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G Protein-Coupled Inwardly-Rectifying Potassium (Girk) Chanels Mediate Entrainment Of Circadian Rhythms, Lauren Marie Hablitz

All ETDs from UAB

Circadian rhythms are 24-hour cycles in biological and behavioral processes. These cycles enable an organism to predict changes in its environment, like changes in food availability and seasonality. Although endogenously driven, these rhythms can entrain or synchronize to daily changes in the environment, allowing the animal to adapt. One way entrainment occurs is shifts in circadian phase following the presentation of nonphotic, or non-light, stimuli, such as exercise, arousal, or stress at certain times of day. The molecular mechanisms underlying nonphotic entrainment are poorly understood - specifically, how nonphotic cues alter excitability within the suprachiasmatic nucleus (SCN) of the hypothalamus, …

The Investigation Of Quality Of Life, Perceived Disease Severity, And Adherence In Patients With The G551d Mutation Receiving Ivacaftor Therapy, Heather Young Hathorne

All ETDs from UAB

Cystic fibrosis (CF), a genetic disorder, is a chronic life threatening illness that affects 30,000 adults and children in the United States and 70,000 worldwide. Treatment for CF is complex and consuming, consisting of multiple time intensive regimens. The therapy regimen has been descried as extraordinary when compared even to therapy regimens for other chronic illnesses. Oral and nebulized medication therapy, airway clearance therapy, pancreatic enzyme replacement therapy and vitamin /nutritional supplements are all required for the multiorgan treatment regimen for CF. Daily prescribed therapy can include as many as 40-50 pills, breathing treatments lasting up to tow hours a …

Nutrient Intake, Nutrient Targets And Feed Application To Promote Optimal Production And Feed Efficiency In The Sea Urchin Lytechinus Variegatus (Echinodermata: Echinoidea), Laura Elizabeth Heflin

All ETDs from UAB

Important considerations for the development of sea urchin aquaculture will include understanding nutrition and feed management. These reported investigations contribute to knowledge of dietary protein and carbohydrate requirements in Lytechinus variegatus and feed management strategies. The first evaluation of economic feasibility of sea urchin aquaculture as related to feed costs is presented and the geometric framework (GF) to assess nutrient intake targets is first applied to cultured aquatic organisms to yield recommendations for nutrient balancing in formulated urchin feed. Data- derived models for dietary protein and carbohydrate intake predict increased rates of growth and production among urchins fed diets containing …

Cortisol Regulation, Perceived Discrimination, And Ethnic Differences In Pain Responses Among Persons With Knee Osteoarthritis, Matthew Herbert

All ETDs from UAB

Plasma cortisol concentrations obtained directly after the Trier Social Stress test are negatively associated with subsequent pain tolerances during the cold pressor task (CPT) among healthy non-Hispanic whites (NHWs), but not healthy African Americans (AAs). It is possible frequent exposure to perceived discrimination, a marker of chronic stress, explains this lack of association between cortisol regulation and pain tolerances among AAs. Our aim was to determine if 1) ethnic differences in pain sensitivity during the CPT could be partially explained by differences in cortisol regulation among persons with knee osteoarthritis (OA), 2) perceived discrimination was related to cortisol dysregulation, which …

Professional Rationality And The Emotional Labor Of Gendered Caring In Nursing, Beverly Kay Hogan

All ETDs from UAB

ABSTRACT This dissertation offers an understanding of how the emotional labor of caring by female nurses is manifested, and whether this has changed from what has previously been described in the literature. A hybrid of Hochschild‘s (1983) theory of emotional labor is used with concepts from symbolic interactionist and critical theory to guide this inquiry. From this lens, relevant concepts affecting emotional labor are considered in order to examine how the organization of work roles for nurses enable or constrain their ability to manifest a caring presence. As the healthcare delivery system and nurses‘ roles have changed dramatically over the …

