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Classification Of Breast Cancer Patients Using Somatic Mutation Profiles And Machine Learning Approaches, Suleyman Vural

Theses & Dissertations

The high degree of heterogeneity observed in breast cancers makes it very difficult to classify cancer patients into distinct clinical subgroups and consequently limits the ability to devise effective therapeutic strategies. In this study, we explore the use of gene mutation profiles to classify, characterize and predict the subgroups of breast cancers. We analyzed the whole exome sequencing data from 358 ethnically similar breast cancer patients in The Cancer Genome Atlas (TCGA) project. Identified somatic and non-synonymous single nucleotide variants were assigned a quantitative score (C-score) that represents the extent of negative impact on the function of the gene. Using …

Preventing 30-Day Readmissions Of Clostridium Difficile Patients Utilizing Targeted Discharge Instructions, Keith A. Howard

Doctor of Nursing Practice (DNP) Projects

The Patient Protection and Affordable Care Act of 2010 ushered in a new era of fiscal accountability for healthcare organizations. Healthcare organizations and providers are now jointly held responsible for the improved quality of patient care and sustained reductions in patient care events termed healthcare-acquired conditions. To ensure compliance with this newly enacted legislation, the Centers for Medicare and Medicaid Services (CMS) began penalizing hospitals for targeted conditions leading to 30-day readmissions beginning in October 2012. Annually, CMS has focused attention on conditions that endanger patient health and welfare while secondarily attempting to reduce the excessive financial expenditures in …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Graduate Students attend Art Basel Miami Beach; Betty Foy Sanders Department of Art Van Painted by Kenny Scharf
• College of Health and Human Sciences students embrace Service opportunities

Dissent, John P. Belli Iii

LSU New Orleans Theses and Dissertations

No abstract provided.

Queering The Wac: The World War Ii Military Experience Of Queer Women, Catherine S. Cauley

LSU New Orleans Theses and Dissertations

The demands of WWII mobilization led to the creation of the first standing women's army in the US known as the Women's Army Corps (WAC). An unintended consequence of this was that the WAC provided queer women with an environment with which to explore their gender and sexuality while also giving them the cover of respectability and service that protected them from harsh societal repercussions. They could eschew family for their military careers. They could wear masculine clothing, exhibit a masculine demeanor, and engage in a homosocial environment without being seen as subversive to the American way of life. Quite …

Field Study Of Electrochemical Disinfection Of Municipal Wastewater, Luis De Grau Vidal

LSU New Orleans Theses and Dissertations

Research on electrochemical disinfection of municipal wastewater has been conducted at the University of New Orleans using a continuous flow electrochemical reactor connected to a direct current (DC) power supply changing its polarity and varying the electrode distance. Bacterial inactivation and chlorine production were the main parameters that were recorded.

After months of research, it was determined that the electrochemical disinfection reactor is efficient and has a great potential for the future. There is no need to use chlorine and it has low operation costs.

The following design recommendations for an electrochemical disinfection unit were given:

• A detention time of …

Truth Or Consequences—Academic Physicians’ Perspective In The Management Of Commercially-Influenced Conflicts Of Interest, Melinda Lawrie Epperson

LSU New Orleans Theses and Dissertations

Since the 1990s, academic physicians have been subjected to increased requirements for disclosure in their roles as educators and researchers and for conflict of interest (COI) resolution in their financial relationships with pharmaceutical, medical device, and biotech companies, collectively referred to as industry. The requirements are the result of the convergence of federal regulations, accreditation guidelines, professional and industry codes of ethics and conduct, and institutional policies. The disclosure and COI resolution requirements are managed and resolved by a review of forms and compliance with relevant guidance documents and policies. In the context of this environmental oversight, the purpose of …

Twice Displaced: Katrina And The Redevelopment Of The Magnolia, Gabriella A. Garza

LSU New Orleans Theses and Dissertations

Where and how to house the urban poor remains a controversial issue. Public housing residents are particularly vulnerable. Issues of race, class and gender intersect in their lives. Public-private partnerships in urban redevelopment projects and a focus on issues that arise from concentrated poverty gave rise to HOPE VI policy aimed at deconcentrating poverty via public housing demolition and redevelopment. In New Orleans, the effects of Hurricane Katrina further complicate this contested process. The purpose of this case study is to understand how residents experienced and framed the process of displacement brought on by disaster and the redevelopment of the …

Venereal Disease And American Policy In A Foreign War Zone: 39th Infantry Regiment In Sidi-Bel-Abbes, Algeria. May Of 1943., Thomas J. Gibbs

LSU New Orleans Theses and Dissertations

Second Lieutenant Charles Scheffel, B Company Platoon Leader, 39^th Infantry Regiment, 9^th Infantry Division modified existing methods of venereal disease control in Algeria, North Africa during Operation Torch after being ordered to reduce the venereal disease rate by his regimental commander, Colonel William Ritter. Tasked with defeating the Germans first, Scheffel learned other enemies lurked as well, and he instituted an illegal policy to solve the problem as fast and as effectively as possible. Official United States policy on the eve of World War Two prohibited the establishment and operation of a brothel. Scheffel operated this brothel as …

Fear Of Inclement Weather, Clare L. Harmon

LSU New Orleans Theses and Dissertations

No abstract provided.

