Digital Commons Network^™

Determining The Mechanisms Generating Soluble Il-15 Complexes, Scott Anthony

Dissertations and Theses (Open Access)

A diverse assortment of infectious pathogens and TLR agonists enhance the expression of Interleukin (IL)-15. Additionally, inducing lymphopenia enhances anti-tumor responses in an IL-15-dependent manner. Paradoxically, despite the limited expression of IL-15 during homeostasis, the role of IL-15 during the steady state is well-known, while its roles during inflammation and infections remain largely undefined. IL-15 uses a unique method of production and presentation to support the development and homeostasis of NK and CD8 T cells. IL-15 is produced with its high affinity IL-15Rα and this IL-15Rα/IL-15 complex is shuttled to the cell surface where it is presented in-trans or cleaved …

Voxel-Level Absorbed Dose Calculations With A Deterministic Grid-Based Boltzmann Solver For Nuclear Medicine And The Clinical Value Of Voxel-Level Calculations, Justin Mikell

Dissertations and Theses (Open Access)

Voxel-level absorbed dose (VLAD) is rarely calculated for nuclear medicine (NM) procedures involving unsealed sources or 90Y microspheres (YM). The current standard of practice for absorbed dose calculations in NM utilizes MIRD S-values, which 1) assume a uniform distribution in organs, 2) do not use patient specific geometry, and 3) lack a tumor model. VLADs overcome these limitations. One reason VLADs are not routinely performed is the difficulty in obtaining accurate absorbed doses in a clinically acceptable time. The deterministic grid-based Boltzmann solver (GBBS) was recently applied to radiation oncology where it was reported as fast and accurate for both …

Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1a Activity And Provides Novel Targets For Inhibiting Tumor Growth, Geoffrey Grandjean Phd

Dissertations and Theses (Open Access)

Normal Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1α Activity and Provides Novel Targets for Inhibiting Tumor Growth

By Geoffrey Grandjean

Advisory Professor: Garth Powis, D. Phil

Unique to proliferating cancer cells is the observation that their increased need for energy is provided by a high rate of glycolysis followed by lactic acid fermentation in a process known as the Warburg Effect, a process many times less efficient than oxidative phosphorylation employed by normal cells to satisfy a similar energy demand ^[1]. This high rate of glycolysis occurs regardless of the concentration of oxygen in the cell and …

Molecular Regulation Of Vascular Calcification In Murine Models Of Atherosclerosis, Shanshan Gao

Dissertations and Theses (Open Access)

Background: Calcification occurs often in the atherosclerotic lesions of patients with coronary heart disease and animals with hypercholesterolemia, such as apolipoprotein-E deficient (ApoE-/-) mice. However, the mechanism(s) underlying the development of calcification in atherosclerosis remains unclear. ApoE acts as a lipid transporter, but also has been recognized as a potential regulator of osteogenesis. Little information is available as to whether ApoE has any direct impact on osteogenesis and calcification in vascular smooth muscle cells (VSMC). Several signal transduction pathways play a role in regulation of calcification, including the Wnt/β-catenin system and potentially GTAP, an ubiquitin-conjugating enzyme responsible for protein …

An Automated Tool For High Resolution Visualization Applied To Transient Watershed Models, Noah Robert Taylor

Theses and Dissertations

Numeric hydrologic models can aid in water resource management by providing predictive simulations of water behavior. As computers become more advanced, the models developed also become more complex using more data to represent larger areas for forecasting hydrologic behavior. Unfortunately, as the simulations use more data, the output often becomes difficult to manage and share without investing time and effort into setting up server environments or decreasing the quality of the output to compensate for an efficient and effective user experience. A proposed solution to facilitate the accessibility of massive hydrologic model output is through the web-based visualization tool developed …

Configuration Scrubbing Architectures For High-Reliability Fpga Systems, Aaron Gerald Stoddard

