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Articles 6151 - 6180 of 53473
Full-Text Articles in Entire DC Network
Pain Response After Maximal Aerobic Exercise In Adolescents Across Weight Status, Stacy Stolzman, Michael E. Danduran, Sandra K. Hunter, Marie K. Hoeger Bement
Pain Response After Maximal Aerobic Exercise In Adolescents Across Weight Status, Stacy Stolzman, Michael E. Danduran, Sandra K. Hunter, Marie K. Hoeger Bement
Physical Therapy Faculty Research and Publications
Introduction
Pain reports are greater with increasing weight status, and exercise can reduce pain perception. It is unknown, however, whether exercise can relieve pain in adolescents of varying weight status. The purpose of this study was to determine whether adolescents across weight status report pain relief after high-intensity aerobic exercise (exercise-induced hypoalgesia (EIH)).
Methods
Sixty-two adolescents (15.1 ± 1.8 yr, 29 males) participated in the following three sessions: 1) pressure pain thresholds (PPT) before and after quiet rest, clinical pain (McGill Pain Questionnaire), and physical activity levels (self-report and ActiSleep Plus Monitors) were measured, 2) PPT were measured with a …
Condylar Hyperplasia: An Updated Review Of The Literature, Luis Eduardo Almeida, Joseph Zacharias, Sean Pierce
Condylar Hyperplasia: An Updated Review Of The Literature, Luis Eduardo Almeida, Joseph Zacharias, Sean Pierce
School of Dentistry Faculty Research and Publications
Condylar hyperplasia (CH) is a rare disorder characterized by excessive bone growth that almost always presents unilaterally, resulting in facial asymmetry. Classification of the different types of CH can differ depending on the authors. Correct diagnosis is critical in determining the proper treatments and timing. This paper is a review of the recent literature on the epidemiology, etiology, diagnosis, classification, and surgical treatments of CH.
Biomaterial Properties Of Titanium In Dentistry, Soni Prasad, Mark Ehrensberger, Monica Prasad Gibson, Hyeongil Kim, Edward A. Monaco, Jr.
Biomaterial Properties Of Titanium In Dentistry, Soni Prasad, Mark Ehrensberger, Monica Prasad Gibson, Hyeongil Kim, Edward A. Monaco, Jr.
School of Dentistry Faculty Research and Publications
Background
Among various dental materials and their successful restorative uses, titanium provides an excellent example of integrating science and technology involving multiple disciplines of dentistry including biomaterials, prosthodontics and surgical sciences. Titanium and its alloys have emerged as a material of choice for dental implants fulfilling all requirements biologically, chemically and mechanically. Several excellent reviews have discussed the properties of titanium and its surface characteristics that render it biocompatible. However, in most patients, titanium implants are used alongside several other metals. Presence of different metals in the same oral environment can alter the properties of titanium. Other influencing factors include …
A Noise Delivery System For Multi-Animal Multi-Level Whole Body Ototoxicity Studies, John E. Stubbs, Jeremy M. Slagley, James E. Reboulet
A Noise Delivery System For Multi-Animal Multi-Level Whole Body Ototoxicity Studies, John E. Stubbs, Jeremy M. Slagley, James E. Reboulet
Faculty Publications
The Naval Medical Research Unit Dayton (NAMRU-D) at Wright-Patterson Air Force Base, Ohio, in conjunction with the U.S. Air Force, studied ototoxic effects of JP-8 in rats. NAMRU-D used a multi-chamber whole body exposure facility for up to 96 test animals and 32 control animals at different exposure levels. The objective was to design a noise delivery system that could provide a white noise source one octave band wide, centered at 8 kHz frequency, delivered from outside the exposure chambers. Sound pressure levels were required to be within ±2 dB at all exposure points within each chamber and within ±2 …
Predicting Public Bicycle Adoption Using The Technology Acceptance Model, Benjamin T. Hazen, Robert E. Overstreet, Yacan Wang
Predicting Public Bicycle Adoption Using The Technology Acceptance Model, Benjamin T. Hazen, Robert E. Overstreet, Yacan Wang
Faculty Publications
Bicycle sharing programs provide a sustainable mode of urban transportation. Although cities across the globe have developed these systems for their citizens and visitors, usage rates are not as high as anticipated. This research uses the technology acceptance model as the basis to understand one’s intention to adopt bicycle sharing programs. Using survey data derived from 421 participants in Beijing, China, the proposed covariance-based structural equation model consisting of perceived quality, perceived convenience, and perceived value is found to predict 50.5% of the variance in adoption intention. The findings of this research contribute to theory and practice in the burgeoning …