Remembering Vietnam War Veterans: Interpreting History Through New Orleans Monuments And Memorials, Catherine Bourg Haws

LSU New Orleans Theses and Dissertations

ABSTRACT

This thesis is concerned with the question of how America’s citizen soldiers are remembered and how their services can be interpreted through monuments and memorials. The paper discusses the concept of memory and the functions of memorialization. It explores whether and how monuments and memorials portray the difficulties, hardships, horror, costs, and consequences of armed combat. The political motivations behind the design, formation and establishment of the edifices are also probed. The paper considers the Vietnam War monuments and memorials erected by Americans and Vietnam expatriates in New Orleans, Louisiana, and examines their illustrative and educational usefulness. Results reflect …

Arsenic, Cadmium, Copper, And Zinc Levels In Crayfish From Southwest Louisiana And Atchafalaya Basin, E. Gerald Hebert

LSU New Orleans Theses and Dissertations

Heavy metal contamination in food is a worldwide concern. Man-made ponds are domestic sites in the production of Procambarus clarkii and Procambarus zonangulus, two edible species of crayfish. Ponds may be constructed in former sugar cane or rice fields. Crayfish farming is an ancillary seasonal business within the rice-growing season. The use of products to control insects, pests, and weeds in rice and sugar cane production, may cause an accumulation of heavy metals in the crayfish tail within pond structures. Arsenic, cadmium, copper, and zinc are heavy metals that are absorbed through the roots of and distributed through rice products. …

“In My Fiction I Never Say Anything Which Is Not Absolutely True”: Reassessing Constance Fenimore Woolson’S Literary Realism, Ashley N. Hemm

LSU New Orleans Theses and Dissertations

Despite her immense popularity in the nineteenth century, Constance Fenimore Woolson's reputation dwindled substantially in the decades which followed. While her works have been rediscovered over the past thirty years, they are often categorized as regionalist writing or, in the case of her penultimate novel, Jupiter Lights, melodrama. What many fail to consider, however, is that Woolson very much considered herself a realist author, and may have been remembered as such were it not for the influence of William Dean Howells and his peers, whose very narrow parameters for literary realism excluded Woolson, among others. Unfortunately, those parameters are …

How The Manipulation Of The Ras Homolog Enriched In Striatum Alters The Behavioral And Molecular Progression Of Huntington’S Disease, Franklin A. Lee

LSU New Orleans Theses and Dissertations

Huntington’s disease is an incurable, progressive neurological disorder characterized by loss of motor control, psychiatric dysfunction, and eventual dystonia leading to death. Despite the fact that this disorder is caused by a mutation in one single gene, there is no cure. The mutant Huntingtin (mHtt) protein is expressed ubiquitously throughout the brain but frank cell death is limited to the striatum. Recent work has suggested that Rhes, Ras homolog enriched in striatum, which is selectively expressed in the striatum, may play a role in Huntington’s disease neuropathology. In vitro studies have shown Rhes to be an E3 ligase for the …

Retirement Planning Decisions Using The 2013 Survey Of Consumer Finances, Yun Doo Lee

LSU New Orleans Theses and Dissertations

Abstract

This dissertation consists of two essays. The first essay analyzes financial preparation for retirement of American men and women, using the 2013 Survey of Finances. Specifically, for retirement plan, income is an important factor for men and women aged 35-45 because of their insufficient income, health (excellent) for men and women aged 46-59 because of continuing work, number of weeks worked per year for men and women aged 60-67 because they have already retired or will retire and many of them are participating in a part time job. Also, health has significantly positive effects on the share of the …

An Actor's Method To Building The Character Of Hamlet In The Tragedy Of Hamlet, Prince Of Denmark, Samuel C. Malone Iii

LSU New Orleans Theses and Dissertations

This thesis will set out to examine the process needed in order to deliver the character of Hamlet as a fully dimensional, complex human being who transcends time periods and class distinctions to connect with any audience of any background. This text will include biographical information about the author, William Shakespeare, as well as historical information about the circumstances and atmosphere surrounding the birth of this play. It will also include information about other performances, which will serve as references for comparison in terms of character development. Included in the scored actor’s script are the Sanford Meisner Techniques of moment-to-moment …

