Digital Commons Network^™

The Depth Of Endurance: A Critical Look At Prolonged Solitary Confinement In Light Of The Constitution And A Call To Reform, Shannon H. Church

Kentucky Law Journal

No abstract provided.

Crowd Crush: How The Law Leaves American Crowds Unprotected, Tracy Hresko Pearl

Kentucky Law Journal

Crowd-related injuries and deaths are startlingly common both in the United States and worldwide. They occur in a wide range of situations and at a vast array of venues: at music concerts, sporting events, retail holiday sales, in and around airports, subway plaorms, and parking lots, among other locations. These "crowd crush" incidents, however, are extremely underreported and rarely litigated, masking the seriousness of this issue and making it difficult for the few victims who pursue legal recourse to recover damages. Given that there is virtually no statutory law in the United States pertaining to crowd management and control, crowd …

Once We're Done Honeymooning: Obergefell V. Hodges, Incrementalism, And Advances For Sexual Orientation Anti-Discrimination, Jeremiah A. Ho

Kentucky Law Journal

Undoubtedly, the Supreme Court's marriage equality decision in Obergefell v. Hodges is the watershed civil rights decision of our time. Since United States v. Windsor, each recent victory for same-sex couples in the federal courts evidenced that the legal recognition of same-sex marriages in the United States was becoming increasingly secure. Meanwhile, momentum was growing for the visibility of sexual minorities nationally. Yet, is marriage equality the last stop in the pro-LGBTQmovement, or should we expect sexual minorities to advance in other legal arenas? Should we expect that the recent strides in marriage equality from Windsor to Obergefell can …

Persecution: How Much Is Enough?, Hillary R. Chambers

Kentucky Law Journal

No abstract provided.

Federal Reverse Preemption Of Uninsured And Underinsured Motorist Coverage Offering In The Digital Age: E-Sign And Ueta Have Not Had A Significant Impact On State Offering Or Rejection Requirements, Steven Plitt, Daniel Maldonado, John Wittwer

Kentucky Law Journal

No abstract provided.

Who's Afraid Of The Hated Political Gerrymander?, Luis Fuentes-Rohwer

Kentucky Law Journal

The political gerrymander has few friends among scholars and commentators. Even a majority on the Supreme Court agreed that the practice violates constitutional and democratic norms. Andyet, this is one of the few issues that the US. Supreme Court refuses to regulate. The justices mask their refusal to regulate this area on a professedi nability to divinej uaicially-manageables tandards. In turn, scholars offer new standards for the justices to consider. This is not only a mistake but also misguided. The history of the political question doctrine makes clear that the discovery of manageable standards has never controlled the Court's prior …

Nursing Care Of Terminal Patients In Intensive Care Units, Pervell Velethia Dunbar

Walden Dissertations and Doctoral Studies

Nursing Care for Terminal Patients in Intensive Care Units

by

Pervell Dunbar

Project Submitted in Partial Fulfillment

of the Requirements for the Degree of

Doctor of Nursing Practice

Walden University

August 2015

Although the goal of the ICU has always been to save lives, ICU now additionally provides end-of life (EOL) care. The objective of this project was to provide ICU nurses with a comprehensive awareness of physical, emotional, and spiritual EOL care issues of patients and their families in order to be better equipped to handle EOL care. The framework used was Jean Watson's Caring model (10 Caritas). A …

Investigating The English Language Arts Placement Of Struggling High School Freshmen, Pamela Burke-Haug

Walden Dissertations and Doctoral Studies

This qualitative case study addressed a suburban school district's placement of academically at-risk English language arts (ELA) 9th graders as the district transitions from the New Jersey Assessment of Skills and Knowledge (NJASK) to use of the unfamiliar and controversial Partnership for Assessment of Readiness for College and Careers (PARCC). Based on the theoretical frameworks of the zone of proximal development, cognitive apprenticeship, and Bandura's model of self-efficacy, the purpose was to understand the characteristics of struggling (labeled 'academic') ELA students, placement practices and perceptions of these practices, and placement improvements. A purposeful sample was recruited of 7 staff members …