Conserving Creativity: The Roles Of Clothing And Cuisine In The French Revolution, Karis Stubblefield
Conserving Creativity: The Roles Of Clothing And Cuisine In The French Revolution, Karis Stubblefield
Armstrong Undergraduate Journal of History
About the author
Karis Stubblefield is a junior at Brown University double-concentrating in history and Egyptology. Her scholarly interests include the study of everyday life in Ancient Egypt as well as more modern revolutionary movements around the world. She has spent the last two summers interning at the San Antonio Museum of Art in her hometown, where she worked in the director's office and served as a curatorial assistant for various exhibits, including a collection showcasing Indian painting under the Mughal Court. At Brown she is involved with various clubs and organizations, including serving as a writer for a student-run …
The Roles Of Natural Environments In The American Civil War, Cameron Boutin
The Roles Of Natural Environments In The American Civil War, Cameron Boutin
Armstrong Undergraduate Journal of History
About the author
Cameron Boutin recently graduated with undergraduate degree in History from Northeastern University in Boston. Currently He is in the Master Program at Northeastern. The area of study that he is interested in is the American Civil War.
The Missus Organization: Eleanor Roosevelt And Her Contributions To The National Youth Administration, Kaitlyn Newman
The Missus Organization: Eleanor Roosevelt And Her Contributions To The National Youth Administration, Kaitlyn Newman
Armstrong Undergraduate Journal of History
About the author
Kaitlyn Newman wrote this article during the senior year at Minnesota State University-Mankato. She graduated in May 2015 with a BS in History and a minor in Geography.
Social Emotional Learning In A Guatemalan Preschool Sample: Does Socioeconomic Status Moderate The Effects Of A School-Based Prevention Program?, Leihua Edstrom, Heather A. Mildon, Lesliann Davila, Amanda B. Clinton
Social Emotional Learning In A Guatemalan Preschool Sample: Does Socioeconomic Status Moderate The Effects Of A School-Based Prevention Program?, Leihua Edstrom, Heather A. Mildon, Lesliann Davila, Amanda B. Clinton
Faculty Publications - Doctor of Psychology (PsyD) Program
Researchers evaluated the effectiveness of a universal social skills program and compared social emotional knowledge on individual skills interviews with 100 Guatemalan preschool children from resource rich (N = 47) and resource poor (N = 53) backgrounds. Participant ages ranged from 3- to 6-years-old. SEL was evaluated prior and subsequent to receiving a school-based social emotional educational program. Results were analysed in terms of effectiveness of SEL by error type. Data show that preschool children from both poor and wealthy families made significant gains in social-emotional knowledge as a result of SEL instruction. In order to better understand …
Developing A Culture Of Inquiry Through Nursing Research: A New Hospital's 3-Year Journey To Magnet® Designation, Denise Harris, Tanya Cohn
Developing A Culture Of Inquiry Through Nursing Research: A New Hospital's 3-Year Journey To Magnet® Designation, Denise Harris, Tanya Cohn
All Publications
No abstract provided.
Tennessee Farm Bureau News - November 2015, Tennessee Farm Bureau Federation
Tennessee Farm Bureau News - November 2015, Tennessee Farm Bureau Federation
Tennessee Farm Bureau News
No abstract provided.
Barriers And Facilitators Of Suicide Risk Assessment In Emergency Departments: A Qualitative Study Of Provider Perspectives, Megan L. Petrik, Peter M. Gutierrez, Jon S. Berlin, Stephen M. Saunders
Barriers And Facilitators Of Suicide Risk Assessment In Emergency Departments: A Qualitative Study Of Provider Perspectives, Megan L. Petrik, Peter M. Gutierrez, Jon S. Berlin, Stephen M. Saunders
Psychology Faculty Research and Publications
Objective
To understand emergency department (ED) providers’ perspectives regarding the barriers and facilitators of suicide risk assessment and to use these perspectives to inform recommendations for best practices in ED suicide risk assessment.
Methods
Ninety-two ED providers from two hospital systems in a Midwestern state responded to open-ended questions via an online survey that assessed their perspectives on the barriers and facilitators to assess suicide risk as well as their preferred assessment methods. Responses were analyzed using an inductive thematic analysis approach.