Emotional And Autonomic Responding To Auditory Stimuli, Jeremy C. Peres

LSU New Orleans Theses and Dissertations

Much of the research examining emotion induction, regulation, and suppression considers solely the visual modality (e.g., pictures of faces) for emotion elicitation. In reality, emotions are cued, expressed, and interpreted through multiple modalities by employing the extensive use of auditory stimuli in addition to visual stimuli. There have been some recent efforts to offset this imbalance in modality preference by using emotional auditory stimuli alone or in addition to visual stimuli. This project aims to further investigate emotional and autonomic responding to auditory stimuli with the added component of examining differential responding across social (nonlinguistic vocal expression) and non-social auditory …

The Role Of Genetic Alterations In Tumor Initiation, Progression And Transformation, Weiwei Zhang

Theses & Dissertations

Follicular lymphoma (FL) is the second most common lymphoma in the United States. Although it is generally an indolent lymphoma, FL is not curable, and, in about 30% of patients, the FL undergoes transformation into an aggressive lymphoma (tFL) with marked worsening of prognosis. To identify mutations preferentially present in tFL, we performed whole exome sequencing (WES) on paired FL and tFL arising in the same patients and developed a mutational analysis pipeline. After we identified potentially important genes that have been found to be mutated in our paired FL and tFL study, we constructed a custom capture platform including …

Interaction Between Angiotensin Ii And Bdnf In Modulating Sympathetic Nerve Activity, Bryan K. Becker

Theses & Dissertations

Over activation of the sympathetic nervous system is prevalent in many forms of cardiovascular disease such as chronic heart failure (CHF) and hypertension. Although increased neuronal renin-angiotensin system activity in presympathetic neurons has been well implicated in mediating this sympatho-excitation, many of the neuronal effects of angiotensin II (Ang II) signaling remain poorly understood. One particular mechanism of Ang II-mediated increases in presympathetic neuronal activity is through reductions in voltage-gated K⁺ currents. Another pathway that has profound effects on neuronal K⁺ currents and that has been previously implicated in Ang II-signaling is brain-derived neurotrophic factor (BDNF) activity through …

Postural Responses To Perturbations Of The Vestibular System During Walking In Healthy Young And Older Adults, Jung Hung Chien

Theses & Dissertations

It has been shown that approximate one-third of US adults aged 40 years and older (69 million US citizens) have some type of vestibular problems. These declining abilities of the vestibular system affect quality of life. Difficulties in performing daily activities (dressing, bathing, getting in and out of the bed and etc.) have been highly correlated to loss of balance due to vestibular disorders. The exact number of people affected by vestibular disorders is still difficult to quantify. This might be because symptoms are difficult to describe and differences exist in the qualifying criteria within and across studies. Thus, it …

The Role Of Tumor Suppressor Co-Chaperone Chip/Stub1 In Erbb2-Mediated Oncogenesis, Haitao Luan

Theses & Dissertations

The epidermal growth factor receptor (EGFR) family member ErbB2 (Her2) is overexpressed in 20 -30% of invasive breast cancers and this overexpression correlates with poor prognosis and shorter overall as well as disease-free survival. Aberrant expression of ErbB2 through gene amplification, transcriptional deregulation and/or altered endocytic trafficking results in overexpression of ErbB2 at the plasma membrane and biases ErbB2 from primarily ligand-driven hetero-dimerization under normal expression conditions to increased ligand-independent homo-dimer and hetero-dimer formation and consequent activation. C-terminus of HSC70-Inteeracting protein (CHIP)/STIP1-homologous U-Box containing protein 1 (STUB1) is an HSP90/HSC70 interacting negative co-chaperone known to promote ubiquitination and degradation of …

The Effects Of Severe Weather Warnings On Limited English Proficient (Lep) Hispanics/Latinos In Rural Nebraska, Joan E. Nelson

Theses & Dissertations

The language barrier may severely restrict how severe weather warnings are received and responded to by Hispanics/Latinos in rural Nebraska, a state well known for frequent, volatile weather patterns. Nearly 50% of Spanish speaking Nebraskans rated their English abilities as “less than very well” (US Census Bureau, 2013). The estimated number of Hispanics/Latinos with limited English proficiency (LEP) in Nebraska equates to approximately 57,000 people. This thesis attempted to assess English ability and how severe weather warnings were received and responded to by LEP Hispanics/Latinos in rural Nebraska. This was accomplished by analysis of data from completed optional Spanish or …

A Role For Ehd Family Endocytic Regulators In Endothelial Biology, Alexandra E. J. Moffitt

Theses & Dissertations

Endocytic trafficking is an essential process in eukaryotic cells, specifically for the transport of nutrients, membrane components, and receptors. Cargo destined for endocytic traffic is internalized at the cell surface via clathrin-dependent and clathrin-independent pathways, and brought to the early or sorting endosomes. From there, cargo is further trafficked to lysosomes for degradation, trafficked to other compartments in the cell, or recycled back to the cell surface (either directly or via the endocytic recycling compartment).

