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Volume 66 Issue 1 (2015), Case Western Reserve Law Review

Case Western Reserve Law Review

No abstract provided.

Literary Translingualism: Multilingual Identity And Creativity, Steven G. Kellman, Natasha Lvovich

Publications and Research

No abstract provided.

How Product Attributes Influence Internationalization: A Framework Of Domain- And Culture-Specificity, Terence P. C. Fan, Alex Tai Loong Tan

Research Collection Lee Kong Chian School Of Business

This paper introduces two important dimensions of product attributes in the context of internationalization: domain- and culture-specificity. Products can be high or low in domain- or culture-specificity, thereby being one of four broad categories in a two-by-two matrix. This framework of product attributes helps explain a series of gradations on how cultural difference influences the difficulty of selling a product internationally. By examining four cases, one from each of these categories, this paper shows that different product attributes affect the difficulty or ease with which the products of these firms were internationalized. While all four cases were able to derive …

How Do General Practitioners Manage Patients With Cancer Symptoms? A Video-Vignette Study, Moyez Jiwa, Xingqiong Meng, Carolyn O'Shea, Parker Magin, Ann Dadich, Vinita Pillai

Medical Papers and Journal Articles

Objectives: Determine how general practitioners (GPs) manage patients with cancer symptoms.

Design: GPs reviewed 24 video-vignettes and case notes on patients with cancer symptoms and indicated whether they would refer the patient and/or prescribe medication, and/or undertake further investigation. According to available guidelines, all cases warranted a referral to a specialist or further investigations.

Setting: Australian primary care sector.

Participants: 102 practising GPs participated in this study, including trainees.

Interventions: The research was part of a larger randomised controlled trial testing a referral pro forma; however, this paper reports on management decisions made throughout the study.

Primary and secondary outcome …

Apoe Ε4 Moderates Abnormal Csf-Abeta-42 Levels, While Neurocognitive Impairment Is Associated With Abnormal Csf Tau Levels In Hiv+ Individuals – A Cross-Sectional Observational Study, Lucette A. Cysique, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph N. Martins, Constance S. Chew, Nicholas N. Davies, Patricia Price, Bruce J. Brew

Medical Papers and Journal Articles

Background: Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer’s Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear.

Methods: Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median HIV duration 20 years, >95% plasma and CSF HIV RNA <50 cp/mL, on cART for a median 24 months). All underwent standard neuropsychological testing (61% had HAND), APOE genotyping (30.9% carried APOE ε4 and 7.1% were ε4 homozygotes) and a lumbar puncture. Concentrations of Aβ1-42, t-tau and p-tau were assessed in the CSF using commercial ELISAs. Current neurocognitive status was defined using the continuous Global Deficit Score, which grades impairment in clinically relevant categories. History of HAND was recorded. Univariate correlations informed multivariate models, which were corrected for nadir CD4-T cell counts and HIV duration.

Results: Carriage of APOE ε4 predicted markedly lower levels of CSF Aβ1-42 in univariate (r = -.50; p = .001) and multivariate analyses (R2 = .25; p < .0003). Greater levels of neurocognitive impairment were associated with higher CSF levels of p-tau in univariate analyses (r = .32; p = .03) and multivariate analyses (R2 = .10; p = .03). AD risk prediction cut-offs incorporating all three CSF biomarkers suggested that 12.5% of participants had a high risk for AD. Having a CSF-AD like profile was more frequent in those with current (p = .05) and past HIV-associated dementia (p = .03).

Conclusions: Similarly to larger studies, APOE ε4 genotype was not directly associated with HAND, but moderated CSF …

Abdominal Compliance: A Bench-To-Bedside Review, Annika R. Blaser, Martin Bjorck, Bart De Keulenaer, Adrian Regli

Medical Papers and Journal Articles

Abdominal compliance is an important determinant and predictor of available workspace during laparoscopic surgery. Furthermore, critically ill patients with a reduced abdominal compliance are at an increased risk of developing intra-abdominal hypertension and abdominal compartment syndrome both of which are associated with high morbidity and mortality. Despite of this, abdominal compliance is a concept, which has been neglected in the past.

Abdominal compliance is defined as a measure of the ease of abdominal expansion, expressed as a change in intra-abdominal volume per change in intra-abdominal pressure:

abdominal compliance = delta intra-abdominal volume / delta intra-abdominal pressure.