Results
Qualitative analysis yielded six themes that impact suicide risk assessment. Time, privacy, collaboration and consultation with other …
Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith
Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith
Psychology Faculty Research and Publications
Cortical atrophy is a biomarker of Alzheimer’s disease (AD) that correlates with clinical symptoms. This study examined changes in cortical thickness from before to after an exercise intervention in mild cognitive impairment (MCI) and healthy elders. Thirty physically inactive older adults (14 MCI, 16 healthy controls) underwent MRI before and after participating in a 12-week moderate intensity walking intervention. Participants were between the ages of 61 and 88. Change in cardiorespiratory fitness was assessed using residualized scores of the peak rate of oxygen consumption (V̇O2peak) from pre- to post-intervention. Structural magnetic resonance images were processed using FreeSurfer v5.1.0. …
Can Contracted Out Health Facilities Improve Access, Equity, And Quality Of Maternal And Newborn Health Services? Evidence From Pakistan., Shehla Zaidi, Atif Riaz, F. Rabbani, Iqbal Azam Syed, Syeda Nida Imran, Nousheen Pradhan, Gul Nawaz Khan Nawaz Khan
Can Contracted Out Health Facilities Improve Access, Equity, And Quality Of Maternal And Newborn Health Services? Evidence From Pakistan., Shehla Zaidi, Atif Riaz, F. Rabbani, Iqbal Azam Syed, Syeda Nida Imran, Nousheen Pradhan, Gul Nawaz Khan Nawaz Khan
Community Health Sciences
BACKGROUND:
The case of contracting out government health services to non-governmental organizations (NGOs) has been weak for maternal, newborn, and child health (MNCH) services, with documented gains being mainly in curative services. We present an in-depth assessment of the comparative advantages of contracting out on MNCH access, quality, and equity, using a case study from Pakistan.
METHODS:
An end-line, cross-sectional assessment was conducted of government facilities contracted out to a large national NGO and government-managed centres serving as controls, in two remote rural districts of Pakistan. Contracting out was specific for augmenting MNCH services but without contractual performance incentives. A …
Residual Barriers For Utilization Of Maternal And Child Health Services: Community Perceptions From Rural Pakistan., Zahid Memon, Shehla Zaidi, Atif Riaz
Residual Barriers For Utilization Of Maternal And Child Health Services: Community Perceptions From Rural Pakistan., Zahid Memon, Shehla Zaidi, Atif Riaz
Community Health Sciences
Low utilization of maternal and child care services in rural areas has constrained Pakistan from meeting targets of Millennium Development Goals (MDGs) 4 and 5. This study explores community barriers in accessing Maternal and Child Health (MCH) services in ten remote rural districts of Pakistan. It further presents how the barriers differ across a range of MCH services, and also whether the presence of Community Health Workers (CHWs) reduces client barriers. Qualitative methods were used involving altogether sixty focus group discussions with mothers, their spouses and community health workers. Low awareness, formidable distances, expense, and poorly functional services were the …
Preliminary Efficacy And Feasibility Of Embedding High Intensity Interval Training Into The School Day: A Pilot Randomized Controlled Trial, S. A. Costigan, N. Eather, R. C. Plotnikoff, Dennis Taaffe, E. Pollock, S. G. Kennedy, D. R. Lubans
Preliminary Efficacy And Feasibility Of Embedding High Intensity Interval Training Into The School Day: A Pilot Randomized Controlled Trial, S. A. Costigan, N. Eather, R. C. Plotnikoff, Dennis Taaffe, E. Pollock, S. G. Kennedy, D. R. Lubans
Research outputs 2014 to 2021
Current physical activity and fitness levels among adolescents are low, increasing the risk of chronic disease. Although the efficacy of high intensity interval training (HIIT) for improving metabolic health is now well established, it is not known if this type of activity can be effective to improve adolescent health. The primary aim of this study is to assess the effectiveness and feasibility of embedding HIIT into the school day. A 3-arm pilot randomized controlled trial was conducted in one secondary school in Newcastle, Australia. Participants (n = 65; mean age = 15.8(0.6) years) were randomized into one of three conditions: …
A Cytotoxic, Co-Operative Interaction Between Energy Deprivation And Glutamate Release From System XC− Mediates Aglycemic Neuronal Cell Death, Trista L. Thorn, Yan He, Nicole A. Jackman, Doug Lobner, James A. Hewett, Sandra J. Hewett
A Cytotoxic, Co-Operative Interaction Between Energy Deprivation And Glutamate Release From System XC− Mediates Aglycemic Neuronal Cell Death, Trista L. Thorn, Yan He, Nicole A. Jackman, Doug Lobner, James A. Hewett, Sandra J. Hewett
Biological Sciences Faculty Research and Publications
