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Exploiting Bacteriophages And Associated Peptidoglycan Hydrolases With Potential For Biocontrol In Food Related Applications, Lorraine Endersen

Theses

The work presented in this thesis describes the isolation and characterisation of novel bacteriophages, and the subsequent exploitation of their bactericidal properties against two opportunistic food related pathogens, Mycobacterium avium subsp. paratuberculosis (MAP) and Cronobacter sakazakii.

MAP is a proven animal pathogen known to cause Johne’s disease in cattle but has been implicated as a causative agent of Crohn’s disease in humans. Despite the fact that this association has yet to be proven, significant focus has been directed towards evaluating the consequences of consuming milk contaminated with MAP. Accordingly, six mycobacteriophages were isolated and characterised in terms of temperature and …

Novel Interventions For Hiv Self-Management In African American Women: A Systematic Review Of Mhealth Interventions, Kimberly Adams Tufts, Kaprea F. Johnson, Jewel Goodman Shepherd, Juyoung Lee, Muna S. Bait Ajzoon, Lauren B. Mahan, Miyoung Kim

Ellmer School of Nursing Faculty Publications

The purpose of this systematic review was to assess the quality of interventions using mobile health (mHealth) technology being developed for and trialed with HIV-infected African American (AA) women. We aimed to assess rigor and to ascertain if these interventions have been expanded to include the broad domain of self-management. After an extensive search using the PRISMA approach and reviewing 450 records (411 published studies and 39 ongoing trials atclinicaltrials.gov), we found little completed research that tested mHealth HIV self-management interventions for AA women. Atclinicaltrials.gov, we found several mHealth HIV intervention studies designed for women in general, forecasting a promising …

Describing The Health Care Needs Of School-Age Children In Sub-Saharan Africa In Order To Develop A Model Of A Nurse-Run School-Based Health Clinic, Bonnie Tong

Yale School of Nursing Digital Theses

Objective: Rural Kenya is affected by health disparities and poor health outcomes among school-age children. This paper identifies gaps in health care among school-aged children in rural Kenya, in order to identify a health care model to meet those gaps.

Design: The results of a systematic review on the health care needs were triangulated with field notes from interviews of stakeholders in a rural Kenyan village. Needs were then compared with currently available health care resources to identify gaps.

Sample: Multiple databases were searched to identify relevant articles published between the years 2000- 2014. Interviews were conducted with health workers, …

Counting Uncounted Gunshot Injuries: A Capture‐Recapture Study Of People Minding Their Own Business, Zev Balsen

Yale Medicine Thesis Digital Library

Objectives. To apply a novel statistical method to create a comprehensive estimate of incidence of firearm related injuries.

Methods. A database of firearms injuries in New Haven, Connecticut, during a five- month period was created with records from law enforcement, emergency departments, emergency medical services (EMS), news media, and the medical examiner. The overlap of these various sources was operationalized in a capture-recapture model to generate an estimate of uncounted firearms injuries, and log linear modeling was used to control for positive and negative dependencies.

Results. The combined data sources revealed 49 firearms injuries occurring during the study period within …

Case Finding For Pulmonary Tuberculosis Among People Who Inject Drugs In Dar Es Salaam, Tanzania, Akash Gupta

Yale Medicine Thesis Digital Library

CASE FINDING FOR PULMONARY TUBERCULOSIS AMONG PEOPLE WHO INJECT DRUGS IN DAR ES SALAAM, TANZANIA. Akash Gupta. Jessie Mbwambo. Ibrahim Mteza. Sheela Shenoi. Barrott Lambdin. Cassian Nyandindi. Basra Ismail Doula, Said Mfaume, and Robert Douglas Bruce. Department of Internal Medicine, Yale University, School of Medicine, New Haven, CT.