Theses and Dissertations

Field Programmable Gate Arrays (FPGAs) are being used more frequently in space applications because of their reconfigurability and intensive processing capabilities. FPGAs in environments like space are susceptible to ionizing radiation which can cause Single Event Upsets (SEUs) in the FPGA's configuration memory. These upsets may cause the programmed user design on the FPGA to deviate from its normal behavior. Space missions cannot afford to allow important data processing applications to become corrupted due to these radiation upsets.Configuration scrubbing is an upset mitigation technique that detects and corrects upsets in an FPGA's configuration memory. Configuration scrubbing periodically monitors an FPGA's …

A Theory Of Presence: Bringing Students And Art Closer Together, Joshua T. Hobbs

Theses and Dissertations

In seeking to create a richer learning environment in a junior high art classroom, the author develops a theory of presence. Closely connected to object-centered learning, a theory of presence in the art classroom places value on students being in the presence of, interacting with, and responding to artworks, artists, and other individuals and objects from the visual arts community. The author then describes how curricular plans are influenced by this theory of presence. Using an action research methodology, the author engages in the spiral process of planning, acting, observing, and reflecting on curriculum that explores the possibilities of connecting …

Evaluating Long-Term Land Cover Changes For Malheur Lake, Oregon Using Envi And Arcgis, Ryan Joseph Woods

Theses and Dissertations

Land cover change over time can be a useful indicator of variations in a watershed, such as the patterns of drought in an area. I present a case study using remotely sensed images from Landsat satellites for over a 30-year period to generate classifications representing land cover categories, which I use to quantify land cover change in the watershed areas that contribute to Malheur, Mud, and Harney Lakes. I selected images, about every 4 to 6 years from late June to late July, in an attempt to capture the peak vegetation growth and to avoid cloud cover. Complete coverage of …

Cooling Before Super-Eruption: No Role For Rejuvenation In The Cottonwood Wash Tuff Magma Body, Southern Great Basin Ignimbrite Province, Utah And Nevada, Keryn Tobler Ross

Theses and Dissertations

The model of rejuvenation of a near-solidus crystal mush to produce large volumes of crystal-rich magma is tested here by analyzing the mineralogical, chemical, modal, and physical characteristics of the 31.1 Ma super-eruptive (2000 km3) Cottonwood Wash Tuff. It is the oldest in a series of three so-called “monotonous intermediate” ignimbrites from the Indian Peak-Caliente volcanic field in southern Utah and Nevada. A crystal-rich (~50% Pl > Qz ≈ Hbl ≈ Bt > Mag ≈ Ilm > Cpx + Zrn + Ap+ Po) dacite (62 – 69 wt% SiO2), the Cottonwood Wash Tuff is similar in age, volume, mineralogy, crystallinity, and elemental composition …

Shaking Table Testing To Evaluate Effectiveness Of Prefabricated Vertical Drains For Liquefaction Mitigation, Caleb Robert Oakes

Theses and Dissertations

This study was designed to evaluate the ability of vertical drains to prevent liquefaction and limit associated settlement. Drain performance was investigated using full-scale tests with vertical drains in liquefiable sand using a laminar shear box with acceleration time histories applied at the base. Performance of the sand box with drains in these tests was compared with performance of the sane box without drains in previous tests. The test data was also used to create case histories which can be used for further research and calibration of computer models. Although some investigations regarding vertical drains have been performed with centrifuge …

Numerical Analysis Of Passive Force On Skewed Bridge Abutments, Zifan Guo

Theses and Dissertations

Accounting for seismic forces and thermal expansion in bridge design requires an accurate passive force-deflection relationship for the abutment wall. Current design codes make no allowance for skew effects on passive force; however, large scale field tests indicate that there is a substantial reduction in peak passive force as skew angle increases. A reduction in passive force also reduces the transverse shear resistance on the abutment. The purpose of this study is to validate three-dimensional model using PLAXIS 3D, against large scale test results performed at Brigham Young University and to develop a set of calibrated finite element models. The …

Consumer Assessment Of New Creative Products Across China And The United States, Eva Teruzzi

Creative Studies Graduate Student Master's Theses

This cross-cultural research investigates how consumers assess creativity in new products and if their assessment impacts desire to own. Implicit and explicit scale-based measures were tested in China and the U.S. in online consumer samples and were positively correlated. Novelty, affect and importance dimensions of creative products were tested through Horn and Salvendy’s (2006, 2009) Product Creativity Measurement (PCM) scale. Findings point to a different role of novelty in determining desirability of creative new products across-cultures.In fact, novelty and affect are key to explain desire to own in China, while affect and importance are the drivers in the U.S. Affect, …

