and estate planning.
Multi-Ancestry Genome-Wide Association Study Of 21,000 Cases And 95,000 Controls Identifies New Risk Loci For Atopic Dermatitis, Lavinia Paternoster, Marie Standl, Johannes Waage, Hansjörg Baurecht, Melanie Hotze, David P. Strachan, John A. Curtin, Klaus Bønnelykke, Chao Tian, Atsushi Takahashi, Jorge Esparza-Gordillo, Alexessander C. Alves, Jacob P. Thyssen, Herman T. Den Dekker, Manuel A. Ferreira, Elisabeth Altmaier, Patrick M. Sleiman, Feng Li Xiao, Juan R. Gonzalez, Ingo Marenholz, Birgit Kalb, Maria Pino Yanes, Cheng-Jian Xu, Lisbeth Carstensen, Maria M. Groen-Blokhuis, Cristina Venturini, Craig E. Pennell, Sheila J. Barton, Albert M. Levin, Ivan Curjuric, Mariona Bustamante, Eskil Kreiner-Møller, Gabrielle A. Lockett, Jonas Bacelis, Supinda Bunyavanich, Rachel A. Myers, Anja Matanovic, Ashish Kumar, Joyce Y. Tung, Tomomitsu Hirota, Michiaki Kubo, Wendy L. Mcardle, A J. Henderson, John P. Kemp, Jie Zheng, George Davey Smith, Franz Rüschendorf, Anja Bauerfeind, Min Ae Lee-Kirsch, Andreas Arnold, Georg Homuth, Carsten O. Schmidt, Elisabeth Mangold, Sven Cichon, Thomas Keil, Elke Rodríguez, Annette Peters, Andre Franke, Wolfgang Lieb, Natalija Novak, Regina Fölster-Holst, Momoko Horikoshi, Juha Pekkanen, Sylvain Sebert, Lise L. Husemoen, Niels Grarup, Johan C. De Jongste, Fernando Rivadeneira, Albert Hofman, Vincent Jaddoe, Suzanne Gma Pasmans, Niels J. Elbert, André G. Uitterlinden, Guy B. Marks, Philip J. Thompson, Melanie C. Matheson, Colin F. Robertson, Janina S. Ried, Jin Li, Xian Bo Zuo, Xiao Dong Zheng, Xian Yong Yin, Liang Dan Sun, Maeve A. Mcaleer, Grainne M O'Regan, Caoimhe Fahy, Linda E. Campbell, Milan Macek, Michael Kurek, Donglei Hu, Celeste Eng, Dirkje S. Postma, Bjarke Feenstra, Frank Geller, Jouke Jan Hottenga, Christel M. Middeldorp, Pirro Hysi, Veronique Bataille, Tim Spector, Carla Mt Tiesler, Elisabeth Thiering, Badri Pahukasahasram, James J. Yang, Medea Imboden, Scott Huntsman, Natàlia Vilor-Tejedor, Caroline L Relton, Ronny Myhre, Wenche Nystad, Adnan Custovic, Scott T Weiss, Deborah A Meyers, Cilla Söderhäll, Erik Melén, Carole Ober, Benjamin A Raby, Angela Simpson, Bo Jacobsson, John W Holloway, Hans Bisgaard, Jordi Sunyer, Nicole M Probst Hensch, Keoki L. Williams, Keith M Godfrey, Carol A Wang, Dorret I Boomsma, Mads Melbye, Gerard H Koppelman, Deborah Jarvis, Wh Irwin Mclean, Alan D Irvine, Xue Jun Zhang, Hakon Hakonarson, Christian Gieger, Esteban G Burchard, Nicholas G Martin, Liesbeth Duijts, Allan Linneberg, Marjo-Riitta Jarvelin, Markus M Noethen, Susanne Lau, Norbert Hübner, Young-Ae Lee, Mayumi Tamari, David A Hinds, Daniel Glass, Sara J Brown, Joachim Heinrich, David M Evans, Stephan Weidinger
Multi-Ancestry Genome-Wide Association Study Of 21,000 Cases And 95,000 Controls Identifies New Risk Loci For Atopic Dermatitis, Lavinia Paternoster, Marie Standl, Johannes Waage, Hansjörg Baurecht, Melanie Hotze, David P. Strachan, John A. Curtin, Klaus Bønnelykke, Chao Tian, Atsushi Takahashi, Jorge Esparza-Gordillo, Alexessander C. Alves, Jacob P. Thyssen, Herman T. Den Dekker, Manuel A. Ferreira, Elisabeth Altmaier, Patrick M. Sleiman, Feng Li Xiao, Juan R. Gonzalez, Ingo Marenholz, Birgit Kalb, Maria Pino Yanes, Cheng-Jian Xu, Lisbeth Carstensen, Maria M. Groen-Blokhuis, Cristina Venturini, Craig E. Pennell, Sheila J. Barton, Albert M. Levin, Ivan Curjuric, Mariona Bustamante, Eskil Kreiner-Møller, Gabrielle A. Lockett, Jonas Bacelis, Supinda Bunyavanich, Rachel A. Myers, Anja Matanovic, Ashish Kumar, Joyce Y. Tung, Tomomitsu Hirota, Michiaki Kubo, Wendy L. Mcardle, A J. Henderson, John P. Kemp, Jie Zheng, George Davey Smith, Franz Rüschendorf, Anja Bauerfeind, Min Ae Lee-Kirsch, Andreas Arnold, Georg Homuth, Carsten O. Schmidt, Elisabeth Mangold, Sven Cichon, Thomas