Active case finding is a World Health Organization (WHO)-endorsed strategy for improving case detection of tuberculosis. Despite WHO recommendations for active case finding among people who inject drugs (PWID), there are few published studies. The historical focus of case finding has been in populations that are HIV-positive, incarcerated, or at higher occupational …

Use Of The Health Belief Model To Understand Hpv Vaccine Behavior In Female Undergraduates, Chu He

Master's Theses and Doctoral Dissertations

Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the US and causes several cancers. HPV vaccines can protect individuals against multiple HPV strains that can cause certain cancers. Despite the benefits, 51% of college women have received the HPV vaccine. The purpose of this study was to better understand why women choose to get the HPV vaccine and others do not. An emailed link was sent to 8,889 EMU female undergraduate students. Chi-Square Tests for Independence were used to determine relationships between variables. Data from 1,126 female undergraduates ranging in age from 18 to 26 were …

Social Contexts Of Infant Feeding And Infant Feeding Decisions, Ellen J. Schafer, Natalie A. Williams, Siri Digney, Marion E. Hare, Sato Ashida

Department of Child, Youth, and Family Studies: Faculty Publications

Background: Infant feeding takes place within a network of social relationships. However, the social context in which infant feeding advice is received remains underresearched.

Objective: The objective of this study was to evaluate the social contexts of infant feeding by examining individual and relationship characteristics of mothers and network members associated with advice to exclusively breastfeed, exclusively formula feed, or use a combination of breast milk and formula.

Methods: Information about 287 network members was reported by 80 low-income mothers during a one-time survey. Characteristics of relationships associated with mothers receiving advice (exclusively breastfeed/formula feed, combination feed) from each network …

The Importance Of The Right To Food For Achieving Global Health, Emilie K. Aguirre

Faculty Scholarship

The Framework Convention on Global Health (FCGH) represents a significant opportunity to realize the right to health globally. However, in order to succeed the FCGH must be carefully considered: it must take a new evidence-based approach that departs meaningfully from past shortcomings in realizing the right to health. Central to this approach is recognizing, formally incorporating, and operationalizing the right to adequate food. This right should be correctly interpreted as a right to a standard of nutritional quality and not as a right to a minimum number of calories. Because nutrition is critical to the achievement and maintenance of good …

Developing Local Guidelines For Management Of Sepsis In Adults: Sepsis Guidelines For Pakistan (Sgp), Madiha Hashmi, Fazal Hameed Khan, Sarwar Zubairi, S. Tipu Sultan, Saeeda Haider, Sadqa Aftab, Javed Husain, Anwar Ul Haq, Zahid Akhtar Rao, Amin Khuwaja, Syed Farjad Sultan, Zunairah Rais, Roohina Baloch, Naseem Salahuddin, Aslam Khan, Faisal Sultan, Kamran Chima, Amjad Ali, Gohar Ali

Department of Anaesthesia

Background: The purpose of developing ‘Sepsis Guidelines for Pakistan’ (SGP) is to provide clinicians practicing in local hospitals with a framework to aid timely recognition and management of adult patients in sepsis by adopting evidence-based recommendations of Surviving Sepsis Campaign (SSC) tailored to available resources. These recommendations are not meant to replace the SSC Guidelines.
Methodology: SGP is an initiative of Pakistan Society of Critical Care Medicine (PSCCM). Four key decision points to be addressed in the guidelines were identified by a thirteen member multidisciplinary committee i.e., grading the hospitals in the country, recognition of sepsis and associated organ dysfunction, …

Knowledge And Risk Perceptions Of The Ebola Virus In The United States, Jj Rolison, Y Hanoch

School of Psychology

OBJECTIVES: The Ebola epidemic has received extensive media coverage since the first diagnosed cases of the virus in the US. We investigated risk perceptions of Ebola among individuals living in the US and measured their knowledge of the virus. METHOD: US residents completed an online survey (conducted 14-18 November 2014) that assessed their Ebola knowledge and risk perceptions. RESULTS: Respondents who were more knowledgeable of Ebola perceived less risk of contracting the virus and were less worried about the virus, but also regarded Ebola as more serious than less knowledgeable respondents. The internet served as a major source of additional …

The Psychological Effects Of Medical Research On Animal Subjects And The Ramifications For The Applicability Of The Research Results, Morgan Damm