Placing Students In Eighth Grade Mathematics: A Case Study Of The Decision-Making Process, Donald Joseph Davis

Walden Dissertations and Doctoral Studies

Algebra 1 is considered an essential course to master in order to understand the concepts of higher-order mathematics, and the California accountability system designates this course for completion in 8th grade. In Shelton County, however, placement of 8th graders in this course is based on feeder school, rather than student ability, resulting in inequitable access. The purpose of this case study was to examine the experiences of administrators who place individual students in mathematics courses and the factors that influence their placement decisions. The conceptual framework for the study was administrative theory as related to processes of effective decision making. …

The Behavioral Impact Of Knowledge On Breast Cancer Risk Reduction, Mia Hung

Walden Dissertations and Doctoral Studies

The purpose of this study was to investigate the behavioral impact of knowledge regarding the relationship between breast cancer, vitamin D supplementation, and sunlight exposure considering levels of self-efficacy and response-efficacy. The study was based on protection motivation theory, which attributes behavior change to cognitive processes related to perceived threats and has demonstrated efficacy in promoting breast cancer risk-reducing behaviors. The study employed a quasi-experimental research design based on a survey using SurveyMonkey. Participants were New York City-residing women ranging in age from 25 to 74 who were recruited via an invitation from SurveyMonkey. Correlation analysis and linear regression analysis …

Reducing Challenging Behaviors In Intellectually Disabled Individuals: A Comparison Of Organizational Culture And Treatment Approach, Frances Mascolo-Glosser

Walden Dissertations and Doctoral Studies

The deinstitutionalization of the intellectually disabled (ID) and their transition to community living in New York State necessitated training initiatives for staff to manage challenging behaviors safely and humanely. However, the use of physical interventions to control self-injury and physical aggression may have become organizationally habituated, and limited research has compared programs that use physical versus nonphysical interventions. This mixed-method, comparative case study compared a restraint-free day habilitation program with one that used physical interventions, examining the differences in reducing self-injury, aggression, and types of interventions applied. Qualitative differences in philosophical approach to behavior intervention strategies and staff training protocols …

A Multiple Case Study Exploring Factors Promoting Nursing Faculty Satisfaction With Teaching Online In Three Schools Of Nursing In The Southeastern United States, Nancy Pope Wingo

All ETDs from UAB

To address nursing shortages in the healthcare workforce and expand access to higher education, many schools of nursing are offering academic degrees that can be completed mostly online. Nursing schools that consider online programs to be a key part of their strategic plan need faculty who are comfortable and satisfied with teaching online. Yet nursing schools nationwide are facing a shortage of nursing faculty, due to the retirement of aging instructors, high workload, low salaries, and other factors. To foster faculty gratification and promote long-term retention of skilled instructors to teach online, nursing schools need to learn more about factors …

Transforming Complexity Into Order: A Grounded Theory Of An Agile Methodology Applied To Complex Problem Domains, R Steven Wingo

All ETDs from UAB

This dissertation is focused on the phenomenon of implementing abstractions from complex problem domains in concrete software systems. The question of this inquiry is to determine how an agile software development process, in particular Extreme Programming, supports the development of large software systems as solutions for complex problem domains. This study used the Grounded Theory Methodology to identify and explain the qualities of software development using the Extreme Programming methodology and to construct a theory grounded in data collected from interviews of experienced practitioners of Extreme Programming, from observations of Extreme Programming in practice, and from a review literature related …

Examining The Relationship Between Driving Styles Of Teen Drivers And Their Parents, Shannon Michelle Oram Wittig

All ETDs from UAB

Teenage drivers, ages 16 to 19, account for about 16.8% of motor vehicle crashes (MVCs) in the United States, even though teenagers only represent about 4.4% of the United States population. Several factors increase teenagers’ risk for MVCs including: lack of driving experience, poor ability to identify and anticipate hazards, lack of sensitivity to road complexity and conditions, and increased willingness to take risks. Research has also suggested the importance of parental influences on risky teenage driving. This study examined the effects of parental driving styles, behaviors, and history on teenagers’ driving style using self-reported measures. Overall, it was hypothesized …

