Digital Commons Network^™

Twitter Sentiment Classification For Measuring Public Health Concerns, Xiang Ji, Soon Ae Chun, Zhi Wei, James Geller

Publications and Research

An important task of public health officials is to keep track of health issues, such as spreading epidemics. In this paper, we are addressing the issue of spreading public concern about epidemics. Public concern about a communicable disease can be seen as a problem of its own. Keeping track of trends in concern about public health and identifying peaks of public concern are therefore crucial tasks. However, monitoring public health concerns is not only expensive with traditional surveillance systems, but also suffers from limited coverage and significant delays. To address these problems, we are using Twitter messages, which are available …

A Compelling Interest? Using Old Conceptions Of Public Health Law To Challenge The Affordable Care Act’S Contraceptive Mandate, Joshua Joel

Georgia State University Law Review

No abstract provided.

Psst! Wanna Buy A Bridge? Ip Transfers Of Non-Existent Property, Stephen T. Black

Georgia State University Law Review

No abstract provided.

A Comparison Of The Effects Of A Web-Based Education Program About The Icu Environment And A Standard Education Program On Anxiety, Depression, And Acute Stress Experienced Among Family Members Of Icu Patients, Chrystal Leigh Lewis

Dissertations

Family members of ICU patients may experience anxiety, depression, and acute stress disorder symptoms. A need identified by the multi-society task for critical care research was to study the usefulness of interventions to quantify and treat anxiety, depression, and stress symptoms experienced by family members of ICU patients (Deutschman et al., 2012). This task force encouraged investigating using technology to address this need. (Deutschman et al.). The purpose of this prospective, quasi-experimental nonequivalent control group (pretest/posttest) design study was to compare the effect of standard ICU education and a web-based education program about the ICU environment on the level of …

Antibodies To Pseudogymnoascus Destructans Are Not Sufficient For Protection Against White-Nose Syndrome, Joseph S. Johnson, Deeann M. Reeder, Thomas M. Lilley

KIP Articles

White-nose syndrome (WNS) is a fungal disease caused by Pseudogymnoascus destructans (Pd) that affects bats during hibernation. Although millions of bats have died from WNS in North America, mass mortality has not been observed among European bats infected by the fungus, leading to the suggestion that bats in Europe are immune. We tested the hypothesis that an antibody-mediated immune response can provide protection against WNS by quantifying antibodies reactive to Pd in blood samples from seven species of free-ranging bats in North America and two free-ranging species in Europe. We also quantified antibodies in blood samples from little brown myotis …

Non-Ost Route Transition Interventions Among Injecting Drug Users In Kabul, Afghanistan: A Qualitative Feasibility Assessment Based On Institutional Stakeholders’ Views, William P. Tootle Jr

Master's Theses

An HIV epidemic threatens injecting drug users in Kabul, Afghanistan. Although opioid substitution therapy (OST) has been proven to reduce the spread of HIV and decrease injecting drug use in many parts of the world, including on a small scale in Afghanistan, political obstacles suggest that at this time it may not be a viable intervention there. In this thesis, therefore, I assess the feasibility of implementing an alternative to OST as an HIV-prevention strategy, namely, a non-OST route-transition intervention (RTI) designed to encourage and enable opiate users to switch from injecting to smoking (also called chasing). Based on semi-structured …

The Human And Environmental Effects Of Cbrn Weapons, Brendan M. Doran

Student Theses 2015-Present

Since the first use of modern weapons of mass destruction during the First World War, the World has lived in fear of these horrifying instruments of death. Gripped by this fear, countries around the world have continued to research, develop, and test these weapons in the spirit of mutually assured destruction. Over the years, science and warfare have continually refined their methods of human extermination, bringing forth some of the most terrifyingly effective weapon systems ever devised. However, the testing and use of these weapons is often a step into the unknown. The repercussions of deploying these weapons are sometimes …

Gene Expression Associated With White Syndromes In A Reef Building Coral, Acropora Hyacinthus, Rachel M. Wright, Galina V. Aglyamova, Eli Meyer, Mikhail V. Matz

Biological Sciences: Faculty Publications

Background: Corals are capable of launching diverse immune defenses at the site of direct contact with pathogens, but the molecular mechanisms of this activity and the colony-wide effects of such stressors remain poorly understood. Here we compared gene expression profiles in eight healthy Acropora hyacinthus colonies against eight colonies exhibiting tissue loss commonly associated with white syndromes, all collected from a natural reef environment near Palau. Two types of tissues were sampled from diseased corals: visibly affected and apparently healthy. Results: Tag-based RNA-Seq followed by weighted gene co-expression network analysis identified groups of co-regulated differentially expressed genes between all health …

The Impact Of Peptide Nucleic Acid Fluorescence In Situ Hybridization (Pna Fish®) Rapid Diagnostic Testing On The Initiation Of Appropriate Antifungal Therapy In Patients With Candida Species Bloodstream Infections, Jenna Lee Ksiazkiewicz

Undergraduate Honors Thesis Collection

Background: Traditional methods for detecting positive blood cultures include the use of broth bottles with sensitive indicators for growth. These techniques can take 24-48 hours to signal a positive test. Another 24 hours are often required to determine the species of the organism. The use of rapid diagnostic testing for Candida species bloodstream infections provides accurate species identification in less than two hours.