Obesity And Mortality In Us-Residing Hispanic Adults, Carrie Howell

All ETDs from UAB

Previous epidemiological studies observed the lack of an association between increased body mass index (BMI: kg/m2) and all-cause mortality in US-residing Hispanic adults. The purpose of this dissertation was to examine the validity of three hypothesized explanations for the absence of significant associations. Using data on Hispanic participants from the National Health and Nutrition Examination Survey (NHANES) [1988-1994 and 1999-2004] and the National Health Interview Survey (NHIS), this dissertation examined whether: (1) BMI was associated with cause-specific mortality; (2) measures of body composition was associated with all-cause mortality; and (3) the BMI-all-cause mortality association differed as a function of Hispanic …

Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez

All ETDs from UAB

Little is known about how weight gain in those born very preterm is associated with blood pressure and if cortisol, a stress biomarker, plays a mediating role. Also, the influence of infant feeding practices on weight gain has been only sporadically addressed. The purpose of this exploratory, descriptive, cross-sectional study was to examine the relationships between infant feeding practices, weight gain, and blood pressure noting any mediating effect cortisol may have between weight gain and blood pressure in 18-to-24 month old corrected age toddlers born very preterm. A convenience sample of 36 18-to-24 month old corrected age toddlers were enrolled. …

Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes

All ETDs from UAB

Bacillus anthracis (Ba) is a Gram,-positive zoonotic bacterium that causes inhala- tional, cutaneous and intestinal Anthrax Disease. Although the infectious form of Ba is its endospore (spore), only the tripartite toxin-producing vegetative bacteria causes disease pathology. While current vaccination strategies target the Protective Antigen (PA) com- ponent of this toxin, vaccine-elicited immunity to the spore form of Ba is lacking. How- ever, vaccines targeting spore components of Ba have the potential to neutralize the in- fectious form of Ba. We sought to determine if antibodies elicited through immunization with the main antigenic component of the spore surface- Bacillus collagen-like protein …

Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach

All ETDs from UAB

In this study, we investigated the role MARCKS's Effector Domain plays in lung and brain cancer biology. Initially, we identified that MARCKS was present in a range of lung cancer histologies including: squamous cell, adenocarcinoma, and normal lung tissues among others. In addition, lung adenocarcinoma patients with a mutation in the MARCKS gene correlated with decreased survival as determined by The Cancer Genome Atlas. In vitro studies identified that the phosphorylation status of MARCKS's Effector Domain was able to influence lung cancer radiation sensitivity. When MARCKS's Effector Domain was in a non-phosphorylated state, A549 lung cancer cell lines experienced increased …

Practical Extensions Of The Continual Reassessment Method, Amber Salter

All ETDs from UAB

This dissertation considers the presence of patient heterogeneity in dose finding studies using the likelihood-based time to event continual reassessment method (TITE-CRM). First, assuming group membership is known and the groups share some information regarding their maximum tolerated dose (MTD), we extend the two-group two-parameter CRM to the TITE-CRM. We examine the performance of the two-group two-parameter TITE-CRM for various scenarios where the true MTD for each group is different. We also consider the situation where the groups are truly homogeneous but a heterogeneous model is employed. Our simulations show that the method has some loss in accuracy compared to …

Role Of Vapb/Als8 Signaling Through Lar Receptor, Jessica Lindsey Winek Schultz

All ETDs from UAB

In humans, a P56S point mutation in the VAPB/ALS8 MSP domain is associated with amyotrophic lateral sclerosis (ALS) and late-onset spinal muscular atrophy (SMA). The N-terminal MSP domain is cleaved from the C-terminus, and secreted through an unknown, nonconventional manner. The P56S mutation inhibits secretion of the MSP domain. We use Caenorhabditis elegans to study live secretion of VPR-1, as well as to understand vMSP receptor signaling in muscle and gonad. To study the secretion mechanism of VPR-1 we created a transgenic line of C. elegans with a fluorescently tagged VPR-1. Using this model, we were able to visualize live …