Exploring The Effects Of Direct Contact Compression On Osteogenesis, Shannel Wright

All ETDs from UAB

Clinically, the concept of bone building being the result of mechanical adaptation in healthy individuals has been accepted since Wollf’s Law in 1892. Despite many attempts to understand this mechanism, very little is known about the role mechanical forces play on bone molecularly. Current biomechanical theory supports the concept of osteocytes and bone lining cells creating a three-dimensional network that provides biochemical signaling as a result of mechanical loading. With pressure gradient and interstitial fluid flow models being used as methods of mechanical loading, yet there are still unanswered questions about the validity of both models. The suggested solution lies …

Nonsense Suppression In A Cftr Mouse Model And Analysis Of Animo Acids Inserted At Cftr Premature Termination Codons In Mammalian Cells, Xiaojiao Xue

All ETDs from UAB

A nonsense mutation introduces a premature terminations codon (PTC) into an open reading frame (ORF) upstream of a normal stop codon and results in truncated protein production. In frame PTCs account for ~11% of all mutations that cause human genetic diseases. To treat PTC-associated disorders, one approach is to use drugs that facilitate the insertion of amino acids carried by near-cognate aminoacyl-tRNAs at PTCs. Aminoglycosides were shown to suppress nonsense mutations and restore full-length protein production. This process is also termed as readthrough. However, their low efficiency and their potential to induce ototoxicity and nephrotoxicity limits their long-term application for …

Domain Interactions And Structural Cooperativity In Two Classes Of Drug Targets Investigated By Differential Scanning Calorimetry: I. Abc Transporters: Cystic Fibrosis Transmembrane Conductance Regulator And P-Glycoprotein; Ii. Bacillus Subtilis Nad+Synthetase., Zhengrong Yang

All ETDs from UAB

PART I. Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) cause the lethal genetic disease cystic fibrosis (CF). The most common CF-causing mutation is the deletion of F508 (F508del) in its N-terminal nucleotide binding domain (NBD1), which causes CFTR misfolding and premature degradation. By studying the in vitro thermal unfolding of the isolated NBD1 ± F508del using differential scanning calorimetry (DSC), we show that F508del significantly reduces the thermodynamic and kinetic stability of NBD1. We propose that the non-native contact between the partially denatured F508del-NBD1 and other domains may cause the misfolding of F508del-CFTR. This work …

Computational Studies On Alpha-Synuclein In Explicit Solvent: Implications In Parkinson’S Disease, Hongyi Yang

All ETDs from UAB

α-Synuclein (αS) is a cytosolic protein expressed at high levels in the human brain and concentrated in presynaptic nerve terminals. Although the precise nature of αS in vivo remains unclear, the aggregation of αS, from its soluble, functional forms into highly organized amyloid fibrils, has been substantially implicated in the pathology of a number of neurodegenerative diseases collectively known as synucleinopathies. The long-term goal of this project is to understand the molecular mechanisms that initiate αS oligomerization in aqueous solution. A novel computational methodology involving protein modeling and atomistic molecular dynamics (MD) simulations is used in this work. The objective …

Impact Of Medicare Part D Coverage Gap On Medicare Beneficiaries With Copd: Adherence, Healthcare Resource Use, And Cost, Yanni Fan Yu

All ETDs from UAB

Medicare Part D provides prescription drug coverage for beneficiaries to support their pharmacological treatment; however, the complex deductible structure within benefit plans creates a major coverage gap and unexpected consequences. Some evidence has demonstrated reduced adherence resulting from the coverage gap; however, little research has evaluated the effect on healthcare resource use (HRU) and cost, and no studies have been conducted for beneficiaries with chronic obstructive pulmonary disease (COPD). This study examined the impact of the coverage gap on medication adherence as well as healthcare resource use and medical cost among beneficiaries with COPD. Claims data based on a 5% …