Objective: Evaluate the time to appropriate antifungal therapy in patients in which rapid diagnostic testing was utilized.

Methods: This study was a retrospective, observational cohort of patients who had positive blood cultures for Candida species and had …

A Ten Year Retrospective Study Of Pediatric Pneumonia Cases In Haiti, Talia A. Savic

Master's Theses

No abstract provided.

The Medical Response To The Black Death, Joseph A. Legan

Senior Honors Projects, 2010-2019

This paper discusses the medical response to the Black Death in both Europe and the Middle East. The Black Death was caused by a series of bacterial strands collectively known as Yersinia pestis. The Plague originated in the Mongolian Steppes. It was spread westward by the east-west trading system. Once it arrived in the Crimea in 1346, Italian merchants helped spread it throughout the Mediterranean. Medicine in Europe and the Middle East were centered on Galen’s theory of humors. There were many religious explanations for the Plague, but the main medical explanation was the spread of bad air, or …

Structural Elucidation Of Aggr-Activated Regulator, Aar, In Enteroaggregative Escherichia Coli, Andrew Heindel

Senior Honors Projects, 2010-2019

Travelers’ Diarrhea is the number one cause of childhood death in the world. Enteroaggregative Escherichia coli (EAEC) is one of the main causes of this disease. EAEC adhere to the surface of the intestine and stack in a brick-like pattern. Via an unstudied quorum-sensing mechanism, these bacteria express a variety of virulence factors that lead to diarrhea. The long-term goal of this research is to elucidate the mechanism by which EAEC changes from benign to virulent. A previously-unstudied open-reading frame in EAEC, AggR activated repressor (Aar), has recently been hypothesized to act as one of the major transcription factors influencing …

Comparative Analysis Of Anti-Bd Bacteria From Six Malagasy Frog Species Of Ranomafana National Park, Kelsey Savage

Senior Honors Projects, 2010-2019

As Malagasy amphibians are facing an impending extinction crisis from the lethal skin fungus Batrachochytrium dendrobatidis (Bd), it has become imperative to proactively mitigate the threat. Bd sporangia develop in the skin of infected amphibians and cause the skin to thicken, leading to ionic imbalance and eventual heart failure. It has been shown that certain bacterial species are able to inhibit Bd growth on amphibians by producing antifungal metabolites. Community-based probiotics are one approach used to combat chytridomycosis by inoculating an environment with Bd-inhibitory bacteria so that many amphibian species are treated at once. With this method, it is important …

Mapping Soil Erosion Risk And Safety Factors Of The Massanutten Trail System, Joshua R. Foery, Philip V. Sturm

Senior Honors Projects, 2010-2019

Public mountain biking and hiking trails can pose challenges to trail-user safety. The purpose of this project is to improve the overall safety factors on the Massanutten Western Slope, in eastern Rockingham County, Virginia, where a 15-plus mile trail system has been made available to a broad range of users. Owned by Massanutten Resort, the trail system is in a remote, forested area frequented by local off-road cyclists, runners, hikers, as well as seasonal tourists and is maintained by the Shenandoah Valley Bicycle Coalition (SVBC). This multifaceted project, which integrates ESRI ArcGIS, Trimble Pathfinder, USDA Soil Survey Geographic (SSURGO) data, …

An Exploration Of Hepatitis Polices And Prevalence In Prison: An Ecological Approach, Kristen Lynn Stives

Theses and Dissertations

Hepatitis is an infectious disease that affects millions of people worldwide. The current project seeks to achieve two objectives: 1) To understand how hepatitis policies affect hepatitis prevalence in prison, and 2) To understand how hepatitis prevalence in prison affects the general population. Using a content analysis of correctional policies available through each state Department of Corrections (DOC) and secondary data from the 2010 Census, Centers for Disease Control and Prevention, and Corrections Compendium; hepatitis prevalence and policies are analyzed. The content analysis employed for this study revealed that some states have more comprehensive policies than others. However, all states …

Characterization Of The Relationship Of Ros And Bcl-2 Family Members During Streptococcus Pneumoniae And Staphylococcus Aureus Challenge, Katie Elizabeth Heath