Tracking Anisotropic Optical Tracers To Study Biophysical Processes And Cytotoxicity, Khanh Van Nguyen

All Dissertations

We use anisotropic optical tracers (also called magnetically modulated optical nanoprobes – MagMOONs or MOONs for non-magnetic nanoprobes in this dissertation) to study biophysical processes such as enzyme-catalyzed cleavage through tissue, intracellular transport of these tracers and cytotoxicity based on this transport. The anisotropic optical properties cause these tracers to blink when rotating. This blinking is distinguishable from the background and can be tracked on a single-particle level in the absence of tissue, or for an ensemble average of tracers blinking through tissue. An alginate gel containing these tracers in the form of a thin film can be used as …

Soviet Launch Of Sputnik: Sputnik-Inspired Educational Reform And Changes In Private Returns In America, Hyeonggu Cha

All Dissertations

On October 4th 1957, the Soviet Union launched the world’s first man-made satellite, Sputnik 1, into an elliptical low Earth orbit. This surprise triggered an arms race between the United States and the Soviet Union, and science-oriented educational reform in the U.S. The Sputnik swung off of the U.S. in military, politics, policies, and education. The Sputnik woke Americans up from complacency came from technology, science, and educational superiority. Educational reform started with emphasizing science and defense education and it was expanded to educations at all level. Early reforms, National Science Foundation (NSF), National Defense Education Act (NDEA) of 1958, …

In Vitro Multi-Scale Patient-Specific Modeling Of Hemodynamics In Stage 1 Norwood Palliation For The Treatment Of Single Ventricle Heart Disease, Tianqi Hang

All Dissertations

Hypoplastic left heart syndrome (HLHS) is a congenital heart defect in which the left ventricle is severely underdeveloped. The Norwood procedure is the first stage procedure to make an unrestrictive systemic blood flow and at the same time balance it with the pulmonary flow. This is done by constructing a neo-aorta using the pulmonary artery root and the autologous aorta, and then installing a shunt to the pulmonary artery. Variations of the Norwood surgery include the modified Blalock-Taussig (mBT) shunt, which diverts blood from the innominate artery to the pulmonary artery (PA), and the Right Ventricle Shunt (RVS), which diverts …

Electromechanical Modeling Of A Honeycomb Core Integrated Vibration Energy Converter With Increased Specific Power For Energy Harvesting Applications, Nataraj Chandrasekharan

All Dissertations

Innovation in integrated circuit technology along with improved manufacturing processes has resulted in considerable reduction in power consumption of electromechanical devices. Majority of these devices are currently powered by batteries. However, the issues posed by batteries, including the need for frequent battery recharge/replacement has resulted in a compelling need for alternate energy to achieve self-sufficient device operation or to supplement battery power. Vibration based energy harvesting methods through piezoelectric transduction provides with a promising potential towards replacing or supplementing battery power source. However, current piezoelectric energy harvesters generate low specific power (power-to-weight ratio) when compared to batteries that the harvesters …

Effects Of Semi-Rigid Plastic Tray Geometry On Thermal Processing And Quality Factors In Retorted Foods, Curtis Stowe

All Dissertations

This research studied the effect of packaging geometry changes on heat penetration and quality attributes of a food system processed in a rotary retort vessel. Studies were conducted to determine the effect of package geometry in a rotary retort on heat penetration, analytical, and physical properties of a model food system processed at optimum conditions. Additionally, heat mapping for each shape was used to determine the heating profiles during retorting. Retort-able trays were filled with a tomato based food simulate and thermally processed in a water immersion, automated batch retort system (ABRS) using rotational speeds of 6 RPM and 11 …

Developing Effective Ground And Space-Based Soil Moisture Sensing Techniques For Irrigating Cotton In Coastal Plain Soils, Xin Qiao

