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Mitochondrial Dysfunction And Lipid Metabolism Play A Major Role In The Lethality Caused By Developmental Alcohol Exposure, Payam Khodabakhshi

Master's Theses

Exposure to ethanol during development causes a variety of physical, developmental, and cognitive abnormalities. In humans, these symptoms are referred to as fetal alcohol syndrome (FAS) or fetal alcohol spectrum disorder (FASD). Previously, we established a Drosophila melanogaster model of FASD and showed that developmental ethanol exposure causes oxidative stress, and that this is a primary cause of the developmental lethality and delay associated with ethanol exposure. In this study, we investigate the role of fatty acid metabolism and lipid accumulation in connection to FASD. Here, we show that developmental ethanol exposure leads to dysregulation of fatty acid metabolism and …

Looking Backward, Moving Forward: The Experiences Of Indo-Fijian Immigrant Women In California, Ambrita Nand

Master's Theses

This study helps address gaps in knowledge concerning the lives of Indo-Fijian immigrant women in California and offers a space for their voices to be heard. The subsequent chapters investigate the lives of five Indo-Fijian immigrant women and their experiences upon migrating to Modesto, California. Using a qualitative research approach, data were collected through participant observations, semi-structured in-depth interviews and informal conversations. The data are presented as anthropological silhouettes, a form of life-writing (the recording of events and experiences of a life), which explores each individual woman’s experience with life in Fiji to her eventual migration and transition to life …

Synthesis, Structural Characterization And Chromatographic Evaluation Of Silica Hydride-Based Perfluorinated Stationary Phase, Harshada Suyog Natekar

Master's Theses

Silica hydride based stationary phases have demonstrated unique selectivity and specificity for small sized polar molecules. The weakly hydrophobic nature of silica hydride is thought to be the key reason for its remarkable retention capabilities. Traditional stationary phases bonded with fluorine moieties have also exhibited enhanced retention of small polar molecules. In this research, a perfluorinated silica hydride stationary phase was synthesized by hydrosilation and silanization procedures. Chromatographic characterization of the newly packed column was carried out by a large number of retention studies. The separation capabilities of the column were evaluated in both the aqueous normal-phase (ANP) and reversed-phase …

Complex Effects Of Nitrogen Pollution And Grazing On Nectar Resources Of The Adult Bay Checkerspot Butterfly (Euphydryas Editha Bayensis), Nidhi Jain

Master's Theses

Recent anthropogenic increases in atmospheric nitrogen due to urbanization and combustion have had many adverse effects on natural systems, including loss of biodiversity, especially in sensitive habitats. One such region is the serpentine ecosystem of Coyote Ridge in San Jose, CA, the last refuge for recurring populations of the federally threatened Bay Checkerspot Butterfly (BCB) (Euphydryas editha bayensis). Increases in non-native grass cover and decreases in native forb cover (including cover of the BCB’s native larval host plants) have been attributed to the fertilizing effects of increased atmospheric nitrogen deposition. To counteract this effect, grazing has been implemented as a …

Chloroflexi: The Tale Of A Bacterium Present In Human And Environmental Habitats, Jayashree Sanjeeviraman

Master's Theses

The phylum Chloroflexi is relatively unexplored, with the majority of its representatives being uncultivable. As a result, these microorganisms have not been characterized beyond their morphology and simple staining reactions, making the study of this phylum extremely challenging. Chloroflexi has been detected in the human oral cavity of patients suffering from peri-implantitis and in the vagina of patients suffering from bacterial vaginosis. Interestingly, Chloroflexi is also present in various environments such as freshwater lakes, soil, deep-sea sponges, hot springs and activated wastewater. Isolation of an environmental Chloroflexi with high 16S rRNA gene homology to a human-associated counterpart could be used …

Identifying The Building Blocks Of Disruptive Innovation In Cornell Cooperative Extension: A Grounded Theory, Andrew S. Turner

Education Doctoral

Cooperative Extension (CE) faces significant challenges as it attempts to adapt core business principles to a rapidly changing 21st century landscape. Disruptive innovation (DI) is a powerful organizational change theory that emerged in the private sector but is now being increasingly utilized in the social sector. The study utilized grounded theory methodology to identify examples of programmatic innovation in CE that align with the characteristics of DI and to look for common building blocks supporting and sustaining innovation in CE. A purposeful sample of nine Cornell Cooperative Extension (CCE) program innovators were identified in three categories of innovation: youth development, …