Theses and Dissertations

Apoptosis of innate immune is an important part of proper resolution of infection and inflammation. One major protein involved in apoptosis is p53 up-regulated mediator of apoptosis (PUMA). We hypothesize apoptosis induced by the p53/PUMA pathway is initially triggered by ROS thereby preventing neutrophils from defaulting to another form of cell death or remaining in a state of hyper-activation that is harmful to the host. HL-60 granulocytic cells were stimulated with the Streptococcus pneumoniae strain SpxB-. Despite inducing both ROS and DNA damage, PUMA transcription and subsequent apoptosis appeared to be independent of both factors. However, PUMA is still relevant …

Cave Cyanobacteria Showing Antibacterial Activity, Vasiliki Lamprinou, Kyriaki Tryfinopoulou, Emmanuel N. Velonakis, Alkiviadis Vatopoulos, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Adriani Pantazidou, Athena Economou-Amilli

International Journal of Speleology

Cave Cyanobacteria - thriving in an ‘extreme’ environment with interesting species biodiversity - are supposed to be a potential source of bioactive compounds. Lipid extracts from pure cultures of two recently established Cyanobacteria from Greek caves, Toxopsis calypsus and Phormidium melanochroun, were used for antibacterial screening against human pathogenic bacteria (reference and clinical isolates). Antimicrobial Susceptibility testing for both taxa was carried out using the disc-diffusion (Kirby Bauer) method, while preliminary data applying the standard broth microdilution method for the determination of the Minimal Inhibitory Concentration (MIC) are given only for T. calypsus. Antibacterial activity was demonstrated against the …

Lyme Disease In The Northeast: Altered Ecosystems And Public Health Impacts, Elisa L. Russo

Student Theses 2015-Present

Lyme disease has spread rapidly throughout the United States since its original discovery in 1975. An increasing threat to public health, this common vector-borne disease is transferred to a human after receiving a bite from an infected blacklegged tick (Ixodes scapularis). Humans have contributed to the massive influx of tick populations and Lyme disease cases through the introduction of invasive flora and fauna, overhunting of apex predators, and altering areas of land for urbanization. Quantitative data from the CDC and USDA on Lyme disease cases and white-tailed deer populations in the United States demonstrates the impact of human …

Bat Hibernacula Inventory And Microclimate Monitoring Study, Grand Canyon-Parashant National Monument, Az, J. Judson Wynne

KIP Data Sets and Technical Reports

Submitted to:Grand Canyon-Parashant National Monument, National Park Service 345 E. Riverside Dr. St. George, Utah 84790 Submitted by:J. Judson Wynne, Ph.D., Department of Biological Sciences Colorado Plateau Biodiversity Center Northern Arizona University Flagstaff, AZ 86011 Submitted under: Task Agreement # H1200-09-0005 Colorado Plateau Cooperative Ecosystem Studies Unit Northern Arizona University Abstract:Addressing a knowledge gap concerning the winter ecology of bats on Grand Canyon-Parashant National Monument in preparation for the western advance of white-nose syndrome (WNS), this paper provides a summary of a three-year study to estimate population trends of two known cave-roosting bat hibernacula (PARA-0901 and PARA-1401 Caves). Beginning in …

Cannabinoid-Mediated Epigenetic Regulation Of Immune Functions, Jessica Margaret Sido

Theses and Dissertations

The cannabinoid system consisting of exogenous and endogenous ligands as well as dedicated receptors has been proposed to play a regulatory role in immune functions. The exogenous cannabinoid Δ9-tetrahydrocannabinol (THC), one of the most widely studied marijuana derivatives, has been associated with multiple anti-inflammatory properties over the years. The majority of THC research has centered on the shift from Th1 to Th2 responses however, the complexity of inflammation has since increased. Recent studies have revealed that epigenome, Th cell subsets, and immunoregulatory cell induction, are all known to impact inflammation. In the current research, we have attempted to look holistically …

Full Issue 44(2)

International Journal of Speleology

No abstract provided.

Functional Recovery: A Mixed Methods Study Of The Specific Variables Within A Post-Hospital Inter-Disciplinary Brain Injury Rehabilitation - Residential Program, Victoria Harding

Dissertations, 2014-2019

The mixed methods explanatory design study examined specific constructs of Post Hospital Interdisciplinary Brain Injury Rehabilitation – Residential (PHIDBIR-R) programs that positively influenced gains in function. The investigation involved exploring the phenomenon of individuals’ experiences while participating in a PHIDBIR-R program as part of recovery from brain injury. The study’ primary purpose was to understand individuals who make the greatest gains in function while participating in these programs, as measured by the Mayo-Portland Adaptability Inventory-4 (MPAI-4) change scores from admission to discharge and what are the components of these programs that may contribute to individuals’ gains in function.