University Honors Theses

Historically, animals have been used in medical research to bring about many of the medical breakthroughs and advances seen today. The successful studies are accompanied by numerous, often concealed, failed studies that are inapplicable to human medicine due to stress and distress changing the "normal" physiological parameters of that animal. The psychological stresses observed on the research animals are numerous and include habitat inconsistencies, exposures to abnormal conditions, experimental stresses, and the anticipation of awaiting a procedure. Often published papers disguise these conditions with delicate terminology to eliminate question of error in their data. When an animal is mentally, or …

The Role Of Speech-Language Pathologists In Swallowing Treatment Of Individuals With Hiv/Aids, Sarah Lynn Warner

Online Theses and Dissertations

The role of speech-language pathologists (SLPs) in the assessment and treatment of dysphagia in individuals living with HIV/AIDS is relatively absent from the literature. Dysphagia is described as difficulty swallowing that can be caused by oral indicators, structural dysfunction, and neurological disease (Bladon & Ross, 2007; Bobba et al., 2007; Nkuize et al., 2010). Dysphagia is a prevalent symptom secondary to the HIV/AIDS virus, yet dysphagia in the HIV/AIDS population often goes untreated (Bladon & Ross, 2007). One way to improve assessment and treatment of dysphagia is to ensure medical professionals are knowledgeable of the communication and swallowing disorders that …

Mucocutaneous Manifestations And The Relationship To Cd4 Lymphocyte Counts Among Turkish Hiv/Aids Patients In İstanbul, Turkey, Özlem Altuntaş Aydin, Hayat Kumbasar Karaosmanoğlu, Ramazan Korkusuz, Mehmet Özeren, Özcan Nazlican

Turkish Journal of Medical Sciences

Dermatologic findings differ among countries but no sufficient data about Turkish HIV-infected patients exist in the literature. Therefore, our aim in this study was to document the dermatologic manifestations and their relationships with CD4 cell counts among HIV/AIDS patients visiting our clinic for the first time in İstanbul, Turkey. Materials and methods: A retrospective analysis of 306 HIV/AIDS patients (260 men, mean age: 38.3 years) was done in a tertiary hospital in İstanbul from January 2006 to September 2012. Information on age, sex, transmission routes, socioeconomic and educational status, CD4 counts, and dermatologic findings was collected retrospectively from medical records. …

Relationship Among Mif, Mcp-1, Viral Loads, And Hbs Ag Levelsin Chronic Hepatitis B Patients, Hayati̇ Güneş, Rafet Mete, Murat Aydin, Bi̇rol Topçu, Mustafa Oran, Mustafa Doğan, Oğuzhan Yildirim, İlknur Erdem, Aynur Eren Topkaya, Ahmet Gürel

Turkish Journal of Medical Sciences

Background/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters. Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant. Results: The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated. Conclusion: We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.

A Novel Approach For Determination Of Chicken Sexing At An Early Stage Of Development By Using Loop-Mediated Isothermal Amplification Method, Sung Woo Kim, Jin Seok Choi, Neelesh Sharma, Yeoung Gyu Ko, Yoon Jung Do, Mijeong Byun, Hwan Hoo Seong, Soo Bong Park, Dong Kee Jeong

Turkish Journal of Veterinary & Animal Sciences

The monomorphism of newly hatched chicks is a major hurdle for poultry farmers at the time of sexing. The traditional sexing techniques are inaccurate and time-consuming. Therefore, the present study aimed to develop a loop-mediated isothermal amplification (LAMP)-based sex determination method to obtain a higher separation accuracy rate as compared to conventional methods. LAMP is a simple, quick, and relatively inexpensive diagnostic tool. Genomic DNA was extracted from the blood samples of Leghorn and Korean native chicks for LAMP. Two sets of primer were designed, consisting of four isothermal amplification primers in each, to amplify the female sex-specific sequence (HUR0417) …

Thinking About Ebola, David Brett-Major

Journal Articles: Epidemiology

No abstract provided.