All Dissertations

Irrigation scheduling based on soil moisture sensor readings has gained popularity in the past few decades since it can enhance crop yield while saving water. Such method is limited since the representativeness of an individual soil moisture sensor measurement is questionable in a large field with variable soil type and texture. The optimum location of soil moisture sensors needs to be determined within such a production field for effective sensor-based irrigation scheduling. Therefore, the first object of this study was to investigate the optimum sensor location and the number of moisture sensors required for irrigating cotton in coastal plain soils. …

Bayesian Minimum Description Length Techniques For Multiple Changepoint Detection, Hewa Anuradha Priyadarshani

All Dissertations

This dissertation develops a minimum description length (MDL) multiple changepoint detection procedure that allows for prior distributions. MDL methods, which are penalized likelihood techniques with penalties based on data description-length information principles, have been successfully applied to many recent multiple changepoint problems. This work shows ow to modify the MDL penalty to account for various prior knowledge. Our motivation lies in climatology. Here, a metadata record, which is a file listing times when a recording station physically moved, instrumentation was changed, etc., sometimes exists. While metadata records are notoriously incomplete, they permit the construct a prior distribution that helps detect …

A Time-Efficient Strategy For Relay Selection And Link Scheduling In Wireless Communication Networks, Chenxi Qiu

All Dissertations

Despite the unprecedented success and proliferation of wireless communication, sustainable reliability and stability among wireless users are still considered important issues in the underlying link protocols. Existing link-layer protocols, like ARQ [44] or HARQ [57,67] approaches are designed to achieve this goal by discarding a corrupted packet at the receiver and performing one or more retransmissions until the packet is successfully decoded or a maximum number of retransmission attempts is reached. These strategies suffer from degradation of throughput and overall system instability since packets need to be en/decode in every hop, leading to high burden for relay nodes especially when …

Essays On Deceptive Counterfeits In Supply Chains: A Behavorial Perspective, Jillian Watson

All Dissertations

This dissertation is comprised of three essays intended to contribute to the operations management discipline, specifically within supply chain management. The first essay provides a research agenda for studying deceptive product counterfeits, which are products that have been manufactured and/or distributed and sold by an entity in violation of another’s intellectual property rights and intentionally misrepresented by the seller as the genuine article. The proliferation of counterfeits into legitimate supply chains presents quality, health and safety and cost concerns for nearly all industries. We identify antecedents of vulnerability to deceptive counterfeits for firms and their supply chain partners using Situational …

A Special Protection Scheme Utilizing Trajectory Sensitivity Analysis In Power Transmission, Dan Suriyamongkol

All Dissertations

In recent years, new measurement techniques have provided opportunities to improve the North American Power System observability, control and protection. This dissertation discusses the formulation and design of a special protection scheme based on a novel utilization of trajectory sensitivity techniques with inputs consisting of system state variables and parameters. Trajectory sensitivity analysis (TSA) has been used in previous publications as a method for power system security and stability assessment, and the mathematical formulation of TSA lends itself well to some of the time domain power system simulation techniques. Existing special protection schemes often have limited sets of goals and …

Web-Based Nutrition Education Intervention For African American Women Using The Theory Of Planned Behavior, Joyce Senior Angulo

All Dissertations

African American women have been disproportionately impacted for decades by the obesity epidemic, which frequently leads to severe chronic diseases such as cardiovascular disease, diabetes and hypertension. This increase in chronic diseases amongst African American women is the motivation for the design of a culturally tailored nutrition education (NE) program that combines a strong theoretical base with the use of technology such as the Internet, since its usage within the college aged African American community has rapidly increased. Little is known about the variables that motivate behavior change in regards to eating and physical activity habits among college aged African …

On Subgrid-Scale Physics In The Convective Atmospheric Surface Layer, Khuong Nguyen

All Dissertations

The dynamics of the subgrid-scale (SGS) stress and scalar flux in the convective atmospheric surface layer are studied using field measurements from the Advection Horizontal Array Turbulence Study (AHATS). We extend the array technique previously used to evaluate the SGS velocity and temperature to include measurements of the fluctuating pressure, enabling separation of the resolvable- and subgrid-scale pressure and allowing for the first-ever observations of the pressure covariance terms and the full SGS budgets. Non-dimensional forms of the budget terms are analysed as functions of the surface-layer stability parameter and the ratio of the wavelength of the spectral peak of …