Data were …

Trypanosoma Cruzi Prevalence In The Domestic Canine Population In Central And Eastern Kentucky, Katelyn Cox

Mahurin Honors College Capstone Experience/Thesis Projects

Domestic canines are regarded as natural sentinelsfor the transmission of vector-borne pathogens since infection in an owner’s dog suggests the presence of the vector in or around the household. In collaboration with the University of Kentucky’s Veterinary Diagnostic Lab in Lexington, Kentucky, we have investigated the prevalence of Trypanosoma cruzi (the causative agent of Chagas disease) in canines from central and eastern Kentucky via a serological test, polymerase chain reaction (PCR), and DNA sequencing. In addition, Canine SNAP 4Dx plus tests (Idexx Laboratories, Inc.) were used to determine the prevalence of four other vector-borne pathogens: Ehrlichia canis/ewingii, Borrelia burgdorferi, Anaplasma …

Experiences Of Slow Violence In Poor Kenyan Communities: Micro Disasters, Formalized Aid Responses, And Community Support Through Social Networks, Jennifer L. Willett

Doctoral Dissertations

Experiences of Slow Violence in Poor Kenyan Communities: Micro Disasters, Formalized Aid Responses, and Community Support through Social Networks

Jennifer Willett, Ph.D.

University of Connecticut, 2015

Despite increasing focus on the physical environment within social work, the profession at-large is failing to integrate concerns about environmental degradation into research, education, and practice. Using a slow violence frame, this study applied a qualitative phenomenological design to collect data through interviews and field notes about environmental degradation and responses in 19 poor communities in Kenya. Rather than describe mega disasters as the source of their environmental problems, participants detailed “micro disasters.” Micro …

Celebration Of Learning 2015: Full Program, Augustana College, Rock Island Illinois

Celebration of Learning

Full program of the 2015 Celebration of Learning at Augustana College.

Using Education And A Prevention Protocol Tool To Decrease The Incidence Of Pressure Ulcers In A Nursing Home, Kristina L. Scalzitti

Evidence-Based Practice Project Reports

Over 1.3 million persons are residents in nursing homes (NHs); one in ten have pressure ulcers. The purpose of this evidence based practice project was to determine if implementation of a pressure ulcer prevention tool, along with staff education, decreases the incidence of pressure ulcers within the NH. Florence Nightingale’s Environmental Model and the Stetler Model were used to guide this project. The setting was a NH in northwest Indiana. Eleven nurses attended a 15 minute educational session on pressure ulcer prevention and implementation of the Pressure Ulcer Prevention Protocol Intervention (PUPPI) tool. PowerPoint slides were distributed and flyers about …

Synchronous Control Of A Reinforcement Learning Based Brain-Machine Interface With Biological Feedback, Noeline W. J. A. L. Prins

Open Access Dissertations

Brain-Machine Interfaces (BMIs) have the potential of restoring functionality of persons suffering from paralysis and amputations. At present, BMIs have been developed to use cortical neural signals and control prosthetic devices or to stimulate paralyzed limbs. However, these BMIs rely on an external training signal (usually desired kinematics) as a reference to infer an error signal to be able to adapt the decoder appropriately and learn the task. For amputees and paralyzed persons, a desired kinematic cannot be measured directly. We propose to acquire an error or reward signal from the brain itself as a training signal for motor decoders. …

Emergence Of Multidrug Resistant Influenza A(H1n1)Pdm09 Virus Variants In An Immunocompromised Child Treated With Oseltamivir And Zanamivir., Daisuke Tamura, Roberta L. Debiasi, Margaret Okomo-Adhiambo, Vasiliy P. Mishin, Angela P. Campbell, Brett Loechelt, Bernhard L. Wiedermann, Alicia M. Fry, Larisa V. Gubareva

Pediatrics Faculty Publications

Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase. When phenotypically evaluated by neuraminidase inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by four neuraminidase inhibitors including oseltamivir, zanamivir, peramivir and laninamivir.

Biological Sciences Newsletter - May 2015, Department Of Biological Sciences, East Tennessee State University

Biological Sciences Newsletters

No abstract provided.

Treatment Options For Carbapenem-Resistant Enterobacteriaceae Infections, Haley J. Morrill, M. Pogue, Keith S. Kaye, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

This article provides a comprehensive review of currently available treatment options for infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance in Gram-negative bacteria is an emerging and serious global public health threat. Carbapenems have been used as the “last-line” treatment for infections caused by resistant Enterobacteriaceae, including those producing extended spectrum ß-lactamases. However, Enterobacteriaceae that produce carbapenemases, which are enzymes that deactivate carbapenems and most other ß-lactam antibiotics, have emerged and are increasingly being reported worldwide. Despite this increasing burden, the most optimal treatment for CRE infections is largely unknown. For the few remaining available treatment options, there are …