Agroecological, Climatic, Land Elevation And Socio-Economic Determinants Of Pesticide Use At The Farm Level In Bangladesh, S Rahman

School of Geography, Earth and Environmental Sciences

This study examines the influence of agroecology, climate, land elevation and socio-economic factors on pesticide use at the farm level using a large survey data of 2083 farms from 17 districts covering 10 agroecological zones in Bangladesh by applying a Tobit model. Overall, 75.4% of farmers used pesticides in any one crop. Within the pesticide users, pesticide use rate is highest in oilseed production estimated at BDT 2508.6ha−1 (3.74% of gross output value) followed by jute at BDT 1976.1ha−1 (1.88% of gross output value). Pesticide use is significantly lower in floodplain agroecologies, high rainfall areas, high land and low land …

Virulence Of Photorhabdus Spp.: Examining The Roles Of Environment, Evolution, And Genetics In Insect Mortality, Dana Blackburn

Theses and Dissertations

Entomopathogenic nematodes (EPNs) (genera Heterorhabditis and Steinernema) kill their invertebrate hosts with the aid of a mutualistic bacterium. The bacteria (Xenorhabdus spp. for steinernematids and Photorhabdus spp. for heterorhabditids) are primarily responsible for killing the host and providing the nematodes with nutrition and defense against secondary invaders. Photorhabdus is a Gram-negative bacterium in the Enterobacteriaceae family with high virulence towards their insect hosts. To achieve high mortality rates Photorhabdus produces a variety of virulence factors such as toxins, lipases, proteases, secretion systems, and fimbriae. EPNs are amenable to laboratory rearing and mass production for biocontrol applications against insects …

Maternal Denning Phenology And Substrate Selection Of Polar Bears (Ursus Maritimus) In The Southern Beaufort And Chukchi Seas, Jay Wesley Olson

Theses and Dissertations

Loss of sea ice due to global warming may affect the phenology and distribution of polar bear (Ursus maritimus) denning by altering access to denning habitats. We examined trends in the selection of maternal denning substrate (land versus sea-ice denning) in the southern Beaufort Sea (SB), addressing the potential influence of summer land-use and fall sea-ice conditions on substrate selection. We developed an algorithm based on statistical process control methods to remotely identify denning bears and estimate denning phenology from temperature sensor data collected on collars deployed 1985–2013 in the SB and Chukchi Sea (CS). We evaluated cub …

The Influence Of Transcranial Random Noise Stimulation On Motor Skill Acquisition And Learning In A Modified Golf Putting Task, Lidio Lima De Albuquerque

UNLV Theses, Dissertations, Professional Papers, and Capstones

Transcranial random noise stimulation (tRNS) is a form of non-invasive brain stimulation (NIBS) that has been shown to increase motor performance in simple motor tasks. The purpose of the present study was to determine the influence of tRNS on motor skill acquisition and learning in a complex, modified golf putting task in young adults. Twenty-four (n = 12 per group) healthy young adult males were allocated to either a tRNS group or a SHAM stimulation group. Both groups performed 6 trials of the golf putting task in a baseline testing block, followed by 4 practice blocks of 15 trials. The …

An Evidence Based Approach To Sepsis: Educational Program, Dolores Perez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Evidence-based guidelines for recognizing and treating sepsis have been available for decades, yet healthcare providers do not adhere to the recommendations. Sepsis can progress rapidly if not recognized early. Literature reports reveal that sepsis is the leading cause of death in non-cardiac intensive care units (ICUs), and it is one of the most expensive conditions to treat. A hospital in the Las Vegas, Nevada area had previously introduced sepsis management prescriptions in 2011 with no formal education of sepsis guidelines to nurses. The original hospital’s sepsis management prescription sets followed guidelines dated 2008. The purpose of this project was to …

Evaluation Of Breastfeeding Curricula In Didactic Programs In Dietetics And Dietetic Internships Across The United States, Maria Diane Swiss

Theses and Dissertations

Background: Breastfeeding is known to have many benefits for both mothers and infants. With the Surgeon General's Call to Action to Support Breastfeeding, health professionals have increased their attention on breastfeeding competency. Objectives: This study aimed to evaluate breastfeeding curricula that are currently being covered in didactic programs in dietetics (DPDs) and dietetic internships (DIs) across the United States. Methods: Two-part surveys were sent to all directors of DPDs and DIs (n=475) with instructions to forward the second portion of the survey to instructors of classes that taught about breastfeeding. Qualtrics software was used for data …