The astrocyte cystine/glutamate antiporter (system xc−) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. Using pure astrocyte cultures, as well as, mixed cortical cell cultures containing both neurons and astrocytes, we found that neither an enhancement in system xc− expression nor activity underlies the excitotoxic effects of aglycemia. In addition, using three separate bioassays, we demonstrate no change in the ability of glucose-deprived astrocytes—either cultured alone or with neurons—to remove glutamate from the extracellular space. Instead, we …
Partial Covariance Based Functional Connectivity Computation Using Ledoit-Wolf Covariance Regularization, Matthew R. Brier, Anish Mitra, John E. Mccarthy, Beau M. Ances, Abraham Z. Snyder
Partial Covariance Based Functional Connectivity Computation Using Ledoit-Wolf Covariance Regularization, Matthew R. Brier, Anish Mitra, John E. Mccarthy, Beau M. Ances, Abraham Z. Snyder
Mathematics Faculty Research
Highlights •We use the well characterized matrix regularization technique described by Ledoit and Wolf to calculate high dimensional partial correlations in fMRI data. •Using this approach we demonstrate that partial correlations reveal RSN structure suggesting that RSNs are defined by widely and uniquely shared variance. •Partial correlation functional connectivity is sensitive to changes in brain state indicating that they contain functional information. Functional connectivity refers to shared signals among brain regions and is typically assessed in a task free state. Functional connectivity commonly is quantified between signal pairs using Pearson correlation. However, resting-state fMRI is a multivariate process exhibiting a …
Apricots In The Home Garden, Michael Caron, Taun Beddes, Brent Black
Apricots In The Home Garden, Michael Caron, Taun Beddes, Brent Black
All Current Publications
This fact sheet provides information about apricots, including how to grow, harvest, store and use them.
Medical Tourism: How Far Are You Willing To Go To Save Money?, Thomas J. Prinsen, Louis K. Falk, Javier Martinez
Medical Tourism: How Far Are You Willing To Go To Save Money?, Thomas J. Prinsen, Louis K. Falk, Javier Martinez
Faculty Work Comprehensive List
Medical needs of Americans are increasing as the population is aging and struggling with obesity. The addition of new medical technology and techniques, their widespread availability, and procedural improvements have created a more open market for medical providers. Costly procedures in cardiology and orthopedics serve as examples of increasingly needed medical treatments. Individuals, businesses and insurance companies have struggled to find ways to pay for these necessary procedures. Traditionally, in the U.S. the majority of medical procedures have been performed locally. Because of the rising costs associated with these procedures individuals and some healthcare providers are now looking to foreign …
The Effect Of A Minimum Credit Diploma Pathway On High School Graduation Rate, Teresa Strickland
The Effect Of A Minimum Credit Diploma Pathway On High School Graduation Rate, Teresa Strickland
Doctoral Dissertations and Projects
There are many paths to high school graduation. The reauthorization of the Elementary and Secondary Education Act has driven schools to be creative in seeking strategies by which students successfully earn their high¬¬¬¬ school diploma. In this non-experimental, causal-comparative study, a large Western North Carolina school district utilizes a minimum credit diploma to help students who previously experienced repeated academic failure achieve high school graduation by earning 21 course credits. The district requires traditional diploma-seeking students to earn seven additional credits to the 21 required by the State. Participants included high school graduates from the 2013-2014 school year. Both traditional …
Relationships Between Experiential Learning And Effects On Senior Nursing Students’ Self-Efficacy And Knowledge: A Non-Experimental Predictive Correlation Multiple Regression Analysis, Shanna Akers
Doctoral Dissertations and Projects
Preparing nursing students to transition into the professional registered nurse role is the task of nurse educators. These educators must train students to function in multiple nursing specialties post-graduation, to include critical care. As more nursing graduates enter into areas such as intensive care units and emergency rooms, nurse educators must prepare them to work with critically ill patients. Increased exposure to critical care clinical experiences and simulations may be one method to prepare them for these complex, high-acuity patient situations. In order to determine whether or not a relationship exists between increased hours of experience and effects on self-efficacy …
A Positive-Negative Mode Of Population Covariation Links Brain Connectivity, Demographics And Behavior, Stephen M. Smith, Thomas E. Nichols, Diego Vidaurre, Anderson M. Winkler, Timothy E J Behrens, Matthew F. Glasser, Kamil Ugurbil, Deanna M. Barch, David C. Van Essen, Karla L. Miller
A Positive-Negative Mode Of Population Covariation Links Brain Connectivity, Demographics And Behavior, Stephen M. Smith, Thomas E. Nichols, Diego Vidaurre, Anderson M. Winkler, Timothy E J Behrens, Matthew F. Glasser, Kamil Ugurbil, Deanna M. Barch, David C. Van Essen, Karla L. Miller