Moral Development And Public Health Nursing, Margaret Avila

Dissertations

Public health nurses (PHNs) have the opportunity and professional obligation to be at the forefront of the fight to eliminate health disparities based on the practice principle of social justice. The overall purpose of this descriptive study was to explore the stage of the moral development in a convenience sample of practicing public health nurses (PHNs) and the differences in moral development stage across selected demographic variables (age, gender, race/ethnicity, level of entry into professional nursing, highest level of education, years practicing as an RN, years practicing in a public health department, self-identified political views, primary language, and region of …

Vaccines, School Mandates, And California's Right To Education, Dorit Rubenstein Reiss

Faculty Scholarship

No abstract provided.

Responding To The Childhood Vaccination Crisis: Legal Frameworks And Tools In The Context Of Parental Vaccine Refusal, Dorit Rubenstein Reiss, Lois A. Weithorn

Faculty Scholarship

No abstract provided.

Virginia Dental Journal (Vol. 92, No. 3 [I.E. 2], 2015)

Virginia Dental Journal

No abstract provided.

Sheep Updates 2015 - Ravensthorpe, Bruce Mullan, Kate Pritchett, Kimbal Curtis, Chris Wilcox, Mike Hyder, Leigh Sonnerman, Lynne Bradshaw, Geoff Lindon, Katherine Davies, Joe Young, Stephen Lee, Ian Robertson, Lucy Anderton, Hayley Norman, Ed Barrett-Lenard, Jackie Jarvis, Ben Patrick

Sheep Updates

This session covers fourteen papers from different authors:

1. The Sheep Industry Business Innovation project, Bruce Mullan, Sheep Industry Development Director, Department of Agriculture and Food, Western Australia

2. Western Australian sheep stocktake, Kate Pritchett and Kimbal Curtis, Research Officers, Department of Agriculture and Food, Western Australia

3. Wool demand and supply - short term volatility, long term opportunities, Chris Wilcox, Principal of Poimena Analysis

4. Lifetime management for maternal ewes, Mike Hyder, Research Officer, Department of Agriculture and Food, Western Australia

5. National Livestock Identification System (NLIS) for sheep and goats - what is the NLIS database? Leigh Sonnermann, …

Risk Factors And Food-Borne Illness: An Analysis Of Restaurant Violations In Georgia, Jovan Harris

Walden Dissertations and Doctoral Studies

Restaurant managers complete certification in food safety in order to ensure that food is handled and prepared in a manner that decreases risk factors associated with food-borne illness. However, the literature has been inconclusive concerning the connection between manager certification and the incidence of critical food-safety violations. The purpose of this quantitative study was to examine the relationship between the presence or absence of a certified food safety manager (CFSM) and the number of risk factors cited on food inspection reports and the food safety score. In addition, this study was designed to determine whether operation type (i.e., chain vs. …

Quantitative Study Of Clostridium Difficile Incidence Related To Influenza And Antimicrobial Use, Eileen M. Yaeger

Walden Dissertations and Doctoral Studies

In the United States, influenza causes approximately 36,000 deaths and over 200,000 hospitalizations each year with elderly most often affected. Clostridium difficile infection (CDI) is another major health care challenge and pressing public health issue associated with 14,000 deaths and over 335,000 hospitalizations annually. The use of antibiotics has been implicated in the development of CDI. This study's purpose was to test the relationship of seasonal influenza incidence and antiviral/antibiotic use in CDI development among hospitalized patients. Grounded in the epidemiologic wheel model of man-environment interactions, this retrospective observational study described and analyzed data from a proprietary, laboratory, and pharmacy-based …

Global Response To Local Problems:The Global Health Community Response To The Ebola Outbreak Of 2014, Nicole Thelen

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Health crises are often met with much support from the global health aid communities, who strive to contain the current health crisis and improve the conditions of the affected society. The recent Ebola outbreak of 2014 is no exception. Driven by public panic and media coverage, the global health community responded in force, dispatching aid organizations, monetary help, and military assistance to both assist those affected with the disease and prevent it from spreading. The World Health Organization, along with Doctors without Borders and many other global organizations, swept in to provide aid to the affected areas. This project examines …

Should Paris Hilton Receive A Lighter Prison Sentence Because She's Rich? An Experimental Study, Josef Montag, Tomáš Sobek

Kentucky Law Journal

The "equal punishment for the same crime" principle is generally agreed upon--yet its implementation differs radically depending on whether the punishment is measured purely in nominal terms or whether the subjective perspective of the punishee is accounted for. This is simply because different people may experience the same punishment with differing intensity.