Educated Birth: Beliefs Vs. Outcomes, Lauren Presley

Human Nutrition and Hospitality Management Undergraduate Honors Theses

“Our infant mortality rate is a national embarrassment.”¹ The words seem shocking and harsh across the headline of a 2014 Washington Post article. The thought of America not only not being the best at something, but falling upsettingly behind, is a foreign concept to many who view America as a nation inferior to none. However, the statistics on infant mortality rate tell the stark truth that of 26 “wealthy” countries, the U.S. ranks last, with a sobering 6.1 deaths per 1,000 live infant births.²

Part of the Healthy People 2020 Objectives is to reduce the rate of infant …

Development And Evaluation Of Amphotericin B Loaded Iron Oxide Nanoparticles For Targeted Drug Delivery To Systemic Fungal Infections, Pavan Balabathula

Theses and Dissertations (ETD)

A targeted nanotheronostic drug delivery system to diagnose and treat life threatening invasive fungal infections (IFIs) such as cryptococcal meningitis was designed, developed, characterized, and evaluated. To address the development processes, first, iron oxide nanoparticles (IONP) (34-40 nm) coated with bovine serum albumin (BSA), loaded and targeted with amphotericin B (AMB) (AMB-IONP) was formulated by applying a layer by layer approach. Several designs (A, B, C, D, & E) of AMB-IONP were developed and their physicochemical properties such as drug loading with HPLC method, particle size, poly dispersity index (PDI), and ζ-potential using dynamic light scattering (DLS) technique, morphology with …

Sleep Disordered Breathing And Pregnancy: Prevalence And Outcomes At Delivery, Ryan Lyle Nations

Dissertations

Introduction
Sleep Disordered Breathing (SDB) during pregnancy is associated with maternal and neonatal morbidity, and in-hospital mortality. A recent prevalence study using the Nationwide Inpatient Sample reported an obstructive sleep apnea (OSA) prevalence of 7.3 per 10,000 in 2013, a rate of 24% per year over the last decade. The rise in prevalence mirrors the rise in obesity. Military Treatment Facilities (MTF) have seen an increase in obesity and related co-morbidities with an unknown prevalence of SDB. Most studies have been conducted in high-risk populations; the general prevalence of SDB and its association with adverse pregnancy outcomes in a military …

Viticulture Performance And Cold Hardiness Attributes Of Select Winegrape Cultivars In The Western Snake River Plain Of Idaho, Jacob Joseph Cragin

Boise State University Theses and Dissertations

This two part study was carried out in the Snake River Valley American viticulture area (SRV AVA) in Idaho. This area is a northern latitude, high elevation plateau where growing season is delimited by cold temperature. For the first part of the study, the performance of red and white-skinned winegrape cultivars (Vitis vinifera, L.) were compared to that of the widely grown cultivars Merlot and Cabernet Sauvignon. Phenology, juice composition, yield, cold injury, and cold hardiness were observed during the 2011 and 2012 growing seasons. Phenological events occurred later in the cooler 2011 season than the warmer 2012 …

Plant Toxins Influence Diet Selection And Intestinal Parasites In A Specialist Herbivore, Marcella Rene Fremgen

Boise State University Theses and Dissertations

Herbivores select plants and patches that generally maximize nutrient intake and minimize intake of plant secondary metabolites (PSMs). Protein is important for growth, reproduction and maintenance, but maximizing intake of protein is often limited by concentrations of PSMs that are potentially toxic to herbivores and energetically expensive to process. However, the consequences of ingesting PSM are often dose-dependent. At high doses, PSMs generally have negative physiological effects and are avoided, but some PSMs can be therapeutic against parasites at low doses and could therefore be selected. We used Greater Sage-grouse (Centrocercus urophasianus, hereafter, sage-grouse) to test how PSMs influence …

Investigations Into The Cross-Infectivity Of Nematode Parasites Of Cattle And Sheep, Eva Marie Wray

Graduate Theses and Dissertations

The existence of anthelmintic resistance is not singular in parasite species, host species or geographic region. It has become a problem of worldly stature, especially when considering sheep nematodes. Recommendations have been modified from chemical-based control to multipart, managerial intervention. Compared with nematodes of cattle, the worldwide resistance of sheep nematodes to anthelmintic remedies is much more pronounced and urgent. As the resistance to essentially all anthelmintic classes approaches a cautionary level, the implementation of non-chemical controls has grown increasingly essential. Six-6 to 8 month old Holstein steer calves, six-5 month old Katahdin ram lambs and eight-5 month old Suffolk …