A Randomized Trial Evaluating Child Dog-Bite Prevention In Rural China Through Video-Based Testimonials, Jiabin Shen

All ETDs from UAB

Dog-bite injuries pose a significant threat to children around the world. School-aged children are especially at risk of injuries because of their cognitively immature tendency toward poor perception of vulnerability regarding risky behaviors. This risk is elevated further for millions of school-aged children living in rural China due to the large number of stray dogs, all potential rabies carriers. Effective intervention programs for pediatric dog-bite injuries are sparse. Most existing programs were based on public health concerns and only involve the impartment of safety knowledge to children. They produced mixed results in changing actual behaviors with dogs. Based on the …

Within Session Repeatability Of The Tear Lab Osmolarity Test And Correlation With Other Clinical Tests For Dry Eye, Pearl Shin

All ETDs from UAB

WITHIN SESSION REPEATABILITY OF THE TEAR LAB OSMOLARITY TEST AND CORRELATION WITH OTHER CLINICAL TESTS FOR DRY EYE PEARL SHIN DEPARTMENT OF VISION SCIENCES ABSTRACT Background The human tear film consists of three primary layers that work in conjunction to provide protection and nutrition to the cornea. When a layer is disrupted, the entire tear film loses its integrity and fails to function normally. Dry eye is the most common cause of tear film disruption. Among several methods to characterize dry eye is measurement of tear osmolarity. The TearLab Osmometer is commonly used clinically for this purpose. Previous studies in …

Gaba(A) Receptor Trafficking And Localization In Schizophrenia, Toni Marie Mueller

All ETDs from UAB

Mechanisms underlying the complex etiology of schizophrenia have long been a subject of scientific inquiry. Early investigations focused on identifying functional deficits in dopaminergic and glutamatergic neurotransmission, but evidence for disrupted GABAergic signaling has also emerged. Recent studies from our lab have identified disrupted N-glycosylation of glutamate receptor and transporter subunits and abnormal subcellular distribution of glutamate receptor subunits, suggesting a potential functional consequence of perturbed N-glycosylation in schizophrenia. N-glycosylation is the posttranslational enzymatic attachment of an oligosaccharide precursor to a protein. This modification plays a significant role in protein processing in the ER and Golgi, and is known to …

The Effects Of 6 Weeks Of High Intensity Interval Training Vs. Moderate Intensity Training On Changes In Body Composition, Corey Noles

All ETDs from UAB

THE EFFECTS OF 6 WEEKS OF HIGH INTENSITY INTERVAL TRAINING VS. MODERATE INTENSITY TRAINING ON CHANGES IN BODY COMPOSITION COREY NOLES KINESIOLOGY ABSTRACT Background: It is important to identify strategies to promote exercise adherence and to identify an optimal exercise stimulus to prevent adverse health outcomes associated with obesity. Low-volume high-intensity interval training (HIIT) has recently been shown to improve a number of cardiometabolic health outcomes similarly to moderate intensity exercise training (MIT) despite requiring 1 hr of training per week for HIIT vs 6 hrs for ET. However, less is known about HIIT and its effects on body composition. …

Auditing Cpr Skills For Campus Recreation Student Employees, Rebecca Mabile

Master of Education in Applied Human Development Graduate Projects

CPR training is an important part of any collegiate recreation facility’s risk management plan for injury prevention. Because student employees are the first line of defense it is important that they are properly prepared to respond to any emergency situation. Oftentimes classroom training alone is not enough to prepare employees for emergencies. The purpose of this project was to build a training and audit program for CPR in order to build confidence and retain knowledge and skills for student employees in a campus recreation department. A training and audit program was created based on researching programs used by other universities …

The Role Of Ncaa Division I University Athletic Departments In The Transition Of Their Career-Ending Injured Athletes Out Of Sports, Kaitin Rohrs