Towards A Greater Understanding Of Hydrothermally Grown Garnets And Sesquioxide Crystals For Laser Applications, Cheryl Moore

All Dissertations

ABSTRACT The hydrothermal method of crystal growth offers many benefits over traditional melt-based techniques such as lower temperature requirements relieving detrimental high temperature effects such as stress fracturing and a closed-environment, which limits impurities. The continued study of this type of growth including hydrothermal epitaxy is crucial in our world of constant miniaturization. Presented in this thesis is the hydrothermal growth of crystals of LuAG and Lu2O3 doped with a variety of dopants. Their room-temperature and cryogenic absorption spectra are also presented. Much like Nature uses heat, pressure, water and a nutrient-rich feedstock we have used this hydrothermal technique to …

An Examination Of Academic Grit In Urban High Schools, Ronald Gorman

Dissertations

Currently, in America’s schools, approximately one in five high school students will not graduate with his or her peers, and many others will never receive a high school diploma (Stillwell & Sable, 2013). Many students arrive in our nation’s high schools without the requisite skills to be successful, and when they exhibit failure for the first time, a large percentage of them do not have the passion and perseverance to accomplish their long term goals – otherwise known as “academic grit,” a term coined by Duckworth (2007), a leading researcher in the area.

To investigate the issues mentioned above, a …

Social Learning Systems: The Design Of Evolutionary, Highly Scalable, Socially Curated Knowledge Systems, Nolan Hemmatazad

Student Work

In recent times, great strides have been made towards the advancement of automated reasoning and knowledge management applications, along with their associated methodologies. The introduction of the World Wide Web peaked academicians’ interest in harnessing the power of linked, online documents for the purpose of developing machine learning corpora, providing dynamical knowledge bases for question answering systems, fueling automated entity extraction applications, and performing graph analytic evaluations, such as uncovering the inherent structural semantics of linked pages. Even more recently, substantial attention in the wider computer science and information systems disciplines has been focused on the evolving study of social …

This Is Really Happening: Criticality And Discussions Of Context In Acrl's Framework For Information Literacy, Kevin Patrick Seeber

Communications in Information Literacy

The development of the ACRL Framework for Information Literacy has sparked an immense amount of conversation among academic librarians, though the profession is still far from consensus with regards to if, when, or how the document should be implemented. This essay argues that despite debates over various points within the text, the overall theme of the Framework is a call for librarians and educators to recognize the importance of context when discussing information literacy. As this relates to the curriculum of higher education, instruction and assignments can no longer afford to separate "school" from "real life." Classroom instruction must recognize …

The Intersection Of Civil And Religious Family Law In The U.S. Constitutional Order: A Mild Legal Pluralism, Linda C. Mcclain

Faculty Scholarship

This chapter considers how civil and religious family law intersect in the U.S. legal system and how U.S. constitutional law shapes and constrains the accommodation of religious pluralism as it pertains to family law. To the question, “Is there too much or too little pluralism in U.S. family law?,” I answer that family law appropriately embraces a mild legal pluralism, while clearly distinguishing between civil and religious marriage. After illustrating this distinction in the context of the recent controversy over same-sex marriage, I consider two categories of cases: (1) cases in which courts consider whether to enforce terms of Jewish …

Unveiling The Crucial Intermediates In Androgen Production, Piotr J. Mak, Michael C. Gregory, Ilia G. Denisov, Stephen G. Sligar, James R. Kincaid

Chemistry Faculty Research and Publications

Significance: The human enzyme cytochrome P450 17A1 (CYP17A1) catalyzes the critical step in the biosynthesis of the male sex hormones, and, as such, it is a key target for the inhibition of testosterone production that is necessary for the progression of certain cancers. CYP17A1 catalyzes two distinct types of chemical transformations. The first is the hydroxylation of the steroid precursors pregnenolone and progesterone. The second is a different reaction involving carbon–carbon (C-C) bond cleavage, the mechanism of which has been actively debated in the literature. Using a combination of chemical and biophysical methods, we have been able to trap and …