Mammalian C-terminal Eps15 homology domain-containing proteins, or EHD proteins (EHD1 to 4), are a family of highly conserved ATPases that function as key regulators of …

The Effect Of Body Mass Index On Graft Function And Kidney Transplant Outcomes, Morgan Galle

Theses & Dissertations

Background: When determining eligibility for kidney transplantation, body mass index (BMI) is often a debatable criterion for transplant due to the clinical indication, an elevated BMI has adverse effects on kidney transplant outcomes. There is a current gap in research on the effect BMI has on kidney transplant outcomes.

Purpose: The purpose of this study was to determine the role BMI plays in post-kidney transplant clinical outcomes including delayed graft function, new onset diabetes after transplant, wound complications, hospital length of stay, albumin, and readmissions to the hospital from initial hospitalization and at six months following kidney transplantation. The primary …

Regulatory Roles Of Mical-L1 And Ehd1 In Cell Signaling And Mitosis, James B. Reinecke

Theses & Dissertations

Membrane trafficking is a basic cell biological process that controls the distribution of proteins and lipids. Our lab is particularly interested in delineating the cellular functions as well as the molecular mechanisms that regulate the C-terminal Eps15 Homology Domain (EHD) protein family of adenosine-5’-triphosphatases in mammalian cells. EHD1-4 are ubiquitously expressed in mammalian tissues and serve partially overlapping but also distinct functions in regulating membrane shaping and fission along the endocytic pathway. Specifically, EHD1 is recruited to tubular recycling endosomes (TREs) by Molecule Interacting with CasL Like-1 (MICAL-L1) and facilitates TRE fission and release of cargo from the perinuclear endocytic …

Biodegradable Hybrid Nanogels For Combination Chemotherapy, Swapnil Desale

Theses & Dissertations

Combination chemotherapy is commonly used to treat cancer, because such a therapy regimens usually involve sequential administration of multiple drugs and allow targeting different cell signaling pathway. The co-delivery of drug combination at a controlled ratio via the same vehicle is offering the advantages such as spatial-temporal synchronization of drug exposure, synergistic therapeutic effects and suppression of drug resistance. Undoubtedly, there are several molecular and pharmacological factors that determine the effectiveness of drug combinations. A rationally designed drug combination is required since certain drug ratios and the definitive exposure to the targets of interest can only be synergistic while others …

The Role Of Cxcr2 In Pancreatic Cancer Development And Progression, Abhilasha Purohit

Theses & Dissertations

This dissertation examines the role of CXCR2, a seven transmembrane G- protein coupled receptor, in mediating autocrine as well as paracrine mechanisms during pancreatic cancer progression. Data presented in the initial section demonstrates the aberrant expression of the CXCR2 biological axis in human pancreatic cancer tissue specimens. A study performed within the first section of this dissertation investigates the contribution of CXCR2 signaling in pancreatic cancer initiation. These studies have identified a novel role of CXCR2 in mediating KRAS^(G12D) -induced autocrine growth transformation of pancreatic cancer cells. The upregulation of the CXCR2 biological axis was found to be directly …

Fearful Temperament Moderates The Effect Of Harsh Parenting On Early Childhood Problem Behaviors Within Dangerous Neighborhoods: A Multilevel Analysis, Brenna Sapotichne

LSU New Orleans Theses and Dissertations

No abstract provided.

The Interaction Of Parenting And The Serotonin Transporter Gene On Trajectories Of Fearfulness In Early Childhood, Moira R. Riley

LSU New Orleans Theses and Dissertations

Children who are more fearful and inhibited during early childhood are at greater risk for social problems (e.g., loneliness, social isolation) and clinically significant internalizing disorders during adolescence and adulthood (e.g., Rubin, Chen, McDougall, Bowker, & McKinnon, 1995; Williams et al., 2009). While the impact of fearful temperament on adjustment indices are regularly the focus of study, less well understood are biological and social processes that may affect the development of fearful temperament. The present study considered the role of the 5-HTTLPR polymorphism and parenting on change in fearful and inhibited temperamental characteristics during early childhood.

The s/s genotype …

Fort Hays State University Tiger Weekly, December 18, 2015, University Relations

Tiger Weekly Newsletters

No abstract provided.