Master of Education in Applied Human Development Graduate Projects

The NCAA and member institutions claim the responsibility to support and protect collegiate athletes with a priority on their well-being (NCAA, 2014). Although the NCAA provides financial assistance to selected career-ending injured athletes, university athletic departments define the assistance they offer their athletes who obtain career-ending injuries before their athletic eligibility is up (NCAA, 2014). Therefore, there are no universal policies, procedures, or standards in place to ensure that each injured athlete’s well-being is supported and protected during this traumatic life event (Walsh, 2013). Due to the lack of knowledge on written policies and procedures enforced by athletic departments when …

Goal Orientation And How A Task Or Ego Mentality Can Affect The Enjoyment For College Hockey Players, Mike Harrington

Master of Education in Applied Human Development Graduate Projects

The purpose of this study is to examine goal orientation in college hockey players and how a task or ego orientation can affect enjoyment. The Task and Ego Orientation Sport Questionnaire (TEOSQ) surveys were used to determine goal orientation as either task or ego, and a scaled score of how much they enjoy participating in college hockey. After surveying (N=28) male college hockey players in the American Collegiate Hockey Association that play for a medium sized University in North central United States, 23 were categorized as having a Task Goal Orientation, and 5 were Ego Goal Orientation. The results of …

Psychological Skills Training Manual For A Youth Baseball Team, Brian J. Guerriero

Master of Education in Applied Human Development Graduate Projects

Research has supported the benefits of psychological skills training (PST) programs such as improving the cognitive processes of athletes, which in turn can improve their performance and enhance its consistency (e.g., Blakeslee & Goff, 2007; Frey et al., 2003; Thellwell, Greenlees, & Weston, 2006). A PST program can help athletes to set more effective goals, manage stress more efficiently, build self-confidence, and improve concentration (Horn, 2008; Weinberg & Gould, 2011). In this project, I developed a psychological skills training manual aimed at youth baseball players. Achievement goal theory provides the framework for this PST program. Creating a task-oriented motivational climate …

Mapping Of The Honey Value Chain And Analysis Of Changes In Gender Roles And Factors Influencing Women Empowerment Among Beekeepers In Kitui County, Kenya, Peter Dennis M. Mburu

All Master’s Theses

Beekeeping is an important activity that helps rural communities to raise additional income to improve their livelihoods. Often, among rural beekeeping households, it has been widely adopted as an income diversification strategy. In addition, it is a sustainable form of agriculture beneficial to the environment. An intervention conducted by the International Centre of Insect Physiology and Ecology (ICIPE), introduced modern hives such as the Langstroth and the stingless beehive through the Commercial Insect Programme (CIP) of the institute. Trainings given to the community were for the development of a value chain and hence the formation of farmer groups that aided …

Amitav Ghosh’S The Circle Of Reason: A Clash Between Superstition And Scientific Reason, Gyanabati Khuraijam, Yumnam Oken Singh

Khazar Journal of Humanities and Social Sciences

In the modern world today, when some people apply logic and reasoning on certain things, other people are still dominated by the age-old practice of superstitious beliefs and it sometimes becomes difficult to accept the principles and works carried out by them. These contradictions often lead to clashes between them. Amitav Ghosh’s Balaramin the Circle of Reason becomes obsessed with scientific reasoning after readingLife of Louis Pasteur and Practical Phrenology. The development of science and technology is taking place at such a fast pace but he starts carrying out all types of irrational activities like campaign for cleanliness of underwear …

Providing Relevant And Effective Leadership For Millennials, Valorie Cannon Nordbye

All Electronic Theses and Dissertations

This thesis surveyed the leadership style preference of Millennials. Other areas focused on their loyalty to bosses, the importance of a company’s values and social practices, and their preferences about working independently or collaboratively. Members of an American college ministry were surveyed using an online survey tool. Based on 261 surveys, 85 percent chose servant leadership as their preferred style. The majority indicated that the values and social practices of their employer were important to them and that they would leave a job to remain with a boss they liked. There was no clear preference on working collaboratively or independently.