Orientalism Redux: Inci Eviner’S Harem, Pinar Zararsiz

All ETDs from UAB

ORIENTALISM REDUX: INCI EVINER’S HAREM PINAR ZARARSIZ (ART HISTORY) ABSTRACT This thesis examines the 2009 video Harem by Turkish artist Inci Eviner (b. 1956). Eviner’s work centralizes issues of gender in Turkish culture, the history of colonialism, and how historical location informs society at large. Eviner lives and works in Turkey, but exhibits internationally. Harem has been exhibited in Turkey, France, and England. Harem is based on a series of nineteenth-century Orientalist engravings by Antoine Ignace Melling, entitled Intérieur d'une partie du Harem du Grand-Seigneur (Interior of Part of the Harem of the Grand Signor) (1803-1819). Melling’s Harem du Grand-Seigneur …

Protumorigenic Role Of Cathelicidin-Related Antimicrobial Peptide In Chemotaxis And Differentiation Of Myeloid Lineage During Prostate Cancer Progression, Ha-Ram Cha

All ETDs from UAB

A growing body of evidence indicates a positive correlation between the expression of human antimicrobial peptide leucine leucine 37 (LL-37) and the progression of epithelial cancers, including carcinomas of the breast, lung, ovary, and prostate. Although the molecular mechanisms for this correlation have not yet been clearly elucidated, the primary function of LL-37 as a chemotactic molecule for innate immune effector cells suggests its possible association in coordinating protumorigenic mechanisms mediated by tumor-infiltrating immune cells. Using a mouse model of epithelial prostate cancer (PCa), the present study identified a unique role for cathelicidin-related antimicrobial peptide (CRAMP), a murine orthologue of …

A New Return Algorithm For Elastoplastic Deformation, David Cooper

All ETDs from UAB

Beginning with a brief introduction to fundamental concepts in computational plasticity, a new return algorithm is presented and its accuracy analyzed against the generalized trapezoid and midpoint rules of Ortiz and Popov (1985). Development of the new scheme, labeled Time Centered Plastic Strain (TCPS), is motivated by the observation that the generalized methods disassociate the evaluation of the two parts of the flow rule, the plastic multiplier and the gradient of the plastic potential. TCPS addresses this flaw by incorporating an explicit evaluation of the flow rule in its formulation. Error plots are presented utilizing two test cases, the von …

Women Manufacturing Methamphetamine: Gender In The Context Of Shake And Bake Cooking In Alabama, Jessica Rae Deitzer

All ETDs from UAB

Researchers of women in the drug economy have been divided, with some portraying women involved in drug manufacturing, dealing, and trafficking as limited participants, and others acknowledging women’s use of agency and gender to successfully accomplish higher roles in drug economies. Additionally, some suggest that the context of the local community and drug market has a strong influence on the roles women occupy within the drug economy. In this study, I examine women’s roles within a particular style of meth cooking (shake and bake) to determine the various opportunities and constraints they face as women meth cooks. To do so, …

Metabolic And Oxidative Regulation Of Neuronal Autophagy And Survival, Matthew Dodson

All ETDs from UAB

Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease and Huntington's disease are all characterized by metabolic dysfunction, increased oxidative damage to proteins and organelles, formation of proteinaceous inclusions, decreased autophagic and proteasomal function, and eventual neuronal and glial cell death. While our understanding of the mechanisms that underlie many of these pathologies is constantly growing, their exact cause, onset, interplay and progression still remain unclear. The gap between the description of disease pathologies and understanding the fundamental mechanisms of disease pathogenesis, progression and potential therapeutics to mitigate disease progression is still large. Based on the observation that altered glucose utilization, …

Robust Production Of Mature Ribosomal Rna Is Directly Influenced By Multiple Steps Within The Transcription Cycle, Krysta Engel

All ETDs from UAB

Cellular growth depends on the capacity for protein synthesis, and likewise ribosome biogenesis. Therefore, robust rRNA synthesis by RNA Polymerase I (Pol I) is a critical component of cell growth. The work reported in this dissertation highlights the contribution of polymerase domains and trans-acting proteins during rRNA synthesis and ribosome biogenesis. Eukaryotes utilize three homologous nuclear RNA polymerases (RNAPs) to express their genomes. The trigger loop (TL) is a well conserved region within the active site of multi-subunit RNAPs that plays a direct role during the nucleotide addition cycle. Analysis of Pol II TL mutants has suggested that catalysis is …