School of Medicine Publications
We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
Increasing Autism Awareness In Inner-City Churches: A Brief Report, Norah L. Johnson, Amy V. Van Hecke
Increasing Autism Awareness In Inner-City Churches: A Brief Report, Norah L. Johnson, Amy V. Van Hecke
College of Nursing Faculty Research and Publications
Autism diagnosis rates trail significantly in the African American community. This pre-test post-test pilot study evaluated an African American inner-city church health ambassadors (HAs) autism spectrum disorder (ASD) awareness training session. The participants included 12 HAs who attended the 1 hour training session organized by the National Baptist Convention, USA, Inc. Results of surveys showed higher mean scores post training for (1) HA attitudes about the potential for children to improve with applied behavior analysis therapy; (2) HA self-efficacy for having information about ASD screening materials; (3) strategies HAs could use to help parents/caregivers of children with developmental delays and …
Elementary And Secondary Special Education Teachers Experiences Of Inclusion For Students With Moderate To Severe Disabilities: A Phenomenolgical Study, Shannon Anders
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to describe the experiences of special education teachers regarding inclusive practices with students with moderate and severe disabilities in a rural North Carolina school district. The purpose of this research was to seek the overall essence of the lived experiences of a purposeful criterion sample of 11 special education teachers as they used inclusion strategies with their students. This study had one central question: How do rural special education teachers describe their experiences with inclusive practices for their students with moderate to severe disabilities? The theories guiding this study were Maslow’s Hierarchy …
Exploring The Relationship Between Attachment Style, Stress Perception, And Religious Coping In The Evangelical Missionary Population, Laurie Tone
Doctoral Dissertations and Projects
This cross-sectional survey design study examined the relationships between attachment style, stress perception and religious coping in a sample of 267 cross-cultural, evangelical missionaries. No significance for effect for attachment style on perceived stress was found. However, both age and gender demonstrated significant effects on perceived stress. There was also a significant association between perception of stress and religious coping, independent of attachment style. Religious coping accounted for a small amount of the variance in perception of stress. The vast majority of the sample reported patterns of positive religious coping, which was not influenced by attachment style. A new tool …
Inquiring Into Activist Publics In Chronic Environmental Issues: Use Of The Mutual Gains Approach For Breaking A Deadlock, Soojin Kim, Jeong-Nam Kim, Laishan Tam, Gwang Tae Kim
Inquiring Into Activist Publics In Chronic Environmental Issues: Use Of The Mutual Gains Approach For Breaking A Deadlock, Soojin Kim, Jeong-Nam Kim, Laishan Tam, Gwang Tae Kim
Research Collection Lee Kong Chian School Of Business
This study aims to understand different publics’ communicative behaviors for problem solving surrounding an oil spill issue in Korea. Specifically, it explores the differences between chronic activists and other types of publics who were affected by this chronic environmental issue. A total of 24 interviews were conducted, from which five different types of publics were identified. The findings suggest that the majority of activists who are currently working on the issue are closed-chronic activists, which are slightly different from Ni and Kim’s findings on chronic activists’ communicative behaviors. Interviews were also conducted with five communication experts to propose viable conflict …
Subjective Interpretation Of Caloric Induced Vertigo In Asymptomatic Diabetic Versus Normal Volunteers:, Ashraf Elsayed Morgan,, Elshahat Ibrahem Ismail Elshokry, Wessam Ibrahim Elshawaf
Subjective Interpretation Of Caloric Induced Vertigo In Asymptomatic Diabetic Versus Normal Volunteers:, Ashraf Elsayed Morgan,, Elshahat Ibrahem Ismail Elshokry, Wessam Ibrahim Elshawaf
Mansoura Medical Journal
objectives: to evaluate if there isvariability in subjective perception ofvertigo in diabetic patients in comparisonto non-diabetic subjects.Methods:28 patients with diabetestype2 and 28 normal volunteersparticipatedin the present study.Monothermalcool caloric test usedtoinduce vertigo and visual analogscale(VAS) used to quantify the intensitythe perceived caloric inducedvertigo.Results: there was no significantdifference between both groupsinall study variables. There was asignificantdifference in VAS scoresbetweenboth ears in diabetic group < br />patients.Conclusion: there is abnormalvestibular performance in diabeticpatients even in the presence of normal vestibular laboratory functions.