AC is a dynamic …

Target Definition For Shipwreck Hunting, Kim Kirsner

Medical Papers and Journal Articles

The research described in the present article was implemented to define the locations of two World War II shipwrecks, the German raider Kormoran, and the Australian light cruiser HMAS Sydney. The paper describes the long and complex trail that led through inefficient oceanographic prediction to ambiguous historical prediction involving a single report and on to precise cognitive prediction based on nine reports from more than 70 survivors, a process that yielded a single target position or “mean” just 2.7NM (nautical miles) from the wreck of Kormoran. Prediction for the position of the wreck of Sydney opened with wishful thinking that …

International Dissemination Of Evidence‑Based Practice, Open Access And The Iacapap Textbook Of Child And Adolescent Mental Health, Joseph Rey

Medical Papers and Journal Articles

Dramatic changes have occurred in both publishing and teaching in the last 20 years stemming from the digital and Internet revolutions. Such changes are likely to grow exponentially in the near future aided by the trend to open access publishing. This revolution has challenged traditional publishing and teaching methods that—largely but not exclusively due to cost—are particularly relevant to professionals in low and middle income countries. The digital medium and the Internet offer boundless opportunities for teaching and training to people in disadvantaged regions. This article describes the development of the IACAPAP eTextbook of child and adolescent mental health, its …

Protocol For The Care-Is Trial: A Randomised Controlled Trial Of A Supportive Educational Intervention For Carers Of Patients With High-Grade Glioma (Hgg), G K B Halkett, Elizabeth A. Lobb, L Miller, J L. Phillips, T Shaw, R Moorin, A Long, A King, J Clarke, S Fewster, P Hudson, M Agar, A K. Nowak

Medical Papers and Journal Articles

Introduction: High-grade glioma (HGG) is a rapidly progressive and debilitating disease. Primary carers experience significant levels of distress which impacts on their experience of caregiving, the quality of care received and the community in terms of the increased reliance on healthcare due to the potential development of complicated grief. This paper describes the protocol for testing the efficacy and feasibility of an intervention for primary carers of patients with HGG in order to improve preparedness to care and reduce carer distress.

Methods: Randomised controlled trial. The target population is carers of patients with HGG who are undergoing combined chemoradiotherapy. The …

Do Patients With Long-Term Side Effects Of Cancer Treatment Benefit From General Practitioner Support? A Literature Review, I Ngune, M Jiwa, A Mcmanus, J Hughes

Medical Papers and Journal Articles

Background: Alongside specialist cancer clinics, general practitioners have an important role in cancer patients’ follow-up care, yet no literature summarises the nature, extent and impact of their involvement. This paper addresses this issue through a review of the literature.

Methods: Studies were sourced from six academic databases - AustHealth (n = 202), CINAHL (n = 500), the Cochrane Library (reviews and trials; n = 200), Embase (n = 368), PHCRIS (n = 132) and PubMed/Medline (n = 410). Studies that focused on interventions designed for patients receiving follow-up care and reported cancer care provided by a general practitioner delivered alongside …

Trans-Arterial Embolisation Therapies For Unresectable Intrahepatic Cholangiocarcinoma: A Systematic Review, L. Yang, J Shan, L Shan, A Saxena, L Bester, D Morris

Medical Papers and Journal Articles

Background: Unresectable intrahepatic cholangiocarcinoma (ICC) portends a poor prognosis despite standard systemic treatments which confer minimal survival benefits and significant adverse effects. This study aimed to assess clinical outcomes, complications and prognostic factors of TAE therapies using chemotherapeutic agents or radiation.

Methods: A literature search and article acquisition was conducted on PubMed (MEDLINE), OVID (MEDLINE) and EBSCOhost (EMBASE). Original articles published after January 2000 on trans-arterial therapies for unresectable ICC were selected using strict eligibility criteria. Radiological response, overall survival, progression-free survival, safety profile, and prognostic factors for overall survival were assessed. Quality appraisal and data tabulation were performed using …

Implementation Of The International Association Of Diabetes And Pregnancy Study Groups Criteria: Not Always A Cause For Concern, P Sibartie, J Quinlivan

Medical Papers and Journal Articles

Background: Controversy surrounds the decision to adopt the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for the diagnosis of gestational diabetes mellitus (GDM) as fears that disease prevalence rates will soar have been raised.