The Interaction Of Community Size And Perceived Local Political Efficacy Among Low-Income Individuals, Dylan Allen Brugman

Electronic Theses and Dissertations

As the world’s population continues to urbanize, urban studies are increasingly important. Studying the social science behind the rise of the city and its effect on various social phenomena should be a priority for scholars in the field of politics, sociology, and communication, because of the reasonable assumption that the environment of the city alters the way that a person engages people and systems within the city. This is especially true for peripheral and marginalized populations that often lack access to the social institutions necessary to improve their livelihoods. Using Diffusion of Innovation and urban studies theories of Anomie, Gemeinschaft …

Calorimetry And Body Composition Research In Broilers And Broiler Breeders, Justina Victoria Caldas Cueva

Graduate Theses and Dissertations

Indirect calorimetry to study heat production (HP) and dual energy X-ray absorptiometry (DEXA) for body composition (BC) are powerful techniques to study the dynamics of energy and protein utilization in poultry. The first two chapters present the BC (dry matter, lean, protein, and fat, bone mineral, calcium and phosphorus) of modern broilers from 1 – 60 d of age analyzed by chemical analysis and DEXA. DEXA has been validated for precision, standardized for position, and equations and validations developed for chickens under two different feeding levels. These equations are unique to the machine and software in use. Research in broilers …

Community-Based Rehabilitation Supports For Social Inclusion And Work Participation Of Young Adults With Visual Impairment In Kenya: A Case Study, Philomena Jepkemboi Tanui

Graduate Theses and Dissertations

Young adults with a visual impairment (VI) experience less interaction with the community that impacts the way they relate to the world as they transition to the larger society where they face significant barriers of adjustment, exclusion, and work participation. Young adults with VI contend with cultural stigma, inequality, poor self-esteem caused by marginalization, a low quality of life (QOL), and lack of Social support systems that exist beyond the home. The aim of this study was to understand the perceptions of young adults with VI in Elgeyo-Marakwet and Kisumu Counties of Kenya concerning the barriers to community inclusion and …

Southeastern Monochamus And Their Interactions With Healthy Shortleaf Pine Trees And Associated Ips Grandicollis Bark Beetles, Matthew Walker Ethington

Graduate Theses and Dissertations

Insects in the genus Monochamus are medium to large-sized, wood-boring beetles whose primary hosts in the Northern Hemisphere are pine trees. These beetles interact with both conifer hosts and associated insects throughout their life history. Past research has demonstrated that Monochamus are saprophagic, but recent findings show that they may colonize healthy pine trees. To determine if southeastern Monochamus could colonize healthy pines, adult Monochamus were attracted to healthy shortleaf pine trees from May to September, 2014, using host volatiles, Ips bark beetle kairomones, and congeneric pheromones. Subsequent development of oviposited eggs from 18 host trees was monitored. The results …

Autophagy And Its Potential Role In Stress And Feed Efficiency Using Avian Lines, Alissa Laura Piekarski

Graduate Theses and Dissertations

Autophagy is a highly conserved cellular mechanism that is responsible for the degradation and recycling of damaged organelles. Recently, autophagy has been involved in critical roles during overall development of the organism and degradation of damaged cellular components. This pathway has witnessed dramatic growth in the last few years and has been extensively studied in yeast and mammals, however, there is a paucity of information in avian (non-mammalian) species. First, we characterized genes involved in the autophagy pathway in male and female Jungle Fowl to determine gender and tissue specific differences. Secondly, tissue and genotype differences in Japanese quail selected …

Evaluation Of Bacillus Spp Candidates For Aflatoxin B1 Biodegradation In Broiler Chickens, Rosario Galarza Seeber

Graduate Theses and Dissertations

Poultry health has been traditionally maintained by hygenic measures, vaccinations, and the use of antibiotics. Modern husbandry management considers the use of probiotics as a natural way to protect birds against many everyday pathogens. Different strains of Bacillus spp. have proved to have beneficial effects in poultry production. However, the most used bacterium in commercial probiotics is Lactobacillus, a vegetative cell. In contrast, Bacillus spp are bacterial spores, highly resistant to harsh conditions, which makes them preferable, in some cases, to Lactobacillus because of shelf life and storage conditions. There is published information regarding mycotoxin detoxification by bacteria. Mycotoxins are …

Field Screening Of Diverse Soybean Cultivars For Flood Tolerance, Jane Achando Khatenje Mokua