Assessment Of Student-Created Videos As An Alternate Laboratory Assignment And Design And Implementation Of Classroom Activities Designed To Improve Student Retention And Learning, Mitzy Ann Erdmann

All ETDs from UAB

This dissertation presents three educationally based research projects and describes how they are related. The first portion of this manuscript describes the development of an alternate assessment for the general chemistry laboratory that harnessed both the availability of and interest in using smart phone technology in an educational setting. Student-created technique videos were implemented into the general chemistry laboratory curriculum in order to asynchronously monitor student use of standard laboratory equipment. A feasibility study was performed first, which showed that students were able to create videos that showed themselves performing standard laboratory techniques. Teaching assistants reported being able to easily …

Translucency, Stain Resistance And Hardness Of Composites Used For Invisalign Attachments, Katelyn Bowman Feinberg

All ETDs from UAB

The purpose of this study is to compare the translucency parameter, stain resistance and hardness of dental restorative composites and orthodontic adhesives in order to determine an ideal esthetic attachment material for Invisalign® treatment. Materials and Methods: Two dental restorative composites (Filtek™ Supreme Ultra, Tetric EvoCeram®) and three orthodontic adhesives (L.C.R.™, Transbond™ XT, Phase II® Dual Cure) were used in this in-vitro study. 2.0 mm thick samples of each material were fabricated in silicone molds covered with a flat sheet of Invisalign attachment template material. To evaluate the translucency parameter and stain resistance, initial L*a*b* values of each material were …

Long-Term Stability Of Lefort I Maxillary Downdraft With Rigid Internal Fixation, Stephen Leonard Strickland

All ETDs from UAB

ABSTRACT Objective: The objective of this study is to evaluate the skeletal and dental stability of a Le Fort I maxillary downgraft after a minimum 4year follow up period. Methods: This retrospective cohort study evaluated 18 patients' post-surgical stability after Le Fort I maxillary downgraft performed by a Z-osteotomy. Pre-surgical (T1), post-surgical (T2), post-orthodontic (T3), and long-term follow-up (T4) cephalometric radiographs were digitized and analyzed with Dolphin Imagining via a custom analysis to evaluate linear and angular skeletal and dental relapse. Results - The average Le Fort I maxillary down graft was 3.6mm. The average post-surgical orthodontic phase was 7.4 …

Three-Dimensional Age-Related Changes Of The Adult Face; African American Female Population, Christina Theresa Sutherland

All ETDs from UAB

Objectives: Treatment of older adults is one of the fastest growing areas in orthodontic practice. The objectives of this study are to: 1. Investigate the aging of the female African American face using three-dimensional surface imaging to understand how the soft tissue of the face matures in relation to the teeth and 2.) Compare the effects of aging on African American female faces to aging of Caucasian female faces. Methods: This is a cross-sectional study of 100 African American females with balanced faces. Five age groups (in years) were included: [20-30], [31-40], [41-50], [51-60], [61-70]. Three-dimensional (3D) surface images of …

Deleterious Effects Of Hyperglycemia On Cognitive Functioning In The Cardia Study Cohort, Michele Holland Talley

All ETDs from UAB

DELETERIOUS EFFECTS OF HYPERGLYCEMIA ON COGNITIVE FUNCTIONING IN THE CARDIA STUDY COHORT MICHELE LYN HOLLAND TALLEY SCHOOL OF NURSING ABSTRACT With an aging society, maintaining cognitive functioning into older age is becoming more important. Because of the impact cognitive functioning has on daily activities, any disruption may inhibit the ability to perform such daily activities successfully. To prevent disruptions, determinants of cognitive functioning must be considered. Such determinants may or may not be modifiable. Some predictors may be demographic, metabolic, or inflammatory in nature. In addition, predictors or determinants may differ based on genetic predisposition to Alzheimer’s disease. As part …