Aims: To investigate the prevalence of pregnancy complicated with GDM before and after the introduction of the IADPSG 2010 diagnostic criteria.

Materials and Methods: A prospective audit of all women who delivered from July 1, 2010, to June 30, 2014, in a predefined geographic region within the North Metropolitan Health Service of Western Australia. Women were diagnosed with GDM according to Australian Diabetes …

Neuropsychological And Functional Outcomes In Recent-Onset Major Depression, Bipolar Disorder And Schizophrenia-Spectrum Disorders: A Longitudinal Cohort Study, R Lee, D Hermens, S Naismith, J Lagopoulos, A Jones, J Scott, K Chitty, D White, R Robillard, E Scott, I Hickie

Medical Papers and Journal Articles

Functional disability is the lead contributor to burden of mental illness. Cognitive deficits frequently limit functional recovery, although whether changes in cognition and disability are longitudinally associated in recent-onset individuals remains unclear. Using a prospective, cohort design, 311 patients were recruited and assessed at baseline. One hundred and sixty-seven patients met eligibility criteria (M = 21.5 years old, s.d. = 4.8) and returned for follow-up (M = 20.6 months later, s.d. = 7.8). Two-hundred and thirty participants were included in the final analysis, comprising clinically stable patients with major depression (n = 71), bipolar disorder (BD; n = 61), schizophrenia-spectrum …

Short Selling Pressure, Stock Price Behavior, And Management Forecast Precision: Evidence From A Natural Experiment, Yinghua Li, Liandong Zhang

Research Collection School Of Accountancy

Using a natural experiment (Regulation SHO), we show that short selling pressure and consequent stock price behavior have a causal effect on managers' voluntary disclosure choices. Specifically, we find that managers respond to a positive exogenous shock to short selling pressure and price sensitivity to bad news by reducing the precision of bad news forecasts. This finding on management forecasts appears to be generalizable to other corporate disclosures. In particular, we find that, in response to increased short selling pressure, managers also reduce the readability (or increase the fuzziness) of bad news annual reports. Overall, our results suggest that maintaining …

Communicating Corporate Social Responsibility In Singapore: Towards More Effective Media Relations, A. Pang, Angela Ka Ying Mak, Joanne M. H. Lee

Research Collection Lee Kong Chian School Of Business

Organizations face several impediments when it comes to communicating their corporate social responsibility (CSR) engagement to the public via the media. This paper examines practitioners’ and journalists’ perception of CSR communication using the agenda-building model (Qiu Q, Cameron GT, Communicating health disparities: building a supportive media agenda. VDM Verlag, Saarbruecken, 2008) by examining news coverage of how practitioners and journalists understand CSR, what types of CSR stories get covered in the media, and how are CSR stories portrayed in the media. News coverage of Singapore’s mainstream publications, The Straits Times, The Business Times, and The New Paper, were analyzed. The …

Hazards To Effective Due Diligence, Michael Benoliel

Research Collection Lee Kong Chian School Of Business

It is not surprising that many business deals fail to realize their expected future value because some deal makers fail to perform effective due diligence. Successful deal makers, however, know that due diligence is one of the most important tasks in successful deal making. Thus, they avoid the psychological and contextual traps that cause poor due diligence. In this article, I describe the hazards – the psychological biases and contextual factors – that might affect the due diligence task. These hazards include information availability bias; confirmation bias; overconfidence bias; time pressure; self-interested agents; deal fever; narrow focus; and complexity. Following …

The Class Size Paradox, Boris Handal, Marguerite Maher, Kevin Watson

Education Papers and Journal Articles

No abstract provided.

Relationship Between Physical Capacity And Match Performance In Semiprofessional Australian Rules Football, Ben G. Piggott, Michael R. Mcguigan, Michael J. Newton

Health Sciences Papers and Journal Articles

This study investigated the relationship between physical performance and match performance in Australian Rules Football (ARF). Thirty-six semiprofessional ARF players participated in this study. Physical capacity was measured using a 3-km time trial. Match performance was measured throughout the 2013 season through 2 methods: direct game involvements (DGIs) per minute and a recording of coaches' vote after the game. The main finding of the study was that 3-km time trial performance was a significant predictor of DGI per minute (p ≤ 0.05). In addition, the number of senior games played was also significant in predicting DGI per minute (p ≤ …