Potential Effect Of Captopril, Valsartan On Nuclear Factor Kappa B And Lipid Peroxidation In Hepatic Ischemiareperfusion Injury In Rats., Sameh Abdel-Ghany, Hala Abdel-Malek Elashry, Maha Mohamad Ameen, Karawan Mohamed Abd-El Rhman, Abdel-Rahman Abdel-Fatah Yassin
Potential Effect Of Captopril, Valsartan On Nuclear Factor Kappa B And Lipid Peroxidation In Hepatic Ischemiareperfusion Injury In Rats., Sameh Abdel-Ghany, Hala Abdel-Malek Elashry, Maha Mohamad Ameen, Karawan Mohamed Abd-El Rhman, Abdel-Rahman Abdel-Fatah Yassin
Mansoura Medical Journal
objectives: to evaluate hepatoprotectiveeffect of captopril, valsartaninhepatic ischemia-reperfusion injuryby assessing nuclear factor kappaB(NF-κB)and lipid peroxidation. Method: Twenty four rats wererandomly divided into four groups,sham-operated group (controlgroup), ischemia-reperfusion model(I/R group), IR with pretreated captopril7 days before surgery(CAPgroup)and IR with pretreated valsartan7days before surgery(VAL group)3hafter induction of IR. Assay of serumliver enzymes alanine transaminase(ALT), aspartate transaminase (AST), serum tumor necrosis factoralpha(TNF- α)and interleukin – beta(IL-1β)as well as superoxide dismutase(SOD), malondialdehyde (MDA)inliver homogenates and liver NF-κBimmunohistochemicalanalysis andhepaticpathology were evaluated insacrificedrats after 3 hours of inductionof IR. Results: There was in IR group < br />decrease of SOD and increase ofMDA levels in liver homogenates 3hours …
Comparing Antiproliferative And Proapoptotic Effects Of The Pan-Deacetylase Inhibitor Panobinostat With Doxorubicin On Hepg2 Hepatocellular Carcinoma Cell Line, Neimat Abd Elhakam Elmetwaly, Mona Younis Youssef, Amal Abd Elhameed Mohammad, Karawan Mohammad Abd Elrahman, Farida Hanem Mohammad Ali Elbanna
Comparing Antiproliferative And Proapoptotic Effects Of The Pan-Deacetylase Inhibitor Panobinostat With Doxorubicin On Hepg2 Hepatocellular Carcinoma Cell Line, Neimat Abd Elhakam Elmetwaly, Mona Younis Youssef, Amal Abd Elhameed Mohammad, Karawan Mohammad Abd Elrahman, Farida Hanem Mohammad Ali Elbanna
Mansoura Medical Journal
Panobinostat is a new histone deacetylaseinhibitor approved fortreatmentof advanced multiple myeloma.In this study we compare itseffectswith doxorubicin which is alreadyused for trans-arterial chemoembolizationof hepatocellular carcinoma. Methods: anti-proliferativeand pro-apoptotic effects of panobinostatand doxorubicin are tested bymeasuringcell viability, P53, pd1 expressionand cell cycle analysis inHepG2cells cultured in suitable mediaand incubated with both drugs for24hours. Results:Panobinostat wasfoundto highly significantly induce apoptosis via increasing expressionof both P53 and pd1 and decreasecell viability and mitosis more thandoxorubicin. Conclusion: These resultssuggest that panobinostat maybea potent alternative to doxorubicinfortreatment of hepatocellular carcinoma.