Role Of Home Environment, Parental Care, Parents’ Personality And Their Relationship To Adolescent Mental Health, Sibnath Deb, Kevin Mcgirr, Banhisikah Bhattacharya, Jiandong Sun

Publications and Research

The study examined relationships among home environment, parents’ personality and mental health of adolescents with a focus on adjustment, anxiety, self-concept and self-confidence. A group of 370 adolescents were interviewed using a semi-structured questionnaire and three psychological tests; subjects were selected following a two-stage sampling technique. Participation of the adolescent students in the study was voluntary. Results indicate that parental care was associated with high self-confidence while parental pressure associated with high anxiety. Fathers’ “friendliness” associated with low emotional adjustment and high self-concept while mothers’ short-temper associated with high anxiety. Disturbed families contributed to adolescent anxiety, inability to share personal …

A Qualitative Analysis Of Moral Leadership Crises In Kenyan Evangelical Churches As It Relates To Developing Authentic Leaders, Peter N. Mulinge

All Electronic Theses and Dissertations

This project addressed the moral leadership crises among the evangelical churches of Kenya. Evangelicalism is the fastest growing religious movement in Kenya, a country that already has Africa’s largest percentage of evangelicals overall. This makes it imperative to promote authentic leadership in Kenyan churches. But the concept of leadership development there is overlooked, and as a result churches suffer from a lack of authentic leaders. In this vacuum, Kenyan churches are heavily influenced by traditional African leadership models that can be authoritarian, hereditary, and overwhelmingly corrupt. The latest Corruption Perception Index of 2013, launched by the global agency of Transparency …

Uav Cattle Tracker, Shaun Finlinson

Electrical and Computer Engineering

Every year cattle ranchers loose millions of dollars to preventable causes or curable illnesses.

The purpose of the UAV Cattle Tracker is to provide cattle ranchers daily cattle health and location monitoring for range cattle, improving overall food production efficiencies and increased profits.

Emergency Vital Signs Monitor, Derek Jensen

Electrical and Computer Engineering

According to the Center for Disease Control, every year there are over 120 million visits to the emergency department.

In 2010 alone, at least 55 milion of those visits required care from a trauma center.

As an EMT, it is expected that an initial assessment and transport decision is made within ten minutes of arriving on scene. They need the best information possible to make an informed decision.

Toward A Standard For A Failure To Accommodate Claim Under The New Jersey Law Against Discrimination, Andrew J. Obergfell

Seton Hall Law Review

No abstract provided.

Tributes To The Honorable Arthur L. Alarcón United States Court Of Appeals For The Ninth Circuit

Loyola of Los Angeles Law Review

The Loyola of Los Angeles Law Review is pleased to publish this Tribute to Judge Arthur L. Alarcón of the United States Court of Appeals for the Ninth Circuit.

TRIBUTE AUTHORS

Laurie L. Levenson
President Jimmy Carter
Justice Nora M. Manella
Judge Gregory W. Alarcón
Paula Mitchell
Judge Stephen Reinhardt
Chief Judge Sidney R. Thomas
Judge Sandra R. Klein
Judge William C. Canby, Jr.
Judge Jerome Farris
Judge Alfred T. Goodwin
Judge Susan Graber
Judge Michael Hawkins
Judge Andrew Kleinfeld
Judge Dorothy Nelson
Judge Mary Schroeder
Judge Richard C. Tallman
Judge J. Clifford Wallace
Judge Kim McLane Wardlaw

The Roberts Court In 2013–14—Looking Beyond The Rhetoric, Evan Gerstmann

Loyola of Los Angeles Law Review

No abstract provided.

Putting The Rabbit Back In The Hat: Noel Canning's Impact On Eighteen Months Of Nlrb Decisions And Future Presidential Appointments, Paul Kind

Loyola of Los Angeles Law Review

No abstract provided.