The Impact Of Maternal Gestational Stress On Motor Development In Late Childhood And Adolescence: A Longitudinal Study, Tegan Grace, Max Bulsara, Monique Robinson, Beth Hands

Health Sciences Papers and Journal Articles

The number and timing of stressors experienced during pregnancy were investigated using longitudinal data from the Western Australian Pregnancy (Raine) Study cohort (N = 2,900). Motor development data were collected at 10 (n = 1,622), 14 (n = 1,584), and 17 (n = 1,222) years using the McCarron Assessment of Neuromuscular Development. Linear mixed models were used to examine the effect of stress on motor development, accounting for repeated measures. Number of stressful events and mean Neuromuscular Development Index were negatively related (β = −1.197, p = .001). Stressful events experienced in late pregnancy were negatively related with offspring motor …

Unethical For The Sake Of The Group: Risk Of Social Exclusion And Pro-Group Unethical Behavior, Stefan Thau, Rellie Derfler-Rozin, Marko Pitesa, Marie S. Mitchell, Madan M. Pillutla

Research Collection Lee Kong Chian School Of Business

This research tested the idea that the risk of exclusion from one's group motivates group members to engage in unethical behaviors that secure better outcomes for the group (pro-group unethical behaviors). We theorized that this effect occurs because those at risk of exclusion seek to improve their inclusionary status by engaging in unethical behaviors that benefit the group; we tested this assumption by examining how the effect of exclusion risk on pro-group unethical behavior varies as a function of group members' need for inclusion. A 2-wave field study conducted among a diverse sample of employees working in groups (Study 1) …

Scoring And Validation Of The Cystic Fibrosis Disclosure Questionnaire, Adrienne P. Borschuk

Theses and Dissertations

As more patients with cystic fibrosis (CF) are living into adulthood, patients may need to disclose their CF status to others, such as in romantic or professional settings. Patients who choose not to disclose their CF status may be limited in their closeness with others, which may negatively affect their psychological functioning and health-related quality of life. Few studies, however, have examined disclosure in CF, and currently no validated measures of CF disclosure exist. The purpose of this study was to explore CF disclosure in adults and validate a new assessment of CF disclosure, the Cystic Fibrosis Disclosure Scale (CFDS). …

Effects Of Brain-Derived Neurotrophic Factor And Its Signaling Pathway On Sensory Neuronal Activation During Colitis, Fiza Hashmi

Theses and Dissertations

Visceral hypersensitivity is the heightened response to sensory stimuli. Visceral sensations are transmitted through primary afferent neurons in the dorsal root ganglion (DRG) and the sensitization of the neural pathway leads to modification in spinal ascending and descending neurons. The aim of this investigation is to determine the effects of brain-derived neurotrophic factor (BDNF) and its signaling pathway on sensory neuronal activation during colitis. In order to evaluate this, levels of calcitonin-gene related peptide (CGRP), a neuropeptide marker for nociceptive transmission, and phosphorylated cAMP-response element binding protein (pCREB), a molecular switch in neuronal plasticity, were studied in response to BDNF …

The Editorial Double Vision Of Maxwell Perkins: How The Editor Of Fitzgerald, Hemingway, And Wolfe Plied His Craft, Rachel F. Van Hart

Theses and Dissertations

Scholars and literary enthusiasts have struggled for decades to account for editor Maxwell Perkins’s unparalleled success in facilitating the careers of many of the early twentieth century’s most enduring and profitable writers, among them F. Scott Fitzgerald, Ernest Hemingway, and Thomas Wolfe. This study seeks to penetrate that mystery by dissecting Perkins’s editorial practice and examining how he navigated the competing tensions between commercial success and aesthetic integrity in various circumstances. At play in the construction of his literary legacy are prevailing perceptions of authorship, complex interpersonal relationships, and the inherent battle between art and commerce. Focusing on his day-to-day …

The Effectiveness Of A Preventive Recall Strategy In Children Following Dental Rehabilitation Under General Anesthesia, Katherine A. Nordeen

Theses and Dissertations

Purpose: This was a pilot study to assess the impact of a preventive strategy following full-mouth dental rehabilitation (FMDR) under general anesthesia in children with early childhood dental caries.