Graduate Theses and Dissertations

Flooding can significantly reduce soybean growth, development, and yield. Therefore, screening and identification of flood-tolerant soybeans will enhance development of cultivars that are well suited for flood-prone areas. Sets of screening tests were conducted in Stuttgart, Arkansas using three separate but related experiments, with the purpose of establishing effective flood tolerance screening protocol that can identify tolerant and sensitive cultivars. Each experiment was completely randomized with three replications. The first experiment involved screening of 256 maturity group (IV and V) cultivars. Flooding was imposed at the fifth-node (V5) or first-bloom (R1) stage for ten days. Post-flood visual ratings and stand …

Evaluation Of The Impact Of Meat And Bone Meal Nutritional Variability On Broiler Performance, Christopher Caleb Eagleson

Graduate Theses and Dissertations

The objective of this trial was to determine if varying the nutritional composition of meat and bone meal (MBM) would impact broiler performance and yield compared to diets which provide a consistent quality of MBM. Twelve hundred day-old male broilers from the Cobb 500 female line were randomly allocated to 48 pens (25 chicks/pen; 22 square feet) and grown to 49 days of age. Starter, grower, and withdrawal diets were formulated to contain MBM at 10, 7.5 and 5% respectively using the Cobb nutritional standards. Four treatments provided were: 1) H.J. Baker proprietary blend, ProPlus 57 fed continuously; 2) MBM …

The Knowledge, Attitude, And Self-Reported Behaviors Of Psychiatric Nurses Towards Obese Psychiatric Patients On Atypical Anti-Psychotic Medications, Marcia D. Williams-Hailey

Theses & Dissertations

Background/Purpose: Obesity has continued to increase over the years with increase in morbidity and mortality. The advancement of psychiatric treatment has resulted in a higher prevalence of obesity among the psychiatric population related to the side-effects of the newer atypical anti-psychotics. This study addresses nurses’ attitudes towards obesity and people who are obese, focusing on psychiatric patients. Negative attitudes and low knowledge about psychiatric patients on atypical anti-psychotics can interfere with psychiatric nurses’ therapeutic potential to support patients with health promotion behaviors. The purpose of this study was to develop an instrument to measure the knowledge, attitudes, and self-reported behavior …

Postcolonialism And The Marshallese Diaspora: Structural Violence And Health In The Marshallese Community In Springdale, Arkansas, Alexander J. Hirata

Master's Theses

Despite moving to the United States for better healthcare, among other benefits, Marshallese Compact of Free Association (COFA) migrants residing in Springdale, Arkansas continue to face similar acute health problems as Marshallese living in the Republic of the Marshall Islands (RMI), and often without access to health services. These problems include high rates of noncommunicable diseases, such as type 2 diabetes and thyroid cancer, as well as rare conditions such as Hansen’s Disease.

To research this, I studied the limited texts surrounding the Marshallese diaspora, as well as relevant bodies of literature: postcolonialism, Pacific migration theory, and global health and …

Efficacy Of Galactooliosaccharide (Gos) And/Or Rhamnose-Based Synbiotics In Enhancing Ecological Performance Of Lactobacillus Reuteri In The Human Gut And Characterization Of Its Gos Metabolic System, Monchaya Rattanaprasert

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Probiotic L. reuteri has potential to produce antimicrobial compounds and secrete immunosuppressive factors. These metabolic attributes could benefit the human host by providing colonization resistance (competitive and metabolic exclusion) against enteropathogens and mitigating inflammation. As metabolically active cells are fundamental to such probiotic properties, synbiotic approaches that supply L. reuteri with a source(s) of carbon, energy, and/or external electron acceptor for cell growth in the gut environment could therefore prompt the probiotic to engage in beneficial activities. In this study, the efficacy of GOS and/or rhamnose-based synbiotic approaches in promoting colonization persistence and metabolic activity of L. reuteri was evaluated. …

Preference Mapping Of Whole Grain And High Fiber Products: Whole Wheat Bread And Extruded Rice And Bean Snack, Ashley J. Bernstein

Department of Food Science and Technology: Dissertations, Theses, and Student Research

The rise of unhealthy lifestyles and diets among Americans is leading to an influx of health-conscious consumers on the search for more nutritious, health-promoting food options that match their taste preferences. The aim of this research is to determine consumer preferences and specific attributes of whole grain and high fiber products that drive acceptability through descriptive analysis and preference mapping on whole wheat breads and an extruded pinto bean and brown rice flour snack puff.

Commercial whole wheat breads, characterized by 26 appearance, aroma, flavor, and texture attributes, were separated into two distinct groups. The first group consisted of attributes …