Legal scholars have recently proposed that improvements in scientific knowledge and advancements in technologies (such as Functional magnetic resonance imaging), which allow us to measure subjective perceptions and feelings, need to be and should be incorporated in our penal systems. This would facilitate calibrating the punishment not only …

Antimicrobial Resistance: Insights From The Declaration Of World Alliance Against Antibiotic Resistance, Mushira A. Enani

Saudi Medical Journal

No abstract provided.

Periodontal Findings In Systemic Lupus Erythematosus Patients And Healthy Controls, Khalid D. Al-Mutairi, Mohammad S. Al-Zahrani, Sami M. Bahlas, Rayyan A. Kayal, Khalid H. Zawawi

Saudi Medical Journal

Objectives: To compare periodontal findings in systemic lupus erythematosus (SLE) patients and healthy controls, and to determine, whether there is a correlation between periodontal parameters and SLE biomarkers. Methods: This cross-sectional study was conducted in the Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between November 2012 and February 2014. Twenty-five participants diagnosed with SLE and 50 healthy controls were selected. Periodontal assessment consisted of clinical attachment level (CAL), probing depth (PD), bleeding on probing, and plaque scores. For the SLE group, several laboratory tests were obtained, such as, white blood cell count, hemoglobin level, platelet count, …

Worldwide Accountability: The Wto's Failure To Create An Infrastructure That Delivers Pharmaceutical Drugs To Developing Countries, Arun J. Mohan

Emory International Law Review Recent Developments

In response to the public outcry over the death of millions of people in developing countries because of a lack of access to life-saving drugs, the World Trade Organization (WTO) recognized the need for developing countries to obtain pharmaceutical drugs at a reduced rate. However, the WTO received significant pushback from patent holders and pharmaceutical companies who insisted that their patents be upheld in every country. The dilemma resulted in the Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement and the 2003 Doha Declaration. Despite these efforts, millions of people are still dying because of a lack of access to …

Rainstorm And Flood Disasters: Case Study Of Shelter Management By Manila Municipal Drr (Disaster Risk Reduction) Teams During Tropical Storm Mario (Fung Wong) In 2014, Ma. Regina Justina E. Estuar, Nlandu Roger Ngatu, Sakiko Kanbara, John Owen Ilagan, John Noel Victorino, Jhoanna Isla, Megumi Nishikawa, Miho Morosawa, Yoko Nakayama, Sayumi Nojima

Department of Information Systems & Computer Science Faculty Publications

Floods are the leading cause of natural disaster-related deaths worldwide. This study aimed at assessing disaster preparedness and response by local Barangay (municipal) DRR (disaster risk reduction) teams during the flooding caused by tropical storm Mario in Manila in 2014. A cross-sectional and descriptive study was conducted, consisting of interviews in which five shelter managers participated. In total, 325 evacuees were received in 4 evacuation centers, whereas the remaining shelter received 30 families housed in tents. Only 3 shelters (60%) had some food and non-food items available prior to the arrival of evacuees. WASH (Water, sanitation and hygiene) services were …

Do Prediction Markets Aid Defenders In A Weak-Link Contest?, Cary Deck, Li Hao, David Porter

ESI Publications

Laboratory experiments have demonstrated that prediction market prices weakly aggregate the disparate information of the traders about states (moves) of nature. However, in many practical applications one is attempting to predict the move of a strategic rival. This is particularly important in aggressor–defender contests. This paper reports an experiment where the defender may have the advantage of observing a prediction market on the aggressor's action. The results of the experiments indicate that: the use of prediction markets does not increase the defender's win rate; prediction markets contain reliable information regarding aggressors’ decisions that is not being exploited by defenders; and …