Methods: Sixty-six patients completed FMDR and were included in the analysis. At the consultation visit, caries risk assessment (CRA) and dental exam information were recorded, and caregivers completed an oral health knowledge (OHK) questionnaire. Patients returned for a post-surgery and recall visit. Caregivers received oral hygiene instructions in a motivational-interviewing style.

Results:At the consultation visit all patients were high risk. At the post-surgery visit, only 47% remained high risk …

Dual Pi3k/Mtor Inhibition With Bez235 Augments The Therapeutic Efficacy Of Doxorubicin In Cancer Without Influencing Cardiac Function, David E. Durrant

Theses and Dissertations

Cancer continues to be a leading cause death in the United States despite improved treatments. Cancerous lesions form after acquiring oncogenic driver mutations or losing tumor suppressor function in normal cells. Traditional therapies have included use of genotoxic substances that take advantage of the increased growth rate and loss of tumor suppressor function to cause cell death. One such drug is the anthracycline antibiotic doxorubicin (DOX). DOX interchelates into DNA and disrupts transcriptional machinery while also poisoning topoisomerase II. This results in single and double stranded DNA breaks, which if severe enough leads to either necrotic or apoptotic cell death. …

Social Performance And Reticence: Mental Negotiations In Austen, Brontë, And Eliot, Meredith L. Spencer

Theses and Dissertations

This thesis examines how three nineteenth-century British novels purvey and critique contemporary standards regarding social performance and reticence and the strains such standards place on those whose dispositions disincline them to conform to the regulations for decorum articulated in conduct books of the time. Utilizing the psychological lens of introversion and extroversion alongside the cognitive narrative theories of Alan Palmer and Lisa Zunshine, this thesis investigates the construction of individual character identities through the reading of interactions among multiple fictional minds in Charlotte Brontë’s Villette (1853), Jane Austen’s Pride and Prejudice (1813), and George Eliot’s The Mill on the Floss …

Thomas Jefferson’S Designs For The Federal District And The National Capitol, 1776-1826, Craig A. Reynolds

Theses and Dissertations

This dissertation examines six major points: 1) it argues that Jefferson is an architect of the United States Capitol, having direct and final say over its design; 2) it asserts that Jefferson set two nationally influential models of architectural taste as part of his movement to reform American architecture, first in Richmond as the Virginia State Capitol and second in Washington as the United States Capitol; 3) it explores those models to define what Jefferson called “cubic” and “spherical” architecture; 4) it suggests that Jefferson used his political appointments to maximize his influence over the design of the United States …

Place-Based Scholarship Program Design, Context, And Intergenerational Mobility: A Case Study Of The Kalamazoo Promise Scholarship Program, Arielle F. Niemeyer

Theses and Dissertations

Earning a college degree correlates with achieving financial security. Thus, improving an individual’s access to college is a key tactic used to mitigate poverty and foster intergenerational mobility. Despite the recognized value of higher education, earning a degree remains unattainable for many because of financial constraints. However, research definitively demonstrates that financial aid overcomes that obstacle. It also reveals that some program designs are more effective than others. The Kalamazoo Promise is a place-based scholarship program that offers four-year, full-tuition scholarships to residents who graduate from a Kalamazoo public high school. It is characterized by first-dollar and universal eligibility features, …

Use And Perspectives Of A Social Marketing Campaign To Improve Fruit And Vegetable Intake, Allison Palmberg

Theses and Dissertations

The current study evaluated the development and acceptability of a social marketing campaign to improve emerging adults’ fruit and vegetable (FV) intake. A social marketing campaign was developed through focus groups with 24 college students. Materials were implemented in two dining locations at Virginia Commonwealth University. Sales of carrots, apples, and chips were collected in three phases: baseline, implementation of the campaign, and washout. In addition, surveys were collected from 303 diners across all phases and locations. Results indicated an increase in carrot sales, decrease in sales of chips sold with a meal, and mixed findings regarding sales of apples …

Limelight & Indigestion, Joshua D. Thorud

Theses and Dissertations

This thesis chronicles the progression toward and creation of my thesis show, Limelight & Indigestion, as well as the cultural, technological and artistic influences and discussions that underpin the works therein. The show is an exploration of celebrity, mass media, and the nature of the desire for fame. I hope to situate my work through an investigation of topics such as Hollywood and the use of green screens and associated technology, our physical and ideological connection to cinema, the absurd in cinema history, and the complex nature of media digestion.