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Metabolic Consequences Of Long-Term Rapamycin Exposure On Common Marmoset Monkeys (Callithrix Jacchus), Corinna N. Ross, A. Salmon, R. Strong, E. Fernandez, M. Javors, A. Richardson, S. Tardif

Biology Faculty Publications (Archived)

Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health and function have been widely debated in both clinical and translational trials. Prior to rapamycin being used as a treatment to extend both lifespan and healthspan in the human population, it is vital to assess the side effects of the treatment on metabolic pathways in animal model systems, including a closely related non-human primate model. In this study, we found that long-term treatment of marmoset monkeys with orally-administered encapsulated rapamycin resulted in no overall effects on body weight and only a small decrease in …

Sensitivity Of Cellular Oxidative Damage To Biosynthetic Rate And Metabolic Rate, Palihawadana Walauwe Kamalika Kaushalya Amunugama

Masters Theses

"The relationship between energy expenditure and longevity is a long standing question in aging studies. The empirical results have contradictory effects on the existing theories. A theoretical model and an experimental test of it were presented, revealing the detailed tradeoffs between metabolic rate, biosynthetic rate and cellular damage level. The dissipative mechanisms of oxidative metabolism cause various forms of cellular damages. To counteract the accumulation of damage, organisms have evolved highly efficient maintenance mechanisms. If there is no other energy demand possess, then most of the cellular damage would be repaired, regardless of how metabolic rate varies. However, the repairing …

The Impact Of Acculturation On Perceptions Of Elder Abuse And Help-Seeking Behaviors Among Elderly Polynesians, Myra Halaevalu Te’O Aukusitino

Theses and Dissertations

This applied dissertation was conducted to determine whether or not acculturation affects the process of help-seeking patterns and behaviors for Polynesian victims of elder abuse. The researcher utilized a quantitative correlation design to employ structured survey measures to collect statistical data to determine the impact of acculturation on perception of elder abuse and help-seeking behaviors among elderly Polynesians. Acculturation was measured using the Polynesian Self-Identify Acculturation Scale and the 13 case scenarios developed by Moon and Williams. The study looked at the extent to which elderly Polynesians perceived that the scenarios depicted abusive situations, and to what extent they indicated …

2015 Ninth Cfw Summit Schedule, Illinois Wesleyan University

Related Documents

No abstract provided.

Defining Young In The Context Of Prostate Cancer, Suzanne Chambers, Anthony Lowe, Melissa Hyde, Leah Zajdlewicz, Robert F. Gardiner, David Sandoe, Jeff Dunn

Research outputs 2014 to 2021

The experience of prostate cancer is for most men a major life stress with the psychological burden of this disease falling more heavily on those who are younger. Despite this, being young as it applies to prostate cancer is not yet clearly defined with varied chronological approaches applied. However, men’s responses to health crises are closely bound to life course and masculinities from which social roles emerge. This paper applied qualitative methodology (structured focus groups and semistructured interviews with expert informants) using interpretative phenomenological analysis to define what it means to be young and have prostate cancer. Structured focus groups …

Trailmaking Test Performance Contributes To Subjective Judgment Of Visual Efficiency In Older Adults, Annalisa Setti, James Loughman, George Savva, Rose Anne Kenny

Articles

Introduction.

The determinant factors that influence self-reported quality of vision have yet to be fully elucidated. This study evaluated a range of contextual information, established psychophysical tests, and in particular, a series of cognitive tests as potentially novel determinant factors.

Materials &Methods. Community dwelling adults (aged 50+) recruited to Wave 1 of The Irish Longitudinal Study on Ageing, excluding those registered blind, participated in this study (N = 5,021). Self-reports of vision were analysed in relation to visual acuity and contrast sensitivity, ocular pathology, visual (Choice Response Time task; TrailMaking Test) and global cognition. Contextual factors such as having visited …

Sexuality, Desire And The Ageing Female Body: An Essay, Lauren Marsh

Theses: Doctorates and Masters

This thesis consists of a novella, ‘One Night in Hong Kong’, and an essay, ‘Sexuality, Desire and the Ageing Female Body.’ The novella tells the story of an erotic affair between the female narrator and a man in a hotel room in the neon city of Hong Kong. Told in four parts, the story shifts in time, reflecting on earlier events in the narrator’s life and a trip she made to the Sicilian city of Catania in 1954.

Older female protagonists and their sexuality are rarely depicted in contemporary Australian fiction. Where representations do exist, they act as ‘interventionist’ texts, …

The Effects Of Emotion And Action On Binding In Memory, Kacie Mennie

LSU Master's Theses

The ability to successfully bind features and objects at different levels of abstraction is important for everyday functioning of memory. The current study examined how actions and emotional arousal influence item recognition and between-item binding across two experiments. According to the Arousal-Biased Competition Theory (ABC; Mather and Sutherland, 2011), binding can be enhanced by emotional arousal, depending upon what is the focus of attention within a scene. In the current study, participants viewed a series of slides, each of which depicted a person performing an action with an object, as well as an object that is not interacted with. All …

Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster

USF Tampa Graduate Theses and Dissertations

Caregivers of persons with dementia, who are often older adults, report sleep disturbance, high rates of depressive symptoms and may be at risk for impaired cognition. This dissertation examined sleep, depressive symptoms, and cognition in older adults and caregivers of persons with dementia. The aims of the review of literature were to understand, in community dwelling adults 60 years and older, the relationships among sleep parameters (sleep onset latency, wake after sleep onset, sleep efficiency, total sleep time, and general sleep complaints), and the domains of cognition (Executive Function, Attention, Episodic Memory, Working Memory, Processing Speed), and global cognition. Based …

Feeling At Home With Grief: An Ethnography Of Continuing Bonds And Re-Membering The Deceased, Blake Paxton

USF Tampa Graduate Theses and Dissertations

Bereavement scholars Silverman, Nickman, and Klass (1996) have argued that rituals to continue a relationship with the deceased do not have to be considered pathological in nature. Since their work, scholars have offered specific strategies for the bereaved to actively construct a bond after death, including telling stories about those who have died, having imagined conversations with the deceased, celebrating their birthdays and anniversaries, and reviewing artifacts that represent or once belonged to them (among other strategies). Hedtke and Winslade (2004) call these “re-membering” processes by which the deceased can regain active membership in their loved ones lives. This dissertation …