Keil, Elke Rodríguez, Annette Peters, Andre Franke, Wolfgang Lieb, Natalija Novak, Regina Fölster-Holst, Momoko Horikoshi, Juha Pekkanen, Sylvain Sebert, Lise L. Husemoen, Niels Grarup, Johan C. De Jongste, Fernando Rivadeneira, Albert Hofman, Vincent Jaddoe, Suzanne Gma Pasmans, Niels J. Elbert, André G. Uitterlinden, Guy B. Marks, Philip J. Thompson, Melanie C. Matheson, Colin F. Robertson, Janina S. Ried, Jin Li, Xian Bo Zuo, Xiao Dong Zheng, Xian Yong Yin, Liang Dan Sun, Maeve A. Mcaleer, Grainne M O'Regan, Caoimhe Fahy, Linda E. Campbell, Milan Macek, Michael Kurek, Donglei Hu, Celeste Eng, Dirkje S. Postma, Bjarke Feenstra, Frank Geller, Jouke Jan Hottenga, Christel M. Middeldorp, Pirro Hysi, Veronique Bataille, Tim Spector, Carla Mt Tiesler, Elisabeth Thiering, Badri Pahukasahasram, James J. Yang, Medea Imboden, Scott Huntsman, Natàlia Vilor-Tejedor, Caroline L Relton, Ronny Myhre, Wenche Nystad, Adnan Custovic, Scott T Weiss, Deborah A Meyers, Cilla Söderhäll, Erik Melén, Carole Ober, Benjamin A Raby, Angela Simpson, Bo Jacobsson, John W Holloway, Hans Bisgaard, Jordi Sunyer, Nicole M Probst Hensch, Keoki L. Williams, Keith M Godfrey, Carol A Wang, Dorret I Boomsma, Mads Melbye, Gerard H Koppelman, Deborah Jarvis, Wh Irwin Mclean, Alan D Irvine, Xue Jun Zhang, Hakon Hakonarson, Christian Gieger, Esteban G Burchard, Nicholas G Martin, Liesbeth Duijts, Allan Linneberg, Marjo-Riitta Jarvelin, Markus M Noethen, Susanne Lau, Norbert Hübner, Young-Ae Lee, Mayumi Tamari, David A Hinds, Daniel Glass, Sara J Brown, Joachim Heinrich, David M Evans, Stephan Weidinger
Center for Health Policy and Health Services Research Articles
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with …
Emerging Biomarkers In Psoriatic Arthritis, So Yeon Paek, Ling Han, Matthew Weiland, Chuan-Jian Lu, Kathleen Maksimowicz-Mckinnon, Li Zhou, Henry W. Lim, James T. Elder, Qing-Sheng Mi
Emerging Biomarkers In Psoriatic Arthritis, So Yeon Paek, Ling Han, Matthew Weiland, Chuan-Jian Lu, Kathleen Maksimowicz-Mckinnon, Li Zhou, Henry W. Lim, James T. Elder, Qing-Sheng Mi
Dermatology Articles
Psoriasis is an immune-mediated skin disease which affects 2-4% of the worldwide population. Approximately 20-30% of patients with psoriasis develop psoriatic arthritis (PsA), a frequently destructive and disabling condition. As skin manifestations precede joint symptoms in nearly all patients with PsA, identification of biomarkers for early prediction of joint damage is an important clinical need. Because not all patients with PsA respond to treatment in the same fashion, identification of biomarkers capable of predicting therapeutic response is also imperative. Here, we review existing literature and discuss current investigations to identify potential biomarkers for PsA disease activity, with particular emphasis on …
New Insights Into Micrornas In Skin Wound Healing, Fatima Fahs, Xinling Bi, Fu-Shin Yu, Li Zhou, Qing-Sheng Mi
New Insights Into Micrornas In Skin Wound Healing, Fatima Fahs, Xinling Bi, Fu-Shin Yu, Li Zhou, Qing-Sheng Mi
Dermatology Articles
Chronic wounds are a major burden to overall healthcare cost and patient morbidity. Chronic wounds affect a large portion of the US, and billions of healthcare dollars are spent in their treatment and management. microRNAs (miRNAs) are small, noncoding double-stranded RNAs that post-transcriptionally downregulate the expression of protein-coding genes. Studies have identified miRNAs involved in all three phases of wound healing including inflammation, proliferation, and remodeling. Some miRNAs have been demonstrated in vitro with primary keratinocyte wound healing model and in vivo with mouse wound healing model through regulation of miRNA expression to affect the wound healing process. This review …